ES2195361T3 - Peptido de union a integrina y uso del mismo. - Google Patents
Peptido de union a integrina y uso del mismo.Info
- Publication number
- ES2195361T3 ES2195361T3 ES98933671T ES98933671T ES2195361T3 ES 2195361 T3 ES2195361 T3 ES 2195361T3 ES 98933671 T ES98933671 T ES 98933671T ES 98933671 T ES98933671 T ES 98933671T ES 2195361 T3 ES2195361 T3 ES 2195361T3
- Authority
- ES
- Spain
- Prior art keywords
- integrine
- union
- peptide
- same
- integrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- 102000012422 Collagen Type I Human genes 0.000 abstract 1
- 108010022452 Collagen Type I Proteins 0.000 abstract 1
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000012292 cell migration Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 108010057670 laminin 1 Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan péptidos cíclicos que comprenden tres aminoácidos colineales, arginina-lisina-lisina (RKK) que se unen al dominio {al}2I de la integrina y que son potentes inhibidores de su interacción con los colágenos I y IV y con la laminina 1. Se proporcionan también procedimientos de uso de dichos péptidos para bloquear el funcionamiento de la integrina y para inhibir la migración celular.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/893,526 US6096707A (en) | 1997-07-11 | 1997-07-11 | Integrin binding peptide and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2195361T3 true ES2195361T3 (es) | 2003-12-01 |
Family
ID=25401719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98933671T Expired - Lifetime ES2195361T3 (es) | 1997-07-11 | 1998-07-09 | Peptido de union a integrina y uso del mismo. |
Country Status (17)
Country | Link |
---|---|
US (1) | US6096707A (es) |
EP (1) | EP0994898B1 (es) |
JP (1) | JP2001509515A (es) |
KR (1) | KR100571046B1 (es) |
CN (1) | CN1262688A (es) |
AT (1) | ATE235510T1 (es) |
AU (1) | AU748134B2 (es) |
BR (1) | BR9810586A (es) |
CA (1) | CA2295219C (es) |
DE (1) | DE69812630T2 (es) |
ES (1) | ES2195361T3 (es) |
HU (1) | HU225326B1 (es) |
NO (1) | NO20000126D0 (es) |
NZ (1) | NZ501767A (es) |
PL (1) | PL338001A1 (es) |
RU (1) | RU2203902C2 (es) |
WO (1) | WO1999002551A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7914814B2 (en) * | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
US7387779B2 (en) | 1998-06-17 | 2008-06-17 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6759047B1 (en) | 1998-06-17 | 2004-07-06 | Beth Israel Deaconess Hospital Corp. | Anti-angiogenic proteins and methods of use thereof |
US6962974B1 (en) | 1998-06-17 | 2005-11-08 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
KR20030080013A (ko) * | 2001-02-21 | 2003-10-10 | 에자이 가부시키가이샤 | 인테그린 발현 억제를 통한 혈관 신생 억제제의 효과를검정하는 방법 |
CA2439852A1 (en) * | 2001-03-02 | 2002-09-12 | Christine Dingivan | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
JP2005525368A (ja) * | 2002-03-04 | 2005-08-25 | メディミューン,インコーポレーテッド | インテグリンαvβ3アンタゴニストをHMG−CoA還元酵素阻害剤またはビスフォスフォネートと併用投与する障害の予防または治療方法 |
CA2478239A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
EP1499352A4 (en) * | 2002-04-12 | 2006-10-11 | Medimmune Inc | ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES |
AU2003232077A1 (en) * | 2002-05-06 | 2003-11-17 | The Scripps Research Institute | Cyclic peptide anti-cancer agents and methods |
CA2514653A1 (en) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
JP4764818B2 (ja) | 2003-04-11 | 2011-09-07 | メディミューン,エルエルシー | 組換えil−9抗体およびその使用 |
US7196061B2 (en) * | 2003-09-10 | 2007-03-27 | Wyeth | Compounds that modulate neuronal growth and their uses |
US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
CA2585717A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
US8987306B2 (en) * | 2005-06-07 | 2015-03-24 | The Trustees Of The University Of Pennsylvania | Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold |
WO2006133338A1 (en) * | 2005-06-07 | 2006-12-14 | The Trustees Of The University Of Pennesylvania | INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN |
EP1924595A2 (en) * | 2005-08-12 | 2008-05-28 | Cartela R & D AB | Novel peptides and uses thereof |
JP4826721B2 (ja) * | 2005-08-18 | 2011-11-30 | 三菱電機株式会社 | マンコンベアの制御装置 |
WO2007027742A2 (en) * | 2005-08-31 | 2007-03-08 | The Trustees Of The University Of Pennsylvania | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS |
US7691839B2 (en) | 2005-09-28 | 2010-04-06 | Biovascular, Inc. | Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation |
WO2007072037A1 (en) * | 2005-12-22 | 2007-06-28 | Novabiotics Limited | Cyclic antimicrobial peptides |
US8637469B2 (en) | 2006-07-11 | 2014-01-28 | Roy C. Levitt | Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors |
JP2010500360A (ja) | 2006-08-10 | 2010-01-07 | アルボア コーポレーション | 炎症性サイトカイン阻害剤による下気道炎症疾患の局所療法 |
GB0618512D0 (en) * | 2006-09-20 | 2006-11-01 | Lexcicon Ltd | Peptides |
FI20075258A0 (fi) * | 2007-04-17 | 2007-04-17 | Biotie Therapies Corp | Menetelmä integriiniinhibiittorirespondereiden seulomiseksi |
WO2009052449A1 (en) * | 2007-10-17 | 2009-04-23 | University Of Southern California | Novel peptides and uses thereof |
US8563690B2 (en) * | 2008-11-03 | 2013-10-22 | The Board Of Trustees Of The University Of Illinois | Modulation of platelet aggregation |
EP2547693B1 (en) | 2010-03-19 | 2015-03-11 | H. Lee Moffitt Cancer Center & Research Institute | Integrin interaction inhibitors for the treatment of cancer |
JP5952840B2 (ja) * | 2011-02-22 | 2016-07-13 | レオ ファーマ アクティーゼルスカブ | ケラチノサイトへの結合のための環状ペプチドおよびその結合体 |
WO2015048477A1 (en) | 2013-09-27 | 2015-04-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
JP6866296B2 (ja) * | 2015-02-27 | 2021-04-28 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | ポリペプチド治療及びその使用 |
EP3849580A4 (en) | 2018-09-10 | 2022-06-15 | Lung Therapeutics, Inc. | MODIFIED PEPTIDE FRAGMENTS OF CAV-1 PROTEIN AND THEIR USE IN THE TREATMENT OF FIBROSIS |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5179007A (en) * | 1989-07-07 | 1993-01-12 | The Texas A & M University System | Method and vector for the purification of foreign proteins |
US5710123A (en) * | 1992-12-18 | 1998-01-20 | Centocor, Inc. | Peptide inhibitors of selectin binding |
US5627263A (en) * | 1993-11-24 | 1997-05-06 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
JPH10502349A (ja) * | 1994-06-29 | 1998-03-03 | テキサス・バイオテクノロジー・コーポレイシヨン | インテグリンα▲下4▼β▲下1▼のVCAM−1またはフィブロネクチンへの結合を阻害する方法 |
-
1997
- 1997-07-11 US US08/893,526 patent/US6096707A/en not_active Expired - Fee Related
-
1998
- 1998-07-09 JP JP2000502070A patent/JP2001509515A/ja active Pending
- 1998-07-09 EP EP98933671A patent/EP0994898B1/en not_active Expired - Lifetime
- 1998-07-09 WO PCT/FI1998/000579 patent/WO1999002551A1/en active IP Right Grant
- 1998-07-09 NZ NZ501767A patent/NZ501767A/xx unknown
- 1998-07-09 BR BR9810586-8A patent/BR9810586A/pt not_active Application Discontinuation
- 1998-07-09 ES ES98933671T patent/ES2195361T3/es not_active Expired - Lifetime
- 1998-07-09 PL PL98338001A patent/PL338001A1/xx not_active Application Discontinuation
- 1998-07-09 KR KR1020007000051A patent/KR100571046B1/ko not_active IP Right Cessation
- 1998-07-09 CA CA002295219A patent/CA2295219C/en not_active Expired - Fee Related
- 1998-07-09 DE DE69812630T patent/DE69812630T2/de not_active Expired - Fee Related
- 1998-07-09 AT AT98933671T patent/ATE235510T1/de not_active IP Right Cessation
- 1998-07-09 RU RU2000103210/04A patent/RU2203902C2/ru not_active IP Right Cessation
- 1998-07-09 CN CN98806979A patent/CN1262688A/zh active Pending
- 1998-07-09 HU HU0002789A patent/HU225326B1/hu not_active IP Right Cessation
- 1998-07-09 AU AU83413/98A patent/AU748134B2/en not_active Ceased
-
2000
- 2000-01-10 NO NO20000126A patent/NO20000126D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
PL338001A1 (en) | 2000-09-25 |
WO1999002551A1 (en) | 1999-01-21 |
NO20000126L (no) | 2000-01-10 |
CA2295219A1 (en) | 1999-01-21 |
DE69812630D1 (de) | 2003-04-30 |
KR100571046B1 (ko) | 2006-04-13 |
EP0994898A1 (en) | 2000-04-26 |
DE69812630T2 (de) | 2004-02-05 |
JP2001509515A (ja) | 2001-07-24 |
HU225326B1 (en) | 2006-09-28 |
CA2295219C (en) | 2007-01-02 |
HUP0002789A3 (en) | 2003-08-28 |
HUP0002789A2 (hu) | 2000-12-28 |
NZ501767A (en) | 2002-08-28 |
US6096707A (en) | 2000-08-01 |
CN1262688A (zh) | 2000-08-09 |
KR20010015547A (ko) | 2001-02-26 |
EP0994898B1 (en) | 2003-03-26 |
AU8341398A (en) | 1999-02-08 |
AU748134B2 (en) | 2002-05-30 |
RU2203902C2 (ru) | 2003-05-10 |
BR9810586A (pt) | 2000-09-05 |
NO20000126D0 (no) | 2000-01-10 |
ATE235510T1 (de) | 2003-04-15 |
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