ES2187501T3 - Derivados de imidazol con cadena lateral de bifenilsulfonilurea o b ifenilsulfoniluretano, procedimiento para su preparacion y su utilizacion. - Google Patents

Derivados de imidazol con cadena lateral de bifenilsulfonilurea o b ifenilsulfoniluretano, procedimiento para su preparacion y su utilizacion.

Info

Publication number
ES2187501T3
ES2187501T3 ES93103301T ES93103301T ES2187501T3 ES 2187501 T3 ES2187501 T3 ES 2187501T3 ES 93103301 T ES93103301 T ES 93103301T ES 93103301 T ES93103301 T ES 93103301T ES 2187501 T3 ES2187501 T3 ES 2187501T3
Authority
ES
Spain
Prior art keywords
sulfonylureae
ifenylsulfonylurethane
biphenyl
imidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93103301T
Other languages
English (en)
Spanish (es)
Inventor
Holger Dr Heitsch
Rainer Dr Henning
Adalbert Dr Wagner
Hermann Dr Gerhards
Reinhard Dr Becker
Bernward Prof Dr Scholkens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2187501T3 publication Critical patent/ES2187501T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
ES93103301T 1992-03-07 1993-03-02 Derivados de imidazol con cadena lateral de bifenilsulfonilurea o b ifenilsulfoniluretano, procedimiento para su preparacion y su utilizacion. Expired - Lifetime ES2187501T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207241 1992-03-07

Publications (1)

Publication Number Publication Date
ES2187501T3 true ES2187501T3 (es) 2003-06-16

Family

ID=6453463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93103301T Expired - Lifetime ES2187501T3 (es) 1992-03-07 1993-03-02 Derivados de imidazol con cadena lateral de bifenilsulfonilurea o b ifenilsulfoniluretano, procedimiento para su preparacion y su utilizacion.

Country Status (25)

Country Link
US (1) US5604251A (cg-RX-API-DMAC10.html)
EP (1) EP0560177B1 (cg-RX-API-DMAC10.html)
JP (1) JP3542813B2 (cg-RX-API-DMAC10.html)
KR (1) KR930019637A (cg-RX-API-DMAC10.html)
CN (1) CN1036341C (cg-RX-API-DMAC10.html)
AT (1) ATE230732T1 (cg-RX-API-DMAC10.html)
AU (1) AU663565B2 (cg-RX-API-DMAC10.html)
BR (1) BR9300761A (cg-RX-API-DMAC10.html)
CA (1) CA2091135A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ281983B6 (cg-RX-API-DMAC10.html)
DE (1) DE59310323D1 (cg-RX-API-DMAC10.html)
DK (1) DK0560177T3 (cg-RX-API-DMAC10.html)
ES (1) ES2187501T3 (cg-RX-API-DMAC10.html)
FI (1) FI930970A7 (cg-RX-API-DMAC10.html)
HU (1) HUT64041A (cg-RX-API-DMAC10.html)
IL (1) IL104971A0 (cg-RX-API-DMAC10.html)
MA (1) MA22814A1 (cg-RX-API-DMAC10.html)
NO (1) NO303632B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ247059A (cg-RX-API-DMAC10.html)
PH (1) PH31466A (cg-RX-API-DMAC10.html)
PL (1) PL173023B1 (cg-RX-API-DMAC10.html)
RU (1) RU2116300C1 (cg-RX-API-DMAC10.html)
SK (1) SK381192A3 (cg-RX-API-DMAC10.html)
TW (1) TW215434B (cg-RX-API-DMAC10.html)
ZA (1) ZA931585B (cg-RX-API-DMAC10.html)

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DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5514696A (en) * 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
NO304429B1 (no) * 1992-12-17 1998-12-14 Sankyo Co Bifenylderivater, farmas°ytisk preparat og deres anvendelse for fremstilling av et medikament for behandling av hypertensjon og hjertesykdom
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
FR2716883B1 (fr) * 1994-03-04 1996-04-26 Roussel Uclaf Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
WO1997029747A1 (en) 1996-02-20 1997-08-21 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
AU729793B2 (en) * 1996-12-13 2001-02-08 Zymogenetics Inc. Compositions and methods for stimulating bone growth
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
WO1998033781A1 (en) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
US6201165B1 (en) 1997-10-16 2001-03-13 Board Of Regents, University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof
DE19802969A1 (de) 1998-01-27 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
MXPA01009362A (es) 1999-03-19 2002-06-04 Squibb Bristol Myers Co Metodos para la preparacion de bifenil isoxazol sulfonamidas.
WO2004002226A1 (en) * 2002-06-28 2004-01-08 Baylor College Of Medicine Modulators of cdk9 as a therapeutic target in cardiac hypertrophy
US20040106647A1 (en) * 2002-06-28 2004-06-03 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
BRPI0410787A (pt) * 2003-05-21 2006-06-20 Univ Texas inibição da proteìna cinase c-mu (pkd) como um tratamento para hipertrofia cardìaca e insuficiência cardìaca
CN1984660B (zh) * 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
CA2544763A1 (en) * 2003-11-03 2005-05-12 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
EP1685108B1 (en) * 2003-11-03 2008-07-23 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
US20060018970A1 (en) * 2003-12-12 2006-01-26 Myogen, Inc. Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
CA2560528A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
JP2007530566A (ja) * 2004-03-22 2007-11-01 ミオゲン インコーポレイティッド （ｒ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用
US20060292213A1 (en) * 2004-06-23 2006-12-28 Myogen, Inc. Enoximone formulations and their use in the treatment of PDE-III mediated diseases
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
WO2007014029A2 (en) * 2005-07-22 2007-02-01 The Regents Of The University Of Colorado, A Body Corporate Yin yang 1 as a treatment for cardiac hypertrophy and heart failure
CA2634437A1 (en) * 2005-12-20 2007-07-05 Gilead Colorado, Inc. 4,7-dihydrothieno¬2,3-b|pyridine compounds and pharmaceutical compositions
AU2007281261B2 (en) 2006-08-01 2013-03-21 Board Of Regents Of The University Of Texas System Identification of a micro-RNA that activates expression of beta-myosin heavy chain
ES2621161T3 (es) 2007-07-31 2017-07-03 The Board Of Regents Of The University Of Texas System Familia de micro-ARN que modula la fibrosis y usos de la misma
US8202848B2 (en) 2008-03-17 2012-06-19 Board Of Regents, The University Of Texas System Identification of micro-RNAS involved in neuromuscular synapse maintenance and regeneration
WO2012064743A2 (en) 2010-11-08 2012-05-18 The Johns Hopkins University Methods for improving heart function
GB2605148A (en) * 2021-03-23 2022-09-28 Vicore Pharma Ab New compounds

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US4355044A (en) * 1980-12-19 1982-10-19 Bernardo Heller D-Phenylalanine treatment
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CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
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Also Published As

Publication number Publication date
TW215434B (cg-RX-API-DMAC10.html) 1993-11-01
PL297955A1 (en) 1993-09-20
HU9300618D0 (en) 1993-05-28
CN1076192A (zh) 1993-09-15
JPH069572A (ja) 1994-01-18
RU2116300C1 (ru) 1998-07-27
JP3542813B2 (ja) 2004-07-14
US5604251A (en) 1997-02-18
DE59310323D1 (de) 2003-02-13
CZ381192A3 (en) 1993-12-15
NO930817D0 (no) 1993-03-05
FI930970A7 (fi) 1993-09-08
NO303632B1 (no) 1998-08-10
KR930019637A (ko) 1993-10-18
ZA931585B (en) 1993-09-27
CN1036341C (zh) 1997-11-05
NZ247059A (en) 1995-03-28
PH31466A (en) 1998-11-03
CA2091135A1 (en) 1993-09-08
ATE230732T1 (de) 2003-01-15
BR9300761A (pt) 1993-09-14
EP0560177B1 (de) 2003-01-08
IL104971A0 (en) 1993-07-08
DK0560177T3 (da) 2003-04-14
PL173023B1 (pl) 1998-01-30
HUT64041A (en) 1993-11-29
CZ281983B6 (cs) 1997-04-16
EP0560177A1 (de) 1993-09-15
AU3401193A (en) 1993-09-09
FI930970A0 (fi) 1993-03-04
SK279109B6 (sk) 1998-06-03
MA22814A1 (fr) 1993-10-01
SK381192A3 (en) 1998-06-03
AU663565B2 (en) 1995-10-12
NO930817L (no) 1993-09-08

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