ES2288550T3 - Compuestos autoinductores y sus utilizaciones. - Google Patents
Compuestos autoinductores y sus utilizaciones. Download PDFInfo
- Publication number
- ES2288550T3 ES2288550T3 ES02727000T ES02727000T ES2288550T3 ES 2288550 T3 ES2288550 T3 ES 2288550T3 ES 02727000 T ES02727000 T ES 02727000T ES 02727000 T ES02727000 T ES 02727000T ES 2288550 T3 ES2288550 T3 ES 2288550T3
- Authority
- ES
- Spain
- Prior art keywords
- animal
- lactone
- thiolactone
- acyl
- homoserine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 68
- 241001465754 Metazoa Species 0.000 claims abstract description 109
- -1 acyl homoserine lactones Chemical class 0.000 claims abstract description 47
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 125000002252 acyl group Chemical group 0.000 claims abstract description 12
- 108010076504 Protein Sorting Signals Proteins 0.000 claims abstract description 6
- 235000019730 animal feed additive Nutrition 0.000 claims abstract description 4
- 235000013305 food Nutrition 0.000 claims description 57
- 238000000034 method Methods 0.000 claims description 30
- 230000001939 inductive effect Effects 0.000 claims description 26
- 238000004519 manufacturing process Methods 0.000 claims description 16
- OROGUZVNAFJPHA-UHFFFAOYSA-N 3-hydroxy-2,4-dimethyl-2H-thiophen-5-one Chemical compound CC1SC(=O)C(C)=C1O OROGUZVNAFJPHA-UHFFFAOYSA-N 0.000 claims description 15
- 230000012010 growth Effects 0.000 claims description 13
- 241001494479 Pecora Species 0.000 claims description 12
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 claims description 11
- QJPWUUJVYOJNMH-VKHMYHEASA-N L-homoserine lactone Chemical compound N[C@H]1CCOC1=O QJPWUUJVYOJNMH-VKHMYHEASA-N 0.000 claims description 10
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 10
- 241000283690 Bos taurus Species 0.000 claims description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 150000002596 lactones Chemical class 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 230000001580 bacterial effect Effects 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
- 239000003674 animal food additive Substances 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 239000008101 lactose Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 230000006872 improvement Effects 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 claims description 4
- OBNCKNCVKJNDBV-UHFFFAOYSA-N ethyl butyrate Chemical compound CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 claims description 4
- RGXWDWUGBIJHDO-UHFFFAOYSA-N ethyl decanoate Chemical compound CCCCCCCCCC(=O)OCC RGXWDWUGBIJHDO-UHFFFAOYSA-N 0.000 claims description 4
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 claims description 4
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 claims description 4
- BYEVBITUADOIGY-UHFFFAOYSA-N ethyl nonanoate Chemical compound CCCCCCCCC(=O)OCC BYEVBITUADOIGY-UHFFFAOYSA-N 0.000 claims description 4
- YYZUSRORWSJGET-UHFFFAOYSA-N ethyl octanoate Chemical compound CCCCCCCC(=O)OCC YYZUSRORWSJGET-UHFFFAOYSA-N 0.000 claims description 4
- QJPWUUJVYOJNMH-UHFFFAOYSA-N homoserine lactone Chemical compound NC1CCOC1=O QJPWUUJVYOJNMH-UHFFFAOYSA-N 0.000 claims description 4
- 239000000411 inducer Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 244000144977 poultry Species 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 241000251468 Actinopterygii Species 0.000 claims description 3
- KQWWVLVLVYYYDT-UHFFFAOYSA-N ethyl 3-oxohexanoate Chemical compound CCCC(=O)CC(=O)OCC KQWWVLVLVYYYDT-UHFFFAOYSA-N 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- UTYLBXYHFVCKFN-GFCCVEGCSA-N (2R)-2-(2-hydroxyethyl)-2-nitroso-3-oxodecanoic acid Chemical compound O=N[C@@](CCO)(C(=O)O)C(CCCCCCC)=O UTYLBXYHFVCKFN-GFCCVEGCSA-N 0.000 claims description 2
