ES2260037T3 - Materiales compuestos a partir de compuestos de calcio y componentes proteicos. - Google Patents
Materiales compuestos a partir de compuestos de calcio y componentes proteicos.Info
- Publication number
- ES2260037T3 ES2260037T3 ES00951293T ES00951293T ES2260037T3 ES 2260037 T3 ES2260037 T3 ES 2260037T3 ES 00951293 T ES00951293 T ES 00951293T ES 00951293 T ES00951293 T ES 00951293T ES 2260037 T3 ES2260037 T3 ES 2260037T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- composite materials
- materials according
- calcium
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 69
- 235000004252 protein component Nutrition 0.000 title claims abstract description 41
- 229940043430 calcium compound Drugs 0.000 title description 3
- 150000001674 calcium compounds Chemical class 0.000 title description 3
- 235000018102 proteins Nutrition 0.000 claims abstract description 43
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 43
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 43
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229910001868 water Inorganic materials 0.000 claims abstract description 30
- 239000003531 protein hydrolysate Substances 0.000 claims abstract description 23
- 239000002245 particle Substances 0.000 claims abstract description 22
- 108010009736 Protein Hydrolysates Proteins 0.000 claims abstract description 17
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 13
- 235000021317 phosphate Nutrition 0.000 claims abstract description 13
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims abstract description 9
- 239000011164 primary particle Substances 0.000 claims abstract description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 4
- 125000005587 carbonate group Chemical group 0.000 claims abstract description 3
- 229920000159 gelatin Polymers 0.000 claims description 27
- 235000019322 gelatine Nutrition 0.000 claims description 27
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 27
- 108010010803 Gelatin Proteins 0.000 claims description 25
- 239000008273 gelatin Substances 0.000 claims description 25
- 235000011852 gelatine desserts Nutrition 0.000 claims description 25
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 229920001436 collagen Polymers 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 20
- 108010035532 Collagen Proteins 0.000 claims description 19
- 102000008186 Collagen Human genes 0.000 claims description 19
- 210000000988 bone and bone Anatomy 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 17
- 239000005018 casein Substances 0.000 claims description 15
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 15
- 235000021240 caseins Nutrition 0.000 claims description 15
- 108010076119 Caseins Proteins 0.000 claims description 14
- 239000002105 nanoparticle Substances 0.000 claims description 14
- 238000001556 precipitation Methods 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 13
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 11
- 241000209140 Triticum Species 0.000 claims description 10
- 235000021307 Triticum Nutrition 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 230000033558 biomineral tissue development Effects 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical group [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 8
- 108010076876 Keratins Proteins 0.000 claims description 6
- 102000011782 Keratins Human genes 0.000 claims description 6
- 210000003298 dental enamel Anatomy 0.000 claims description 6
- 239000007943 implant Substances 0.000 claims description 6
- 229910021529 ammonia Inorganic materials 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims description 4
- 235000007164 Oryza sativa Nutrition 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 150000004673 fluoride salts Chemical class 0.000 claims description 4
- 235000009566 rice Nutrition 0.000 claims description 4
- 239000000606 toothpaste Substances 0.000 claims description 4
- 244000144725 Amygdalus communis Species 0.000 claims description 3
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 3
- 108010073771 Soybean Proteins Proteins 0.000 claims description 3
- 235000020224 almond Nutrition 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 3
- 230000008023 solidification Effects 0.000 claims description 3
- 229940001941 soy protein Drugs 0.000 claims description 3
- 230000007547 defect Effects 0.000 claims description 2
- 230000000395 remineralizing effect Effects 0.000 claims description 2
- 238000011282 treatment Methods 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 150000002222 fluorine compounds Chemical class 0.000 abstract description 3
- -1 Apatite compound Chemical class 0.000 description 23
- 239000000126 substance Substances 0.000 description 21
- 239000011575 calcium Substances 0.000 description 17
- 125000004432 carbon atom Chemical group C* 0.000 description 16
- 150000003839 salts Chemical class 0.000 description 16
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- 229910052791 calcium Inorganic materials 0.000 description 14
- 102000011632 Caseins Human genes 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 235000014113 dietary fatty acids Nutrition 0.000 description 12
- 239000006185 dispersion Substances 0.000 description 12
- 239000000194 fatty acid Substances 0.000 description 12
- 229930195729 fatty acid Natural products 0.000 description 12
- 150000004665 fatty acids Chemical class 0.000 description 12
- 235000015110 jellies Nutrition 0.000 description 9
- 239000008274 jelly Substances 0.000 description 9
- 230000004048 modification Effects 0.000 description 9
- 238000012986 modification Methods 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 150000001413 amino acids Chemical group 0.000 description 6
- 239000003995 emulsifying agent Substances 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 150000002191 fatty alcohols Chemical class 0.000 description 5
- 229910052587 fluorapatite Inorganic materials 0.000 description 5
- 229940077441 fluorapatite Drugs 0.000 description 5
- 235000012239 silicon dioxide Nutrition 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 108091005658 Basic proteases Proteins 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000000316 bone substitute Substances 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 description 4
- 150000005690 diesters Chemical class 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 229930182470 glycoside Natural products 0.000 description 4
- 239000002563 ionic surfactant Substances 0.000 description 4
- 108010020132 microbial serine proteinases Proteins 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- 238000004627 transmission electron microscopy Methods 0.000 description 4
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 238000005903 acid hydrolysis reaction Methods 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 3
- 235000019568 aromas Nutrition 0.000 description 3
- 229910001634 calcium fluoride Inorganic materials 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
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- 125000005624 silicic acid group Chemical class 0.000 description 3
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- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
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- 241000283690 Bos taurus Species 0.000 description 2
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- 108010082495 Dietary Plant Proteins Proteins 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
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- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 2
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- 235000004443 Ricinus communis Nutrition 0.000 description 2
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
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- 125000002252 acyl group Chemical group 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
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- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 2
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 2
