PT887418E - Utilizacao da ectoina e da hidroxiectoina como medicamentos - Google Patents
Utilizacao da ectoina e da hidroxiectoina como medicamentosInfo
- Publication number
- PT887418E PT887418E PT98113132T PT98113132T PT887418E PT 887418 E PT887418 E PT 887418E PT 98113132 T PT98113132 T PT 98113132T PT 98113132 T PT98113132 T PT 98113132T PT 887418 E PT887418 E PT 887418E
- Authority
- PT
- Portugal
- Prior art keywords
- state
- cell contents
- hydroxytein
- ectoine
- medicines
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4244580A DE4244580A1 (de) | 1992-12-31 | 1992-12-31 | Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT887418E true PT887418E (pt) | 2003-03-31 |
Family
ID=6476850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98113132T PT887418E (pt) | 1992-12-31 | 1993-12-24 | Utilizacao da ectoina e da hidroxiectoina como medicamentos |
Country Status (7)
| Country | Link |
|---|---|
| EP (4) | EP1493432A1 (pt) |
| AT (3) | ATE226943T1 (pt) |
| DE (4) | DE4244580A1 (pt) |
| DK (2) | DK0677044T3 (pt) |
| ES (2) | ES2234065T3 (pt) |
| PT (1) | PT887418E (pt) |
| WO (1) | WO1994015923A2 (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4342560A1 (de) | 1993-12-14 | 1995-06-22 | Marbert Gmbh | Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten |
| DE4427617B4 (de) * | 1994-08-04 | 2005-09-01 | bitop Aktiengesellschaft für biotechnische Optimierung | Verfahren zur Gewinnung von Zellinhaltsstoffen aus halophilen und osmophilen sowie halo- und osmotoleranten Mikroorganismen |
| DE19711082A1 (de) * | 1997-03-18 | 1998-09-24 | Degussa | Verfahren zur Abtrennung von Tetrahydropyrimidinen aus wäßrigen Lösungen |
| CA2376894C (en) | 1999-06-12 | 2009-10-20 | Bitop Gmbh | Pharmaceutical composition comprising a protein and an ectoine |
| EP1125583A1 (de) * | 2000-02-14 | 2001-08-22 | Bitop Gesellschaft für biotechnische Optimierung MbH | Verwendung von kompatiblen Soluten als Inhibitoren des enzymatischen Abbaus von makromolekularen Biopolymeren |
| DE10014632A1 (de) * | 2000-03-24 | 2001-09-27 | Merck Patent Gmbh | Verwendung von Ectoin oder Ectoin-Derivaten zum Schutz der Streßproteine in der Haut |
| US7048910B2 (en) | 2000-09-07 | 2006-05-23 | Merck Patent Gmbh | Use of ectoine or ectoine derivatives for oral care |
| DE10214257A1 (de) | 2002-03-28 | 2003-10-16 | Merck Patent Gmbh | Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden |
| DE10330768A1 (de) | 2003-07-07 | 2005-02-24 | bitop Aktiengesellschaft für biotechnische Optimierung | Verwendung von aus extremophilen Bakterien gewonnenen Osmolyten zur Herstellung von inhalierbaren Arzneimitteln zur Prophylaxe und Behandlung pulmonaler und kardiovaskulärer Erkrankungen, sowie eines Osmolyte als Wirkstoffbestandteil enthaltende Inhalationsvorrichtung |
| US8900856B2 (en) | 2004-04-08 | 2014-12-02 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| DE102006060953A1 (de) | 2006-12-12 | 2008-08-07 | Farco-Pharma Gmbh | Pharmazeutische Zubereitung für die Behandlung entzündlicher Erkrankungen des Urogenitaltraktes |
| DE102007003765A1 (de) | 2007-01-19 | 2008-07-24 | Farco-Pharma Gmbh | Pharmazeutische Zusammensetzung zur Behandlung von Inkontinenz |
| DE102007013857A1 (de) | 2007-03-20 | 2008-09-25 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Neue Zusammensetzungen, insbesondere für die topische Behandlung von Hauterkrankungen |
| DE102007052380A1 (de) | 2007-10-31 | 2009-05-07 | Bitop Ag | Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten |
| DE102008006780A1 (de) * | 2008-01-30 | 2009-08-06 | Bitop Ag | Verwendung von Tetrahydropyrimidinen |
| DE102008036725B4 (de) | 2008-08-07 | 2021-01-28 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Pharmazeutische Zusammensetzung für die nasale Applikation |
