ES2228832T3 - Metodo para la preparacion de fluticasona y esteres 17beta carbotioicos relacionados usando una nueva sintesis de acido carbotioico y nuevos metodos de purificacion. - Google Patents

Metodo para la preparacion de fluticasona y esteres 17beta carbotioicos relacionados usando una nueva sintesis de acido carbotioico y nuevos metodos de purificacion.

Info

Publication number
ES2228832T3
ES2228832T3 ES01916231T ES01916231T ES2228832T3 ES 2228832 T3 ES2228832 T3 ES 2228832T3 ES 01916231 T ES01916231 T ES 01916231T ES 01916231 T ES01916231 T ES 01916231T ES 2228832 T3 ES2228832 T3 ES 2228832T3
Authority
ES
Spain
Prior art keywords
formula
compound
methyl
salt
difluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01916231T
Other languages
English (en)
Spanish (es)
Inventor
Jufang Barkalow
Steven A. Chamberlin
Arthur J. Cooper
Azad Hossain
John J. Hufnagel
Denton C. Langridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2228832T3 publication Critical patent/ES2228832T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES01916231T 2000-02-25 2001-02-23 Metodo para la preparacion de fluticasona y esteres 17beta carbotioicos relacionados usando una nueva sintesis de acido carbotioico y nuevos metodos de purificacion. Expired - Lifetime ES2228832T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/513,399 US20020133032A1 (en) 2000-02-25 2000-02-25 Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
US513399 2000-02-25

Publications (1)

Publication Number Publication Date
ES2228832T3 true ES2228832T3 (es) 2005-04-16

Family

ID=24043095

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01916231T Expired - Lifetime ES2228832T3 (es) 2000-02-25 2001-02-23 Metodo para la preparacion de fluticasona y esteres 17beta carbotioicos relacionados usando una nueva sintesis de acido carbotioico y nuevos metodos de purificacion.

Country Status (11)

Country Link
US (2) US20020133032A1 (enExample)
EP (1) EP1257531B1 (enExample)
JP (1) JP3986313B2 (enExample)
AT (1) ATE276235T1 (enExample)
CA (1) CA2400919C (enExample)
DE (1) DE60105555T2 (enExample)
DK (1) DK1257531T3 (enExample)
ES (1) ES2228832T3 (enExample)
MX (1) MXPA02008275A (enExample)
PT (1) PT1257531E (enExample)
WO (1) WO2001062722A2 (enExample)

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GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
SI1305329T2 (sl) 2000-08-05 2015-07-31 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-(2-furanilkarboksil)oksi-11beta-hidroksi- 16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CA2445839A1 (en) 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
AU2002321884A1 (en) * 2001-08-03 2003-02-24 Smithkline Beecham Corporation A method for preparing fluticasone derivatives
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
AU2003263575A1 (en) 2002-06-20 2004-01-06 Sun Pharmaceutical Industries Limited Convenient synthesis of s-fluoromethyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- methyl-17alpha-propionyloxy-3-oxoandrosta-1, 4-diene-17beta-carbothioate
IL153462A0 (en) * 2002-12-16 2003-07-06 Chemagis Ltd Thiocarboxylic acid organic salts and processes utilizing the same
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
CA2530680A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
PT103202B (pt) 2004-10-19 2011-01-27 Hovione Farmaciencia S A Processo para a esterificação de um ácido carbotiótico
CN100560598C (zh) * 2005-07-26 2009-11-18 上海奥锐特国际贸易有限公司 氟替卡松丙酸酯的合成方法
EP2402361B1 (en) * 2006-06-14 2020-04-15 Generics [UK] Limited Process for the preparation of s-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1,4-diene-17-carbothioate and intermediates
US7265247B1 (en) 2006-07-28 2007-09-04 Im&T Research, Inc. Substituted phenylsulfur trifluoride and other like fluorinating agents
US8399720B2 (en) * 2007-03-23 2013-03-19 Ube Industries, Ltd. Methods for producing fluorinated phenylsulfur pentafluorides
RU2472779C2 (ru) * 2007-03-23 2013-01-20 УБЭ Индастриз, Лтд. Способ получения пентафторидов арилсеры
US8030516B2 (en) * 2007-10-19 2011-10-04 Ube Industries, Ltd. Methods for producing perfluoroalkanedi(sulfonyl chloride)
JP2011518765A (ja) * 2007-12-11 2011-06-30 宇部興産株式会社 ジフルオロメチレン−及びトリフルオロメチル−含有化合物を製造するための方法及び組成物
TW201006787A (en) * 2008-03-07 2010-02-16 Im & T Res Inc Fluorination processes with arylsulfur halotetrafluorides
WO2010022001A1 (en) * 2008-08-18 2010-02-25 Im&T Research, Inc. Methods for preparing fluoroalkyl arylsulfinyl compounds and fluorinated compounds thereto
KR101676054B1 (ko) * 2008-09-22 2016-11-14 우베 고산 가부시키가이샤 폴리(펜타플루오로설파닐)방향족 화합물을 제조하기 위한 공정
US20100174096A1 (en) * 2009-01-05 2010-07-08 Im&T Research, Inc. Methods for Production of Optically Active Fluoropyrrolidine Derivatives
WO2010081014A1 (en) 2009-01-09 2010-07-15 Im&T Research, Inc. Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods
EP2611821A2 (en) 2010-09-01 2013-07-10 Cadila Healthcare Limited Process for preparing fluticasone propionate/furoate
CN102558273B (zh) * 2010-12-14 2014-07-02 浙江省天台县奥锐特药业有限公司 氟替卡松糠酸酯的制备方法
US9303060B1 (en) 2014-10-03 2016-04-05 Amphaster Pharmaceuticals, Inc. Methods of preparing intermediate of fluticasone propionate

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US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4198403A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
GB2137206B (en) 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
CY1291A (en) 1980-02-15 1985-10-18 Glaxo Group Ltd Androstane 17 beta carbothioates
CA1201114A (en) * 1980-02-15 1986-02-25 Gordon H. Phillipps Androstane carbothioates
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
IL109656A (en) 1994-05-15 1998-02-22 Chemagis Ltd Process for the manufacture of androstane - 17 - carbothioates and androstane - 17 - carbothioates prepared thereby
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
IL150654A (en) * 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate

Also Published As

Publication number Publication date
DE60105555T2 (de) 2005-09-29
DK1257531T3 (da) 2005-01-17
WO2001062722A3 (en) 2002-05-16
US20020133032A1 (en) 2002-09-19
JP3986313B2 (ja) 2007-10-03
PT1257531E (pt) 2005-01-31
ATE276235T1 (de) 2004-10-15
JP2003529564A (ja) 2003-10-07
MXPA02008275A (es) 2003-01-28
EP1257531B1 (en) 2004-09-15
US7214807B2 (en) 2007-05-08
EP1257531A2 (en) 2002-11-20
DE60105555D1 (de) 2004-10-21
US20040209854A1 (en) 2004-10-21
WO2001062722A2 (en) 2001-08-30
CA2400919C (en) 2009-01-20
CA2400919A1 (en) 2001-08-30

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