ES2186059T3 - Empleo de ectoina e hidroxiectoina como medicamento. - Google Patents

Empleo de ectoina e hidroxiectoina como medicamento.

Info

Publication number
ES2186059T3
ES2186059T3 ES98113132T ES98113132T ES2186059T3 ES 2186059 T3 ES2186059 T3 ES 2186059T3 ES 98113132 T ES98113132 T ES 98113132T ES 98113132 T ES98113132 T ES 98113132T ES 2186059 T3 ES2186059 T3 ES 2186059T3
Authority
ES
Spain
Prior art keywords
state
hydroxyectoine
ectoin
cell contents
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98113132T
Other languages
English (en)
Inventor
Erwin A Dr Galinski
Hans G Prof Dr Truper
Thomas Sauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bitop AG
Original Assignee
Bitop AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bitop AG filed Critical Bitop AG
Application granted granted Critical
Publication of ES2186059T3 publication Critical patent/ES2186059T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA RECUPERACION IN VIVO DE SUSTANCIAS INTERNAS DE LAS CELULAS, EN EL CUAL LAS CELULAS ESTAN EN UN PRIMER ESTADO EN EL QUE EXISTEN UNAS CONDICIONES CASI ESTACIONARIAS ENTRE CELULA Y AMBIENTE, SE CAMBIAN DE REPENTE A UN SEGUNDO ESTADO, EN EL CUAL LAS CELULAS ESTAN OBLIGADAS A REACCIONAR EXPULSANDO SUSTANCIAS INTERNAS AL EXTERIOR, PARA CONSEGUIR ADAPTARSE A LAS CONDICIONES DEL SEGUNDO ESTADO.
ES98113132T 1992-12-31 1993-12-24 Empleo de ectoina e hidroxiectoina como medicamento. Expired - Lifetime ES2186059T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4244580A DE4244580A1 (de) 1992-12-31 1992-12-31 Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen

Publications (1)

Publication Number Publication Date
ES2186059T3 true ES2186059T3 (es) 2003-05-01

Family

ID=6476850

Family Applications (2)

Application Number Title Priority Date Filing Date
ES98121244T Expired - Lifetime ES2234065T3 (es) 1992-12-31 1993-12-24 Procedimiento para la obtencion en vivo de contenidos de celulas.
ES98113132T Expired - Lifetime ES2186059T3 (es) 1992-12-31 1993-12-24 Empleo de ectoina e hidroxiectoina como medicamento.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES98121244T Expired - Lifetime ES2234065T3 (es) 1992-12-31 1993-12-24 Procedimiento para la obtencion en vivo de contenidos de celulas.

Country Status (7)

Country Link
EP (4) EP1493432A1 (es)
AT (3) ATE226943T1 (es)
DE (4) DE4244580A1 (es)
DK (2) DK0677044T3 (es)
ES (2) ES2234065T3 (es)
PT (1) PT887418E (es)
WO (1) WO1994015923A2 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342560A1 (de) 1993-12-14 1995-06-22 Marbert Gmbh Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten
DE4427617B4 (de) * 1994-08-04 2005-09-01 bitop Aktiengesellschaft für biotechnische Optimierung Verfahren zur Gewinnung von Zellinhaltsstoffen aus halophilen und osmophilen sowie halo- und osmotoleranten Mikroorganismen
DE19711082A1 (de) * 1997-03-18 1998-09-24 Degussa Verfahren zur Abtrennung von Tetrahydropyrimidinen aus wäßrigen Lösungen
CA2376894C (en) 1999-06-12 2009-10-20 Bitop Gmbh Pharmaceutical composition comprising a protein and an ectoine
EP1125583A1 (de) * 2000-02-14 2001-08-22 Bitop Gesellschaft für biotechnische Optimierung MbH Verwendung von kompatiblen Soluten als Inhibitoren des enzymatischen Abbaus von makromolekularen Biopolymeren
DE10014632A1 (de) * 2000-03-24 2001-09-27 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten zum Schutz der Streßproteine in der Haut
US7048910B2 (en) 2000-09-07 2006-05-23 Merck Patent Gmbh Use of ectoine or ectoine derivatives for oral care
DE10214257A1 (de) 2002-03-28 2003-10-16 Merck Patent Gmbh Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden
DE10330768A1 (de) 2003-07-07 2005-02-24 bitop Aktiengesellschaft für biotechnische Optimierung Verwendung von aus extremophilen Bakterien gewonnenen Osmolyten zur Herstellung von inhalierbaren Arzneimitteln zur Prophylaxe und Behandlung pulmonaler und kardiovaskulärer Erkrankungen, sowie eines Osmolyte als Wirkstoffbestandteil enthaltende Inhalationsvorrichtung
US8900856B2 (en) 2004-04-08 2014-12-02 Biomatrica, Inc. Integration of sample storage and sample management for life science
DE102006060953A1 (de) 2006-12-12 2008-08-07 Farco-Pharma Gmbh Pharmazeutische Zubereitung für die Behandlung entzündlicher Erkrankungen des Urogenitaltraktes
DE102007003765A1 (de) 2007-01-19 2008-07-24 Farco-Pharma Gmbh Pharmazeutische Zusammensetzung zur Behandlung von Inkontinenz
DE102007013857A1 (de) 2007-03-20 2008-09-25 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Neue Zusammensetzungen, insbesondere für die topische Behandlung von Hauterkrankungen
DE102007052380A1 (de) 2007-10-31 2009-05-07 Bitop Ag Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten
DE102008006780A1 (de) * 2008-01-30 2009-08-06 Bitop Ag Verwendung von Tetrahydropyrimidinen
DE102008036725B4 (de) 2008-08-07 2021-01-28 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Pharmazeutische Zusammensetzung für die nasale Applikation
DE102008045237B4 (de) 2008-08-28 2010-07-29 Helmholtz-Zentrum Für Umweltforschung Gmbh - Ufz Verfahren zur simultanen Produktion von PHA und kompatiblen Soluten in halophilen Bakterien
EP2168570B1 (en) 2008-09-30 2013-12-25 Symrise AG Extracts of isochrysis sp.
EP2193785B1 (en) 2008-12-05 2018-07-18 Symrise AG Extracts of Tetraselmis sp. for cosmetic and therapeutic purposes
DE102010010279A1 (de) * 2009-03-07 2010-09-16 Hertel, Marcus, Dr. Ing. Verfahren und Vorrichtung zur Behandlung von Getränken
EP2430195B1 (en) 2009-05-11 2019-01-23 Biomatrica, INC. Compositions and methods for biological sample storage
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
DE102011113059A1 (de) 2011-09-09 2013-03-14 Bitop Ag Therapeutische Anwendungen von Ectoin
DE202012000247U1 (de) 2011-11-24 2012-12-05 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Zusammensetzung für die topische Applikation II
DE102012000430B4 (de) 2011-11-24 2021-11-04 Farco-Pharma Gmbh Zusammensetzung für die topische Anwendung I
DE102011122236A1 (de) 2011-12-09 2013-06-13 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Zusammensetzung für die topische Anwendung bei entzündlichen Erkrankungen der Haut und/oder Schleimhaut
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
DE102012005177A1 (de) * 2012-03-16 2013-09-19 Bitop Ag Organlagerlösung
WO2014100755A2 (en) 2012-12-20 2014-06-26 Biomatrica, Inc. Formulations and methods for stabilizing pcr reagents
EP2772245B1 (en) 2013-02-27 2018-08-22 Symrise AG Ginger extract for the protection of stem cells
EP2862852B1 (en) 2013-10-18 2018-07-04 Symrise AG Urea derivatives for the protection of stem cells
EP2921157B1 (en) 2014-03-18 2017-08-16 Symrise AG Coated titanium dioxide to reduce whitening effect on skin
EP2939710B1 (en) 2014-04-29 2020-06-17 Symrise AG Active Mixtures
EP3154338B1 (en) 2014-06-10 2020-01-29 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
EP3045161A1 (en) 2015-01-18 2016-07-20 Symrise AG Active compositions comprising 1,2-hexanediol and 1,2-octanediol
EP4242628A3 (en) 2015-12-08 2023-11-08 Biomatrica, INC. Reduction of erythrocyte sedimentation rate
DE202017101350U1 (de) 2017-02-24 2018-02-27 Farco-Pharma Gmbh Zusammensetzung, insbesondere Gel, zur Anwendung im Urogenitaltrakt
JP7132935B2 (ja) 2017-03-06 2022-09-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 適合溶質の使用
CN107333750A (zh) * 2017-06-11 2017-11-10 成都吱吖科技有限公司 一种长时血液细胞稳定剂
WO2021018990A1 (en) 2019-08-01 2021-02-04 Merck Patent Gmbh Prevention and reduction of cornification disorders and related cosmetic agents

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US4286660A (en) * 1979-03-23 1981-09-01 Gesellschaft Fur Biotechnologische Forschung Gmbh Process and installation for the flooding of petroleum deposits and oil shale
US4720458A (en) * 1983-10-19 1988-01-19 Sullivan Cornelius W Heat sensitive bacterial alkaline phosphatase
DE3515650A1 (de) * 1985-05-02 1986-11-06 Biochemie GmbH, Kundl, Tirol Verfahren zur abtrennung von biotechnologisch hergestellten wertstoffen durch querstrom-mikrofiltration
JPH0759545B2 (ja) * 1987-06-17 1995-06-28 富士写真フイルム株式会社 塩基プレカ−サ−
FR2635113B1 (fr) * 1988-08-05 1992-07-24 Sanofi Sa Procede d'obtention d'interleukine-1 (beta) mature a partir de cellules d'e. coli transformees
JPH0331265A (ja) * 1989-06-26 1991-02-12 Takeda Chem Ind Ltd テトラヒドロピリミジン誘導体の製造方法
CA2089261A1 (en) * 1990-08-30 1992-03-01 John F.W. Keana Substituted amidines having high binding to the sigma receptor and the use thereof
IL100810A (en) * 1992-01-30 1996-12-05 Yeda Res & Dev Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods

Also Published As

Publication number Publication date
EP0677044B1 (de) 1998-10-28
DK0677044T3 (da) 1999-07-12
EP0677044A1 (de) 1995-10-18
EP0887418B1 (de) 2002-10-30
DE59310311D1 (de) 2002-12-05
ES2234065T3 (es) 2005-06-16
EP0915167A1 (de) 1999-05-12
WO1994015923A2 (de) 1994-07-21
EP0915167B1 (de) 2004-12-08
EP0887418A3 (de) 1999-01-13
DE59309101D1 (de) 1998-12-03
DE59310369D1 (de) 2005-01-13
WO1994015923A3 (de) 1994-09-29
ATE172750T1 (de) 1998-11-15
ATE226943T1 (de) 2002-11-15
EP1493432A1 (de) 2005-01-05
DE4244580A1 (de) 1994-07-07
EP0887418A2 (de) 1998-12-30
PT887418E (pt) 2003-03-31
ATE284448T1 (de) 2004-12-15
DK0887418T3 (da) 2003-02-24

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