ES2255121T3 - Procedimiento para la determinacion del potencial anticoagulante de una muestra y procedimiento para la determinacion de la glicosilacion de trombomodulina. - Google Patents

Procedimiento para la determinacion del potencial anticoagulante de una muestra y procedimiento para la determinacion de la glicosilacion de trombomodulina.

Info

Publication number
ES2255121T3
ES2255121T3 ES98118971T ES98118971T ES2255121T3 ES 2255121 T3 ES2255121 T3 ES 2255121T3 ES 98118971 T ES98118971 T ES 98118971T ES 98118971 T ES98118971 T ES 98118971T ES 2255121 T3 ES2255121 T3 ES 2255121T3
Authority
ES
Spain
Prior art keywords
thrombomodulin
thrombin
protein
sample
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98118971T
Other languages
English (en)
Spanish (es)
Inventor
Michael Dr. Kraus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Application granted granted Critical
Publication of ES2255121T3 publication Critical patent/ES2255121T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7452—Thrombomodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES98118971T 1997-11-07 1998-10-07 Procedimiento para la determinacion del potencial anticoagulante de una muestra y procedimiento para la determinacion de la glicosilacion de trombomodulina. Expired - Lifetime ES2255121T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19749197 1997-11-07
DE19749197A DE19749197A1 (de) 1997-11-07 1997-11-07 Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe

Publications (1)

Publication Number Publication Date
ES2255121T3 true ES2255121T3 (es) 2006-06-16

Family

ID=7847900

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98118971T Expired - Lifetime ES2255121T3 (es) 1997-11-07 1998-10-07 Procedimiento para la determinacion del potencial anticoagulante de una muestra y procedimiento para la determinacion de la glicosilacion de trombomodulina.

Country Status (8)

