ES2216079T3 - Procedimiento para la elaboracion de composiciones de carotenoides. - Google Patents

Procedimiento para la elaboracion de composiciones de carotenoides.

Info

Publication number
ES2216079T3
ES2216079T3 ES97106957T ES97106957T ES2216079T3 ES 2216079 T3 ES2216079 T3 ES 2216079T3 ES 97106957 T ES97106957 T ES 97106957T ES 97106957 T ES97106957 T ES 97106957T ES 2216079 T3 ES2216079 T3 ES 2216079T3
Authority
ES
Spain
Prior art keywords
carotenoid
suspension
powder
procedure
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97106957T
Other languages
English (en)
Spanish (es)
Inventor
Ray Edward Kowalski
William Joseph Mergens
Leonard Joseph Scialpi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of ES2216079T3 publication Critical patent/ES2216079T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
ES97106957T 1996-05-14 1997-04-26 Procedimiento para la elaboracion de composiciones de carotenoides. Expired - Lifetime ES2216079T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17568 1993-02-16
US1756896P 1996-05-14 1996-05-14

Publications (1)

Publication Number Publication Date
ES2216079T3 true ES2216079T3 (es) 2004-10-16

Family

ID=21783319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97106957T Expired - Lifetime ES2216079T3 (es) 1996-05-14 1997-04-26 Procedimiento para la elaboracion de composiciones de carotenoides.

Country Status (10)

Country Link
US (1) US6093348A (member.php)
EP (1) EP0807431B1 (member.php)
JP (1) JP3961070B2 (member.php)
CN (1) CN1079212C (member.php)
AT (1) ATE262316T1 (member.php)
BR (1) BR9703134A (member.php)
DE (1) DE69728206T2 (member.php)
DK (1) DK0807431T3 (member.php)
ES (1) ES2216079T3 (member.php)
IN (1) IN183685B (member.php)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69724231T3 (de) * 1996-01-22 2012-09-20 Chr. Hansen A/S In wasser dispergierbare zusammensetzungen, die ein natuerliches hydrophobes pigment enthalten, verfahren zu ihrer herstellung und ihre verwendung
AU767154B2 (en) 1998-11-20 2003-10-30 Skyepharma Canada Inc. Dispersible phospholipid stabilized microparticles
EP1276465B1 (en) * 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
US20030104090A1 (en) * 2000-05-05 2003-06-05 Levy Pedro E. Supplements containing annatto extracts and carotenoids and methods for using the same
NZ525306A (en) * 2000-09-20 2004-11-26 Skyepharma Canada Inc Spray drying process and compositions of fenofibrate
DE10064387A1 (de) 2000-12-21 2002-06-27 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
WO2002077105A1 (en) * 2001-03-22 2002-10-03 Fuji Chemical Industry Co., Ltd. Stable astaxanthin-containing powdery compositions and process for producing the same
US6811801B2 (en) * 2001-12-12 2004-11-02 Abbott Laboratories Methods and compositions for brightening the color of thermally processed nutritionals
WO2004002453A1 (en) 2002-06-28 2004-01-08 Protiva Biotherapeutics Ltd. Method and apparatus for producing liposomes
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20050143475A1 (en) * 2002-07-29 2005-06-30 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
US7375133B2 (en) * 2002-07-29 2008-05-20 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US7345091B2 (en) * 2002-07-29 2008-03-18 Cardax Pharmaceuticals, Inc. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
AU2003256982A1 (en) 2002-07-29 2004-02-16 Cardax Pharmaceuticals, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US20050148517A1 (en) * 2002-07-29 2005-07-07 Lockwood Samuel F. Carotenoid ether analogs or derivatives for controlling connexin 43 expression
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US7521584B2 (en) * 2002-07-29 2009-04-21 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
US7320997B2 (en) * 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US7723327B2 (en) 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US7763649B2 (en) 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
KR101143708B1 (ko) * 2003-03-27 2012-05-09 디에스엠 아이피 어셋츠 비.브이. 비드렛의 제조방법
US7110827B2 (en) * 2003-04-25 2006-09-19 Medtronic, Inc. Electrical connectors for medical lead having weld-less wiring connection
US7332178B2 (en) 2003-04-25 2008-02-19 Abbott Laboratories Stable nutritional powder containing ascorbyl palmitate
US9247765B2 (en) * 2004-01-14 2016-02-02 Omniactive Health Technologies Limited Stable beadlets of lipophilic nutrients
EP1750723A1 (en) * 2004-04-14 2007-02-14 Hawaii Biotech, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
JP4562174B2 (ja) * 2004-08-23 2010-10-13 カゴメ株式会社 カロテノイド含有物の製造方法
BRPI0515122A (pt) * 2004-08-31 2008-07-08 Akzo Nobel Nv método para solubilização de pigmento, uma composição de pigmento e seu uso
US10463061B2 (en) * 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
US8755258B2 (en) 2005-02-16 2014-06-17 Mitsubishi Electric Corporation Optical disc and optical disc device
CN100421650C (zh) * 2005-03-23 2008-10-01 浙江新和成股份有限公司 水分散性类胡萝卜素粉的制备方法
CA2616877C (en) * 2005-07-27 2014-01-28 Protiva Biotherapeutics, Inc. Systems and methods for manufacturing liposomes
AU2006281638B2 (en) * 2005-08-15 2012-05-03 Phares Pharmaceutical Research N.V. Crystal forms of astaxanthin
US7435846B2 (en) * 2006-08-18 2008-10-14 Industrial Organica, S.A. De C.V. Absorption and bioavailability of carotenoids, formulations and applications
CA2677897A1 (en) * 2007-03-15 2008-09-18 Dsm Ip Assets B.V. Stabilized micronised particles
WO2009093595A1 (ja) * 2008-01-25 2009-07-30 Fujifilm Corporation カロテノイド含有エマルション組成物の製造方法、それにより得られるカロテノイド含有エマルション組成物並びにカロテノイド含有粉末組成物、該組成物を含む機能性食品及び化粧品
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
WO2010111132A2 (en) 2009-03-27 2010-09-30 Bend Research, Inc. Spray-drying process
US8853172B2 (en) 2009-09-14 2014-10-07 National University Corporation Hokkaido University Anti-plant-virus agent
KR102049488B1 (ko) * 2010-06-08 2019-11-28 산에이겐 에후.에후. 아이. 가부시키가이샤 카로테노이드 색소의 용기로의 부착 방지 방법
JP5600513B2 (ja) * 2010-07-29 2014-10-01 理研ビタミン株式会社 クロセチン製剤の製造方法
PT2611529T (pt) 2010-09-03 2019-05-09 Bend Res Inc Método de secagem por pulverização
WO2012031133A2 (en) 2010-09-03 2012-03-08 Bench Research, Inc. Spray-drying apparatus and methods of using the same
US9248584B2 (en) 2010-09-24 2016-02-02 Bend Research, Inc. High-temperature spray drying process and apparatus
EP2642872A1 (en) * 2010-11-26 2013-10-02 DSM IP Assets B.V. Protective hydrocolloid for active ingredients
US20120157547A1 (en) 2010-12-21 2012-06-21 Ricardo Montoya-Olvera Compositions and applications of carotenoids of improved absorption and bioavailability
US20150272188A1 (en) * 2012-10-18 2015-10-01 Dsm Ip Assets B.V. Beadlets comprising carotenoids
WO2015044222A1 (en) * 2013-09-24 2015-04-02 Dsm Ip Assets B.V. Stable formulations for coloring beverages and food products
EP3212169B1 (en) 2014-10-31 2021-01-13 Bend Research, Inc. Process for forming active domains dispersed in a matrix
WO2017158010A1 (en) * 2016-03-15 2017-09-21 Dsm Ip Assets B.V. Coated particles
CN108777981A (zh) * 2016-03-24 2018-11-09 巴斯夫欧洲公司 多相活性物质制剂
MX387178B (es) * 2016-07-19 2025-03-18 Basf Se Preparaciones de vitaminas que contienen galato de propilo.
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
US11197493B2 (en) * 2017-09-12 2021-12-14 Omniactive Health Technologies Limited Stabilized fat soluble nutrient compositions and process for the preparation thereof
JP7225820B2 (ja) 2019-01-21 2023-02-21 株式会社アイシン 車両用開閉体制御装置
EP3982935A1 (en) * 2019-06-17 2022-04-20 DSM IP Assets B.V. Composition comprising metformin hci, vitamin b12 and at least one flow additive
CN113993506A (zh) * 2019-06-17 2022-01-28 帝斯曼知识产权资产管理有限公司 包含二甲双胍和柠檬酸钙的药物剂型
US20220096519A1 (en) * 2019-06-17 2022-03-31 Dsm Ip Assets B.V. Solid pharmaceutical dosage form comprising spray dried vitamin b12
CN112438950A (zh) * 2019-08-16 2021-03-05 北京化工大学 一种β-胡萝卜素透明水分散液及其制备方法
CN111471317B (zh) * 2020-03-26 2021-06-04 广东省农业科学院蚕业与农产品加工研究所 一种稳态化玉米黄色素及其制备方法
CN111838648B (zh) * 2020-06-16 2023-04-25 嘉必优生物技术（武汉）股份有限公司 一种生产纳米级类胡萝卜素乳液的装置及方法
MX2023000614A (es) 2020-07-16 2023-02-13 Acuitas Therapeutics Inc Lipidos cationicos para usarse en nanoparticulas lipidicas.
CN112841645A (zh) * 2021-01-14 2021-05-28 江南大学 一种β-胡萝卜素微胶囊的制备方法
CN113426355A (zh) * 2021-06-25 2021-09-24 骏马化纤股份有限公司 一种化纤生产用油剂乳液自动化控制系统及制备方法
CN118647600A (zh) 2021-12-16 2024-09-13 爱康泰生治疗公司 用于脂质纳米颗粒制剂的脂质
CN118525919A (zh) * 2023-02-22 2024-08-23 浙江可明生物医药有限公司 类胡萝卜素制剂的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2756177A (en) * 1953-03-09 1956-07-24 Hoffmann La Roche Process for making fat-soluble vitamin active powder
US2861891A (en) * 1956-12-13 1958-11-25 Hoffmann La Roche Water dispersible carotenoid compositions and process of making the same
DE1211911B (de) * 1959-09-08 1966-03-03 Hoffmann La Roche Verfahren zur Herstellung eines insbesondere zum Faerben von Lebens- und Futtermitteln geeigneten Carotinoidpraeparates
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
DE3048000A1 (de) * 1980-12-19 1982-07-15 Basf Ag Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4908154A (en) * 1981-04-17 1990-03-13 Biotechnology Development Corporation Method of forming a microemulsion
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
SE8604117D0 (sv) * 1986-09-29 1986-09-29 Kabivitrum Ab Composition
DE3702031A1 (de) * 1987-01-24 1988-08-04 Basf Ag Verfahren zur herstellung von mikrodispersen fischoelpraeparaten
ATE96312T1 (de) * 1989-07-25 1993-11-15 Hoffmann La Roche Verfahren zur herstellung von carotinoidpraeparaten.
DK546289D0 (da) * 1989-11-02 1989-11-02 Danochemo As Carotenoidpulvere
DK19393D0 (da) * 1993-02-19 1993-02-19 Danochemo As Fremgangsmaade til fremstilling af et i vand dispergerbart pulverformigt carotenoidpraeparat
DE4329446A1 (de) * 1993-09-01 1995-03-02 Basf Ag Verfahren zur Herstellung von feinteiligen Farb- oder Wirkstoffzubereitungen
DE19649062A1 (de) * 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen

Also Published As

Publication number Publication date
ATE262316T1 (de) 2004-04-15
IN183685B (member.php) 2000-03-18
EP0807431A3 (en) 1998-08-12
DE69728206T2 (de) 2005-03-10
JPH1046041A (ja) 1998-02-17
EP0807431B1 (en) 2004-03-24
EP0807431A2 (en) 1997-11-19
DE69728206D1 (de) 2004-04-29
DK0807431T3 (da) 2004-07-26
US6093348A (en) 2000-07-25
JP3961070B2 (ja) 2007-08-15
BR9703134A (pt) 1998-08-18
CN1176760A (zh) 1998-03-25
CN1079212C (zh) 2002-02-20

Similar Documents

Publication Publication Date Title
ES2216079T3 (es) Procedimiento para la elaboracion de composiciones de carotenoides.
JP2572877B2 (ja) コロイド分散カロチノイド調剤の新規製造方法
CN1096264C (zh) 类胡萝卜素和维生素的稳定含水增溶物
EP0498824B1 (en) Process of preparing a water dispersible hydrophobic or aerophilic solid
KR100695589B1 (ko) 미분된 분말상 카로테노이드 제제의 제조방법
EP1476032B1 (en) Coenzyme q10 formulation
CN101312655B (zh) 新颖的稳定的类胡萝卜素组合物
US20210322371A1 (en) Nanosized carotenoid cyclodextrin complexes
JP2003516720A (ja) 安定なカロテン−キサントフィル・ビードレット組成物及び使用方法
JPH09328419A (ja) 安定な水中油形エマルジョン及びその製造方法
US9655849B2 (en) Solid particulate compositions comprising coenzyme Q10
ES2400351T3 (es) Composiciones pulverulentas de derivados de astaxantina ll
CN101217885A (zh) 微溶于水和不溶于水的活性成分的含水悬浮液和由其生产的干燥粉末
Črnivec et al. Thermal protection and pH-gated release of folic acid in microparticles and nanoparticles for food fortification
EP2222180B1 (de) Verfahren zur herstellung von carotinoid-lösungen
JP2000106844A (ja) 水分散性カロテノイド組成物
JP2012131768A (ja) 改善された吸収性及びバイオアベイラビリティを有するカロテノイド組成物及びその適用
JP2009505809A (ja) 乳化剤系、そのエマルジョンおよびその使用
JPH06172170A (ja) カロチノイド含有粉末製剤
US20140099386A1 (en) Compositions and applications of carotenoids of improved absorption and bioavailability
JP3051093B2 (ja) 製 剤
CN119257247A (zh) 叶黄素酯和／或玉米黄质的护眼组合物及制备方法和应用
JPH0899872A (ja) 異臭のない安定なカロチノイド製剤の製造法
JPH05247364A (ja) カロチノイド含有水溶性製剤
EP2917177B1 (de) Beta-carotin zubereitung