ES2293643T5 - Secuencias nucleotídicas de antígenos retrovíricos vih-1 del grupo (o subgrupo) o. - Google Patents
Secuencias nucleotídicas de antígenos retrovíricos vih-1 del grupo (o subgrupo) o. Download PDFInfo
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- ES2293643T5 ES2293643T5 ES95935996T ES95935996T ES2293643T5 ES 2293643 T5 ES2293643 T5 ES 2293643T5 ES 95935996 T ES95935996 T ES 95935996T ES 95935996 T ES95935996 T ES 95935996T ES 2293643 T5 ES2293643 T5 ES 2293643T5
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Classifications
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- A—HUMAN NECESSITIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
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- Biotechnology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9412554A FR2726006B1 (fr) | 1994-10-20 | 1994-10-20 | Sequences nucleotidiques codant des antigenes d'un retrovirus du type vih-1 groupe o |
| FR9412554 | 1994-10-20 | ||
| FR9502526A FR2731225B1 (fr) | 1995-03-03 | 1995-03-03 | Peptides de glycoproteine transmembranaire d'enveloppe et de proteine de capside du retrovirus humain du type hiv-1 et peptides presentant avec eux une parente immunologique |
| FR9502526 | 1995-03-03 | ||
| PCT/FR1995/001391 WO1996012809A2 (fr) | 1994-10-20 | 1995-10-20 | Sequences nucleotidiques d'antigenes retroviraux vih-1 groupe (ou sous-groupe) o |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2293643T3 ES2293643T3 (es) | 2008-03-16 |
| ES2293643T5 true ES2293643T5 (es) | 2012-02-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES95935996T Expired - Lifetime ES2293643T5 (es) | 1994-10-20 | 1995-10-20 | Secuencias nucleotídicas de antígenos retrovíricos vih-1 del grupo (o subgrupo) o. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6399294B1 (enExample) |
| EP (2) | EP0787191B2 (enExample) |
| JP (4) | JP4278174B2 (enExample) |
| CN (3) | CN102134609A (enExample) |
| AT (1) | ATE374253T1 (enExample) |
| AU (3) | AU715731B2 (enExample) |
| CA (2) | CA2202408C (enExample) |
| DE (1) | DE69535601T3 (enExample) |
| DK (1) | DK0787191T4 (enExample) |
| ES (1) | ES2293643T5 (enExample) |
| PT (1) | PT787191E (enExample) |
| WO (1) | WO1996012809A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PT787191E (pt) * | 1994-10-20 | 2007-12-06 | Pasteur Institut | Sequências nucleotídicas de antigénios retroviraisde vih do tipo (ou sub-tipo) o |
| AU710468B2 (en) * | 1995-01-27 | 1999-09-23 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods for sensitive detection of reverse transcriptase |
| DE19505262C2 (de) * | 1995-02-16 | 1998-06-18 | Behring Diagnostics Gmbh | Retrovirus aus der HIV-Gruppe und dessen Verwendung |
| IL132166A0 (en) * | 1997-04-09 | 2001-03-19 | Pasteur Sanofi Diagnostics | Synthetic peptides which can be used in biological tests for the detection of infections due to group o hiv-1 viruses |
| FR2761993B1 (fr) * | 1997-04-09 | 1999-05-21 | Pasteur Sanofi Diagnostics | Peptides synthetiques utilisables dans les essais biologiques pour la detection des infections dues aux virus vih 1 groupe 0 |
| FR2775287B1 (fr) * | 1998-02-24 | 2000-11-24 | Pasteur Sanofi Diagnostics | Peptides synthetiques consensus utilisables dans les essais biologiques pour la detection des infections dues aux virus vih 1 du groupe o |
| US6511801B1 (en) | 1997-07-18 | 2003-01-28 | Innogenetics, N.V. | HIV-1 group O antigens and uses thereof |
| US6846905B2 (en) | 1997-08-15 | 2005-01-25 | Abbott Laboratories | Antigen constructs useful in the detection and differentiation of antibodies to HIV |
| US5922533A (en) * | 1997-08-15 | 1999-07-13 | Abbott Laboratories | Rapid assay for simultaneous detection and differentiation of antibodies to HIV groups |
| AU2345399A (en) * | 1998-01-28 | 1999-08-16 | Universal Health-Watch, Inc. | Divergent hiv-1 peptides |
| CN1061092C (zh) * | 1998-02-27 | 2001-01-24 | 中国科学院上海生物化学研究所 | 白色念珠菌具有逆转录转座子结构的元件 |
