ES2190075T3 - Formulaciones farmaceuticas solidas que contienen una mezcla fisica de sulfoalquil-eter-ciclodextrina y un agente terapeutico. - Google Patents

Formulaciones farmaceuticas solidas que contienen una mezcla fisica de sulfoalquil-eter-ciclodextrina y un agente terapeutico.

Info

Publication number
ES2190075T3
ES2190075T3 ES98918648T ES98918648T ES2190075T3 ES 2190075 T3 ES2190075 T3 ES 2190075T3 ES 98918648 T ES98918648 T ES 98918648T ES 98918648 T ES98918648 T ES 98918648T ES 2190075 T3 ES2190075 T3 ES 2190075T3
Authority
ES
Spain
Prior art keywords
sae
therapeutic agent
pharmaceutical formulations
sulfoalquil
cyclodextrine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98918648T
Other languages
English (en)
Inventor
Valentino K Stella
James Macginity
Roger A Rajewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cydex Pharmaceuticals Inc
Original Assignee
Cydex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cydex Inc filed Critical Cydex Inc
Application granted granted Critical
Publication of ES2190075T3 publication Critical patent/ES2190075T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a formulaciones farmacéuticas a base de sulfoalquil éter-ciclodextrina (SAE-CD), las cuales contienen derivados de SAE-CD y un agente terapéutico, cuya mayor parte no está unida por complejo a la SAE-CD. Las formulaciones de la presente invención frecen la ventaja de una preparación más fácil que las otras formulaciones a base de SAE-CD del estado anterior de la técnica a la par que tienen una eficacia similar, incluso mejorada. El derivado de SAE-CD puede utilizarse para modificar la biodisponibilidad y/o el nivel de bioabsorción de los agentes terapéuticos.
ES98918648T 1997-05-05 1998-04-20 Formulaciones farmaceuticas solidas que contienen una mezcla fisica de sulfoalquil-eter-ciclodextrina y un agente terapeutico. Expired - Lifetime ES2190075T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/851,006 US5874418A (en) 1997-05-05 1997-05-05 Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use

Publications (1)

Publication Number Publication Date
ES2190075T3 true ES2190075T3 (es) 2003-07-16

Family

ID=25309709

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98918648T Expired - Lifetime ES2190075T3 (es) 1997-05-05 1998-04-20 Formulaciones farmaceuticas solidas que contienen una mezcla fisica de sulfoalquil-eter-ciclodextrina y un agente terapeutico.

Country Status (10)

Country Link
US (1) US5874418A (es)
EP (1) EP0980262B1 (es)
JP (1) JP3745382B2 (es)
KR (1) KR100378031B1 (es)
AT (1) ATE234634T1 (es)
AU (1) AU729671B2 (es)
CA (1) CA2289202C (es)
DE (1) DE69812343T2 (es)
ES (1) ES2190075T3 (es)
WO (1) WO1998050077A1 (es)

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* Cited by examiner, † Cited by third party
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KR20010012233A (ko) 2001-02-15
AU729671B2 (en) 2001-02-08
KR100378031B1 (ko) 2003-04-16
EP0980262B1 (en) 2003-03-19
ATE234634T1 (de) 2003-04-15
AU7153598A (en) 1998-11-27
DE69812343T2 (de) 2004-04-01
CA2289202A1 (en) 1998-11-12
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DE69812343D1 (de) 2003-04-24
CA2289202C (en) 2005-03-15

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