JP2004521076A - シグナルコード障害の回復に使用するためのトロンボモジュリン類似体 - Google Patents

シグナルコード障害の回復に使用するためのトロンボモジュリン類似体 Download PDF

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Publication number
JP2004521076A
JP2004521076A JP2002522926A JP2002522926A JP2004521076A JP 2004521076 A JP2004521076 A JP 2004521076A JP 2002522926 A JP2002522926 A JP 2002522926A JP 2002522926 A JP2002522926 A JP 2002522926A JP 2004521076 A JP2004521076 A JP 2004521076A
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Japan
Prior art keywords
thrombomodulin
analog
seq
native
pharmaceutical composition
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JP2002522926A
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English (en)
Japanese (ja)
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JP2004521076A5 (enExample
Inventor
ダブリュー フェストフ バリー
ジョン モーザー マイケル
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Bayer Pharma AG
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Schering AG
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Publication of JP2004521076A publication Critical patent/JP2004521076A/ja
Publication of JP2004521076A5 publication Critical patent/JP2004521076A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/366Thrombomodulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Communication Cables (AREA)
  • Signal Processing Not Specific To The Method Of Recording And Reproducing (AREA)
  • Ropes Or Cables (AREA)
JP2002522926A 2000-08-31 2001-08-31 シグナルコード障害の回復に使用するためのトロンボモジュリン類似体 Withdrawn JP2004521076A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22971400P 2000-08-31 2000-08-31
US09/938,405 US20020111296A1 (en) 2000-08-31 2001-08-23 Thrombomodulin analogs for use in recovery of spinal cord injury
PCT/US2001/041930 WO2002017953A2 (en) 2000-08-31 2001-08-31 Thrombomodulin analogs for use in recovery of signal cord injury

Publications (2)

Publication Number Publication Date
JP2004521076A true JP2004521076A (ja) 2004-07-15
JP2004521076A5 JP2004521076A5 (enExample) 2008-09-11

Family

ID=26923554

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002522926A Withdrawn JP2004521076A (ja) 2000-08-31 2001-08-31 シグナルコード障害の回復に使用するためのトロンボモジュリン類似体

Country Status (13)

Country Link
US (3) US20020111296A1 (enExample)
EP (1) EP1365788B1 (enExample)
JP (1) JP2004521076A (enExample)
AT (1) ATE361755T1 (enExample)
AU (2) AU9322901A (enExample)
CA (1) CA2420900A1 (enExample)
DE (1) DE60128399T2 (enExample)
DK (1) DK1365788T3 (enExample)
ES (1) ES2287161T3 (enExample)
IL (2) IL154600A0 (enExample)
NO (1) NO20030919L (enExample)
PT (1) PT1365788E (enExample)
WO (1) WO2002017953A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011527992A (ja) * 2008-07-16 2011-11-10 パイオン ドイチュラント ゲーエムベーハー 放射線傷害の予防および治療

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006005362A1 (en) * 2004-07-13 2006-01-19 Paion Deutschland Gmbh Production of mammalian proteins in plant cells
US20060148695A1 (en) * 2005-01-03 2006-07-06 National Cheng Kung University Novel angiogenic composition and use thereof
US8293710B2 (en) * 2005-01-03 2012-10-23 Blue Blood Biotech Corp. Method for treating wounds using an EGF-like domain of thrombomodulin
EP1912660A1 (en) * 2005-08-11 2008-04-23 Medigenes Co., Ltd. Pharmaceutical composition for the treatment of nerve damage comprising blood plasma or serum
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
NZ702242A (en) 2012-05-31 2016-03-31 Asahi Kasei Pharma Corp Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
AU2019347406B9 (en) * 2018-09-28 2023-11-16 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5466668A (en) * 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
JP3789147B2 (ja) * 1995-04-11 2006-06-21 旭化成ファーマ株式会社 脊髄損傷後の神経障害に対する治療剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011527992A (ja) * 2008-07-16 2011-11-10 パイオン ドイチュラント ゲーエムベーハー 放射線傷害の予防および治療

Also Published As

Publication number Publication date
WO2002017953A2 (en) 2002-03-07
EP1365788A2 (en) 2003-12-03
IL154600A (en) 2009-02-11
US20090143281A1 (en) 2009-06-04
WO2002017953A3 (en) 2003-10-09
CA2420900A1 (en) 2002-03-07
DK1365788T3 (da) 2007-09-17
DE60128399D1 (de) 2007-06-21
EP1365788B1 (en) 2007-05-09
ATE361755T1 (de) 2007-06-15
NO20030919D0 (no) 2003-02-27
NO20030919L (no) 2003-04-10
ES2287161T3 (es) 2007-12-16
HK1062398A1 (en) 2004-11-05
IL154600A0 (en) 2003-09-17
DE60128399T2 (de) 2008-01-10
US20040002446A1 (en) 2004-01-01
PT1365788E (pt) 2007-08-10
AU2001293229B2 (en) 2007-04-05
AU9322901A (en) 2002-03-13
US20020111296A1 (en) 2002-08-15

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