ES2216079T3 - Procedimiento para la elaboracion de composiciones de carotenoides. - Google Patents

Procedimiento para la elaboracion de composiciones de carotenoides.

Info

Publication number
ES2216079T3
ES2216079T3 ES97106957T ES97106957T ES2216079T3 ES 2216079 T3 ES2216079 T3 ES 2216079T3 ES 97106957 T ES97106957 T ES 97106957T ES 97106957 T ES97106957 T ES 97106957T ES 2216079 T3 ES2216079 T3 ES 2216079T3
Authority
ES
Spain
Prior art keywords
carotenoid
suspension
powder
procedure
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97106957T
Other languages
English (en)
Spanish (es)
Inventor
Ray Edward Kowalski
William Joseph Mergens
Leonard Joseph Scialpi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of ES2216079T3 publication Critical patent/ES2216079T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
ES97106957T 1996-05-14 1997-04-26 Procedimiento para la elaboracion de composiciones de carotenoides. Expired - Lifetime ES2216079T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1756896P 1996-05-14 1996-05-14
US17568 1996-05-14

Publications (1)

Publication Number Publication Date
ES2216079T3 true ES2216079T3 (es) 2004-10-16

Family

ID=21783319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97106957T Expired - Lifetime ES2216079T3 (es) 1996-05-14 1997-04-26 Procedimiento para la elaboracion de composiciones de carotenoides.

Country Status (10)

