ES2211073T3 - Procedimiento de molienda utilizando la energia de un fluido y aparato asociado. - Google Patents
Procedimiento de molienda utilizando la energia de un fluido y aparato asociado.Info
- Publication number
- ES2211073T3 ES2211073T3 ES99918105T ES99918105T ES2211073T3 ES 2211073 T3 ES2211073 T3 ES 2211073T3 ES 99918105 T ES99918105 T ES 99918105T ES 99918105 T ES99918105 T ES 99918105T ES 2211073 T3 ES2211073 T3 ES 2211073T3
- Authority
- ES
- Spain
- Prior art keywords
- compressed air
- procedure
- air
- humidity
- grinding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims description 33
- 238000000227 grinding Methods 0.000 title claims description 27
- 239000012530 fluid Substances 0.000 title claims description 15
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 claims abstract description 23
- 238000001035 drying Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 238000011144 upstream manufacturing Methods 0.000 claims description 3
- 239000011236 particulate material Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000005070 sampling Methods 0.000 claims description 2
- 238000009795 derivation Methods 0.000 claims 1
- 239000003897 fog Substances 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 8
- 150000004683 dihydrates Chemical class 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000002674 ointment Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229940088679 drug related substance Drugs 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 238000003109 Karl Fischer titration Methods 0.000 description 1
- ARLZGEXVMUDUQZ-UHFFFAOYSA-N O.O.[Ca] Chemical compound O.O.[Ca] ARLZGEXVMUDUQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229940028420 bactroban Drugs 0.000 description 1
- 229940055248 bactroban nasal product Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007707 calorimetry Methods 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004807 desolvation Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- -1 glycerin ester Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 229960003128 mupirocin Drugs 0.000 description 1
- 229930187697 mupirocin Natural products 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C25/00—Control arrangements specially adapted for crushing or disintegrating
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Disintegrating Or Milling (AREA)
- Crushing And Grinding (AREA)
- Medicines Containing Plant Substances (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9808470 | 1998-04-22 | ||
| GBGB9808470.0A GB9808470D0 (en) | 1998-04-22 | 1998-04-22 | Novel process and apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2211073T3 true ES2211073T3 (es) | 2004-07-01 |
Family
ID=10830710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99918105T Expired - Lifetime ES2211073T3 (es) | 1998-04-22 | 1999-04-19 | Procedimiento de molienda utilizando la energia de un fluido y aparato asociado. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1073524B1 (cs) |
| JP (1) | JP2002512117A (cs) |
| KR (1) | KR20010042863A (cs) |
| CN (1) | CN1108151C (cs) |
| AR (3) | AR015000A1 (cs) |
| AT (1) | ATE255466T1 (cs) |
| AU (1) | AU748262B2 (cs) |
| BR (1) | BR9909806A (cs) |
| CA (1) | CA2329732A1 (cs) |
| CO (1) | CO4820444A1 (cs) |
| CZ (1) | CZ292385B6 (cs) |
| DE (1) | DE69913331T2 (cs) |
| ES (1) | ES2211073T3 (cs) |
| GB (1) | GB9808470D0 (cs) |
| HU (1) | HUP0102244A3 (cs) |
| IL (1) | IL138874A0 (cs) |
| NO (1) | NO20005235D0 (cs) |
| NZ (1) | NZ507489A (cs) |
| PL (1) | PL343563A1 (cs) |
| TR (1) | TR200003035T2 (cs) |
| TW (1) | TW558453B (cs) |
| WO (1) | WO1999054048A1 (cs) |
| ZA (1) | ZA200005739B (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9826284D0 (en) * | 1998-12-01 | 1999-01-20 | Rhone Poulence Rorer Limited | Process |
| AR022695A1 (es) * | 1999-01-28 | 2002-09-04 | Schering Corp | PORTADOR SoLIDO PARTICULADO Y MÉTODO PARA PROVEER CONTROL DE LA PARTICULADA PARA LA DISTRIBUCIoN DE TAMANO DE PARTíCULAS Y DE CONTENIDO AMORFO CONVERTIBLE DURANTE SU PREPARACION |
| US6623760B1 (en) | 1999-01-28 | 2003-09-23 | Schering Corporation | Method of preparing particles for agglomeration |
| GB0409703D0 (en) | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| WO2007144901A1 (en) * | 2006-06-12 | 2007-12-21 | Jubilant Organosys Limited | Process for stabilization of olanzapine polymorphic form i |
| US8235314B2 (en) * | 2009-02-12 | 2012-08-07 | Linde Aktiengesellschaft | Nonequilibrium humidity control for jet milling |
| JO3510B1 (ar) * | 2011-03-04 | 2020-07-05 | Heptares Therapeutics Ltd | استخدام جلايكوبيرولات لعلاج عدم انتظام دقات القلب |
| DE102012215511A1 (de) | 2012-08-31 | 2014-06-12 | Schülke & Mayr GmbH | Verfahren zur Herstellung einer Bispyridiniumalkan enthaltenden halbfesten Zubereitung |
