ES2248997T3 - Proteina-quinasas ste20-relacionadas. - Google Patents
Proteina-quinasas ste20-relacionadas.Info
- Publication number
- ES2248997T3 ES2248997T3 ES99918539T ES99918539T ES2248997T3 ES 2248997 T3 ES2248997 T3 ES 2248997T3 ES 99918539 T ES99918539 T ES 99918539T ES 99918539 T ES99918539 T ES 99918539T ES 2248997 T3 ES2248997 T3 ES 2248997T3
- Authority
- ES
- Spain
- Prior art keywords
- kinase
- seq
- polypeptide
- amino acid
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Microbiology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Publications (1)
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| ES2248997T3 true ES2248997T3 (es) | 2006-03-16 |
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| US7078182B1 (en) * | 1998-04-14 | 2006-07-18 | Board Of Regents, The University Of Texas System | TAO protein kinase polypeptides and methods of use therefor |
| US6013500A (en) | 1998-05-21 | 2000-01-11 | The Trustees Of Columbia University In The City Of New York | PAK4, a novel gene encoding a serine/threonine kinase |
| EP1112368A1 (en) * | 1998-09-10 | 2001-07-04 | Smithkline Beecham Plc | Use of protein kinase kiaa0551 as pharmaceutical |
| CA2362936A1 (en) * | 1999-02-19 | 2000-08-24 | Mcmaster University | A caspase activated protein kinase |
| AU3566200A (en) * | 1999-04-01 | 2000-10-23 | Astrazeneca Uk Limited | Human signal transduction serine/threonine protein kinase |
| US6558903B1 (en) * | 1999-06-30 | 2003-05-06 | Millennium Pharmaceuticals, Inc. | Kinases and uses thereof |
| AU6181000A (en) * | 1999-07-29 | 2001-02-19 | Chugai Research Institute For Molecular Medicine, Inc. | Novel genes encoding protein kinase/protein phosphatase |
| US20030104622A1 (en) * | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
| US6861239B1 (en) | 1999-09-20 | 2005-03-01 | New York University | Genes and polynucleotides associated with ultraviolet radiation-mediated skin damage and uses thereof |
| WO2001036602A2 (en) * | 1999-11-15 | 2001-05-25 | Pharmacia Italia S.P.A. | Pak5 a member of the p21-activated kinase (pak) protein family, nucleic acids and methods related to the same |
| EP1254214A2 (en) * | 2000-01-25 | 2002-11-06 | Sugen, Inc. | Human protein kinases and protein kinase-like enzymes |
| EP1385992A2 (en) * | 2000-09-20 | 2004-02-04 | Kinetek Pharmaceuticals, Inc. | Cancer associated protein kinases and their uses |
| AU2002243539A1 (en) * | 2001-01-12 | 2002-07-24 | Incyte Genomics, Inc. | Molecules for disease detection and treatment |
| US7265214B2 (en) * | 2001-10-19 | 2007-09-04 | Rigel Pharmaceuticals, Inc. | Germinal center kinase proteins, compositions and methods of use |
| JP2005518198A (ja) | 2001-12-28 | 2005-06-23 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | Ｐａｋ５関連の組成物及び方法 |
| US7439329B2 (en) * | 2002-07-05 | 2008-10-21 | Sugen, Inc. | GEF-H1b: biomarkers, complexes assays and therapeutic uses thereof |
| GB0220770D0 (en) * | 2002-09-06 | 2002-10-16 | Ares Trading Sa | Proteins |
| US20050054017A1 (en) * | 2002-11-27 | 2005-03-10 | Sugen, Inc. | Phosphospecific PAK antibodies and diagnostic kits |
| AU2003296696A1 (en) * | 2002-12-23 | 2004-07-14 | Devgen Nv | Kinase sequences |
| GB2396615A (en) * | 2002-12-23 | 2004-06-30 | Devgen Nv | Kinase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases |
| US20040242461A1 (en) * | 2003-04-08 | 2004-12-02 | Schneider Michael D. | Modulators of telomere stability |
| DK1653844T3 (da) * | 2003-08-13 | 2013-03-11 | Novartis Vaccines & Diagnostic | Prionspecifikke peptidreagenser |
| US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
| AU2004275876B2 (en) * | 2003-09-25 | 2011-03-31 | Coley Pharmaceutical Gmbh | Nucleic acid-lipophilic conjugates |
| WO2005111234A2 (en) * | 2004-05-12 | 2005-11-24 | Sugen, Inc. | Methods of using zc1 and zc3 kinase substrate phosphorylation as biomarkers |
| NZ587255A (en) * | 2005-01-13 | 2012-03-30 | Novartis Vaccines & Diagnostic | Elisa assays using prion-specific peptide reagents |
| WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
| US20090099343A1 (en) * | 2005-01-13 | 2009-04-16 | David Peretz | Isolation of pathogenic prions |
| NZ566020A (en) * | 2005-09-09 | 2012-08-31 | Novartis Ag | Prion-specific peptoid reagents |
| WO2009134942A1 (en) * | 2008-04-30 | 2009-11-05 | Novartis Ag. | Assay for pathogenic conformers |
| KR101219395B1 (ko) * | 2010-07-15 | 2013-01-11 | 전자부품연구원 | 리튬이차전지용 양극재료 및 그의 제조방법 |