- VPGUYEBVVIQDBX-NSHDSACASA-N (2s)-4-hydroxy-2-(nonanoylamino)butanoic acid Chemical compound CCCCCCCCC(=O)N[C@H](C(O)=O)CCO VPGUYEBVVIQDBX-NSHDSACASA-N 0.000 claims description 2
- LGQBYLSSSHXBCX-ZETCQYMHSA-N (2s)-4-hydroxy-2-(pentanoylamino)butanoic acid Chemical compound CCCCC(=O)N[C@H](C(O)=O)CCO LGQBYLSSSHXBCX-ZETCQYMHSA-N 0.000 claims description 2
- 241000282472 Canis lupus familiaris Species 0.000 claims description 2
- 241000195493 Cryptophyta Species 0.000 claims description 2
- 241000283086 Equidae Species 0.000 claims description 2
- ICMAFTSLXCXHRK-UHFFFAOYSA-N Ethyl pentanoate Chemical compound CCCCC(=O)OCC ICMAFTSLXCXHRK-UHFFFAOYSA-N 0.000 claims description 2
- 241000282326 Felis catus Species 0.000 claims description 2
- FTMZLSDESAOPSZ-VIFPVBQESA-N N-Heptanoylhomoserine lactone Chemical compound CCCCCCC(=O)N[C@H]1CCOC1=O FTMZLSDESAOPSZ-VIFPVBQESA-N 0.000 claims description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 2
- 241000282887 Suidae Species 0.000 claims description 2
- 239000006227 byproduct Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 235000013339 cereals Nutrition 0.000 claims description 2
- 238000004440 column chromatography Methods 0.000 claims description 2
- 235000013601 eggs Nutrition 0.000 claims description 2
- UKRVECBFDMVBPU-UHFFFAOYSA-N ethyl 3-oxoheptanoate Chemical compound CCCCC(=O)CC(=O)OCC UKRVECBFDMVBPU-UHFFFAOYSA-N 0.000 claims description 2
- ZQZBPLVTKYAPOF-UHFFFAOYSA-N ethyl 3-oxononanoate Chemical compound CCCCCCC(=O)CC(=O)OCC ZQZBPLVTKYAPOF-UHFFFAOYSA-N 0.000 claims description 2
- YGRJFGCEOYRREO-UHFFFAOYSA-N ethyl 3-oxooctanoate Chemical compound CCCCCC(=O)CC(=O)OCC YGRJFGCEOYRREO-UHFFFAOYSA-N 0.000 claims description 2
- UDRCONFHWYGWFI-UHFFFAOYSA-N ethyl 3-oxopentanoate Chemical compound CCOC(=O)CC(=O)CC UDRCONFHWYGWFI-UHFFFAOYSA-N 0.000 claims description 2
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 239000003925 fat Substances 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 235000012041 food component Nutrition 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- 235000013372 meat Nutrition 0.000 claims description 2
- 244000005700 microbiome Species 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- MELCHBVBYGSSOC-UHFFFAOYSA-N naphthalene-1-carboximidamide Chemical compound C1=CC=C2C(C(=N)N)=CC=CC2=C1 MELCHBVBYGSSOC-UHFFFAOYSA-N 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000011541 reaction mixture Substances 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- 150000008163 sugars Chemical class 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- 239000008096 xylene Substances 0.000 claims description 2
- 239000000306 component Substances 0.000 claims 3
- 239000002778 food additive Substances 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- 239000005428 food component Substances 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 150000002241 furanones Chemical class 0.000 abstract 1
- 210000004767 rumen Anatomy 0.000 description 31
- 230000000694 effects Effects 0.000 description 23
- 241000271566 Aves Species 0.000 description 13
- 230000008034 disappearance Effects 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 241000894006 Bacteria Species 0.000 description 11
- 230000037396 body weight Effects 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- 241000287828 Gallus gallus Species 0.000 description 10
- 241000894007 species Species 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000003242 anti bacterial agent Substances 0.000 description 7
- 229940088710 antibiotic agent Drugs 0.000 description 7
- 235000005911 diet Nutrition 0.000 description 7
- 230000037213 diet Effects 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
- 230000000813 microbial effect Effects 0.000 description 6
- 230000011664 signaling Effects 0.000 description 6
