ES2235170T3 - Enantiomero r de n-propargil-1-aminoindano para su tratamiento de diversas enfermedades y mesilato, esilato y sulfato del mismo. - Google Patents
Enantiomero r de n-propargil-1-aminoindano para su tratamiento de diversas enfermedades y mesilato, esilato y sulfato del mismo.Info
- Publication number
- ES2235170T3 ES2235170T3 ES95903505T ES95903505T ES2235170T3 ES 2235170 T3 ES2235170 T3 ES 2235170T3 ES 95903505 T ES95903505 T ES 95903505T ES 95903505 T ES95903505 T ES 95903505T ES 2235170 T3 ES2235170 T3 ES 2235170T3
- Authority
- ES
- Spain
- Prior art keywords
- salt
- pai
- pharmaceutical composition
- aminoindane
- propargil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US139517 | 1987-12-30 | ||
| US13951793A | 1993-10-18 | 1993-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2235170T3 true ES2235170T3 (es) | 2005-07-01 |
Family
ID=22487049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95903505T Expired - Lifetime ES2235170T3 (es) | 1993-10-18 | 1994-10-12 | Enantiomero r de n-propargil-1-aminoindano para su tratamiento de diversas enfermedades y mesilato, esilato y sulfato del mismo. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0812190B1 (enExample) |
| JP (3) | JPH09505806A (enExample) |
| AT (1) | ATE284208T1 (enExample) |
| AU (1) | AU1253495A (enExample) |
| CA (1) | CA2174449C (enExample) |
| DE (2) | DE69434178T2 (enExample) |
| DK (1) | DK0812190T3 (enExample) |
| ES (1) | ES2235170T3 (enExample) |
| FR (1) | FR05C0033I2 (enExample) |
| HU (1) | HU226138B1 (enExample) |
| IL (1) | IL111240A (enExample) |
| LU (1) | LU91191I2 (enExample) |
| MX (1) | MXPA94008019A (enExample) |
| NL (1) | NL300205I2 (enExample) |
| PT (1) | PT812190E (enExample) |
| WO (1) | WO1995011016A1 (enExample) |
| ZA (1) | ZA948013B (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
| US5844003A (en) * | 1991-04-04 | 1998-12-01 | Innovations Foundation | Use of deprenyl compounds to maintain, prevent loss, or recover nerve cell function |
| DE4327516A1 (de) * | 1993-08-17 | 1995-02-23 | Asta Medica Ag | Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin |
| HU225986B1 (en) * | 1994-01-10 | 2008-02-28 | Teva Pharma | Use of 1-aminoindan derivatives for preparing pharmaceutical compns. and 1-aminoindan derivatives |
| US5877218A (en) | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| EP0808160A1 (en) | 1995-02-10 | 1997-11-26 | The University Of Toronto Innovations Foundation | Deprenyl compounds for treatment of glaucoma |
| ATE241346T1 (de) * | 1995-03-02 | 2003-06-15 | Scherer Technologies Inc R P | Arzneimittel enthaltend monoaminooxidase-b-hemmer |
| IL115357A (en) * | 1995-09-20 | 2000-01-31 | Teva Pharma | Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols |
| IL118836A (en) * | 1996-07-11 | 2001-01-11 | Teva Pharma | Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan |
| IL119417A (en) * | 1996-10-13 | 2003-02-12 | Moshe Kushnir | Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease |
| ATE377585T1 (de) | 1996-12-18 | 2007-11-15 | Teva Pharma | Aminoindanderivate |
| GB9715082D0 (en) * | 1997-07-17 | 1997-09-24 | Scherer Ltd R P | Treatment of attention deficit hyperactivity disorder and narcolepsy |
| AU2472499A (en) * | 1998-01-27 | 1999-08-09 | Thomas N. Thomas | Methods of treatment using mao-a and mao-b inhibitors such as l-deprenyl |
| US6737547B1 (en) | 1998-12-31 | 2004-05-18 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using N-acyl-1H-aminoindenes |
| JP2003512426A (ja) | 1999-10-27 | 2003-04-02 | テバ ファーマシューティカル インダストリーズ リミティド | 双極性気分障害における躁病の治療のための１−アミノインダンの使用。 |
| US7396860B2 (en) * | 2002-11-15 | 2008-07-08 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis |
| AR044007A1 (es) * | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
| EP1588704A1 (en) * | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
| AU2006216696B2 (en) * | 2005-02-23 | 2011-08-18 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
| JP2009521402A (ja) * | 2005-11-17 | 2009-06-04 | テバ ファーマシューティカル インダストリーズ リミティド | プロパルギル化アミノインダンの分離のための方法 |
| US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
| AU2006326642B2 (en) | 2005-12-09 | 2012-05-03 | Technion Research And Development Foundation Ltd. | Use of low-dose ladostigil for neuroprotection |
| EP1991214B1 (en) * | 2006-02-21 | 2015-08-05 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of multiple system atrophy |
| TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
| US8946300B2 (en) * | 2006-04-03 | 2015-02-03 | Teva Pharmaceutical Industries, Ltd. | Use of rasagilline for the treatment of restless legs syndrome |
| EP1892233A1 (de) * | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
| ATE528989T1 (de) | 2006-12-14 | 2011-11-15 | Teva Pharma | Kristalline feste rasagilin-base |
| US7547806B2 (en) | 2006-12-14 | 2009-06-16 | Teva Pharmaceutical Industries, Ltd. | Tannate salt of rasagiline |
| AU2008296908B2 (en) * | 2007-09-05 | 2014-01-09 | Teva Pharmaceutical Industries, Ltd. | Method of treating glaucoma using rasagiline |
| NZ585752A (en) * | 2007-12-24 | 2011-11-25 | Cipla Ltd | Process for the synthesis of propargylated aminoindan derivatives |
| EP2271612B1 (en) * | 2008-03-31 | 2016-08-10 | Actavis Group PTC EHF | Rasagiline mesylate particles and process for the preparation thereof |
| US7781616B2 (en) | 2008-05-23 | 2010-08-24 | Medichem, S.A. | Method for obtaining an aminoindan mesylate derivative |
| CN102123980B (zh) * | 2008-06-02 | 2014-05-07 | 基因里克斯(英国)有限公司 | 用于制备对映异构纯胺的方法 |
| CN102203053B (zh) * | 2008-06-02 | 2015-11-25 | 基因里克斯(英国)有限公司 | 用于制备胺的改进方法 |
| JP2011525489A (ja) * | 2008-06-19 | 2011-09-22 | テバ ファーマシューティカル インダストリーズ リミティド | ラサリジン塩基の精製方法 |
| EP2328861A2 (en) | 2008-07-11 | 2011-06-08 | Synthon BV | Polymorphs of rasagiline hydrochloride |
| WO2010007181A2 (en) * | 2008-07-18 | 2010-01-21 | Medichem, S.A. | New salt forms of an aminoindan derivative |
| DE102008064061A1 (de) | 2008-12-19 | 2010-06-24 | Ratiopharm Gmbh | Feste Zusammensetzung mit dem Wirkstoff Rasagilin |
| US20100189788A1 (en) | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline base formulation |
| HRP20140845T1 (hr) * | 2009-07-09 | 2014-11-07 | Ratiopharm Gmbh | Soli rasagilina i farmaceutski pripravci od njih |
| CN102048717B (zh) † | 2009-10-29 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种稳定的雷沙吉兰组合物 |
| EP2325159A1 (en) | 2009-11-24 | 2011-05-25 | LEK Pharmaceuticals d.d. | Novel salts of rasagiline |
| EP2939669A1 (en) | 2009-12-22 | 2015-11-04 | Teva Pharmaceutical Industries, Ltd. | 3-keto-n-propargyl-1-aminoindan |
| WO2011080589A2 (en) | 2009-12-30 | 2011-07-07 | Actavis Group Ptc Ehf | Solid state forms of rasagiline salts |
| US9943489B2 (en) * | 2010-02-03 | 2018-04-17 | Pharmatwob Ltd. | Extended release formulations of rasagiline and uses thereof |
| WO2011121607A2 (en) * | 2010-03-29 | 2011-10-06 | Cadila Healthcare Limited | Rasagiline and its pharmaceutically acceptable salts |
| EP2389927A1 (en) | 2010-05-30 | 2011-11-30 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Pharmaceutical formulations of rasagiline |
| CN102464589A (zh) * | 2010-11-17 | 2012-05-23 | 凯瑞斯德生化(苏州)有限公司 | 雷沙吉兰、其甲磺酸盐及其中间体的制备方法 |
| EP2663545B1 (en) | 2011-01-13 | 2015-07-01 | Nobel Ilaç Sanayii Ve Ticaret A.S. | A new method for the synthesis of rasagiline |
| WO2012116752A1 (en) | 2011-03-03 | 2012-09-07 | Synthon Bv | Process of resolution of 1-aminoindan |
| WO2012153349A2 (en) | 2011-05-04 | 2012-11-15 | Cadila Healthcare Limited | Rasagiline and its pharmaceutically acceptable salts |
| EA201490761A1 (ru) * | 2011-10-10 | 2014-11-28 | Тева Фармасьютикал Индастриз Лтд. | R(+)-n-формилпропаргиламиноиндан |