Country Link
US (1) US6093348A (online.php)
EP (1) EP0807431B1 (online.php)
JP (1) JP3961070B2 (online.php)
CN (1) CN1079212C (online.php)
AT (1) ATE262316T1 (online.php)
BR (1) BR9703134A (online.php)
DE (1) DE69728206T2 (online.php)
DK (1) DK0807431T3 (online.php)
ES (1) ES2216079T3 (online.php)
IN (1) IN183685B (online.php)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026802A1 (en) * 1996-01-22 1997-07-31 Chr. Hansen A/S Water dispersible compositions containing natural hydrophobic pigment, method of preparing same and their use
US7939105B2 (en) 1998-11-20 2011-05-10 Jagotec Ag Process for preparing a rapidly dispersing solid drug dosage form
JP5102423B2 (ja) * 2000-04-20 2012-12-19 オバン・エナジー・リミテッド 改善された水不溶性薬剤粒子の処理
US20030104090A1 (en) * 2000-05-05 2003-06-05 Levy Pedro E. Supplements containing annatto extracts and carotenoids and methods for using the same
EP1322289B1 (en) * 2000-09-20 2007-07-25 Jagotec AG Spray drying process of compositions containing fenofibrate
DE10064387A1 (de) * 2000-12-21 2002-06-27 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
JPWO2002077105A1 (ja) * 2001-03-22 2004-07-15 富士化学工業株式会社 安定なアスタキサンチン含有粉体組成物及びその製造方法
US6811801B2 (en) * 2001-12-12 2004-11-02 Abbott Laboratories Methods and compositions for brightening the color of thermally processed nutritionals
EP1519714B1 (en) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Method and apparatus for producing liposomes
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US7145025B2 (en) * 2002-07-29 2006-12-05 Hawaii Biotech, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
US7375133B2 (en) * 2002-07-29 2008-05-20 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US7763649B2 (en) 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
US7521584B2 (en) * 2002-07-29 2009-04-21 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US7723327B2 (en) 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US20050148517A1 (en) * 2002-07-29 2005-07-07 Lockwood Samuel F. Carotenoid ether analogs or derivatives for controlling connexin 43 expression
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20050143475A1 (en) * 2002-07-29 2005-06-30 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US7320997B2 (en) * 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US7345091B2 (en) * 2002-07-29 2008-03-18 Cardax Pharmaceuticals, Inc. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
EP1605917B1 (en) 2003-03-27 2015-04-22 DSM IP Assets B.V. Process for the production of cross-linked gelatin microbeadlets
US7332178B2 (en) 2003-04-25 2008-02-19 Abbott Laboratories Stable nutritional powder containing ascorbyl palmitate
US7110827B2 (en) * 2003-04-25 2006-09-19 Medtronic, Inc. Electrical connectors for medical lead having weld-less wiring connection
US9247765B2 (en) * 2004-01-14 2016-02-02 Omniactive Health Technologies Limited Stable beadlets of lipophilic nutrients
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
WO2005102356A1 (en) * 2004-04-14 2005-11-03 Hawaii Biotech, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
JP4562174B2 (ja) * 2004-08-23 2010-10-13 カゴメ株式会社 カロテノイド含有物の製造方法
CA2578903A1 (en) * 2004-08-31 2006-03-09 Akzo Nobel N.V. Method for pigment solubilisation, a pigment composition and its use
US10463061B2 (en) * 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
US8755258B2 (en) 2005-02-16 2014-06-17 Mitsubishi Electric Corporation Optical disc and optical disc device
CN100421650C (zh) * 2005-03-23 2008-10-01 浙江新和成股份有限公司 水分散性类胡萝卜素粉的制备方法
CN103989633A (zh) * 2005-07-27 2014-08-20 普洛体维生物治疗公司 制造脂质体的系统和方法
CA2618447C (en) * 2005-08-15 2015-06-02 Phares Pharmaceutical Research N.V. Crystal forms of astaxanthin
US7435846B2 (en) * 2006-08-18 2008-10-14 Industrial Organica, S.A. De C.V. Absorption and bioavailability of carotenoids, formulations and applications
MX2009009817A (es) * 2007-03-15 2009-09-24 Dsm Ip Assets Bv Particulas micronizadas estabilizadas.
WO2009093595A1 (ja) * 2008-01-25 2009-07-30 Fujifilm Corporation カロテノイド含有エマルション組成物の製造方法、それにより得られるカロテノイド含有エマルション組成物並びにカロテノイド含有粉末組成物、該組成物を含む機能性食品及び化粧品
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
WO2010111132A2 (en) 2009-03-27 2010-09-30 Bend Research, Inc. Spray-drying process
EP2478768A4 (en) * 2009-09-14 2014-05-07 Univ Hokkaido Nat Univ Corp AGGREGATE AGAINST PLANT VIRUSES
WO2011155535A1 (ja) * 2010-06-08 2011-12-15 三栄源エフ・エフ・アイ株式会社 カロテノイド色素の容器への付着防止方法
JP5600513B2 (ja) * 2010-07-29 2014-10-01 理研ビタミン株式会社 クロセチン製剤の製造方法
EP2611529B1 (en) 2010-09-03 2019-01-23 Bend Research, Inc. Spray-drying method