| CA2288869A1 (en) * | 1998-03-04 | 1999-09-10 | Mary Ann Childs | Rapid confirmatory test for microbial infections |
| AU3670999A (en) * | 1998-04-30 | 1999-11-16 | Universal Health-Watch, Inc. | Immunoassay with mixed peptides |
| WO1999062945A2 (en) * | 1998-06-05 | 1999-12-09 | Peptide Solutions, Inc. | Peptide antigens for detection of hiv, hcv and other microbial infections |
| CA2676762C (en) * | 1998-11-30 | 2015-12-29 | Ortho-Clinical Diagnostics, Inc. | Peptides for the detection of hiv-1 group o |
| EP1187939B9 (en) * | 1999-07-09 | 2009-08-12 | Gen-Probe Incorporated | Detection of hiv-1 by nucleic acid amplification |
| US6818392B2 (en) | 2000-12-06 | 2004-11-16 | Abbott Laboratories | Monoclonal antibodies to human immunodeficiency virus and uses thereof |
| EP2251442B9 (en) | 2003-12-19 | 2012-04-25 | Gen-Probe Incorporated | Compositions, methods and kits for detecting the nucleic acids of HIV-1 and HIV-2 |
| TW200613554A (en) * | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| AU2005335203A1 (en) | 2004-09-08 | 2007-02-15 | The United States Of America As Represented By The Secretary Of Health And Human Services, Nih | Compositions and methods for the detection of HIV-1/HIV-2 infection |
| EP1989326A4 (en) | 2006-01-17 | 2009-09-30 | Health Research Inc | BIO-HETERODUPLEX TRACKING TEST |
| US8405379B1 (en) | 2008-09-18 | 2013-03-26 | Luc Montagnier | System and method for the analysis of DNA sequences in biological fluids |
| US20130302364A1 (en) * | 2010-11-10 | 2013-11-14 | Laboratorios Del Dr. Esteve, S.A. | Highly immunogenic hiv p24 sequences |
| EP2864787B1 (en) * | 2012-06-22 | 2017-11-01 | Bio-Rad Laboratories, Inc. | Human factor xiii as a normalization control for immunoassays |
| US9823249B2 (en) * | 2012-12-12 | 2017-11-21 | Brigham And Women's Hospital, Inc. | System and method for detecting pathogens |
| KR102056520B1 (ko) | 2017-03-24 | 2019-12-18 | (주)셀아이콘랩 | 인간 섬유아세포에서 콜라겐 합성 촉진 및 콜라겐 분해 효소 활성화 억제를 유도하는 펩타이드를 함유한 화장품 조성물 및 제조방법 |
| CN108997482B (zh) | 2018-08-09 | 2025-09-09 | 东莞市朋志生物科技有限公司 | 用于检测hiv-1的合成肽 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030714A (en) | 1986-06-23 | 1991-07-09 | Institut Pasteur | Variant of LAV viruses |
| JPH0762031B2 (ja) * | 1986-12-30 | 1995-07-05 | アメリカ合衆国 | エイズウイルスおよびエイズウイルスのタンパク質に対する細胞性免疫を誘導する合成ペプチド |
| NO881151L (no) * | 1987-03-27 | 1988-09-28 | Syntello Ab | Syntetisk hiv-1-antigen. |
| CA1339363C (en) * | 1987-05-01 | 1997-08-26 | Alan Ray Flesher | Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use |
| JPH0215098A (ja) * | 1987-05-18 | 1990-01-18 | Virovahl Sa | Hiv−1感染検出用合成ペプチド杭原、その組成物およびその使用方法 |
| US5019387A (en) * | 1987-09-08 | 1991-05-28 | Duke University | Production of antibodies to HIV |
| IL88963A (en) * | 1988-01-27 | 1996-05-14 | Iaf Biochem Int | Circular synthetic peptides and their mixtures for the detection of VIH antibodies and for the formation of vaccines |
| EP0330359A3 (en) | 1988-02-25 | 1991-06-05 | Bio-Rad Laboratories, Inc. | Composition useful in the diagnosis and treating of hiv-1 infection |
| ES2072853T3 (es) | 1988-06-09 | 1995-08-01 | Innogenetics Nv | Retrovirus hiv-3 y su utilizacion. |
| ATE135113T1 (de) * | 1988-12-20 | 1996-03-15 | Clarity Technologies Inc | Synthetische hiv ähnliche peptide, deren zusammensetzungen und verwendungen |
| GB8910145D0 (en) * | 1989-05-03 | 1989-06-21 | Connaught Lab | Synthetic peptides for an hiv-1 vaccine |
| ZA903492B (en) * | 1989-05-15 | 1991-02-27 | Akzo Nv | T-lymphotropic retrovirus monoclonal antibodies |
| FR2647810B1 (fr) * | 1989-06-02 | 1994-07-22 | Pasteur Institut | Amorces oligonucleotidiques pour l'amplification du genome des retrovirus du type hiv-2 et siv, et leurs applications au diagnostic in vitro des infections dues a ces virus |
| DE3934366A1 (de) * | 1989-10-14 | 1991-04-18 | Chemotherapeutisches Forschungsinstitut Georg Speyer Haus | Vakzine zum schutz vor hiv-virusinfektionen, verfahren zu ihrer herstellung und ihre verwendung als diagnostikum und immuntherapeutikum |
