DE69732712T2 - INHIBITOREN DES INTERLEUKIN-1beta KONVERTIERENDEN ENZYMS - Google Patents
INHIBITOREN DES INTERLEUKIN-1beta KONVERTIERENDEN ENZYMS Download PDFInfo
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- DE69732712T2 DE69732712T2 DE69732712T DE69732712T DE69732712T2 DE 69732712 T2 DE69732712 T2 DE 69732712T2 DE 69732712 T DE69732712 T DE 69732712T DE 69732712 T DE69732712 T DE 69732712T DE 69732712 T2 DE69732712 T2 DE 69732712T2
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- Prior art keywords
- alkyl
- heteroaryl
- aryl
- alkylaryl
- alkylheteroaryl
- Prior art date
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- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 description 1
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- KBDOSCSBNLAADN-LURJTMIESA-N tert-butyl (3s)-3-amino-n-carbamoyl-4-oxobutanehydrazonate Chemical compound O=C[C@@H](N)CC(OC(C)(C)C)=NNC(N)=O KBDOSCSBNLAADN-LURJTMIESA-N 0.000 description 1
- RWSLZMDNVVHMPK-KRWDZBQOSA-N tert-butyl (3s)-n-carbamoyl-3-(9h-fluoren-1-ylmethoxycarbonylamino)-4-oxobutanehydrazonate Chemical compound C1C2=CC=CC=C2C2=C1C(COC(=O)N[C@@H](CC(OC(C)(C)C)=NNC(N)=O)C=O)=CC=C2 RWSLZMDNVVHMPK-KRWDZBQOSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- 229940124597 therapeutic agent Drugs 0.000 description 1
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- 229960000984 tocofersolan Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000010891 toxic waste Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
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- 230000004565 tumor cell growth Effects 0.000 description 1
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- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 230000036967 uncompetitive effect Effects 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
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- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3279296P | 1996-12-06 | 1996-12-06 | |
| US32792P | 1996-12-06 | ||
| US4266097P | 1997-04-04 | 1997-04-04 | |
| US42660P | 1997-04-04 | ||
| US5300197P | 1997-06-26 | 1997-06-26 | |
| US53001P | 1997-06-26 | ||
| PCT/US1997/022289 WO1998024805A1 (en) | 1996-12-06 | 1997-12-05 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69732712D1 DE69732712D1 (de) | 2005-04-14 |
| DE69732712T2 true DE69732712T2 (de) | 2006-04-13 |
Family
ID=27364225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69732712T Expired - Lifetime DE69732712T2 (de) | 1996-12-06 | 1997-12-05 | INHIBITOREN DES INTERLEUKIN-1beta KONVERTIERENDEN ENZYMS |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6329365B1 (enExample) |
| EP (1) | EP0944645B1 (enExample) |
| JP (1) | JP4274584B2 (enExample) |
| AT (1) | ATE290545T1 (enExample) |
| AU (1) | AU5896098A (enExample) |
| CA (1) | CA2274249A1 (enExample) |
| DE (1) | DE69732712T2 (enExample) |
| ES (1) | ES2239788T3 (enExample) |
| PT (1) | PT944645E (enExample) |
| WO (1) | WO1998024805A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4274584B2 (ja) * | 1996-12-06 | 2009-06-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | インターロイキン−１β変換酵素のインヒビター |
| US20010049381A1 (en) | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
| US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
| US6184210B1 (en) * | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
| JP2001522800A (ja) | 1997-11-10 | 2001-11-20 | ブリストル−マイヤーズ スクイブ カンパニー | ベンゾチアゾールたんぱくチロシン・キナーゼ抑制剤 |
| US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| SK18302000A3 (sk) | 1998-06-03 | 2001-06-11 | Gpi Nil Holdings, Inc. | N-viazané sulfónamidy n-heterocyklických karboxylových kyselín a izosterov karboxylových kyselín, farmaceutický prostriedok s ich obsahom a ich použitie |