| DE102012000786A1 (de) | 2012-01-18 | 2013-07-18 | Stada Arzneimittel Ag | Verfahren zur Herstellung einer festen pharmazeutischen Zusammensetzung, enthaltend den Wirkstoff Rasagilin |
| WO2013139387A1 (en) | 2012-03-21 | 2013-09-26 | Synthon Bv | Stabilized pharmaceutical compositions comprising rasagiline salts |
| WO2013175493A1 (en) | 2012-04-09 | 2013-11-28 | Cadila Healthcare Limited | Stable oral pharmaceutical compositions |
| ES2524865T1 (es) | 2013-02-06 | 2014-12-15 | Galenicum Health S.L. | Composiciones farmacéuticas estables en forma de comprimidos de liberación inmediata |
| EP2764862A1 (en) | 2013-02-06 | 2014-08-13 | Galenicum Health S.L. | Immediate release tablets of rasagiline hemitartrate |
| IN2013MU01782A (enExample) * | 2013-05-20 | 2015-06-26 | Cadila Healthcare Ltd |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1187017A (en) * | 1966-07-16 | 1970-04-08 | Aspro Nicholas Ltd | Substituted 1-Amino Indanes and Tetrahydronaphthalens |
| DE252290T1 (de) * | 1986-06-10 | 1988-06-09 | Chiesi Farmaceutici S.P.A., Parma | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
| IL92952A (en) * | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| IL99759A (en) * | 1991-10-16 | 1997-06-10 | Teva Pharma | Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them |
-
1994
- 1994-10-11 IL IL11124094A patent/IL111240A/en not_active IP Right Cessation
- 1994-10-12 AU AU12534/95A patent/AU1253495A/en not_active Abandoned
- 1994-10-12 EP EP95903505A patent/EP0812190B1/en not_active Expired - Lifetime
- 1994-10-12 HU HU9601012A patent/HU226138B1/hu active Protection Beyond IP Right Term
- 1994-10-12 WO PCT/US1994/011567 patent/WO1995011016A1/en not_active Ceased
- 1994-10-12 ES ES95903505T patent/ES2235170T3/es not_active Expired - Lifetime
- 1994-10-12 AT AT95903505T patent/ATE284208T1/de active
- 1994-10-12 DE DE69434178T patent/DE69434178T2/de not_active Expired - Lifetime
- 1994-10-12 DK DK95903505T patent/DK0812190T3/da active
- 1994-10-12 CA CA002174449A patent/CA2174449C/en not_active Expired - Lifetime
- 1994-10-12 DE DE200512000044 patent/DE122005000044I2/de active Active
- 1994-10-12 JP JP7512014A patent/JPH09505806A/ja not_active Withdrawn
- 1994-10-12 PT PT95903505T patent/PT812190E/pt unknown
- 1994-10-13 ZA ZA948013A patent/ZA948013B/xx unknown
- 1994-10-17 MX MXPA94008019A patent/MXPA94008019A/es active IP Right Grant
-
2002
- 2002-10-17 JP JP2002303097A patent/JP2003160481A/ja not_active Withdrawn
-
2005
- 2005-08-09 FR FR05C0033C patent/FR05C0033I2/fr active Active
- 2005-08-10 LU LU91191C patent/LU91191I2/fr unknown
- 2005-08-15 NL NL300205C patent/NL300205I2/nl unknown
-
2009
- 2009-09-24 JP JP2009219662A patent/JP2010018626A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995011016A1 (en) | 1995-04-27 |
| DE122005000044I1 (de) | 2005-12-22 |
| DK0812190T3 (da) | 2005-04-11 |
| IL111240A0 (en) | 1994-12-29 |
| NL300205I1 (nl) | 2005-10-03 |
| DE69434178T2 (de) | 2005-12-01 |
| NL300205I2 (nl) | 2006-03-01 |
| AU1253495A (en) | 1995-05-08 |
| IL111240A (en) | 2001-10-31 |
| LU91191I2 (fr) | 2005-10-10 |
| JP2003160481A (ja) | 2003-06-03 |
| DE122005000044I2 (de) | 2007-09-13 |
| PT812190E (pt) | 2005-04-29 |
| HU9601012D0 (en) | 1996-06-28 |
| EP0812190B1 (en) | 2004-12-08 |
| FR05C0033I2 (fr) | 2006-12-29 |
| HUT77934A (hu) | 1998-11-30 |
| CA2174449C (en) | 2007-01-16 |
| FR05C0033I1 (enExample) | 2005-09-30 |
| ATE284208T1 (de) | 2004-12-15 |
| CA2174449A1 (en) | 1995-04-27 |
| MXPA94008019A (es) | 2004-08-10 |
| ZA948013B (en) | 1995-05-31 |
| DE69434178D1 (de) | 2005-01-13 |
| HU226138B1 (en) | 2008-05-28 |
| JP2010018626A (ja) | 2010-01-28 |
| EP0812190A4 (en) | 1998-03-04 |
| EP0812190A1 (en) | 1997-12-17 |
| JPH09505806A (ja) | 1997-06-10 |
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