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| US4343940A (en) | 1979-02-13 | 1982-08-10 | Mead Johnson & Company | Anti-tumor quinazoline compounds |
| DE3069468D1 (en) | 1979-12-19 | 1984-11-22 | Nat Res Dev | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| DE3611194A1 (de) | 1986-04-04 | 1987-10-08 | Bayer Ag | Cancerostatisches mittel |
| US5217999A (en) | 1987-12-24 | 1993-06-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Styryl compounds which inhibit EGF receptor protein tyrosine kinase |
| DE3920029C2 (de) | 1988-06-30 | 1999-05-20 | Clariant Finance Bvi Ltd | Farbstoffe zum Färben von Kunststoffen |
| ATE114661T1 (de) | 1990-04-02 | 1994-12-15 | Pfizer | Benzylphosphonsäure-tyrosinkinaseinhibitoren. |
| US5302606A (en) | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
| AU658646B2 (en) | 1991-05-10 | 1995-04-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| JPH06503095A (ja) | 1991-05-29 | 1994-04-07 | ファイザー・インコーポレーテッド | 三環式ポリヒドロキシ系のチロシンキナーゼ阻害薬 |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| US5298422A (en) | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| GB9205320D0 (en) | 1992-03-11 | 1992-04-22 | Ici Plc | Anti-tumour compounds |
| EP0654024A1 (en) | 1992-08-06 | 1995-05-24 | Warner-Lambert Company | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties |
| US5330992A (en) | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
| US5366889A (en) * | 1992-11-30 | 1994-11-22 | The General Hospital Corporation | DNA encoding a protein-coupled receptor kinase |
| GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
| GB9501567D0 (en) | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5830699A (en) * | 1996-05-07 | 1998-11-03 | The General Hospital Corporation | SOK-1 and methods of use |
| AU4448597A (en) | 1996-10-04 | 1998-05-05 | Connaught Laboratories Limited | Treatment of cancer using a recombinant poxvirus containing nucleic acid sequence encoding a cytokine |
| AU8296698A (en) * | 1997-07-08 | 1999-02-08 | Cadus Pharmaceutical Corporation | (kds) protein kinase molecules and uses related thereto |
| AU8778698A (en) * | 1997-08-11 | 1999-03-01 | Ontogeny, Inc. | Serine/threonine kinase, and uses related thereto |
| GB9719920D0 (en) * | 1997-09-19 | 1997-11-19 | Zeneca Ltd | Human Ste20-Like Stress Activated Serine/Threonine Kinase |
| GB9726851D0 (en) * | 1997-12-19 | 1998-02-18 | Zeneca Ltd | Human signal transduction serine/threonine kinase |
| US6013500A (en) * | 1998-05-21 | 2000-01-11 | The Trustees Of Columbia University In The City Of New York | PAK4, a novel gene encoding a serine/threonine kinase |
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1999
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- 1999-04-13 WO PCT/US1999/008150 patent/WO1999053036A2/en not_active Ceased
- 1999-04-13 DK DK99918539T patent/DK1073723T3/da active
- 1999-04-13 US US09/291,417 patent/US6680170B2/en not_active Expired - Fee Related
- 1999-04-13 JP JP2000543584A patent/JP2002522009A/ja not_active Withdrawn
- 1999-04-13 AU AU36424/99A patent/AU3642499A/en not_active Abandoned
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- 1999-04-13 AT AT99918539T patent/ATE302269T1/de not_active IP Right Cessation
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- 1999-04-13 EP EP99918539A patent/EP1073723B1/en not_active Expired - Lifetime
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2000
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2003
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- 2003-12-02 US US10/725,121 patent/US20050142625A1/en not_active Abandoned
- 2003-12-02 US US10/725,330 patent/US20070072261A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE302269T1 (de) | 2005-09-15 |
| US6680170B2 (en) | 2004-01-20 |
| CA2369172A1 (en) | 1999-10-21 |
| US20050142625A1 (en) | 2005-06-30 |
| WO1999053036A2 (en) | 1999-10-21 |
| DK1073723T3 (da) | 2006-01-02 |
| JP2002522009A (ja) | 2002-07-23 |
| EP1073723A2 (en) | 2001-02-07 |
| WO1999053036A3 (en) | 2000-05-11 |
| AU3642499A (en) | 1999-11-01 |
| US20030050230A1 (en) | 2003-03-13 |
| DE69926742T2 (de) | 2006-06-14 |
| EP1073723B1 (en) | 2005-08-17 |
| US20040224323A1 (en) | 2004-11-11 |
| DE69926742D1 (de) | 2005-09-22 |
| US20070072261A1 (en) | 2007-03-29 |
| US6656716B1 (en) | 2003-12-02 |
| WO1999053036A9 (en) | 2000-02-17 |
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