- 229910001868 water Inorganic materials 0.000 description 6
- 230000034994 death Effects 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 244000025254 Cannabis sativa Species 0.000 description 4
- KQXDHUJYNAXLNZ-XQSDOZFQSA-N Salinomycin Chemical compound O1[C@@H]([C@@H](CC)C(O)=O)CC[C@H](C)[C@@H]1[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(C=C[C@@H](O)[C@@]3(O[C@@](C)(CC3)[C@@H]3O[C@@H](C)[C@@](O)(CC)CC3)O2)O1 KQXDHUJYNAXLNZ-XQSDOZFQSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- YRYOXRMDHALAFL-UHFFFAOYSA-N N-(3-oxohexanoyl)homoserine lactone Chemical compound CCCC(=O)CC(=O)NC1CCOC1=O YRYOXRMDHALAFL-UHFFFAOYSA-N 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 240000008042 Zea mays Species 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 235000013330 chicken meat Nutrition 0.000 description 3
- 230000002860 competitive effect Effects 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000009246 food effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 235000013594 poultry meat Nutrition 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 108010001478 Bacitracin Proteins 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- YRYOXRMDHALAFL-QMMMGPOBSA-N N-(3-oxohexanoyl)-L-homoserine lactone Chemical compound CCCC(=O)CC(=O)N[C@H]1CCOC1=O YRYOXRMDHALAFL-QMMMGPOBSA-N 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 102000015636 Oligopeptides Human genes 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 239000004189 Salinomycin Substances 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000011888 autopsy Methods 0.000 description 2
- 229960003071 bacitracin Drugs 0.000 description 2
- 229930184125 bacitracin Natural products 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000029918 bioluminescence Effects 0.000 description 2
- 238000005415 bioluminescence Methods 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000011436 cob Substances 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 244000005709 gut microbiome Species 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 235000019378 salinomycin Nutrition 0.000 description 2
- 229960001548 salinomycin Drugs 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- CBWALJHXHCJYTE-OAHLLOKOSA-N (R)-3-hydroxypalmitic acid Chemical compound CCCCCCCCCCCCC[C@@H](O)CC(O)=O CBWALJHXHCJYTE-OAHLLOKOSA-N 0.000 description 1
- IKQUESGRCDRZTI-UHFFFAOYSA-N 3-Hydroxy-N-(2-oxooxolan-3-yl)tetradecanamide Chemical compound CCCCCCCCCCCC(O)CC(=O)NC1CCOC1=O IKQUESGRCDRZTI-UHFFFAOYSA-N 0.000 description 1
- FIXDIFPJOFIIEC-UHFFFAOYSA-N 3-hydroxy-n-(2-oxooxolan-3-yl)butanamide Chemical compound CC(O)CC(=O)NC1CCOC1=O FIXDIFPJOFIIEC-UHFFFAOYSA-N 0.000 description 1
- FXCMGCFNLNFLSH-JTQLQIEISA-N 3-oxo-octanoic acid (2-oxo-tetrahydro-furan-3-yl)-amide Chemical compound CCCCCC(=O)CC(=O)N[C@H]1CCOC1=O FXCMGCFNLNFLSH-JTQLQIEISA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000588879 Chromobacterium violaceum Species 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 206010011906 Death Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 229920002444 Exopolysaccharide Polymers 0.000 description 1
- 206010016275 Fear Diseases 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229920002488 Hemicellulose Polymers 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 206010024652 Liver abscess Diseases 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 208000006758 Marek Disease Diseases 0.000 description 1
- PHSRRHGYXQCRPU-AWEZNQCLSA-N N-(3-oxododecanoyl)-L-homoserine lactone Chemical compound CCCCCCCCCC(=O)CC(=O)N[C@H]1CCOC1=O PHSRRHGYXQCRPU-AWEZNQCLSA-N 0.000 description 1