| US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
| US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
| FR2782997A1 (fr) * | 1998-09-08 | 2000-03-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la benzodiazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicaments et compositions pharmaceutiques les renfermant |
| US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| DE60026568D1 (de) | 1999-12-21 | 2006-05-04 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
| WO2002066063A1 (en) * | 2001-02-23 | 2002-08-29 | Nippon Organon K.K. | Remedies for metabolic bone diseases |
| DE10129715A1 (de) * | 2001-06-22 | 2003-01-02 | Bayer Ag | Thiazolylamide |
| US7001899B2 (en) * | 2002-06-10 | 2006-02-21 | The Procter & Gamble Company | Interleukin converting enzyme inhibitors |
| CA2490401A1 (en) | 2002-06-28 | 2004-01-08 | Life Technologies Corporation | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US7060698B2 (en) * | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| US20060128696A1 (en) * | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
| JP4980358B2 (ja) * | 2005-09-19 | 2012-07-18 | アロー セラピューティクス リミテッド | Ｃ型肝炎感染症を治療するためのベンゾジアゼピン誘導体 |
| JP5806670B2 (ja) | 2009-09-16 | 2015-11-10 | セルジーン アビロミクス リサーチ， インコーポレイテッド | プロテインキナーゼコンジュゲート及びインヒビター |
| CN102812167A (zh) | 2009-12-30 | 2012-12-05 | 阿维拉制药公司 | 蛋白的配体-介导的共价修饰 |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| WO2020110143A1 (en) | 2018-11-26 | 2020-06-04 | Rai Balwant | Methods, systems, and a kit for diagnosis, detection, monitoring and treatment of traumatic brain injury |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970207A (en) * | 1988-07-07 | 1990-11-13 | Fujisawa Pharmaceutical Company, Ltd. | Benzodiazepine derivatives |
| CA2160786A1 (en) * | 1993-05-14 | 1994-11-24 | James C. Marsters, Jr. | Ras farnesyl transferase inhibitors |
| US5580979A (en) * | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5852010A (en) * | 1996-04-03 | 1998-12-22 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP4274584B2 (ja) * | 1996-12-06 | 2009-06-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | インターロイキン−１β変換酵素のインヒビター |
-
1997
- 1997-12-05 JP JP52581898A patent/JP4274584B2/ja not_active Expired - Lifetime
- 1997-12-05 CA CA002274249A patent/CA2274249A1/en not_active Abandoned
- 1997-12-05 AT AT97954531T patent/ATE290545T1/de not_active IP Right Cessation
- 1997-12-05 DE DE69732712T patent/DE69732712T2/de not_active Expired - Lifetime
- 1997-12-05 AU AU58960/98A patent/AU5896098A/en not_active Abandoned
- 1997-12-05 PT PT97954531T patent/PT944645E/pt unknown
- 1997-12-05 ES ES97954531T patent/ES2239788T3/es not_active Expired - Lifetime
- 1997-12-05 EP EP97954531A patent/EP0944645B1/en not_active Expired - Lifetime
- 1997-12-05 WO PCT/US1997/022289 patent/WO1998024805A1/en not_active Ceased
-
1999
- 1999-06-04 US US09/326,495 patent/US6329365B1/en not_active Expired - Fee Related
-
2001
- 2001-10-23 US US10/035,850 patent/US6573259B2/en not_active Expired - Fee Related
-
2003
- 2003-04-25 US US10/424,576 patent/US6974809B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0944645B1 (en) | 2005-03-09 |
| US6974809B2 (en) | 2005-12-13 |
| ATE290545T1 (de) | 2005-03-15 |
| US6573259B2 (en) | 2003-06-03 |
| JP4274584B2 (ja) | 2009-06-10 |
| US6329365B1 (en) | 2001-12-11 |
| JP2001505883A (ja) | 2001-05-08 |
| ES2239788T3 (es) | 2005-10-01 |
| DE69732712D1 (de) | 2005-04-14 |
| PT944645E (pt) | 2005-06-30 |
| AU5896098A (en) | 1998-06-29 |
| CA2274249A1 (en) | 1998-06-11 |
| US20040048855A1 (en) | 2004-03-11 |
| EP0944645A1 (en) | 1999-09-29 |
| US20030069228A1 (en) | 2003-04-10 |
| WO1998024805A1 (en) | 1998-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |