ES2222822B1 - Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos. - Google Patents

Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos.

Info

Publication number
ES2222822B1
ES2222822B1 ES200301781A ES200301781A ES2222822B1 ES 2222822 B1 ES2222822 B1 ES 2222822B1 ES 200301781 A ES200301781 A ES 200301781A ES 200301781 A ES200301781 A ES 200301781A ES 2222822 B1 ES2222822 B1 ES 2222822B1
Authority
ES
Spain
Prior art keywords
aromatic
formula
administration
mmol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES200301781A
Other languages
English (en)
Spanish (es)
Other versions
ES2222822A1 (es
Inventor
Jean Sarkis Mardiguian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Farmaceuticos Rovi SA
Original Assignee
Laboratorios Farmaceuticos Rovi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200301781A priority Critical patent/ES2222822B1/es
Application filed by Laboratorios Farmaceuticos Rovi SA filed Critical Laboratorios Farmaceuticos Rovi SA
Priority to PL04742074T priority patent/PL1652836T3/pl
Priority to BRPI0413032-4A priority patent/BRPI0413032A/pt
Priority to ES04742074T priority patent/ES2289534T3/es
Priority to AU2004261417A priority patent/AU2004261417C1/en
Priority to US10/563,994 priority patent/US7462735B2/en
Priority to PT04742074T priority patent/PT1652836E/pt
Priority to ZA200600165A priority patent/ZA200600165B/xx
Priority to AT04742074T priority patent/ATE367373T1/de
Priority to DK04742074T priority patent/DK1652836T3/da
Priority to EP04742074A priority patent/EP1652836B1/en
Priority to DE602004007665T priority patent/DE602004007665T2/de
Priority to KR1020067001803A priority patent/KR100970216B1/ko
Priority to CNB2004800220400A priority patent/CN100475776C/zh
Priority to CA002533639A priority patent/CA2533639A1/en
Priority to RU2006101630/04A priority patent/RU2368599C2/ru
Priority to PCT/ES2004/000346 priority patent/WO2005012230A1/es
Priority to JP2006521597A priority patent/JP4343227B2/ja
Publication of ES2222822A1 publication Critical patent/ES2222822A1/es
Application granted granted Critical
Publication of ES2222822B1 publication Critical patent/ES2222822B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
ES200301781A 2003-07-28 2003-07-28 Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos. Expired - Lifetime ES2222822B1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ES200301781A ES2222822B1 (es) 2003-07-28 2003-07-28 Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos.
DE602004007665T DE602004007665T2 (de) 2003-07-28 2004-07-23 Aminosäurediamide in nicht-alpha-stellung, die sich als adjuvantien für die verabreichung biologisch aktiver mittel eignen
ES04742074T ES2289534T3 (es) 2003-07-28 2004-07-23 Diamidas de aminoacidos en posicion no alfa que son utiles como adyuvantes para la administracion de agentes biologicamente activos.
AU2004261417A AU2004261417C1 (en) 2003-07-28 2004-07-23 Amino acid diamides in non alpha position useful as adjuvants for the administration of active biological agents
US10/563,994 US7462735B2 (en) 2003-07-28 2004-07-23 Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents
PT04742074T PT1652836E (pt) 2003-07-28 2004-07-23 Diamidas de aminoácidos em posição não & que são úteis como adjuvantes para a administração de agentes biologicamente activos
ZA200600165A ZA200600165B (en) 2003-07-28 2004-07-23 Amino acid diamides in non alpha position useful as adjuvants for the administration of active biological agents
AT04742074T ATE367373T1 (de) 2003-07-28 2004-07-23 Aminosäurediamide in nicht-alpha-stellung, die sich als adjuvantien für die verabreichung biologisch aktiver mittel eignen
DK04742074T DK1652836T3 (da) 2003-07-28 2004-07-23 Aminosyrediamider i non-alfa-stilling, som egner sig som adjuvanser til administration af aktrive biologiske midler
CNB2004800220400A CN100475776C (zh) 2003-07-28 2004-07-23 用作给药生物活性剂的辅助剂的非α位上的氨基酸二酰胺
PL04742074T PL1652836T3 (pl) 2003-07-28 2004-07-23 Diamidy nie-α-aminokwasów użyteczne jako środki wspomagające do podawania środków biologicznie czynnych
BRPI0413032-4A BRPI0413032A (pt) 2003-07-28 2004-07-23 diamidas de aminoacidos em uma posição não-(alfa), úteis como adjuvantes na administração de agentes biológicos ativos
EP04742074A EP1652836B1 (en) 2003-07-28 2004-07-23 Amino acid diamides in non alpha position useful as adjuvants for the administration of active biological agents
CA002533639A CA2533639A1 (en) 2003-07-28 2004-07-23 Amino acid diamides in non alpha position useful as adjuvants for the administration of active biological agents
RU2006101630/04A RU2368599C2 (ru) 2003-07-28 2004-07-23 ДИАМИДЫ АМИНОКИСЛОТ ПО ПОЛОЖЕНИЮ, НЕ ЯВЛЯЮЩЕМУСЯ α-ПОЛОЖЕНИЕМ, ПОЛЕЗНЫЕ В КАЧЕСТВЕ АДЪЮВАНТОВ ДЛЯ ВВЕДЕНИЯ БИОЛОГИЧЕСКИ АКТИВНЫХ АГЕНТОВ
PCT/ES2004/000346 WO2005012230A1 (es) 2003-07-28 2004-07-23 DIAMIDAS DE AMINOACIDOS EN POSICION NO α UTILES COMO ADYUVANTES PARA LA ADMINISTRACION DE AGENTES BIOLOGICOS ACTIVOS
JP2006521597A JP4343227B2 (ja) 2003-07-28 2004-07-23 生物活性剤の投与のためのアジュバントとして有効である非α位のアミノ酸ジアミド
KR1020067001803A KR100970216B1 (ko) 2003-07-28 2004-07-23 생물학적 활성제 투여용 보조제로서 유용한 비-α위치의 아미노산 디아미드