- MVTQIFVKRXBCHS-SMMNFGSLSA-N N-[(3S,6S,12R,15S,16R,19S,22S)-3-benzyl-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide (10R,11R,12E,17E,19E,21S)-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone Chemical compound CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c2coc(CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1C)n2.CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O)c1ccccc1 MVTQIFVKRXBCHS-SMMNFGSLSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- FXCMGCFNLNFLSH-UHFFFAOYSA-N OOHL Natural products CCCCCC(=O)CC(=O)NC1CCOC1=O FXCMGCFNLNFLSH-UHFFFAOYSA-N 0.000 description 1
- 241000932831 Pantoea stewartii Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000607568 Photobacterium Species 0.000 description 1
- 241000611831 Prevotella sp. Species 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 241000589774 Pseudomonas sp. Species 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 241000606009 Ruminobacter Species 0.000 description 1
- 241000134861 Ruminococcus sp. Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 239000004188 Virginiamycin Substances 0.000 description 1
- 108010080702 Virginiamycin Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000003855 acyl compounds Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 239000006053 animal diet Substances 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
- 235000021168 barbecue Nutrition 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003224 coccidiostatic agent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000009615 deamination Effects 0.000 description 1
- 238000006481 deamination reaction Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000021196 dietary intervention Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 235000020676 food antibiotic Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 150000002243 furanoses Chemical class 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000002555 ionophore Substances 0.000 description 1
- 230000000236 ionophoric effect Effects 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 101150006217 lex1 gene Proteins 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000003345 natural gas Substances 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000000238 one-dimensional nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 150000003248 quinolines Chemical group 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 238000003044 randomized block design Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000033458 reproduction Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- LLYYNOVSVPBRGV-MVNKZKPCSA-N valnemulin Chemical compound CC(C)[C@@H](N)C(=O)NCC(C)(C)SCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 LLYYNOVSVPBRGV-MVNKZKPCSA-N 0.000 description 1
- 229950008166 valnemulin Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019373 virginiamycin Nutrition 0.000 description 1
- 229960003842 virginiamycin Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Paper (AREA)
- Supplying Of Containers To The Packaging Station (AREA)
- Vehicle Body Suspensions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0100387A GB0100387D0 (en) | 2001-01-08 | 2001-01-08 | The application of quorum sensing signals to improve ruminant performance |
| GB0100387 | 2001-01-08 | ||
| GB0109477A GB0109477D0 (en) | 2001-04-18 | 2001-04-18 | The application of quorum sensing signals to improve animal performance |
| GB0109477 | 2001-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2288550T3 true ES2288550T3 (es) | 2008-01-16 |
Family
ID=26245534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02727000T Expired - Lifetime ES2288550T3 (es) | 2001-01-08 | 2002-01-08 | Compuestos autoinductores y sus utilizaciones. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7651699B2 (enExample) |
| EP (1) | EP1361801B1 (enExample) |
| JP (2) | JP4499355B2 (enExample) |
| AT (1) | ATE363839T1 (enExample) |
| AU (1) | AU2002219348B2 (enExample) |
| CA (1) | CA2434117C (enExample) |
