ES2214130B1 - 2-3'-bipiridinas. - Google Patents
2-3'-bipiridinas.Info
- Publication number
- ES2214130B1 ES2214130B1 ES200300354A ES200300354A ES2214130B1 ES 2214130 B1 ES2214130 B1 ES 2214130B1 ES 200300354 A ES200300354 A ES 200300354A ES 200300354 A ES200300354 A ES 200300354A ES 2214130 B1 ES2214130 B1 ES 2214130B1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- phenyl
- cox
- chloro
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Rheumatology (AREA)
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- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200300354A ES2214130B1 (es) | 2003-02-13 | 2003-02-13 | 2-3'-bipiridinas. |
| PCT/EP2004/001297 WO2004072037A1 (en) | 2003-02-13 | 2004-02-12 | 2,3'-bipyridines derivatives as selective cox-2 inhibitors |
| JP2006501817A JP2006517562A (ja) | 2003-02-13 | 2004-02-12 | 選択的ｃｏｘ−２阻害剤としての２，３’−ビピリジン誘導体 |
| EP04710355A EP1592666A1 (en) | 2003-02-13 | 2004-02-12 | 2,3 -bipyridines derivatives as selective cox-2 inhibitors |
| CNB2004800098767A CN100408561C (zh) | 2003-02-13 | 2004-02-12 | 2,3＇-联吡啶类衍生物作为环加氧酶-2的抑制剂 |
| US10/544,360 US20060229338A1 (en) | 2003-02-13 | 2004-02-12 | 2,3'-bipyridines derivatives as selective cox-2 inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200300354A ES2214130B1 (es) | 2003-02-13 | 2003-02-13 | 2-3'-bipiridinas. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2214130A1 ES2214130A1 (es) | 2004-09-01 |
| ES2214130B1 true ES2214130B1 (es) | 2005-12-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200300354A Expired - Fee Related ES2214130B1 (es) | 2003-02-13 | 2003-02-13 | 2-3'-bipiridinas. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060229338A1 (https=) |
| EP (1) | EP1592666A1 (https=) |
| JP (1) | JP2006517562A (https=) |
| CN (1) | CN100408561C (https=) |
| ES (1) | ES2214130B1 (https=) |
| WO (1) | WO2004072037A1 (https=) |
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| ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
| MY163379A (en) * | 2010-11-15 | 2017-09-15 | Virdev Intermediates Pvt Ltd | A process for cyclooxygenase-2 selective inhibitor |
| CN103204803A (zh) * | 2012-01-13 | 2013-07-17 | 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 | 用于合成依托考昔的方法 |
| EP2846793A1 (en) | 2012-05-09 | 2015-03-18 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
| CN104788362A (zh) * | 2014-01-21 | 2015-07-22 | 济南三元化工有限公司 | 一种依托考昔或其药学上可接受的盐的制备方法 |
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| US6486194B2 (en) * | 1993-06-24 | 2002-11-26 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
| US6231888B1 (en) * | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
| IL127441A (en) * | 1996-07-18 | 2003-02-12 | Merck Frosst Canada Inc | Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors |
| US6307047B1 (en) * | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| ES2256817T3 (es) * | 1997-09-05 | 2006-07-16 | Glaxo Group Limited | Composiciones farmaceuticas que comprenden derivados de 2,3-diaril-pirazolo(1,5-b)piridazina. |
| US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
| KR100295206B1 (ko) * | 1998-08-22 | 2001-07-12 | 서경배 | 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 |
| TW587079B (en) * | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
| DZ3265A1 (fr) * | 1999-04-14 | 2000-10-19 | Pacific Corp | Derives de 4,5-diaryl-3(2h)-furanone comme inhibiteurs de cyclo-oxygenase-2 |
| AU5873000A (en) * | 1999-06-24 | 2001-01-31 | Pharmacia Corporation | Combination of tumors necrocis factor (tnf) antagonists and cox-2 inhibitors forthe treatment of inflammation |
| DE60006057T2 (de) * | 1999-12-03 | 2004-05-27 | Pfizer Products Inc., Groton | Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| CA2412651A1 (en) * | 2000-05-22 | 2001-11-29 | Dr. Reddy's Laboratories Limited | Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them |
| WO2001091856A2 (en) * | 2000-06-01 | 2001-12-06 | Pharmacia Corporation | Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation |
| AU2001282886A1 (en) * | 2000-07-13 | 2002-01-30 | Pharmacia Corporation | Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain |
| JP2004505060A (ja) * | 2000-07-27 | 2004-02-19 | ファルマシア・コーポレーション | 炎症関連心臓血管障害を防止するかまたは治療するためのアルドステロンアンタゴニストおよびシクロオキシゲナーゼ−２阻害剤併用療法 |
| WO2002055502A1 (en) * | 2001-01-02 | 2002-07-18 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine derivatives useful as cyclooxygenase inhibitor |
| EP1492773B1 (en) * | 2002-04-05 | 2009-02-04 | Cadila Healthcare Ltd. | 4-(heterocyclyl)-benzenesulfoximine compounds for the treatment of inflammation |
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
-
2003
- 2003-02-13 ES ES200300354A patent/ES2214130B1/es not_active Expired - Fee Related
-
2004
- 2004-02-12 WO PCT/EP2004/001297 patent/WO2004072037A1/en not_active Ceased
- 2004-02-12 JP JP2006501817A patent/JP2006517562A/ja active Pending
- 2004-02-12 CN CNB2004800098767A patent/CN100408561C/zh not_active Expired - Fee Related
- 2004-02-12 US US10/544,360 patent/US20060229338A1/en not_active Abandoned
- 2004-02-12 EP EP04710355A patent/EP1592666A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006517562A (ja) | 2006-07-27 |
| CN100408561C (zh) | 2008-08-06 |
| ES2214130A1 (es) | 2004-09-01 |
| WO2004072037A8 (en) | 2005-09-29 |
| EP1592666A1 (en) | 2005-11-09 |
| WO2004072037A1 (en) | 2004-08-26 |
| US20060229338A1 (en) | 2006-10-12 |
| CN1774422A (zh) | 2006-05-17 |
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