ES2188983T3 - Nuevas benzofuran-4-carboxamidas. - Google Patents

Nuevas benzofuran-4-carboxamidas.

Info

Publication number
ES2188983T3
ES2188983T3 ES97942858T ES97942858T ES2188983T3 ES 2188983 T3 ES2188983 T3 ES 2188983T3 ES 97942858 T ES97942858 T ES 97942858T ES 97942858 T ES97942858 T ES 97942858T ES 2188983 T3 ES2188983 T3 ES 2188983T3
Authority
ES
Spain
Prior art keywords
carboxamidas
new benzofuran
benzofuran
new
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97942858T
Other languages
English (en)
Other versions
ES2188983T4 (es
Inventor
Wolf-Rudiger Ulrich
Dieter Flockerzi
Beate Schmidt
Ulrich Thibaut
Armin Hatzelmann
Christian Schudt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2188983T3 publication Critical patent/ES2188983T3/es
Publication of ES2188983T4 publication Critical patent/ES2188983T4/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Table Devices Or Equipment (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE FORMULA (I), DONDE R1 ES 1 - 2C - ALCOXI O 1 - 2C - ALCOXI SUSTITUIDO PARCIAL O TOTALMENTE POR FLUOR; R2 ES 1 - 7C - ALQUILO, 3 - 7C CICLOALQUILO O 3 - 7C - CICLOALQUILMETILO, AR ES FENILO, PIRIDILO, FENILO SUSTITUIDO POR R3, R4 Y R5 O PIRIDILO SUSTITUIDO POR R6, R7, R8 Y R9, DONDE R3 ES HIDROXILO, HALOGENO, CIANO, CARBOXILO, TRIFLUOROMETILO, 1 - 4C - ALQUILO, 1 - 4C ALCOXI, 1 - 4C - ALCOXICARBONILO, 1 - 4C - ALQUILCARBONILO, 1 4C - ALQUILCARBONILOXI, AMINO, MONO - O DI - 1 - 4C ALQUILAMINO O 1 - 4C - ALQUILCARBONILAMINO, R4 ES HIDROGENO, HIDROXILO, HALOGENO, AMINO, TRIFLUOROMETILO, 1 - 4C - ALQUILO, 1 - 4C - ALCOXI, 1 - 4C - ALCOXICARBONILO O AMINO, R7 ES HIDROGENO, HALOGENO, AMINO O 1 - 4C - ALQUILO, R8 ES HIDROGENO O HALOGENO Y R9 ES HIDROGENO O HALOGENO. SE INCLUYEN ASIMISMO LAS SALES DE DICHOS COMPUESTOS Y LOS N - OXIDOS DE LAS PIRIDINAS Y SUS SALES. DICHOS COMPUESTOS SON AGENTES TERAPEUTICOS BRONQUIALES EFECTIVOS.
ES97942858T 1996-08-19 1997-08-13 Nuevas benzofuran-4-carboxamidas. Expired - Lifetime ES2188983T4 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19633052 1996-08-19
DE19633052 1996-08-19

Publications (2)

Publication Number Publication Date
ES2188983T3 true ES2188983T3 (es) 2003-07-01
ES2188983T4 ES2188983T4 (es) 2004-06-01

Family

ID=7802799

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97942858T Expired - Lifetime ES2188983T4 (es) 1996-08-19 1997-08-13 Nuevas benzofuran-4-carboxamidas.

Country Status (11)

Country Link
US (1) US6211203B1 (es)
EP (1) EP0923568B9 (es)
JP (1) JP4309475B2 (es)
AT (1) ATE229516T1 (es)
AU (1) AU4454597A (es)
CY (1) CY2458B1 (es)
DE (1) DE69717827T2 (es)
DK (1) DK0923568T5 (es)
ES (1) ES2188983T4 (es)
PT (1) PT923568E (es)
WO (1) WO1998007715A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ371998A3 (cs) * 1996-05-20 1999-03-17 Darwin Discovery Limited Benzofuranové karboxamidy a jejich terapeutické použití
WO1999040085A1 (en) * 1998-02-09 1999-08-12 Darwin Discovery Limited Benzofuran-4-carboxamides and their therapeutic use
TW555759B (en) * 1998-06-08 2003-10-01 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
ATE245642T1 (de) 1998-06-10 2003-08-15 Altana Pharma Ag Benzamide mit tetrahydrofuranyloxy-substituenten als inhibitoren der phosphodiesterase 4
JP2002529444A (ja) * 1998-11-12 2002-09-10 アリアド・ファーマシューティカルズ・インコーポレイテッド 二環式シグナル伝達阻害剤、それを含む組成物とその用途
DE19924340A1 (de) 1999-05-27 2000-11-30 Basf Ag Verfahren zur selektiven Hydrierung von ethylenisch ungesättigten Doppelbindungen in Polymeren
CZ302882B6 (cs) 1999-08-21 2012-01-04 Nycomed Gmbh Farmaceutický prostredek
GB0003257D0 (en) 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
GEP20135793B (en) 2008-09-11 2013-03-25 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
DK2406253T3 (da) 2009-03-11 2013-08-12 Pfizer Benzofuranylderivater anvendt som glucokinase-inhibitorer
RU2446143C2 (ru) * 2010-05-19 2012-03-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ЯГТУ) Способ получения эфиров замещенных 5,6-дицианобензофуран-2-карбоновых кислот
US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
EP2582674B1 (en) * 2010-06-16 2014-10-01 Cymabay Therapeutics, Inc. Gpr120 receptor agonists and uses thereof
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2019091450A1 (zh) 2017-11-10 2019-05-16 江苏恒瑞医药股份有限公司 一种苯并呋喃衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046939C (zh) * 1993-07-02 1999-12-01 比克·古尔顿·劳姆贝尔格化学公司 氟烷氧基取代的苯甲酰胺类及其制备方法和应用
EP0772610B9 (de) * 1994-07-22 2001-07-25 Byk Gulden Lomberg Chemische Fabrik GmbH Dihydrobenzofurane
CN1163493C (zh) * 1995-05-19 2004-08-25 协和发酵工业株式会社 含氧杂环化合物
EP0873331B1 (en) * 1995-12-05 2002-04-03 Darwin Discovery Limited Benzofuran carboxamides and sulphonamides
CZ371998A3 (cs) * 1996-05-20 1999-03-17 Darwin Discovery Limited Benzofuranové karboxamidy a jejich terapeutické použití

Also Published As

Publication number Publication date
DK0923568T3 (da) 2003-04-07
WO1998007715A1 (en) 1998-02-26
DK0923568T5 (da) 2003-11-03
ATE229516T1 (de) 2002-12-15
DE69717827D1 (de) 2003-01-23
EP0923568B9 (en) 2003-08-13
WO1998007715A9 (en) 1999-04-29
PT923568E (pt) 2003-04-30
DE69717827T2 (de) 2003-09-04
AU4454597A (en) 1998-03-06
JP2000516932A (ja) 2000-12-19
JP4309475B2 (ja) 2009-08-05
ES2188983T4 (es) 2004-06-01
CY2458B1 (en) 2005-06-03
US6211203B1 (en) 2001-04-03
EP0923568A1 (en) 1999-06-23
EP0923568B1 (en) 2002-12-11

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