ES2194861T3 - Peptidos opiodes. - Google Patents
Peptidos opiodes.Info
- Publication number
- ES2194861T3 ES2194861T3 ES94901304T ES94901304T ES2194861T3 ES 2194861 T3 ES2194861 T3 ES 2194861T3 ES 94901304 T ES94901304 T ES 94901304T ES 94901304 T ES94901304 T ES 94901304T ES 2194861 T3 ES2194861 T3 ES 2194861T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- acid selected
- image
- identifying group
- dimethoxyphenylalanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
PEPTIDOS OPIODES QUE INCLUYEN LOS DE FORMULA (I), EN EL QUE A1 ES EL GRUPO IDENTIFICADOR DE UN ACIDO AMINO SELECCIONADO DE DIHIDROXIFENILALANINA-3,4, DIMETOXIFENILALANINA-3,4, AZATIROSINA, Y DIMETILTIROSINA-2,6; A2 ES EL GRUPO IDENTIFICADOR DE UN ACIDO AMINO SELECCIONADO DE D-ALA Y D-ARG; A3 ES H, O EL GRUPO IDENTIFICADOR DE UN ACIDO AMINO SELECCIONADO DE DIHIDROXIFENILALANINA-3,4 Y DIMETOXIFENILALANINA-3,4, A4 ES H, CICLOHEXILMETILO, EL GRUPO IDENTIFICADOR DE UN ACIDO AMINO SELECCIONADO DE DIHIDROXIFENILALANINA-3,4, DIMETOXIFENILALANINA-3,4, PHE, Y PHE SUSTITUIDO CON SU ANILLO BENCENO SUSTITUIDO POR HALOGENO, NO2, OH, O CH3; A5 ES EL GRUPO IDENTIFICADOR DE UN ACIDO AMINO-L O -D SELECCIONADO DE LEU, NLE, LYS, MET Y MET(O), O ES SUPRIMIDO JUNTO CON EL R4-CH LIGADO A ELLO; CADA R1 Y R2 SON -H, -C(NH2)=NH, O ALQUILO C1-12; R3 ES -(A) O (B); R4 ES (C);(D), O (E); Y R5 ES -(CH2)N+1OH, (F), O (G); EN DONDE M ES 0-6, N ES 0-6, Y X ES H, ALQUILO C1-12, ARILO C6-12, ARALQUILO C7-18, ALCARILO C7-18,PIRIDILALQUILO C6-17, O ALQUILPIRIDILO C6-17; PROVISTOS QUE CUANDO UNO DE R1 Y R2 SON C(NH2) = NH, EL OTRO DEBE SER H; O SUS SALES ACEPTABLES FARMACEUTICAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97494392A | 1992-11-12 | 1992-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194861T3 true ES2194861T3 (es) | 2003-12-01 |
Family
ID=25522535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94901304T Expired - Lifetime ES2194861T3 (es) | 1992-11-12 | 1993-11-04 | Peptidos opiodes. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5663295A (es) |
EP (1) | EP0644772B1 (es) |
JP (1) | JPH07503485A (es) |
AT (1) | ATE235911T1 (es) |
AU (1) | AU672077B2 (es) |
CA (1) | CA2126697A1 (es) |
CZ (1) | CZ168194A3 (es) |
DE (1) | DE69332826T2 (es) |
DK (1) | DK0644772T3 (es) |
ES (1) | ES2194861T3 (es) |
NZ (1) | NZ258345A (es) |
PL (1) | PL304662A1 (es) |
PT (1) | PT644772E (es) |
RU (1) | RU94035760A (es) |
WO (1) | WO1994011018A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1164141A3 (en) * | 1994-02-21 | 2002-01-02 | AstraZeneca AB | Opioid peptides and their use for treatment of pain |
IS4261A (is) * | 1994-02-21 | 1995-08-22 | Astra Aktiebolag | Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra |
WO1996032409A1 (fr) | 1995-04-12 | 1996-10-17 | Kyowa Hakko Kogyo Co., Ltd. | Facteur de croissance de cellule vegetale |
CA2231220A1 (en) * | 1995-09-11 | 1997-03-20 | Masaharu Nakano | Peptide derivatives |
JP3746847B2 (ja) * | 1996-08-02 | 2006-02-15 | 協和醗酵工業株式会社 | 植物細胞増殖因子 |
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
TW509699B (en) | 1998-09-24 | 2002-11-11 | Chugau Pharmaceutical Co Ltd | Ethylamine derivatives |
AU1623801A (en) * | 1999-11-19 | 2001-05-30 | Palatin Technologies, Inc. | Opioid metallopeptide compositions and methods |
AU4876701A (en) | 2000-04-14 | 2001-10-30 | Nippon Shinyaku Co. Ltd. | Peptide derivatives and medicinal compositions |
US20070142287A1 (en) * | 2005-12-20 | 2007-06-21 | Biomed Solutions, Llc | Compositions And Methods For Treatment Of Cancer |
ES2936256T3 (es) * | 2008-02-01 | 2023-03-15 | Massachusetts Gen Hospital | Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas |
EP3461912B1 (en) | 2009-09-09 | 2022-07-13 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
JP2013520489A (ja) | 2010-02-25 | 2013-06-06 | ファイザー・リミテッド | ペプチド類似体 |
WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
CA2817111C (en) | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
RU2517628C1 (ru) * | 2012-12-24 | 2014-05-27 | Государственное научное учреждение Всероссийский научно-исследовательский институт мясной промышленности им. В.М. Горбатова Российской академии сельскохозяйственных наук | Способ определения природных аминокислот в составе белков пищевых продуктов |
RS62633B1 (sr) | 2013-03-15 | 2021-12-31 | Protagonist Therapeutics Inc | Analozi hepcidina i njihove primene |
JP6585162B2 (ja) | 2014-05-16 | 2019-10-02 | プロタゴニスト セラピューティクス, インコーポレイテッド | α4β7インテグリンチオエーテルペプチドアンタゴニスト |
RU2736637C9 (ru) | 2014-07-17 | 2021-02-08 | Протагонист Терепьютикс, Инк. | Пептидные ингибиторы рецептора интерлейкина-23 для перорального приема и их применение для лечения воспалительных заболеваний кишечника |
WO2017117411A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
EP3710467A4 (en) * | 2017-11-17 | 2021-08-04 | Cytogel Pharma, LLC | POLYMER AGONISTS OF MU-OPIOID RECEPTORS |
CA3089868A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
JP7441955B2 (ja) | 2020-01-15 | 2024-03-01 | ヤンセン バイオテツク,インコーポレーテツド | インターロイキン23受容体のペプチド阻害剤および炎症性疾患を治療するためのその使用 |
CN111635335B (zh) * | 2020-06-24 | 2021-07-13 | 上海交通大学 | 一种手性γ-氨基酸的合成方法及采用该方法合成的手性γ-氨基酸 |
IL302996A (en) | 2020-11-20 | 2023-07-01 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of the interleukin-23 receptor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI70228C (fi) * | 1976-01-26 | 1986-09-15 | Wellcome Found | Foerfarande foer framstaellning av en enkefalin-analog-peptid |
US4216128A (en) * | 1979-07-05 | 1980-08-05 | American Home Products Corporation | Enkephalin analogues |
US4599325A (en) * | 1984-02-16 | 1986-07-08 | G. D. Searle & Co. | Substituted tyrosyl alanine dipeptide amides |
US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
-
1993
- 1993-11-04 DE DE69332826T patent/DE69332826T2/de not_active Expired - Fee Related
- 1993-11-04 CZ CZ941681A patent/CZ168194A3/cs unknown
- 1993-11-04 WO PCT/US1993/010711 patent/WO1994011018A1/en active IP Right Grant
- 1993-11-04 AT AT94901304T patent/ATE235911T1/de not_active IP Right Cessation
- 1993-11-04 PL PL93304662A patent/PL304662A1/xx unknown
- 1993-11-04 RU RU94035760/04A patent/RU94035760A/ru unknown
- 1993-11-04 DK DK94901304T patent/DK0644772T3/da active
- 1993-11-04 AU AU55943/94A patent/AU672077B2/en not_active Ceased
- 1993-11-04 PT PT94901304T patent/PT644772E/pt unknown
- 1993-11-04 NZ NZ258345A patent/NZ258345A/en unknown
- 1993-11-04 CA CA002126697A patent/CA2126697A1/en not_active Abandoned
- 1993-11-04 EP EP94901304A patent/EP0644772B1/en not_active Expired - Lifetime
- 1993-11-04 ES ES94901304T patent/ES2194861T3/es not_active Expired - Lifetime
- 1993-11-04 JP JP6512244A patent/JPH07503485A/ja active Pending
-
1994
- 1994-12-08 US US08/352,391 patent/US5663295A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2126697A1 (en) | 1994-05-26 |
EP0644772A4 (en) | 1997-01-29 |
NZ258345A (en) | 1996-03-26 |
PL304662A1 (en) | 1995-01-09 |
DK0644772T3 (da) | 2003-06-30 |
DE69332826T2 (de) | 2004-01-29 |
DE69332826D1 (de) | 2003-05-08 |
CZ168194A3 (en) | 1994-12-15 |
EP0644772B1 (en) | 2003-04-02 |
US5663295A (en) | 1997-09-02 |
AU672077B2 (en) | 1996-09-19 |
RU94035760A (ru) | 1996-08-10 |
EP0644772A1 (en) | 1995-03-29 |
JPH07503485A (ja) | 1995-04-13 |
PT644772E (pt) | 2003-08-29 |
AU5594394A (en) | 1994-06-08 |
WO1994011018A1 (en) | 1994-05-26 |
ATE235911T1 (de) | 2003-04-15 |
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