| DE (1) | DE60220503T2 (enExample) |
| DK (1) | DK1361801T3 (enExample) |
| ES (1) | ES2288550T3 (enExample) |
| WO (1) | WO2002052949A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE523209C2 (sv) * | 2002-05-14 | 2004-04-06 | Akzo Nobel Nv | Förfarande för att reducera metanbildningen från matspjälkningsaktiviteter hos djur |
| ATE433445T1 (de) | 2003-03-03 | 2009-06-15 | Eisai Corp North America | Thiolactone als naaladase inhibitoren |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| US7662967B2 (en) | 2007-08-02 | 2010-02-16 | Cambridge Enterprise Limited | Anti-inflammatory compounds and compositions |
| GB2452696B (en) | 2007-08-02 | 2009-09-23 | Cambridge Entpr Ltd | 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions |
| WO2010150691A1 (ja) * | 2009-06-22 | 2010-12-29 | 住友重機械工業株式会社 | アンモニア態窒素含有排水処理方法 |
| US8624063B2 (en) | 2009-06-30 | 2014-01-07 | Wisconsin Alumni Research Foundation | Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing |
| US8952192B2 (en) | 2011-03-24 | 2015-02-10 | University Of Maryland, College Park | Phosphorylated and branched dihydroxy-pentane-dione (DPD) analogs as quorum sensing inhibitors in bacteria |
| ES2856207T3 (es) | 2014-05-23 | 2021-09-27 | Phibro Animal Health Corporation | Combinación, composición y método de administración de la combinación o composición a los animales |
| CN104206920A (zh) * | 2014-09-25 | 2014-12-17 | 冀照明 | 一种中草药羊饲料添加剂 |
| US10526278B2 (en) | 2017-10-19 | 2020-01-07 | Wisconsin Alumni Research Foundation | Inhibitors of quorum sensing receptor LasR |
| CN113930462A (zh) * | 2021-10-19 | 2022-01-14 | 江南大学 | 高丝氨酸内酯信号分子促进碳链延长微生物合成己酸的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH538476A (de) * | 1966-09-29 | 1973-06-30 | Ciba Geigy Ag | Verfahren zur Herstellung von heterocyclischen Carbonsäuren |
| US4591872A (en) * | 1982-09-27 | 1986-05-27 | Power Science, Inc. | X-Y distinguishable multi-trace coding for multiparameter recording of a single stylus recorder |
| US4994379A (en) * | 1983-03-09 | 1991-02-19 | Cetus Corporation | Modified signal peptides |
| DE3312425A1 (de) * | 1983-04-07 | 1984-10-11 | Basf Ag, 6700 Ludwigshafen | Stoffmischungen mit wachstumsfoerdernder und leistungssteigernder wirkung sowie futtermittel und traenkfluessigkeiten, die geringe mengen dieser stoffmischungen enthalten |
| US4815016A (en) * | 1986-07-24 | 1989-03-21 | Unisys Corp. | High speed logical circuit simulator |
| NO882653D0 (no) * | 1988-06-15 | 1988-06-15 | Apothekernes Lab | Doseringsform. |
| US5162337A (en) * | 1990-10-05 | 1992-11-10 | Merck & Co., Inc. | Animal growth promotion |
| GB9108307D0 (en) | 1991-04-18 | 1991-06-05 | Univ Nottingham | Autoinducer |
| US5776974A (en) * | 1993-07-02 | 1998-07-07 | The University Of Nottingham | Immunosuppressant compounds |
| US5591872A (en) * | 1993-08-09 | 1997-01-07 | The University Of Iowa Research Foundation | Autoinducer molecule |
| US6936447B1 (en) * | 2000-04-03 | 2005-08-30 | University Of Iowa Research Foundation | Autoinducer molecule |
| US5698246A (en) * | 1996-01-29 | 1997-12-16 | Cargill, Incorporated | Foodstuff for and method of feeding crustaceans and fish |
| WO1997027851A1 (en) | 1996-02-01 | 1997-08-07 | The Johns-Hopkins University | L-homoserine and l-homoserine lactone as bacteriostatic agents for m. tuberculosis and m. bovis |
| JP3865461B2 (ja) | 1997-06-16 | 2007-01-10 | 株式会社日立製作所 | Ｉｃカード読み書き装置 |
| DE69836218T2 (de) | 1997-06-18 | 2007-09-06 | Montana State University - Bozeman | Homoserinlactone zum regulieren von biofilmen und methoden zur anwendung |
| JP3834763B2 (ja) * | 1997-09-03 | 2006-10-18 | 岡部産業株式会社 | 混合飼料 |
| JPH11269142A (ja) * | 1998-03-18 | 1999-10-05 | Toa Yakuhin Kogyo Kk | アゼチジン誘導体、それを有効成分とするビフィズス菌分裂促進組成物およびその製造方法 |