| US5480967A (en) * | 1990-01-05 | 1996-01-02 | United Biomedical, Inc. | HIV-1 core protein fragments |
| IL99077A0 (en) * | 1990-08-13 | 1992-07-15 | Merck & Co Inc | New embodiments of the hiv principal neutralizing determinant and pharmaceutical compositions containing them |
| JPH06500923A (ja) * | 1990-09-21 | 1994-01-27 | カイロン コーポレイション | パッケージング細胞 |
| US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
| JP2541030B2 (ja) * | 1991-04-22 | 1996-10-09 | 富士ゼロックス株式会社 | ヒドロキシインジウムフタロシアニンの新規結晶及びそれを用いた電子写真感光体 |
| JP3443809B2 (ja) * | 1992-03-06 | 2003-09-08 | エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム | 免疫学的に重要なエピトープに相当するペプチドの決定方法、及び免疫学的に重要なエピトープに相当するビオチニル化ペプチド又は抗体の決定のための方法におけるその利用、その調製方法及びそれを含む組成物 |
| ES2053413T3 (es) * | 1992-05-14 | 1997-11-16 | Polymun Scient Immunbio Forsch | Peptidos que inducen anticuerpos que neutralizan aislados de vih-1 geneticamente divergentes. |
| JP3207535B2 (ja) | 1992-08-07 | 2001-09-10 | 森永乳業株式会社 | 抗酸化剤 |
| ES2126620T5 (es) | 1992-10-06 | 2010-05-21 | Siemens Healthcare Diagnostics Products Gmbh | Retrovirus del grupo de los vih y su utilizacion. |
| WO1994028871A1 (en) | 1993-06-07 | 1994-12-22 | Endocon, Inc. | Implant stimulated cellular immunity |
| KR960703136A (ko) | 1993-06-09 | 1996-06-19 | 미첼 클레인 | 탠덤 합성 hiv-1 펩티드들 |
| FR2707091B1 (fr) * | 1993-06-30 | 1997-04-04 | Cohen Haguenauer Odile | Vecteur rétroviral pour le transfert et l'expression de gènes dans des cellules eucaryotes. |
| PT787191E (pt) | 1994-10-20 | 2007-12-06 | Pasteur Institut | Sequências nucleotídicas de antigénios retroviraisde vih do tipo (ou sub-tipo) o |
| DE19622088A1 (de) | 1996-05-31 | 1997-12-04 | Boehringer Mannheim Gmbh | Anti-HIV-Antikörper als Kontrollproben |
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1995
- 1995-10-20 PT PT95935996T patent/PT787191E/pt unknown
- 1995-10-20 DK DK95935996.9T patent/DK0787191T4/da active
- 1995-10-20 EP EP95935996A patent/EP0787191B2/fr not_active Expired - Lifetime
- 1995-10-20 CA CA2202408A patent/CA2202408C/fr not_active Expired - Lifetime
- 1995-10-20 ES ES95935996T patent/ES2293643T5/es not_active Expired - Lifetime
- 1995-10-20 WO PCT/FR1995/001391 patent/WO1996012809A2/fr not_active Ceased
- 1995-10-20 CN CN2010102008955A patent/CN102134609A/zh active Pending
- 1995-10-20 EP EP07003648A patent/EP1849869A3/fr not_active Withdrawn
- 1995-10-20 CA CA2652992A patent/CA2652992C/fr not_active Expired - Lifetime
- 1995-10-20 JP JP51369296A patent/JP4278174B2/ja not_active Expired - Lifetime
- 1995-10-20 US US08/817,441 patent/US6399294B1/en not_active Expired - Lifetime
- 1995-10-20 AU AU38089/95A patent/AU715731B2/en not_active Expired
- 1995-10-20 CN CNB951963678A patent/CN1147586C/zh not_active Expired - Lifetime
- 1995-10-20 AT AT95935996T patent/ATE374253T1/de active
- 1995-10-20 DE DE69535601T patent/DE69535601T3/de not_active Expired - Lifetime
- 1995-10-20 CN CN2004100078820A patent/CN1651457B/zh not_active Expired - Lifetime
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2001
- 2001-12-27 US US10/026,741 patent/US7157225B2/en not_active Expired - Fee Related
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2005
- 2005-05-24 AU AU2005202281A patent/AU2005202281B2/en not_active Expired
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2006
- 2006-11-02 US US11/591,678 patent/US8236324B2/en not_active Expired - Fee Related
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2008
- 2008-05-07 JP JP2008121431A patent/JP4589420B2/ja not_active Expired - Lifetime
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2009
- 2009-06-09 JP JP2009138688A patent/JP2009240315A/ja not_active Withdrawn
- 2009-09-10 AU AU2009213045A patent/AU2009213045B2/en not_active Expired
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2010
- 2010-03-04 JP JP2010048112A patent/JP2010172335A/ja not_active Withdrawn
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