| EP2968152B2 (en) | 2013-03-15 | 2022-06-22 | Pearl Therapeutics, Inc. | Methods and systems for conditioning of particulate crystalline materials |
| AP2017009777A0 (en) | 2014-09-09 | 2017-03-31 | Vectura Ltd | Formulation comprising glycopyrrolate, method and apparatus |
| CA2996072C (en) * | 2015-09-09 | 2020-06-30 | Vectura Limited | Jet milling method |
| US10967345B2 (en) | 2016-04-18 | 2021-04-06 | Premex S.A.S. | Multiple modular system for the formation of particles in powder and microcapsule form for different processes |
| CN115737610B (zh) * | 2021-12-13 | 2024-02-27 | 苏州欧米尼医药有限公司 | 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2704635A (en) * | 1951-06-02 | 1955-03-22 | Conrad M Trost | Pulverizing mill having opposed jets and circulatory classification |
| GB8415579D0 (en) * | 1984-06-19 | 1984-07-25 | Beecham Group Plc | Compounds |
| GB8530796D0 (en) | 1985-12-13 | 1986-01-22 | Beecham Group Plc | Pharmaceutical composition |
| IE59628B1 (en) | 1986-06-26 | 1994-03-09 | Beecham Group Plc | Treatment of fungal infections |
| JPH02251535A (ja) * | 1989-03-27 | 1990-10-09 | Asahi Chem Ind Co Ltd | ポリ―β―アラニン共重合体の微粉化法 |
| DE69427589T2 (de) | 1993-10-22 | 2002-04-25 | Smithkline Beecham Corp | Neue zusammensetzung |
| US5711489A (en) * | 1994-08-18 | 1998-01-27 | Nihon Parkerizing Co., Ltd. | Electrostatic powder coating method and apparatus |
| NZ334913A (en) | 1996-10-01 | 2001-03-30 | Smithkline Beecham Plc | Use of mupirocin (pseudomonic acid) for the manufacture of a medicament for the treatment of bacterial infections associated with colonisation of the nasopharynx by pathogenic organisms effective as a sprayable topical agent |
-
1998
- 1998-04-22 GB GBGB9808470.0A patent/GB9808470D0/en not_active Ceased
-
1999
- 1999-04-19 NZ NZ507489A patent/NZ507489A/xx unknown
- 1999-04-19 CA CA002329732A patent/CA2329732A1/en not_active Abandoned
- 1999-04-19 IL IL13887499A patent/IL138874A0/xx unknown
- 1999-04-19 WO PCT/GB1999/001189 patent/WO1999054048A1/en not_active Ceased
- 1999-04-19 PL PL99343563A patent/PL343563A1/xx unknown
- 1999-04-19 KR KR1020007011637A patent/KR20010042863A/ko not_active Withdrawn
- 1999-04-19 AR ARP990101808A patent/AR015000A1/es not_active Application Discontinuation
- 1999-04-19 DE DE1999613331 patent/DE69913331T2/de not_active Expired - Fee Related
- 1999-04-19 HU HU0102244A patent/HUP0102244A3/hu unknown
- 1999-04-19 TR TR2000/03035T patent/TR200003035T2/xx unknown
- 1999-04-19 JP JP2000544437A patent/JP2002512117A/ja active Pending
- 1999-04-19 EP EP99918105A patent/EP1073524B1/en not_active Expired - Lifetime
- 1999-04-19 AT AT99918105T patent/ATE255466T1/de not_active IP Right Cessation
- 1999-04-19 CZ CZ20003895A patent/CZ292385B6/cs not_active IP Right Cessation
- 1999-04-19 CN CN99805243A patent/CN1108151C/zh not_active Expired - Fee Related
- 1999-04-19 AU AU36149/99A patent/AU748262B2/en not_active Ceased
- 1999-04-19 ES ES99918105T patent/ES2211073T3/es not_active Expired - Lifetime
- 1999-04-19 BR BR9909806-7A patent/BR9909806A/pt not_active IP Right Cessation
- 1999-04-20 CO CO99023658A patent/CO4820444A1/es unknown
- 1999-04-23 TW TW088106573A patent/TW558453B/zh active
-
2000
- 2000-03-08 AR ARP000101026A patent/AR022868A2/es not_active Application Discontinuation
- 2000-03-08 AR ARP000101027A patent/AR022869A2/es unknown
- 2000-10-17 ZA ZA200005739A patent/ZA200005739B/xx unknown
- 2000-10-18 NO NO20005235A patent/NO20005235D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU748262B2 (en) | 2002-05-30 |
| CO4820444A1 (es) | 1999-07-28 |
| DE69913331D1 (de) | 2004-01-15 |
| CN1108151C (zh) | 2003-05-14 |
| AR022869A2 (es) | 2002-09-04 |
| NO20005235L (no) | 2000-10-18 |
| ATE255466T1 (de) | 2003-12-15 |
| AR015000A1 (es) | 2001-04-11 |
| ZA200005739B (en) | 2002-03-25 |
| CZ292385B6 (cs) | 2003-09-17 |
| NZ507489A (en) | 2003-06-30 |
| JP2002512117A (ja) | 2002-04-23 |
| HUP0102244A3 (en) | 2002-08-28 |
| NO20005235D0 (no) | 2000-10-18 |
| CZ20003895A3 (cs) | 2001-08-15 |
| HK1034216A1 (en) | 2001-10-19 |
| PL343563A1 (en) | 2001-08-27 |
| EP1073524A1 (en) | 2001-02-07 |
| TW558453B (en) | 2003-10-21 |
| CA2329732A1 (en) | 1999-10-28 |
| DE69913331T2 (de) | 2004-11-18 |
| CN1297378A (zh) | 2001-05-30 |
| AU3614999A (en) | 1999-11-08 |
| HUP0102244A2 (hu) | 2001-10-28 |
| EP1073524B1 (en) | 2003-12-03 |
| BR9909806A (pt) | 2000-12-26 |
| KR20010042863A (ko) | 2001-05-25 |
| GB9808470D0 (en) | 1998-06-17 |
| AR022868A2 (es) | 2002-09-04 |
| WO1999054048A1 (en) | 1999-10-28 |
| IL138874A0 (en) | 2001-11-25 |
| TR200003035T2 (tr) | 2001-02-21 |
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