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200301781A ES2222822B1 (es) 2003-07-28 2003-07-28 Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos.

Publications (2)

Publication Number Publication Date
ES2222822A1 ES2222822A1 (es) 2005-02-01
ES2222822B1 true ES2222822B1 (es) 2005-12-16

Family

ID=34112519

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200301781A Expired - Lifetime ES2222822B1 (es) 2003-07-28 2003-07-28 Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos.
ES04742074T Expired - Lifetime ES2289534T3 (es) 2003-07-28 2004-07-23 Diamidas de aminoacidos en posicion no alfa que son utiles como adyuvantes para la administracion de agentes biologicamente activos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04742074T Expired - Lifetime ES2289534T3 (es) 2003-07-28 2004-07-23 Diamidas de aminoacidos en posicion no alfa que son utiles como adyuvantes para la administracion de agentes biologicamente activos.

Country Status (17)

Country Link
US (1) US7462735B2 (enExample)
EP (1) EP1652836B1 (enExample)
JP (1) JP4343227B2 (enExample)
KR (1) KR100970216B1 (enExample)
CN (1) CN100475776C (enExample)
AT (1) ATE367373T1 (enExample)
AU (1) AU2004261417C1 (enExample)
BR (1) BRPI0413032A (enExample)
CA (1) CA2533639A1 (enExample)
DE (1) DE602004007665T2 (enExample)
DK (1) DK1652836T3 (enExample)
ES (2) ES2222822B1 (enExample)
PL (1) PL1652836T3 (enExample)
PT (1) PT1652836E (enExample)
RU (1) RU2368599C2 (enExample)
WO (1) WO2005012230A1 (enExample)
ZA (1) ZA200600165B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060253A1 (en) 2007-11-14 2009-05-20 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
ES2296529B1 (es) * 2006-08-07 2009-04-01 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con promotores de absorcion.
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
EP2213282A1 (en) 2009-01-30 2010-08-04 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
CN104230745B (zh) * 2014-07-10 2016-06-22 南京医科大学 一类n-苄基取代的氨基水杨酸与4-氨基丁酸的酰胺衍生物及其药物用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007979A2 (en) * 1998-08-07 2000-02-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20020006614A1 (en) * 1998-11-23 2002-01-17 Timothy J. Mitchison Detecting structural or synthetic information about chemical compounds
US20030008900A1 (en) * 1997-02-07 2003-01-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2003015774A1 (en) * 2001-08-17 2003-02-27 Astrazeneca Ab Compounds effecting glucokinase
US20030045579A1 (en) * 1995-03-31 2003-03-06 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045579A1 (en) * 1995-03-31 2003-03-06 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20030008900A1 (en) * 1997-02-07 2003-01-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2000007979A2 (en) * 1998-08-07 2000-02-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20020006614A1 (en) * 1998-11-23 2002-01-17 Timothy J. Mitchison Detecting structural or synthetic information about chemical compounds
WO2003015774A1 (en) * 2001-08-17 2003-02-27 Astrazeneca Ab Compounds effecting glucokinase

Also Published As

Publication number Publication date
KR100970216B1 (ko) 2010-07-16
AU2004261417B2 (en) 2010-07-01
ATE367373T1 (de) 2007-08-15
ES2222822A1 (es) 2005-02-01
CN100475776C (zh) 2009-04-08
DE602004007665D1 (de) 2007-08-30
EP1652836B1 (en) 2007-07-18
RU2368599C2 (ru) 2009-09-27
US7462735B2 (en) 2008-12-09
AU2004261417A1 (en) 2005-02-10
PT1652836E (pt) 2007-10-23
ZA200600165B (en) 2007-03-28
DE602004007665T2 (de) 2008-05-15
AU2004261417C1 (en) 2011-02-24
KR20060079184A (ko) 2006-07-05
ES2289534T3 (es) 2008-02-01
RU2006101630A (ru) 2007-09-10
US20070191302A1 (en) 2007-08-16
PL1652836T3 (pl) 2007-12-31
DK1652836T3 (da) 2007-11-05
JP2007533600A (ja) 2007-11-22
CN1829682A (zh) 2006-09-06
EP1652836A1 (en) 2006-05-03
BRPI0413032A (pt) 2006-10-03
CA2533639A1 (en) 2005-02-10
JP4343227B2 (ja) 2009-10-14
WO2005012230A1 (es) 2005-02-10

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