| US6395282B1 (en) * | 1998-04-16 | 2002-05-28 | University Of Rochester | Immunogenic conjugates of Gram-negative bacterial autoinducer molecules |
| US6337347B1 (en) * | 1998-06-18 | 2002-01-08 | The Research & Development Institute, Inc. | Autoinducer compounds |
| US6723321B2 (en) * | 1998-07-31 | 2004-04-20 | The Board Of Trustees Of The University Of Illinois | Autoinducer synthase modulating compounds and uses thereof |
| JP2000069985A (ja) | 1998-09-01 | 2000-03-07 | Basic Industries Bureau Miti | 細菌培養による化合物の製造方法及び植物生育促進剤 |
| GB0007588D0 (en) * | 2000-03-30 | 2000-05-17 | Univ Nottingham | N-Acyl homoserine lactones |
| MXPA02012825A (es) | 2000-06-23 | 2004-07-30 | Acuabiotec Llc | Complejo bioactivo alimenticio, metodo para preparar producto complejo bioactivo alimenticio y metodo para controlar la enfermedad. |
| US20030078231A1 (en) * | 2001-06-22 | 2003-04-24 | Wilburn Michael D. | Orthomolecular sulpho-adenosylmethionine derivatives with antioxidant properties |
-
2002
- 2002-01-08 AT AT02727000T patent/ATE363839T1/de not_active IP Right Cessation
- 2002-01-08 ES ES02727000T patent/ES2288550T3/es not_active Expired - Lifetime
- 2002-01-08 EP EP02727000A patent/EP1361801B1/en not_active Expired - Lifetime
- 2002-01-08 AU AU2002219348A patent/AU2002219348B2/en not_active Ceased
- 2002-01-08 WO PCT/GB2002/000072 patent/WO2002052949A1/en not_active Ceased
- 2002-01-08 DE DE60220503T patent/DE60220503T2/de not_active Expired - Lifetime
- 2002-01-08 DK DK02727000T patent/DK1361801T3/da active
- 2002-01-08 CA CA2434117A patent/CA2434117C/en not_active Expired - Fee Related
- 2002-01-08 US US10/250,842 patent/US7651699B2/en not_active Expired - Fee Related
- 2002-01-08 JP JP2002553913A patent/JP4499355B2/ja not_active Expired - Fee Related
-
2007
- 2007-12-19 JP JP2007327905A patent/JP2008079623A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE363839T1 (de) | 2007-06-15 |
| DK1361801T3 (da) | 2007-10-08 |
| DE60220503T2 (de) | 2008-01-31 |
| JP2004525617A (ja) | 2004-08-26 |
| JP4499355B2 (ja) | 2010-07-07 |
| JP2008079623A (ja) | 2008-04-10 |
| WO2002052949A1 (en) | 2002-07-11 |
| CA2434117C (en) | 2011-03-01 |
| DE60220503D1 (de) | 2007-07-19 |
| EP1361801A1 (en) | 2003-11-19 |
| US7651699B2 (en) | 2010-01-26 |
| EP1361801B1 (en) | 2007-06-06 |
| AU2002219348B2 (en) | 2006-11-16 |
| US20040115245A1 (en) | 2004-06-17 |
| CA2434117A1 (en) | 2002-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008079623A (ja) | 自己誘導因子化合物およびその使用 | |
| SU997646A1 (ru) | Кормова добавка | |
| ES2233706T3 (es) | Utilizacion de alcaloides de benzofenantridina como aditivos para pienso. | |
| AU2002219348A1 (en) | Autoinducer compounds and their uses | |
| CN107410187A (zh) | 一种黄牛的饲养方法 | |
| US20240090533A1 (en) | Methods and formulations for reducing bovine emissions | |
| JP2004525617A5 (enExample) | ||
| CS253570B2 (en) | Fodder ingredient | |
| ES2307179T3 (es) | Pienso que contiene alacaloide o aditivo para pienso. | |
| RU2676318C1 (ru) | Способ применения кормовой добавки для бычков | |
| RU2340204C1 (ru) | Способ кормления цыплят-бройлеров | |
| CA1254437A (en) | Growth stimulant for animals | |
| KR20020059730A (ko) | 가축 생산성 개선을 위한 아릴옥시 프로판올아민 | |
| Kan et al. | Feed additives: do they add to animal welfare? An evaluation | |
| SU1521432A1 (ru) | Способ выращивани молодн ка сельскохоз йственных животных | |
| CN107518192A (zh) | 一种生态猪饲料及其使用方法 | |
| Flores-Tejeida et al. | A review of hot and sweet pepper added in animal nutrition: alternative against the use of antibiotics | |
| Milton et al. | Supplementation of cattle browsing tagasaste (Chamaecytisus proliferus) during autumn improves liveweight gain | |
| CN119563770A (zh) | 一种动物用非抗生素抑菌促生长饲料添加剂及其应用 | |
| CN108992448A (zh) | 一种观赏鱼用含盐除菌片剂及其制备方法 | |
| JPH07132080A (ja) | 菌体組成物 | |
| JPS59227250A (ja) | 有用動物の飼育及び肥育における非特異性作用物質の組合せの投与法 |