PT2611530T (pt) 2010-09-03 2019-05-09 Bend Res Inc Aparelho de secagem por pulverização e métodos de utilização do mesmo
EP2618924A1 (en) 2010-09-24 2013-07-31 Bend Research, Inc. High-temperature spray drying process and apparatus
WO2012069322A1 (en) 2010-11-26 2012-05-31 Dsm Ip Assets B.V. Protective hydrocolloid for active ingredients
US20120157547A1 (en) 2010-12-21 2012-06-21 Ricardo Montoya-Olvera Compositions and applications of carotenoids of improved absorption and bioavailability
JP6305414B2 (ja) * 2012-10-18 2018-04-04 ディーエスエム アイピー アセッツ ビー．ブイ． カロテノイドを含むビードレット
WO2015044222A1 (en) * 2013-09-24 2015-04-02 Dsm Ip Assets B.V. Stable formulations for coloring beverages and food products
EP3212169B1 (en) 2014-10-31 2021-01-13 Bend Research, Inc. Process for forming active domains dispersed in a matrix
BR112018068553B1 (pt) * 2016-03-15 2022-12-13 Dsm Ip Assets B.V Uso de partículas secas de cor vermelho-laranja e pó para bebida instantânea
JP6954917B2 (ja) * 2016-03-24 2021-10-27 ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ 多相活性物質調製物
PL3435786T3 (pl) * 2016-04-01 2020-12-14 Dsm Ip Assets B.V. Napoje zawierające stabilne granulki mielonej luteiny
US10835456B2 (en) 2016-07-19 2020-11-17 Basf Se Propyl gallate-containing vitamin preparations
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
US11197493B2 (en) * 2017-09-12 2021-12-14 Omniactive Health Technologies Limited Stabilized fat soluble nutrient compositions and process for the preparation thereof
JP7225820B2 (ja) 2019-01-21 2023-02-21 株式会社アイシン 車両用開閉体制御装置
JP2022537106A (ja) * 2019-06-17 2022-08-24 ディーエスエム アイピー アセッツ ビー．ブイ． メトホルミン及びクエン酸カルシウムを含む医薬剤形
JP2022537105A (ja) * 2019-06-17 2022-08-24 ディーエスエム アイピー アセッツ ビー．ブイ． メトホルミンＨＣｌ、ビタミンＢ１２、及び少なくとも１つの流動性添加物を含む組成物
BR112021025180A2 (pt) * 2019-06-17 2022-02-01 Dsm Ip Assets Bv Forma de dosagem farmacêutica sólida compreendendo vitamina b12 seca por pulverização
CN112438950A (zh) * 2019-08-16 2021-03-05 北京化工大学 一种β-胡萝卜素透明水分散液及其制备方法
CN111471317B (zh) * 2020-03-26 2021-06-04 广东省农业科学院蚕业与农产品加工研究所 一种稳态化玉米黄色素及其制备方法
CN111838648B (zh) * 2020-06-16 2023-04-25 嘉必优生物技术（武汉）股份有限公司 一种生产纳米级类胡萝卜素乳液的装置及方法
JP7798855B2 (ja) 2020-07-16 2026-01-14 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子に使用するためのカチオン性脂質
CN112841645A (zh) * 2021-01-14 2021-05-28 江南大学 一种β-胡萝卜素微胶囊的制备方法
CN113426355A (zh) * 2021-06-25 2021-09-24 骏马化纤股份有限公司 一种化纤生产用油剂乳液自动化控制系统及制备方法
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CN118525919A (zh) * 2023-02-22 2024-08-23 浙江可明生物医药有限公司 类胡萝卜素制剂的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2756177A (en) * 1953-03-09 1956-07-24 Hoffmann La Roche Process for making fat-soluble vitamin active powder
US2861891A (en) * 1956-12-13 1958-11-25 Hoffmann La Roche Water dispersible carotenoid compositions and process of making the same
DE1211911B (de) * 1959-09-08 1966-03-03 Hoffmann La Roche Verfahren zur Herstellung eines insbesondere zum Faerben von Lebens- und Futtermitteln geeigneten Carotinoidpraeparates
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
DE3048000A1 (de) * 1980-12-19 1982-07-15 Basf Ag Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung
US4908154A (en) * 1981-04-17 1990-03-13 Biotechnology Development Corporation Method of forming a microemulsion
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
SE8604117D0 (sv) * 1986-09-29 1986-09-29 Kabivitrum Ab Composition
DE3702031A1 (de) * 1987-01-24 1988-08-04 Basf Ag Verfahren zur herstellung von mikrodispersen fischoelpraeparaten
DE59003205D1 (de) * 1989-07-25 1993-12-02 Hoffmann La Roche Verfahren zur Herstellung von Carotinoidpräparaten.
DK546289D0 (da) * 1989-11-02 1989-11-02 Danochemo As Carotenoidpulvere
DK19393D0 (da) * 1993-02-19 1993-02-19 Danochemo As Fremgangsmaade til fremstilling af et i vand dispergerbart pulverformigt carotenoidpraeparat
DE4329446A1 (de) * 1993-09-01 1995-03-02 Basf Ag Verfahren zur Herstellung von feinteiligen Farb- oder Wirkstoffzubereitungen
DE19649062A1 (de) * 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen

Also Published As

Publication number Publication date
CN1176760A (zh) 1998-03-25
ATE262316T1 (de) 2004-04-15
EP0807431A2 (en) 1997-11-19
BR9703134A (pt) 1998-08-18
EP0807431B1 (en) 2004-03-24
JPH1046041A (ja) 1998-02-17
US6093348A (en) 2000-07-25
DK0807431T3 (da) 2004-07-26
IN183685B (online.php) 2000-03-18
JP3961070B2 (ja) 2007-08-15
CN1079212C (zh) 2002-02-20
DE69728206D1 (de) 2004-04-29
EP0807431A3 (en) 1998-08-12
DE69728206T2 (de) 2005-03-10

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