ES2287161T3 - Analogos de trombomodulina para uso en la recuperacion de la lesion de la medula espinal. - Google Patents

Analogos de trombomodulina para uso en la recuperacion de la lesion de la medula espinal. Download PDF

Info

Publication number
ES2287161T3
ES2287161T3 ES01973674T ES01973674T ES2287161T3 ES 2287161 T3 ES2287161 T3 ES 2287161T3 ES 01973674 T ES01973674 T ES 01973674T ES 01973674 T ES01973674 T ES 01973674T ES 2287161 T3 ES2287161 T3 ES 2287161T3
Authority
ES
Spain
Prior art keywords
thrombomodulin
injury
amino acid
baselineskip
native
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01973674T
Other languages
English (en)
Spanish (es)
Inventor
Barry W. Festoff
Michael John Morser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paion Deutschland GmbH
Original Assignee
Paion Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Deutschland GmbH filed Critical Paion Deutschland GmbH
Application granted granted Critical
Publication of ES2287161T3 publication Critical patent/ES2287161T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/366—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Communication Cables (AREA)
  • Signal Processing Not Specific To The Method Of Recording And Reproducing (AREA)
  • Ropes Or Cables (AREA)
ES01973674T 2000-08-31 2001-08-31 Analogos de trombomodulina para uso en la recuperacion de la lesion de la medula espinal. Expired - Lifetime ES2287161T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22971400P 2000-08-31 2000-08-31
US229714P 2000-08-31
US938405 2001-08-23
US09/938,405 US20020111296A1 (en) 2000-08-31 2001-08-23 Thrombomodulin analogs for use in recovery of spinal cord injury

Publications (1)

Publication Number Publication Date
ES2287161T3 true ES2287161T3 (es) 2007-12-16

Family

ID=26923554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01973674T Expired - Lifetime ES2287161T3 (es) 2000-08-31 2001-08-31 Analogos de trombomodulina para uso en la recuperacion de la lesion de la medula espinal.

Country Status (13)

Country Link
US (3) US20020111296A1 (enExample)
EP (1) EP1365788B1 (enExample)
JP (1) JP2004521076A (enExample)
AT (1) ATE361755T1 (enExample)
AU (2) AU9322901A (enExample)
CA (1) CA2420900A1 (enExample)
DE (1) DE60128399T2 (enExample)
DK (1) DK1365788T3 (enExample)
ES (1) ES2287161T3 (enExample)
IL (2) IL154600A0 (enExample)
NO (1) NO20030919L (enExample)
PT (1) PT1365788E (enExample)
WO (1) WO2002017953A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006005362A1 (en) * 2004-07-13 2006-01-19 Paion Deutschland Gmbh Production of mammalian proteins in plant cells
US20060148695A1 (en) * 2005-01-03 2006-07-06 National Cheng Kung University Novel angiogenic composition and use thereof
US8293710B2 (en) * 2005-01-03 2012-10-23 Blue Blood Biotech Corp. Method for treating wounds using an EGF-like domain of thrombomodulin
EP1912660A1 (en) * 2005-08-11 2008-04-23 Medigenes Co., Ltd. Pharmaceutical composition for the treatment of nerve damage comprising blood plasma or serum
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
US20110144024A1 (en) * 2008-07-16 2011-06-16 Paion Deutschland Gmbh Prevention and treatment of radiation injury
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
NZ702242A (en) 2012-05-31 2016-03-31 Asahi Kasei Pharma Corp Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
AU2019347406B9 (en) * 2018-09-28 2023-11-16 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5466668A (en) * 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
JP3789147B2 (ja) * 1995-04-11 2006-06-21 旭化成ファーマ株式会社 脊髄損傷後の神経障害に対する治療剤

Also Published As

Publication number Publication date
WO2002017953A2 (en) 2002-03-07
EP1365788A2 (en) 2003-12-03
IL154600A (en) 2009-02-11
US20090143281A1 (en) 2009-06-04
WO2002017953A3 (en) 2003-10-09
CA2420900A1 (en) 2002-03-07
DK1365788T3 (da) 2007-09-17
DE60128399D1 (de) 2007-06-21
EP1365788B1 (en) 2007-05-09
ATE361755T1 (de) 2007-06-15
NO20030919D0 (no) 2003-02-27
NO20030919L (no) 2003-04-10
HK1062398A1 (en) 2004-11-05
IL154600A0 (en) 2003-09-17
DE60128399T2 (de) 2008-01-10
US20040002446A1 (en) 2004-01-01
PT1365788E (pt) 2007-08-10
AU2001293229B2 (en) 2007-04-05
AU9322901A (en) 2002-03-13
US20020111296A1 (en) 2002-08-15
JP2004521076A (ja) 2004-07-15

Similar Documents

Publication Publication Date Title
JP6250282B2 (ja) 出血性障害の治療および予防的治療における非静脈内投与のためのアルブミン融合凝固因子
ES2788075T3 (es) Uso terapéutico sinérgico de concentrados de complejo de protrombina con concentrados de FVIII
US20090143281A1 (en) Thrombomodulin analogs for use in recovery of spinal cord injury
ES2242309T3 (es) Composiciones farmaceuticas que contienen pentraxina larga ptx3.
PT639079E (pt) Composicao para tratamento de doencas mediadas por interleuquina-1 e factor de necrose tumoral
KR20140084208A (ko) 정제된 인자 ｖｉｉｉ의 재구성 후의 안정성을 향상시키는 방법
JP5208135B2 (ja) 組換え白血球阻害因子とヒルゲンのキメラタンパク質及びその薬物組成物
JPH06184196A (ja) ビトロネクチン由来合成ペプチドおよびそれらを含有する医薬組成物
ES2256266T3 (es) Analogos de trombomodulina y su uso farmaceutico.
AU2001293229A1 (en) Thrombomodulin analogs for use in recovery of spinal cord injury
US7867974B2 (en) Induction of tolerance by oral administration of factor VIII and treatment of hemophilia
ES2221457T3 (es) Preparado farmaceutico para el tratamiento de trastornos de la coagulacion sanguinea.
ES2449044T3 (es) Procedimiento de administración de fVIII sin dominio B porcino
WO2024077335A1 (en) Factor ix variant polypeptides for administration to soft tissue
Holst et al. Local application of recombinant active-site inhibited human clotting factor VIIa reduces thrombus weight and improves patency in a rabbit venous thrombosis model
ES2772802T3 (es) Composiciones y procedimientos para tratar la hemorragia intracerebral
US7977460B2 (en) Compositions comprising coagulation factors IXA and VIII for the treatment of haemophilia A or B
ES2206752T3 (es) Usos medicos del complejo scupa/scupar.
JPH07502989A (ja) 血友病の治療
ES2288524T3 (es) Factor xiii en combinacion con factor ix para tratar la hemofilia b.
KR102597725B1 (ko) 혈우병의 예방적 치료를 위해 인자 ix 및 사람 알부민을 포함하는 융합 단백질에 대한 21-일 투여 용법 및 이의 방법
HK1062398B (en) Thrombomodulin analogs for use in recovery of spinal cord injury
HK40105119A (en) Compositions for treating neural injury by inhibiting the activity of lar family phosphatases
ES2354129T3 (es) Complementación de la deficiencia en factor xi mediante mutantes del factor v.
Prasant Recent trends and advances in hemophilia-its management and new therapeutic outcomes