DK1257531T3 - Fremgangsmåde til fremstilling af carbothiosyre - Google Patents

Fremgangsmåde til fremstilling af carbothiosyre

Info

Publication number
DK1257531T3
DK1257531T3 DK01916231T DK01916231T DK1257531T3 DK 1257531 T3 DK1257531 T3 DK 1257531T3 DK 01916231 T DK01916231 T DK 01916231T DK 01916231 T DK01916231 T DK 01916231T DK 1257531 T3 DK1257531 T3 DK 1257531T3
Authority
DK
Denmark
Prior art keywords
preparation
carbothioic acid
carbothioic
acids
carbothiolates
Prior art date
Application number
DK01916231T
Other languages
Danish (da)
English (en)
Inventor
Steven A Chamberlin
Jufang Barkalow
Arthur J Cooper
Azad Hossain
John J Hufnagel
Denton C Langridge
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1257531T3 publication Critical patent/DK1257531T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01916231T 2000-02-25 2001-02-23 Fremgangsmåde til fremstilling af carbothiosyre DK1257531T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/513,399 US20020133032A1 (en) 2000-02-25 2000-02-25 Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
PCT/US2001/006055 WO2001062722A2 (en) 2000-02-25 2001-02-23 Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods

Publications (1)

Publication Number Publication Date
DK1257531T3 true DK1257531T3 (da) 2005-01-17

Family

ID=24043095

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01916231T DK1257531T3 (da) 2000-02-25 2001-02-23 Fremgangsmåde til fremstilling af carbothiosyre

Country Status (11)

Country Link
US (2) US20020133032A1 (enExample)
EP (1) EP1257531B1 (enExample)
JP (1) JP3986313B2 (enExample)
AT (1) ATE276235T1 (enExample)
CA (1) CA2400919C (enExample)
DE (1) DE60105555T2 (enExample)
DK (1) DK1257531T3 (enExample)
ES (1) ES2228832T3 (enExample)
MX (1) MXPA02008275A (enExample)
PT (1) PT1257531E (enExample)
WO (1) WO2001062722A2 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
CA2417826A1 (en) 2000-08-05 2002-02-14 Glaxo Group Limited 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
AR033290A1 (es) 2001-04-30 2003-12-10 Glaxo Group Ltd Derivados antiinflamatorios de androstano
AU2002321884A1 (en) * 2001-08-03 2003-02-24 Smithkline Beecham Corporation A method for preparing fluticasone derivatives
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US7208613B2 (en) 2002-06-20 2007-04-24 Sun Pharmaceutical Industries Limited Synthesis of s-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
IL153462A0 (en) * 2002-12-16 2003-07-06 Chemagis Ltd Thiocarboxylic acid organic salts and processes utilizing the same
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
AU2004226318B2 (en) * 2003-04-04 2008-06-05 Xellia Pharmaceuticals Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
PT103202B (pt) * 2004-10-19 2011-01-27 Hovione Farmaciencia S A Processo para a esterificação de um ácido carbotiótico
CN100560598C (zh) 2005-07-26 2009-11-18 上海奥锐特国际贸易有限公司 氟替卡松丙酸酯的合成方法
SI2044099T1 (sl) * 2006-06-14 2012-09-28 Generics Uk Ltd Postopek priprave S-fluorometil-6,9-difluoro-11-hidroksi-16-metil-17-propioniloksi-3-okso -androsta-1,4-dien-17-karbotioata in vmesnih spojin
US7265247B1 (en) 2006-07-28 2007-09-04 Im&T Research, Inc. Substituted phenylsulfur trifluoride and other like fluorinating agents
US8399720B2 (en) * 2007-03-23 2013-03-19 Ube Industries, Ltd. Methods for producing fluorinated phenylsulfur pentafluorides
CA2857831C (en) * 2007-03-23 2017-01-03 Ube Industries, Ltd. Process for producing arylsulfur pentafluorides
US8030516B2 (en) * 2007-10-19 2011-10-04 Ube Industries, Ltd. Methods for producing perfluoroalkanedi(sulfonyl chloride)
US20100234605A1 (en) * 2007-12-11 2010-09-16 Im&T Research, Inc. Methods and compositions for producing difluoromethylene-and trifluoromethyl-containing compounds
TW201006787A (en) * 2008-03-07 2010-02-16 Im & T Res Inc Fluorination processes with arylsulfur halotetrafluorides
WO2010022001A1 (en) * 2008-08-18 2010-02-25 Im&T Research, Inc. Methods for preparing fluoroalkyl arylsulfinyl compounds and fluorinated compounds thereto
EP2334661B1 (en) * 2008-09-22 2017-08-30 Ube Industries, Ltd. Processes for preparing poly(pentafluorosulfanyl)aromatic compounds
US20100174096A1 (en) * 2009-01-05 2010-07-08 Im&T Research, Inc. Methods for Production of Optically Active Fluoropyrrolidine Derivatives
WO2010081014A1 (en) 2009-01-09 2010-07-15 Im&T Research, Inc. Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods
US8841442B2 (en) 2010-09-01 2014-09-23 Cadila Healthcare Limited Process for preparing fluticasone propionate/furoate
CN102558273B (zh) * 2010-12-14 2014-07-02 浙江省天台县奥锐特药业有限公司 氟替卡松糠酸酯的制备方法
US9303060B1 (en) * 2014-10-03 2016-04-05 Amphaster Pharmaceuticals, Inc. Methods of preparing intermediate of fluticasone propionate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198403A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
GB2137206B (en) 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
GB2088877B (en) 1980-02-15 1984-07-04 Glaxo Group Ltd Androstane 17 carbothioates
BE887518A (fr) * 1980-02-15 1981-08-13 Glaxo Group Ltd Cartothioates d'androstanes
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
IL109656A (en) 1994-05-15 1998-02-22 Chemagis Ltd Process for the manufacture of androstane - 17 - carbothioates and androstane - 17 - carbothioates prepared thereby
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
IL150654A (en) * 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate

Also Published As

Publication number Publication date
US7214807B2 (en) 2007-05-08
PT1257531E (pt) 2005-01-31
WO2001062722A2 (en) 2001-08-30
CA2400919A1 (en) 2001-08-30
DE60105555T2 (de) 2005-09-29
JP3986313B2 (ja) 2007-10-03
EP1257531A2 (en) 2002-11-20
ATE276235T1 (de) 2004-10-15
DE60105555D1 (de) 2004-10-21
US20020133032A1 (en) 2002-09-19
WO2001062722A3 (en) 2002-05-16
ES2228832T3 (es) 2005-04-16
MXPA02008275A (es) 2003-01-28
CA2400919C (en) 2009-01-20
US20040209854A1 (en) 2004-10-21
EP1257531B1 (en) 2004-09-15
JP2003529564A (ja) 2003-10-07

Similar Documents

Publication Publication Date Title
PT1257531E (pt) Processo de preparacao de acidos carbotioicos
NO20072863L (no) Fremgangsmate til a rense FSH
WO2001045678A3 (de) Arzneimittel, verfahren zu dessen herstellung und dessen verwendung
DE50114998D1 (de) Verfahren zur herstellung von monolithischen chromatographiesäulen
DE60322852D1 (de) Verfahren zur herstellung von eplerenon
DK1644469T4 (da) Fremgangsmåde til fremstilling af oprensede fedtsyrer
NO20023276D0 (no) Fremgangsmåte til å fremstille betulinsyre
DK1097130T3 (da) Fremgangsmåde til fremstilling af hydroxymethylthiosmörsyre
WO2003029391A1 (fr) Procede de production de compositions de matiere grasse renfermant de l'acide oleanolique et/ou de l'acide maslinique
DE60129032D1 (de) Creatinester-pronutrient-verbindungen und formulierungen
EP1831239B8 (en) A process for the preparation of 17-hydroxy-6 beta, 7 beta, 15 beta, 16 beta -bismethylene-17 alpha-pregn-4-ene-3-one-21-carboxylic acid gamma-lactone and key-intermediates for this process
HUP0303907A2 (hu) Javított eljárás szteroidok előállítására
FI20020593A0 (fi) Menetelmä konjugoidun linolihapon valmistamiseksi
DE602005021395D1 (de) GROßTECHNISCHES VERFAHREN ZUR HERSTELLUNG VON 17-HYDROXY-6BETA, 7BETA, 15BETA,16BETA-BISMETHYLEN-3-OXO-17ALPHA-PREGN-4-EN-21-CARBONSÄURE-GAMMA-LACTON UND SCHLÜSSELZWISCHENPRODUKTE FÜR DIESES VERFAHREN
DK1214321T3 (da) Proces til fremstilling af naphthyridin-3-carboxylsyre-derivater
DK1565421T3 (da) Fremgangsmåde til fremstilling af indan -1,3-dicarboxylsyre
ATE437178T1 (de) Analgetisches antitumorpeptid aus skorpionen und verfahren zu dessen herstellung
WO2005044759A3 (en) Acetalization process for preparation of steroid compounds
ATE339437T1 (de) 5-androsten-3-olsteroidzwischenprodukte und verfahren zu deren herstellung
NO20022361L (no) Fremgangsmåte for fremstilling av konjugert linolsyre
ATE377020T1 (de) Kristallines gamma-lacton der17beta-hydroxy-
NO20054636L (no) Fremgangsmate for fremstilling av steroidale karbotiosyrederivater og -intermediater
ATE442371T1 (de) Víllig lísungsmittelfreie cefotetan säure und verfahren zu ihrer herstellung.
WO2005040175A3 (en) Process for the preparation of cephem carboxylic acids
DK1114174T3 (da) Fremgangsmåde til fremstilling af polycarboxylsyrer