WO2001045678A3 - Arzneimittel, verfahren zu dessen herstellung und dessen verwendung - Google Patents

Arzneimittel, verfahren zu dessen herstellung und dessen verwendung Download PDF

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Publication number
WO2001045678A3
WO2001045678A3 PCT/EP2000/013036 EP0013036W WO0145678A3 WO 2001045678 A3 WO2001045678 A3 WO 2001045678A3 EP 0013036 W EP0013036 W EP 0013036W WO 0145678 A3 WO0145678 A3 WO 0145678A3
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WO
WIPO (PCT)
Prior art keywords
production
medicament
compound
composition
relates
Prior art date
Application number
PCT/EP2000/013036
Other languages
English (en)
French (fr)
Other versions
WO2001045678A2 (de
Inventor
Helmut Kasch
Carsten Goldschmidt
Original Assignee
Id Pharma Gmbh
Helmut Kasch
Carsten Goldschmidt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Id Pharma Gmbh, Helmut Kasch, Carsten Goldschmidt filed Critical Id Pharma Gmbh
Priority to AU31620/01A priority Critical patent/AU3162001A/en
Publication of WO2001045678A2 publication Critical patent/WO2001045678A2/de
Publication of WO2001045678A3 publication Critical patent/WO2001045678A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft eine Zusammensetzung, die als Bestandteile (a) ein Lokalanästhetikum und (b) eine entzündungshemmende Verbindung und/oder eine immunstimmulierende Verbindung und/oder eine als Träger für das Lokalanästhetikum wirkende Verbindung umfasst, sowie Verfahren zu deren Herstellung und deren Verwendung.
PCT/EP2000/013036 1999-12-21 2000-12-20 Arzneimittel, verfahren zu dessen herstellung und dessen verwendung WO2001045678A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU31620/01A AU3162001A (en) 1999-12-21 2000-12-20 Medicament, a method for its production and the use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19961834 1999-12-21
DE19961834.8 1999-12-21

Publications (2)

Publication Number Publication Date
WO2001045678A2 WO2001045678A2 (de) 2001-06-28
WO2001045678A3 true WO2001045678A3 (de) 2002-04-11

Family

ID=7933684

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/013036 WO2001045678A2 (de) 1999-12-21 2000-12-20 Arzneimittel, verfahren zu dessen herstellung und dessen verwendung

Country Status (2)

Country Link
AU (1) AU3162001A (de)
WO (1) WO2001045678A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945558B2 (en) 2005-10-21 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Methods for treating myocardial infarction comprising administering an IL-6 inhibitor