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- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
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- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 2
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- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19930335A DE19930335A1 (de) | 1999-07-02 | 1999-07-02 | Kompositmaterialien aus Calciumverbindungen und Proteinkomponenten |
| DE19930335 | 1999-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2260037T3 true ES2260037T3 (es) | 2006-11-01 |
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| ES00951293T Expired - Lifetime ES2260037T3 (es) | 1999-07-02 | 2000-06-23 | Materiales compuestos a partir de compuestos de calcio y componentes proteicos. |
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| Country | Link |
|---|---|
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| EP (2) | EP1676555A3 (enExample) |
| JP (1) | JP4707909B2 (enExample) |
| AT (2) | ATE319406T1 (enExample) |
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| CA (1) | CA2373955C (enExample) |
| DE (3) | DE19930335A1 (enExample) |
| DK (1) | DK1189582T3 (enExample) |
| ES (1) | ES2260037T3 (enExample) |
| WO (1) | WO2001001930A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10028975B4 (de) * | 2000-06-16 | 2005-06-30 | Henkel Kgaa | Zusammensetzungen zur Behandlung von Zahn- und/oder Knochengewebe |
| DE10063945A1 (de) * | 2000-12-20 | 2002-07-04 | Henkel Kgaa | Remineralisierende Dental-Klebefolie |
| US20020115742A1 (en) | 2001-02-22 | 2002-08-22 | Trieu Hai H. | Bioactive nanocomposites and methods for their use |
| WO2003000588A1 (de) | 2001-06-22 | 2003-01-03 | Basf Aktiengesellschaft | Stäbchenförmige apatitkristalle mit einem bestimmten länge-zu-breite-verhältnis |
| DE10260958A1 (de) * | 2002-12-20 | 2004-07-08 | Sustech Gmbh & Co. Kg | Kompositmaterialien aus Calciumverbindungen und Glucuronsäure- und/oder Iduronsäurehaltigen Polysacchariden |
| ITMI20030186A1 (it) * | 2003-02-05 | 2004-08-06 | Consiglio Nazionale Ricerche | Procedimento di sintesi di tessuto osseo artificiale, |
| DE10340542A1 (de) * | 2003-09-01 | 2005-03-24 | Henkel Kgaa | Mund- und Zahnpflegemittel |
| DE10340543A1 (de) * | 2003-09-01 | 2005-03-24 | Henkel Kgaa | Mund- und Zahnpflegemittel |
| WO2005023210A1 (ja) * | 2003-09-05 | 2005-03-17 | Kabushiki Kaisha Sangi | 再石灰化促進剤、口腔用組成物、食品及び飲料 |
| DE102004025030A1 (de) * | 2004-05-18 | 2005-12-15 | S&C Polymer Silicon- und Composite-Spezialitäten GmbH | Nano-Apatit-Füllstoffe enthaltende härtbare Restaurationsmaterialien |
| CN1328322C (zh) * | 2005-01-27 | 2007-07-25 | 浙江大学 | 生物可降解医用磷酸钙/胶原复合材料及其制备方法 |
| DE102005024296B4 (de) * | 2005-05-19 | 2007-02-01 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Resorbierbarer, biokompatibler Formkörper und Verfahren zur Herstellung |
| DE102005027813A1 (de) * | 2005-06-15 | 2006-12-28 | Henkel Kgaa | Remineralisierende Mund- und Zahnpflege- und -reinigungsmittel |
| DE102006009793A1 (de) * | 2005-10-31 | 2007-09-06 | Sus Tech Gmbh & Co. Kg | Verwendung von schwer wasserlöslichen Calciumsalzen und/oder deren Kompositen |
| DE102006009781A1 (de) * | 2005-10-31 | 2007-09-06 | Sus Tech Gmbh & Co. Kg | Kompositmaterialien aus Calciumverbindungen und spezieller Gelatine |
| DE102006009825A1 (de) * | 2005-10-31 | 2007-09-06 | Sus Tech Gmbh & Co. Kg | Kompositmaterialien aus Calciumverbindungen und ampholytische Polymerkomponenten |
| DE102005053705A1 (de) * | 2005-11-10 | 2007-05-16 | S & C Polymer Silicon & Compos | Nano-kristalline Erdalkali-Füllstoffe enthaltende Restaurationsmaterialien |
| ZA200804292B (en) * | 2005-11-30 | 2009-09-30 | Unilever Plc | Calcium fortified food product and additive |
| GB0524803D0 (en) * | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Novel compositions |
| DE102006009799A1 (de) * | 2006-03-01 | 2007-09-06 | Henkel Kgaa | Vorwiegend plättchenförmige schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien, umfassend diese |
| DE102006009797A1 (de) * | 2006-03-01 | 2007-09-06 | Sus Tech Gmbh & Co. Kg | Verfahren zur Mund- und Zahnreinigung und/oder Remineralisierung |
| DE102006014522A1 (de) * | 2006-03-29 | 2007-10-04 | Dot Gmbh | Verfahren zur Herstellung eines Knochenersatzmaterials |
| GB0618963D0 (en) * | 2006-09-26 | 2006-11-08 | Ucl Business Plc | Formulations and composites with reactive fillers |
| DE102006055224B4 (de) | 2006-11-21 | 2008-09-04 | Heraeus Kulzer Gmbh | Kits, deren Herstellung und Verwendung zur aufhellenden Beschichtung von Zähnen |
| DE102006055223A1 (de) | 2006-11-21 | 2008-05-29 | Heraeus Kulzer Gmbh | Mittel zum Schutz von Zahnflächen im Anschluss an konventionelle Bleichverfahren durch biomimetische Abscheidung von Fluorapatit |
| DE102006055439A1 (de) * | 2006-11-22 | 2008-05-29 | Henkel Kgaa | Homogene lagerstabile Dispersionen |
| DE102006060910A1 (de) | 2006-12-20 | 2008-07-03 | Henkel Kgaa | Suspensionen von Kompositmaterialien |
| US9386783B2 (en) | 2007-07-31 | 2016-07-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Confectionery products and process for obtaining them |
| DE102007039335A1 (de) * | 2007-08-20 | 2009-02-26 | Henkel Ag & Co. Kgaa | Lumineszierende Kompositmaterialien |
| DE102008017721A1 (de) | 2008-04-07 | 2009-10-08 | Sus Tech Gmbh & Co. Kg | Stabile Suspensionen von Kompositmaterialien |
| DE102008062238A1 (de) * | 2008-12-16 | 2010-06-17 | Henkel Ag & Co. Kgaa | Remineralisierende Mund- und Zahnpflege- und -reinigungsmittel mit spezieller Wirkstoffkombination |
| US20100196514A1 (en) * | 2009-02-02 | 2010-08-05 | Chung Shan Medical University | Calcium silicate-based composite cement and methods for the preparation |
| WO2011034916A2 (en) | 2009-09-15 | 2011-03-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bone substitute compositions, methods of preparation and clinical applications |
| BR112012014660B1 (pt) * | 2009-12-18 | 2018-02-06 | Stokely-Van Camp, Inc. | Bebida isotônicas e reidratantes e método para sua produção |
| DE102011052396A1 (de) | 2011-08-04 | 2013-02-07 | Gelita Ag | Verfahren zur Herstellung einer stabilen Dispersion von Nanopartikeln, hergestellte Dispersion und deren Verwendung |
| DE102013109848A1 (de) | 2013-09-09 | 2015-03-12 | Heraeus Kulzer Gmbh | Applikationssystem zur einfachen, 3-dimensionalen Anwendung von medizinischen, kosmetischen oder Arzneimittel enthaltenden Zahnpflegeprodukten |
| DE102013109847A1 (de) | 2013-09-09 | 2015-03-12 | Heraeus Kulzer Gmbh | Formulierungen und Kit zur biomimetischen Abscheidung von Apatit auf Zähnen |
| DE102013109846A1 (de) | 2013-09-09 | 2015-03-12 | Heraeus Kulzer Gmbh | Formulierungen und Kit zur biomimetischen Abscheidung von Apatit auf Zähnen |
| RU2673820C2 (ru) | 2013-09-25 | 2018-11-30 | Кредентис Аг | Стоматологический продукт для отбеливания зубов |
| CN108473957B (zh) | 2015-04-17 | 2024-07-16 | 诺华股份有限公司 | 改善嵌合抗原受体表达细胞的功效和扩增的方法 |
| US20180318200A1 (en) * | 2015-10-26 | 2018-11-08 | Colgate-Palmolive Company | Mouthwash products and methods |
| US10105289B2 (en) | 2016-05-26 | 2018-10-23 | Essential Dental Systems, Inc. | Biomimetic mineral based endodontic cement composition and uses thereof |
| CN107115565B (zh) * | 2017-06-28 | 2020-10-16 | 陕西师范大学 | 一种羟基磷灰石/相转变溶菌酶涂层杂化材料及其制备方法 |
| DE102017115672B4 (de) * | 2017-07-12 | 2020-08-27 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Isotropes Hydroxylapatit/Gelatine-Kompositmaterial, Verfahren zu dessen Herstellung und dessen Verwendung |
| CN111097071B (zh) * | 2019-11-28 | 2022-08-02 | 上海摩漾生物科技有限公司 | 多孔材料、酪蛋白钙磷微球及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1165574B (de) | 1960-08-08 | 1964-03-19 | Dehydag Gmbh | Verfahren zur Herstellung von als Emulgiermittel fuer Salbengrundlagen dienenden Mischestern |
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| GB8811829D0 (en) * | 1988-05-19 | 1988-06-22 | Unilever Plc | Oral compositions |
| US5240659A (en) * | 1988-09-15 | 1993-08-31 | Asahi Kogaku K.K. | Process for producing shaped article of oriented calcium phosphate type compound |
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| DE4137636A1 (de) * | 1991-11-15 | 1993-05-19 | Henkel Kgaa | Verfahren zur herstellung von alkyl- und/oder alkenyloligoglycosiden |
| US5320844A (en) * | 1992-03-12 | 1994-06-14 | Liu Sung Tsuen | Composite materials for hard tissue replacement |
| US5277147A (en) * | 1992-07-22 | 1994-01-11 | Dupuis James L | Bird feed holder |
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| JP2775386B2 (ja) * | 1993-10-04 | 1998-07-16 | 科学技術庁無機材質研究所長 | アパタイト・有機物複合体とその製造法 |
| US5514299A (en) * | 1994-07-11 | 1996-05-07 | Bridgestone/Firestone, Inc. | Static dissipative container liner and method of making same |
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| DE19502168C1 (de) | 1995-01-25 | 1996-06-27 | Henkel Kgaa | Verfahren zur Herstellung von Weizenproteinhydrolysaten |
| DE19502167C2 (de) | 1995-01-25 | 1997-02-06 | Henkel Kgaa | Verfahren zur Herstellung von Reisproteinhydrolysaten |
| DE19515820A1 (de) * | 1995-04-29 | 1996-10-31 | Inst Neue Mat Gemein Gmbh | Verfahren zur Herstellung schwach agglomerierter nanoskaliger Teilchen |
| US5652056A (en) * | 1995-08-25 | 1997-07-29 | Pepin; John N. | Hydroxyapatite filament |
| US5783217A (en) * | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
| JP4040705B2 (ja) * | 1996-01-24 | 2008-01-30 | 株式会社サンギ | 口腔組成物 |
| US5741773A (en) * | 1996-04-26 | 1998-04-21 | Colgate Palmolive Company | Storage stable dentifrice composition containing an antibacterial casein glycomacropeptide adjuvant |
| JPH1017449A (ja) * | 1996-07-05 | 1998-01-20 | Sangi Co Ltd | 知覚過敏症用組成物 |
| US5702677A (en) * | 1996-07-10 | 1997-12-30 | Osteotech, Inc. | Spherical hydroxyapatite particles and process for the production thereof |
| RU2122520C1 (ru) * | 1996-10-31 | 1998-11-27 | Акционерное общество закрытого типа "ОСТИМ" | Способ получения суспензии гидроксиапатита |
| US6013591A (en) * | 1997-01-16 | 2000-01-11 | Massachusetts Institute Of Technology | Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production |
| US6919070B1 (en) * | 1997-10-17 | 2005-07-19 | Zakrytoe Aktsionernoe Obschestvo “OSTIM” | Stomatic composition |
| IT1299563B1 (it) * | 1998-07-17 | 2000-03-16 | Giovanni Dolci | Uso odontostomatologico di materiali a base apatitica nanostrutturati |
| DE19858662A1 (de) | 1998-12-18 | 2000-06-21 | Henkel Kgaa | Feinteilige Suspensionen schwerlöslicher Calciumsalze und deren Verwendung in Zahnpflegemitteln |
-
1999
- 1999-07-02 DE DE19930335A patent/DE19930335A1/de not_active Withdrawn
-
2000
- 2000-06-23 WO PCT/EP2000/005813 patent/WO2001001930A2/de not_active Ceased
- 2000-06-23 JP JP2001507428A patent/JP4707909B2/ja not_active Expired - Lifetime
- 2000-06-23 ES ES00951293T patent/ES2260037T3/es not_active Expired - Lifetime
- 2000-06-23 AU AU64285/00A patent/AU6428500A/en not_active Abandoned
- 2000-06-23 AT AT00951293T patent/ATE319406T1/de active
- 2000-06-23 CA CA2373955A patent/CA2373955C/en not_active Expired - Lifetime
- 2000-06-23 DK DK00951293T patent/DK1189582T3/da active
- 2000-06-23 EP EP06004167A patent/EP1676555A3/de not_active Withdrawn
- 2000-06-23 EP EP00951293A patent/EP1189582B1/de not_active Expired - Lifetime
- 2000-06-23 DE DE20023797U patent/DE20023797U1/de not_active Expired - Lifetime
- 2000-06-23 DE DE50012369T patent/DE50012369D1/de not_active Expired - Lifetime
-
2006
- 2006-04-03 AT AT0026106U patent/AT8957U1/de not_active IP Right Cessation
-
2007
- 2007-09-28 US US11/864,252 patent/US20080160091A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080160091A1 (en) | 2008-07-03 |
| CA2373955A1 (en) | 2001-01-11 |
| WO2001001930A3 (de) | 2001-07-12 |
| JP4707909B2 (ja) | 2011-06-22 |
| DE19930335A1 (de) | 2001-01-18 |
| ATE319406T1 (de) | 2006-03-15 |
| EP1189582A2 (de) | 2002-03-27 |
| DE50012369D1 (de) | 2006-05-04 |
| DE20023797U1 (de) | 2006-05-24 |
| DK1189582T3 (da) | 2006-07-17 |
| EP1676555A2 (de) | 2006-07-05 |
| EP1189582B1 (de) | 2006-03-08 |
| CA2373955C (en) | 2011-04-26 |
| AT8957U1 (de) | 2007-03-15 |
| JP2003503434A (ja) | 2003-01-28 |
| EP1676555A3 (de) | 2009-06-17 |
| AU6428500A (en) | 2001-01-22 |
| WO2001001930A2 (de) | 2001-01-11 |
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