Country Link
US (2) US20020019021A1 (enExample)
EP (1) EP0915340B1 (enExample)
JP (1) JP4361980B2 (enExample)
AT (1) ATE315233T1 (enExample)
AU (1) AU751525B2 (enExample)
CA (1) CA2252983C (enExample)
DE (2) DE19749197A1 (enExample)
ES (1) ES2255121T3 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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PT947585E (pt) * 1998-03-19 2001-11-30 Instrumentation Lab Spa Metodo in vitro melhorado, kits e reagentes para a peaquisa de defeitos de coagulacao sanguinea
AU2001274597A1 (en) * 2000-06-22 2002-01-02 Mochida Pharmaceutical Co., Ltd. Kit for assaying coagulatory capability of blood
US6432658B1 (en) * 2000-09-13 2002-08-13 Affinity Biologicals, Inc. Method for measuring antithrombin activity
US6448024B1 (en) 2000-10-03 2002-09-10 Roche Diagnostics Corporation Method, reagent, cartridge, and device for determining fibrinogen
US6645768B1 (en) 2000-10-27 2003-11-11 Biomerieux, Inc. Reagent and kit for determining global coagulability and hemostatic potential
US6743596B1 (en) 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
EP1367135A1 (en) * 2002-05-29 2003-12-03 Pentapharm AG Improved method for the assessment of thrombin formation in blood or plasma
EP1682863B1 (en) * 2003-09-22 2012-07-04 University Of North Carolina At Chapel Hill Soluble phospholipids for use in clotting factor assays
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
CN101151533A (zh) * 2005-02-16 2008-03-26 伊利诺斯大学理事会 基于金属螯合脂质的促凝血剂
US7682808B2 (en) * 2005-03-04 2010-03-23 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
GB2433592A (en) * 2005-12-23 2007-06-27 Pentapharm Ag Assay for thrombin inhibitors
US8821861B2 (en) 2007-10-05 2014-09-02 The Board Of Trustees Of The University Of Illinois Fibrin sealant
US20100297257A1 (en) * 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
JP2009198506A (ja) * 2009-04-10 2009-09-03 Shino Test Corp 血液凝固反応抑制血漿タンパク質の活性測定方法及び活性測定試薬
US10385381B2 (en) * 2010-09-20 2019-08-20 Paul Masci Serum preparation
JP5818299B2 (ja) * 2010-12-27 2015-11-18 国立大学法人名古屋大学 凝固因子として作用する異常トロンビンのためのトロンビン不活化動態測定方法
KR102001662B1 (ko) * 2011-06-17 2019-10-01 학교법인 히가시-니뽄-가쿠엔 루프스 안티코아귤란트 검출용 혈액 응고시간의 측정방법
WO2014020183A1 (de) 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
CN104374621A (zh) * 2014-11-03 2015-02-25 温州市倍可特医疗器械有限公司 用于血液采集容器的血液促凝剂及其制备方法和应用
US10809393B2 (en) * 2015-04-23 2020-10-20 Fermi Research Alliance, Llc Monocrystal-based microchannel plate image intensifier
WO2019193777A1 (ja) 2018-04-04 2019-10-10 三菱電機株式会社 赤外線固体撮像装置
US20240060999A1 (en) * 2020-12-28 2024-02-22 Fujimori Kogyo Co., Ltd Blood coagulation inspection method
CN115219292B (zh) * 2022-06-09 2025-09-30 常熟常江生物技术有限公司 全自动血栓弹力图仪质控品及其制备方法、应用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221614A (en) * 1988-03-03 1993-06-22 Nippon Shoji Kabushiki Kaisha Method and reagent for determining the biological activity of antithrombin III by measuring coagulation time
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US5486599A (en) * 1989-03-29 1996-01-23 The Board Of Trustees Of The Leland Stanford Junior University Construction and use of synthetic constructs encoding syndecan
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5051357A (en) * 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor
WO1991004276A1 (en) * 1989-09-25 1991-04-04 Asahi Kasei Kogyo Kabushiki Kaisha Isolated, physiologically active human thrombomodulin polypeptide
CA2648350A1 (en) * 1990-08-15 1992-03-05 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
IL100093A0 (en) * 1990-11-30 1992-08-18 Kowa Co Thrombin-binding substance and process for preparing the same
US5273962A (en) * 1990-11-30 1993-12-28 Kowa Co., Ltd. Human urinary thrombomodulin with a modified glycosaminoglycan (GAG) binding site
WO1993007491A1 (en) * 1991-10-04 1993-04-15 Board Of Regents Of The University Of Nebraska A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
SE470274B (sv) * 1991-11-13 1993-12-20 Bjoern Dahlbaeck Användning av en in vitro-metod för diagnos av blodkoagulationssjukdomar
FR2689640B1 (fr) * 1992-04-06 1997-08-08 Bio Merieux Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique.
DE4229933A1 (de) * 1992-09-08 1994-03-10 Max Planck Gesellschaft Verfahren zur Bestimmung von Thrombose verursachenden Lupus-anticoagulant-Antikörpern
DE4427785A1 (de) * 1994-08-08 1996-02-15 Behringwerke Ag Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
EP0711838B2 (de) * 1994-11-10 2007-06-20 Dade Behring Marburg GmbH Verfahren zum spezifischen Nachweis eines aktivierten Gerinnungsfaktors V mit einer erhöhten Stabilität gegenüber aktiviertem Protein C

Also Published As

Publication number Publication date
AU9139798A (en) 1999-05-27
ATE315233T1 (de) 2006-02-15
DE19749197A1 (de) 1999-05-12
JP4361980B2 (ja) 2009-11-11
CA2252983A1 (en) 1999-05-07
US20020019021A1 (en) 2002-02-14
AU751525B2 (en) 2002-08-22
EP0915340B1 (de) 2006-01-04
US20030207343A1 (en) 2003-11-06
EP0915340A1 (de) 1999-05-12
JPH11225796A (ja) 1999-08-24
CA2252983C (en) 2010-07-13
DE59813326D1 (de) 2006-03-30

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