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GB0105944D0 (en) * 2001-03-10 2001-04-25 Royal Devon & Exeter Healthcar Anaesthetic Formulation
ES2214126B1 (es) * 2003-01-20 2006-02-16 Montserrat Torne Cabanes Nueva formulacion para anestesia topica, su correspondiente kit monodosis y sus aplicaciones en cirugia.
DE10303669A1 (de) * 2003-01-28 2004-07-29 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Tetraalkylammoniumsalze vom Kohlensäureestertyp, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
AU2006300234B2 (en) 2005-10-14 2013-01-10 Chugai Seiyaku Kabushiki Kaisha Agents for suppressing damage to transplanted islets after islet transplantation
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
CN104189907A (zh) 2006-01-27 2014-12-10 学校法人庆应义塾 伴有脉络膜血管生成的疾病的治疗药
EP2025346B1 (de) * 2006-04-07 2016-08-10 Osaka University Mittel zur förderung der muskelregeneration
DK2101819T3 (da) 2006-11-20 2013-04-29 Harvard College Fremgangsmåder, sammensætninger og kits til behandling af smerte og pruritis
MX2009007830A (es) 2007-01-23 2009-10-07 Univ Shinshu Inhibidor de rechazo cronico.
JP5276020B2 (ja) * 2007-02-13 2013-08-28 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ カチオン性エストラジオール誘導体、その合成方法、及び医薬組成物
US10717781B2 (en) 2008-06-05 2020-07-21 National Cancer Center Neuroinvasion inhibitor
EP3485881B1 (de) 2009-07-10 2024-03-13 President and Fellows of Harvard College Permanent geladene natrium- und calciumkanalblocker als entzündungshemmende mittel
ES2932398T3 (es) 2010-05-28 2023-01-18 Chugai Pharmaceutical Co Ltd Potenciador de la respuesta de las células T antitumorales
CN105315170B (zh) * 2014-08-01 2017-08-25 四川大学华西医院 二甲基苯铵类长链化合物、制备、自组装结构及用途
CA2994545A1 (en) 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
WO2018203545A1 (ja) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
EP3698808A4 (de) 2017-10-20 2021-07-14 Hyogo College Of Medicine Anti-il-6 rezeptorantikörper enthaltende medizinische zusammensetzung zur verhinderung von postoperativer adhäsion
CN109574866B (zh) * 2019-01-15 2022-07-15 中国科学院成都有机化学有限公司 一种2,6-二甲基苯胺类长链化合物的制备方法
KR20210145164A (ko) 2019-03-11 2021-12-01 녹시온 테라퓨틱스 인코포레이티드 에스테르 치환된 이온 채널 차단제 및 사용 방법
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2022525856A (ja) 2019-03-11 2022-05-20 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3129117A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Charged ion channel blockers and methods for use
IL292505A (en) 2019-11-06 2022-06-01 Nocion Therapeutics Inc Charged ion channel blockers and methods of use
EP4054586A4 (de) 2019-11-06 2023-11-22 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
AU2021236130A1 (en) 2020-03-11 2022-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

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GB1279214A (en) * 1970-01-22 1972-06-28 Forest Laboratories Long-acting oral carrier
US3821375A (en) * 1970-11-05 1974-06-28 Alper C Treatment of otitis of dogs and cats with chloramphenicol-squalane composition
JPS5576814A (en) * 1978-12-06 1980-06-10 Green Cross Corp:The Preservative solution for organ transplant
EP0035856A2 (de) * 1980-03-07 1981-09-16 Efamol Limited Pharmazeutische und diätetische Zusammensetzungen
US4446140A (en) * 1981-12-10 1984-05-01 Nelson Research & Development Company Method and composition for treating mouth pain
JPS6450815A (en) * 1987-08-21 1989-02-27 Ajinomoto Kk Plaster for oral cavity application
RU1824187C (ru) * 1990-04-09 1993-06-30 Харьковский Медицинский Институт Способ лечени миастении
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JPH08245369A (ja) * 1995-03-08 1996-09-24 Tendou Seiyaku Kk 粘膜保護剤
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GB1279214A (en) * 1970-01-22 1972-06-28 Forest Laboratories Long-acting oral carrier
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JPS5576814A (en) * 1978-12-06 1980-06-10 Green Cross Corp:The Preservative solution for organ transplant
EP0035856A2 (de) * 1980-03-07 1981-09-16 Efamol Limited Pharmazeutische und diätetische Zusammensetzungen
US4446140A (en) * 1981-12-10 1984-05-01 Nelson Research & Development Company Method and composition for treating mouth pain
JPS6450815A (en) * 1987-08-21 1989-02-27 Ajinomoto Kk Plaster for oral cavity application
RU1824187C (ru) * 1990-04-09 1993-06-30 Харьковский Медицинский Институт Способ лечени миастении
CN1092987A (zh) * 1993-04-02 1994-10-05 中国人民解放军81378部队医院 椎管去炎混合液
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CN1114190A (zh) * 1994-06-07 1996-01-03 周波 高分子合成材料重睑术混合处理液
JPH08245369A (ja) * 1995-03-08 1996-09-24 Tendou Seiyaku Kk 粘膜保護剤
DE19715594A1 (de) * 1997-04-15 1998-10-22 Bayer Ag Analgetika-Kombination
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945558B2 (en) 2005-10-21 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Methods for treating myocardial infarction comprising administering an IL-6 inhibitor

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Publication number Publication date
AU3162001A (en) 2001-07-03
WO2001045678A2 (de) 2001-06-28

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