ES2237807T3 - Procedimiento de preparacion de un producto intermedio util para la sintesis de medios de contraste yodados. - Google Patents
Procedimiento de preparacion de un producto intermedio util para la sintesis de medios de contraste yodados.Info
- Publication number
- ES2237807T3 ES2237807T3 ES97953815T ES97953815T ES2237807T3 ES 2237807 T3 ES2237807 T3 ES 2237807T3 ES 97953815 T ES97953815 T ES 97953815T ES 97953815 T ES97953815 T ES 97953815T ES 2237807 T3 ES2237807 T3 ES 2237807T3
- Authority
- ES
- Spain
- Prior art keywords
- dichloride
- preparation
- amino
- triiodoisophthaloyl
- acetoxypropionyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 230000015572 biosynthetic process Effects 0.000 title description 5
- 238000003786 synthesis reaction Methods 0.000 title description 5
- 239000013067 intermediate product Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000011541 reaction mixture Substances 0.000 claims abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 5
- -1 L-2-acetoxypropionyl Chemical group 0.000 claims description 26
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 11
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 8
- 229960004647 iopamidol Drugs 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 7
- ALHZEIINTQJLOT-VKHMYHEASA-N [(2s)-1-chloro-1-oxopropan-2-yl] acetate Chemical compound ClC(=O)[C@H](C)OC(C)=O ALHZEIINTQJLOT-VKHMYHEASA-N 0.000 claims description 6
- 239000000010 aprotic solvent Substances 0.000 claims description 3
- FBJVWRITWDYUAC-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl chloride Chemical compound NC1=C(I)C(C(Cl)=O)=C(I)C(C(Cl)=O)=C1I FBJVWRITWDYUAC-UHFFFAOYSA-N 0.000 claims 2
- GMPOMLNJZPYPGR-VKHMYHEASA-N [(2s)-1-(3,5-dicarbonochloridoyl-2,4,6-triiodoanilino)-1-oxopropan-2-yl] acetate Chemical compound CC(=O)O[C@@H](C)C(=O)NC1=C(I)C(C(Cl)=O)=C(I)C(C(Cl)=O)=C1I GMPOMLNJZPYPGR-VKHMYHEASA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 11
- 229940126062 Compound A Drugs 0.000 description 10
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 10
- 230000003197 catalytic effect Effects 0.000 description 7
- 230000006340 racemization Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 3
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000193 iodinated contrast media Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- WMWMTXHVEPHGQU-KKMMWDRVSA-N 1-n,3-n-bis(2,3-dihydroxypropyl)-5-[[(2s)-2-hydroxypropanoyl]amino]-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I WMWMTXHVEPHGQU-KKMMWDRVSA-N 0.000 description 1
- 239000002841 Lewis acid Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- RERHJVNYJKZHLJ-UHFFFAOYSA-N bis(2-hydroxyethyl)azanium;2-(3,5-diiodo-4-oxopyridin-1-yl)acetate Chemical compound OCCNCCO.OC(=O)CN1C=C(I)C(=O)C(I)=C1 RERHJVNYJKZHLJ-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI962736 | 1996-12-24 | ||
| IT96MI002736A IT1289520B1 (it) | 1996-12-24 | 1996-12-24 | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2237807T3 true ES2237807T3 (es) | 2005-08-01 |
Family
ID=11375487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97953815T Expired - Lifetime ES2237807T3 (es) | 1996-12-24 | 1997-12-15 | Procedimiento de preparacion de un producto intermedio util para la sintesis de medios de contraste yodados. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0900196B1 (h) |
| AU (1) | AU5757898A (h) |
| DE (1) | DE69732626T2 (h) |
| ES (1) | ES2237807T3 (h) |
| IN (1) | IN184017B (h) |
| IT (1) | IT1289520B1 (h) |
| NO (1) | NO308700B1 (h) |
| PT (1) | PT900196E (h) |
| WO (1) | WO1998028259A1 (h) |
| ZA (1) | ZA9711509B (h) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2093206A1 (en) | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Process for the iodination of aromatic compounds |
| FR2941503B1 (fr) | 2009-01-27 | 2011-03-04 | Snecma | Propulseur a derive fermee d'electrons |
| EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
| KR101699065B1 (ko) | 2009-07-07 | 2017-01-23 | 브라코 이미징 에스.피.에이. | 요오드화제의 제조방법 |
| CA2897700C (en) | 2012-12-11 | 2022-05-03 | Bracco Imaging S.P.A. | Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride |
| HRP20181122T1 (hr) | 2013-11-05 | 2018-09-21 | Bracco Imaging S.P.A | Postupak za pripremu jopamidola |
| AU2015273640B2 (en) | 2014-06-10 | 2019-01-24 | Bracco Imaging Spa | Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof |
| JP7012722B2 (ja) | 2016-12-05 | 2022-01-28 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 放射線画像診断剤中間体の機械化学的合成 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (h) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| CH616403A5 (en) * | 1975-10-29 | 1980-03-31 | Bracco Ind Chimica Spa | Process for the preparation of 2,4,6-triodoisophthalamides which are readily soluble in water. |
| IT1256162B (it) * | 1992-10-27 | 1995-11-29 | Zambon Spa | Processo per la preparazione di un intermedio della sintesi organica |
| SK8897A3 (en) * | 1995-05-23 | 1997-08-06 | Fructamine Spa | Process for the preparation of s-(-)-5-££2-(acetoxy)-1- -oxopropyl|amino|-2,4,6-triiodine-1,3-benzenedicarboxylic acid dichloride |
-
1996
- 1996-12-24 IT IT96MI002736A patent/IT1289520B1/it active IP Right Grant
-
1997
- 1997-12-15 PT PT97953815T patent/PT900196E/pt unknown
- 1997-12-15 AU AU57578/98A patent/AU5757898A/en not_active Abandoned
- 1997-12-15 WO PCT/EP1997/007026 patent/WO1998028259A1/en active IP Right Grant
- 1997-12-15 DE DE69732626T patent/DE69732626T2/de not_active Expired - Lifetime
- 1997-12-15 ES ES97953815T patent/ES2237807T3/es not_active Expired - Lifetime
- 1997-12-15 EP EP97953815A patent/EP0900196B1/en not_active Expired - Lifetime
- 1997-12-22 ZA ZA9711509A patent/ZA9711509B/xx unknown
- 1997-12-22 IN IN2958MA1997 patent/IN184017B/en unknown
-
1998
- 1998-08-21 NO NO983874A patent/NO308700B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0900196B1 (en) | 2005-03-02 |
| IN184017B (h) | 2000-06-03 |
| EP0900196A1 (en) | 1999-03-10 |
| DE69732626T2 (de) | 2005-07-21 |
| DE69732626D1 (de) | 2005-04-07 |
| ZA9711509B (en) | 1998-06-24 |
| WO1998028259A1 (en) | 1998-07-02 |
| NO983874D0 (no) | 1998-08-21 |
| PT900196E (pt) | 2005-05-31 |
| ITMI962736A1 (it) | 1998-06-24 |
| NO308700B1 (no) | 2000-10-16 |
| AU5757898A (en) | 1998-07-17 |
| IT1289520B1 (it) | 1998-10-15 |
| NO983874L (no) | 1998-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2237807T3 (es) | Procedimiento de preparacion de un producto intermedio util para la sintesis de medios de contraste yodados. | |
| CN101213180B (zh) | 制备二氢喹唑啉的方法 | |
| CA1201126A (en) | Non-ionic 5-c-substituted 2,4,6-triiodo-isophthalic acid derivatives | |
| ES2595236T3 (es) | Procedimiento de preparación de la sal de L-arginina de perindopril | |
| CN104829599B (zh) | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 | |
| JP6104241B2 (ja) | トリヨード造影剤の製造 | |
| ES2334875B1 (es) | Metodo para preparar escitalopram. | |
| ES2240335T3 (es) | Procedimiento de preparacion de isomeros de salbutamol. | |
| CN103497330A (zh) | 一种基于聚氨基酸的两亲分子水凝胶 | |
| EP0901461B1 (en) | A process for the preparation of an intermediate useful in the synthesis of iodinated contrast media | |
| CA2593010C (en) | Process for the preparation of tamsulosin and intermediates thereof | |
| CA1170268A (en) | Ionic 5-c-substituted 2,4,6-triiodo-isophthalic acid derivatives | |
| WO2012165607A1 (ja) | プロリン化合物の製造方法 | |
| ES2228171T3 (es) | Procedimiento de preparacion de esteres beta-hidroxi. | |
| ES2327816T3 (es) | Procedimiento para la preparacion de esteres de acido amico. | |
| ES2214414T3 (es) | Procedimiento e intermedios para la preparacion de 1-(9h-carbazol-4-iloxi)-3-(2-(2-metoxifenoxi)etilamino)propan-2-ol, carvedilol o sales de adicion acidas del mismo. | |
| JP3046258B2 (ja) | １−クロロカルボニル−４−ピペリジノピペリジンまたはその塩酸塩の製造方法 | |
| JPH11501919A (ja) | ４，６−ジメトキシ−２−（（フェノキシカルボニル）アミノ）−ピリミジンの製造 | |
| CN110872256B (zh) | 一种3-甲基-4-溴-7-（三氟甲基）-1h-吲唑的合成方法 | |
| ES2311830T3 (es) | Procedimiento para la preparacion de un producto intermedio imina. | |
| JPS62155243A (ja) | α―ｄ―プロポキシフェン塩酸塩の製造方法 | |
| JPH069543A (ja) | クロロスルホニル化物の製造方法 | |
| JP2911976B2 (ja) | 新規なアジド化合物およびその製造方法並びにネフィラトキシン類の製造方法 | |
| JP3812371B2 (ja) | ３，４−ジヒドロキシベンゾニトリルの製造法 | |
| KR820001453B1 (ko) | 페니실란산 유도체의 제조방법 |