DE69332826T2 - Opioidpeptide - Google Patents

Opioidpeptide Download PDF

Info

Publication number
DE69332826T2
DE69332826T2 DE69332826T DE69332826T DE69332826T2 DE 69332826 T2 DE69332826 T2 DE 69332826T2 DE 69332826 T DE69332826 T DE 69332826T DE 69332826 T DE69332826 T DE 69332826T DE 69332826 T2 DE69332826 T2 DE 69332826T2
Authority
DE
Germany
Prior art keywords
amino acid
acid selected
image
identifying group
dimethoxyphenylalanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69332826T
Other languages
English (en)
Other versions
DE69332826D1 (de
Inventor
Hyuk Kim
Jacques-Pierre Moreau
E Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of DE69332826D1 publication Critical patent/DE69332826D1/de
Application granted granted Critical
Publication of DE69332826T2 publication Critical patent/DE69332826T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69332826T 1992-11-12 1993-11-04 Opioidpeptide Expired - Fee Related DE69332826T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97494392A 1992-11-12 1992-11-12
PCT/US1993/010711 WO1994011018A1 (en) 1992-11-12 1993-11-04 Opioid peptides

Publications (2)

Publication Number Publication Date
DE69332826D1 DE69332826D1 (de) 2003-05-08
DE69332826T2 true DE69332826T2 (de) 2004-01-29

Family

ID=25522535

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332826T Expired - Fee Related DE69332826T2 (de) 1992-11-12 1993-11-04 Opioidpeptide

Country Status (15)

Country Link
US (1) US5663295A (de)
EP (1) EP0644772B1 (de)
JP (1) JPH07503485A (de)
AT (1) ATE235911T1 (de)
AU (1) AU672077B2 (de)
CA (1) CA2126697A1 (de)
CZ (1) CZ168194A3 (de)
DE (1) DE69332826T2 (de)
DK (1) DK0644772T3 (de)
ES (1) ES2194861T3 (de)
NZ (1) NZ258345A (de)
PL (1) PL304662A1 (de)
PT (1) PT644772E (de)
RU (1) RU94035760A (de)
WO (1) WO1994011018A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS4261A (is) * 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
EP1164141A3 (de) * 1994-02-21 2002-01-02 AstraZeneca AB Opioid-Peptide und ihre Verwendung zur Behandlung von Schmerz
AU3673495A (en) * 1995-04-12 1996-10-30 Kyowa Hakko Kogyo Co. Ltd. Plant cell growth factor
KR19990044554A (ko) * 1995-09-11 1999-06-25 요이치로 다케다 펩티드 유도체
JP3746847B2 (ja) * 1996-08-02 2006-02-15 協和醗酵工業株式会社 植物細胞増殖因子
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
TW509699B (en) 1998-09-24 2002-11-11 Chugau Pharmaceutical Co Ltd Ethylamine derivatives
WO2001036006A1 (en) * 1999-11-19 2001-05-25 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
AU4876701A (en) * 2000-04-14 2001-10-30 Nippon Shinyaku Co. Ltd. Peptide derivatives and medicinal compositions
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
KR101970908B1 (ko) * 2008-02-01 2019-04-19 더 제너럴 하스피탈 코포레이션 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도
EP3461912B1 (de) 2009-09-09 2022-07-13 The General Hospital Corporation Verwendung von mikrovesikeln bei der analyse von nukleinsäureprofilen
EP2539358A1 (de) * 2010-02-25 2013-01-02 Pfizer Limited Peptidanaloga
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
US20130295574A1 (en) 2010-11-10 2013-11-07 Exosome Diagnostics, Inc. Method for Isolation of Nucleic Acid Containing Particles and Extraction of Nucleic Acids Therefrom
RU2517628C1 (ru) * 2012-12-24 2014-05-27 Государственное научное учреждение Всероссийский научно-исследовательский институт мясной промышленности им. В.М. Горбатова Российской академии сельскохозяйственных наук Способ определения природных аминокислот в составе белков пищевых продуктов
PT2968443T (pt) 2013-03-15 2021-12-28 Protagonist Therapeutics Inc Análogos de hepcidina e seus usos
LT3143037T (lt) 2014-05-16 2021-10-11 Protagonist Therapeutics, Inc. Alfa4beta7 integrino tioeterio peptidų antagonistaii
CN107206254B (zh) 2014-07-17 2021-08-24 领导医疗有限公司 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途
CA3009834A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
WO2019051494A1 (en) 2017-09-11 2019-03-14 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND USES THEREOF
CN111511757A (zh) * 2017-11-17 2020-08-07 细胞凝胶制药有限责任公司 μ阿片受体的聚合物激动剂
EP3749345A4 (de) 2018-02-08 2022-04-06 Protagonist Therapeutics, Inc. Konjugierte hepcidin-mimetika
US11845808B2 (en) 2020-01-15 2023-12-19 Janssen Biotech, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
MX2022008740A (es) 2020-01-15 2022-09-23 Janssen Biotech Inc Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias.
CN111635335B (zh) * 2020-06-24 2021-07-13 上海交通大学 一种手性γ-氨基酸的合成方法及采用该方法合成的手性γ-氨基酸
IL302996A (en) 2020-11-20 2023-07-01 Janssen Pharmaceutica Nv Compositions of peptide inhibitors of the interleukin-23 receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK33177A (da) * 1976-01-26 1977-07-27 Wellcome Found Fremgangsmade til fremstilling af peptider
US4216128A (en) * 1979-07-05 1980-08-05 American Home Products Corporation Enkephalin analogues
US4599325A (en) * 1984-02-16 1986-07-08 G. D. Searle & Co. Substituted tyrosyl alanine dipeptide amides
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof

Also Published As

Publication number Publication date
EP0644772A1 (de) 1995-03-29
PL304662A1 (en) 1995-01-09
AU672077B2 (en) 1996-09-19
AU5594394A (en) 1994-06-08
CZ168194A3 (en) 1994-12-15
EP0644772B1 (de) 2003-04-02
DE69332826D1 (de) 2003-05-08
WO1994011018A1 (en) 1994-05-26
RU94035760A (ru) 1996-08-10
PT644772E (pt) 2003-08-29
JPH07503485A (ja) 1995-04-13
ATE235911T1 (de) 2003-04-15
NZ258345A (en) 1996-03-26
EP0644772A4 (de) 1997-01-29
ES2194861T3 (es) 2003-12-01
CA2126697A1 (en) 1994-05-26
DK0644772T3 (da) 2003-06-30
US5663295A (en) 1997-09-02

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee