ES2239788T3 - Inhibidores de la enzima de conversion de la interleuquina-1-beta. - Google Patents
Inhibidores de la enzima de conversion de la interleuquina-1-beta.Info
- Publication number
- ES2239788T3 ES2239788T3 ES97954531T ES97954531T ES2239788T3 ES 2239788 T3 ES2239788 T3 ES 2239788T3 ES 97954531 T ES97954531 T ES 97954531T ES 97954531 T ES97954531 T ES 97954531T ES 2239788 T3 ES2239788 T3 ES 2239788T3
- Authority
- ES
- Spain
- Prior art keywords
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- alkyl
- aryl
- alkylaryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3279296P | 1996-12-06 | 1996-12-06 | |
| US32792P | 1996-12-06 | ||
| US4266097P | 1997-04-04 | 1997-04-04 | |
| US42660P | 1997-04-04 | ||
| US5300197P | 1997-06-26 | 1997-06-26 | |
| US53001P | 1997-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2239788T3 true ES2239788T3 (es) | 2005-10-01 |
Family
ID=27364225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97954531T Expired - Lifetime ES2239788T3 (es) | 1996-12-06 | 1997-12-05 | Inhibidores de la enzima de conversion de la interleuquina-1-beta. |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6329365B1 (enExample) |
| EP (1) | EP0944645B1 (enExample) |
| JP (1) | JP4274584B2 (enExample) |
| AT (1) | ATE290545T1 (enExample) |
| AU (1) | AU5896098A (enExample) |
| CA (1) | CA2274249A1 (enExample) |
| DE (1) | DE69732712T2 (enExample) |
| ES (1) | ES2239788T3 (enExample) |
| PT (1) | PT944645E (enExample) |
| WO (1) | WO1998024805A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4274584B2 (ja) * | 1996-12-06 | 2009-06-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | インターロイキン−１β変換酵素のインヒビター |
| US20010049381A1 (en) | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
| US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
| US6184210B1 (en) * | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
| JP2001522800A (ja) | 1997-11-10 | 2001-11-20 | ブリストル−マイヤーズ スクイブ カンパニー | ベンゾチアゾールたんぱくチロシン・キナーゼ抑制剤 |
| US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| SK18302000A3 (sk) | 1998-06-03 | 2001-06-11 | Gpi Nil Holdings, Inc. | N-viazané sulfónamidy n-heterocyklických karboxylových kyselín a izosterov karboxylových kyselín, farmaceutický prostriedok s ich obsahom a ich použitie |
| US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
| US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
| FR2782997A1 (fr) * | 1998-09-08 | 2000-03-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la benzodiazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicaments et compositions pharmaceutiques les renfermant |
| US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| DE60026568D1 (de) | 1999-12-21 | 2006-05-04 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
| WO2002066063A1 (en) * | 2001-02-23 | 2002-08-29 | Nippon Organon K.K. | Remedies for metabolic bone diseases |
| DE10129715A1 (de) * | 2001-06-22 | 2003-01-02 | Bayer Ag | Thiazolylamide |
| US7001899B2 (en) * | 2002-06-10 | 2006-02-21 | The Procter & Gamble Company | Interleukin converting enzyme inhibitors |
| CA2490401A1 (en) | 2002-06-28 | 2004-01-08 | Life Technologies Corporation | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US7060698B2 (en) * | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| US20060128696A1 (en) * | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
| JP4980358B2 (ja) * | 2005-09-19 | 2012-07-18 | アロー セラピューティクス リミテッド | Ｃ型肝炎感染症を治療するためのベンゾジアゼピン誘導体 |
| JP5806670B2 (ja) | 2009-09-16 | 2015-11-10 | セルジーン アビロミクス リサーチ， インコーポレイテッド | プロテインキナーゼコンジュゲート及びインヒビター |
| CN102812167A (zh) | 2009-12-30 | 2012-12-05 | 阿维拉制药公司 | 蛋白的配体-介导的共价修饰 |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| WO2020110143A1 (en) | 2018-11-26 | 2020-06-04 | Rai Balwant | Methods, systems, and a kit for diagnosis, detection, monitoring and treatment of traumatic brain injury |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970207A (en) * | 1988-07-07 | 1990-11-13 | Fujisawa Pharmaceutical Company, Ltd. | Benzodiazepine derivatives |
| CA2160786A1 (en) * | 1993-05-14 | 1994-11-24 | James C. Marsters, Jr. | Ras farnesyl transferase inhibitors |
| US5580979A (en) * | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5852010A (en) * | 1996-04-03 | 1998-12-22 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP4274584B2 (ja) * | 1996-12-06 | 2009-06-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | インターロイキン−１β変換酵素のインヒビター |
-
1997
- 1997-12-05 JP JP52581898A patent/JP4274584B2/ja not_active Expired - Lifetime
- 1997-12-05 CA CA002274249A patent/CA2274249A1/en not_active Abandoned
- 1997-12-05 AT AT97954531T patent/ATE290545T1/de not_active IP Right Cessation
- 1997-12-05 DE DE69732712T patent/DE69732712T2/de not_active Expired - Lifetime
- 1997-12-05 AU AU58960/98A patent/AU5896098A/en not_active Abandoned
- 1997-12-05 PT PT97954531T patent/PT944645E/pt unknown
- 1997-12-05 ES ES97954531T patent/ES2239788T3/es not_active Expired - Lifetime
- 1997-12-05 EP EP97954531A patent/EP0944645B1/en not_active Expired - Lifetime
- 1997-12-05 WO PCT/US1997/022289 patent/WO1998024805A1/en not_active Ceased
-
1999
- 1999-06-04 US US09/326,495 patent/US6329365B1/en not_active Expired - Fee Related
-
2001
- 2001-10-23 US US10/035,850 patent/US6573259B2/en not_active Expired - Fee Related
-
2003
- 2003-04-25 US US10/424,576 patent/US6974809B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69732712T2 (de) | 2006-04-13 |
| EP0944645B1 (en) | 2005-03-09 |
| US6974809B2 (en) | 2005-12-13 |
| ATE290545T1 (de) | 2005-03-15 |
| US6573259B2 (en) | 2003-06-03 |
| JP4274584B2 (ja) | 2009-06-10 |
| US6329365B1 (en) | 2001-12-11 |
| JP2001505883A (ja) | 2001-05-08 |
| DE69732712D1 (de) | 2005-04-14 |
| PT944645E (pt) | 2005-06-30 |
| AU5896098A (en) | 1998-06-29 |
| CA2274249A1 (en) | 1998-06-11 |
| US20040048855A1 (en) | 2004-03-11 |
| EP0944645A1 (en) | 1999-09-29 |
| US20030069228A1 (en) | 2003-04-10 |
| WO1998024805A1 (en) | 1998-06-11 |
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