| DE102008045237B4 (de) | 2008-08-28 | 2010-07-29 | Helmholtz-Zentrum Für Umweltforschung Gmbh - Ufz | Verfahren zur simultanen Produktion von PHA und kompatiblen Soluten in halophilen Bakterien |
| EP2168570B1 (en) | 2008-09-30 | 2013-12-25 | Symrise AG | Extracts of isochrysis sp. |
| EP2193785B1 (en) | 2008-12-05 | 2018-07-18 | Symrise AG | Extracts of Tetraselmis sp. for cosmetic and therapeutic purposes |
| DE102010010279A1 (de) * | 2009-03-07 | 2010-09-16 | Hertel, Marcus, Dr. Ing. | Verfahren und Vorrichtung zur Behandlung von Getränken |
| EP2430195B1 (en) | 2009-05-11 | 2019-01-23 | Biomatrica, INC. | Compositions and methods for biological sample storage |
| EP2598660B1 (en) | 2010-07-26 | 2017-03-15 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| US9845489B2 (en) | 2010-07-26 | 2017-12-19 | Biomatrica, Inc. | Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| DE102011113059A1 (de) | 2011-09-09 | 2013-03-14 | Bitop Ag | Therapeutische Anwendungen von Ectoin |
| DE202012000247U1 (de) | 2011-11-24 | 2012-12-05 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Zusammensetzung für die topische Applikation II |
| DE102012000430B4 (de) | 2011-11-24 | 2021-11-04 | Farco-Pharma Gmbh | Zusammensetzung für die topische Anwendung I |
| DE102011122236A1 (de) | 2011-12-09 | 2013-06-13 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Zusammensetzung für die topische Anwendung bei entzündlichen Erkrankungen der Haut und/oder Schleimhaut |
| EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
| DE102012005177A1 (de) * | 2012-03-16 | 2013-09-19 | Bitop Ag | Organlagerlösung |
| WO2014100755A2 (en) | 2012-12-20 | 2014-06-26 | Biomatrica, Inc. | Formulations and methods for stabilizing pcr reagents |
| EP2772245B1 (en) | 2013-02-27 | 2018-08-22 | Symrise AG | Ginger extract for the protection of stem cells |
| EP2862852B1 (en) | 2013-10-18 | 2018-07-04 | Symrise AG | Urea derivatives for the protection of stem cells |
| EP2921157B1 (en) | 2014-03-18 | 2017-08-16 | Symrise AG | Coated titanium dioxide to reduce whitening effect on skin |
| EP2939710B1 (en) | 2014-04-29 | 2020-06-17 | Symrise AG | Active Mixtures |
| EP3154338B1 (en) | 2014-06-10 | 2020-01-29 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
| EP3045161A1 (en) | 2015-01-18 | 2016-07-20 | Symrise AG | Active compositions comprising 1,2-hexanediol and 1,2-octanediol |
| EP4242628A3 (en) | 2015-12-08 | 2023-11-08 | Biomatrica, INC. | Reduction of erythrocyte sedimentation rate |
| DE202017101350U1 (de) | 2017-02-24 | 2018-02-27 | Farco-Pharma Gmbh | Zusammensetzung, insbesondere Gel, zur Anwendung im Urogenitaltrakt |
| JP7132935B2 (ja) | 2017-03-06 | 2022-09-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 適合溶質の使用 |
| CN107333750A (zh) * | 2017-06-11 | 2017-11-10 | 成都吱吖科技有限公司 | 一种长时血液细胞稳定剂 |
| WO2021018990A1 (en) | 2019-08-01 | 2021-02-04 | Merck Patent Gmbh | Prevention and reduction of cornification disorders and related cosmetic agents |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4286660A (en) * | 1979-03-23 | 1981-09-01 | Gesellschaft Fur Biotechnologische Forschung Gmbh | Process and installation for the flooding of petroleum deposits and oil shale |
| US4720458A (en) * | 1983-10-19 | 1988-01-19 | Sullivan Cornelius W | Heat sensitive bacterial alkaline phosphatase |
| DE3515650A1 (de) * | 1985-05-02 | 1986-11-06 | Biochemie GmbH, Kundl, Tirol | Verfahren zur abtrennung von biotechnologisch hergestellten wertstoffen durch querstrom-mikrofiltration |
| JPH0759545B2 (ja) * | 1987-06-17 | 1995-06-28 | 富士写真フイルム株式会社 | 塩基プレカ−サ− |
| FR2635113B1 (fr) * | 1988-08-05 | 1992-07-24 | Sanofi Sa | Procede d'obtention d'interleukine-1 (beta) mature a partir de cellules d'e. coli transformees |
| JPH0331265A (ja) * | 1989-06-26 | 1991-02-12 | Takeda Chem Ind Ltd | テトラヒドロピリミジン誘導体の製造方法 |
| CA2089261A1 (en) * | 1990-08-30 | 1992-03-01 | John F.W. Keana | Substituted amidines having high binding to the sigma receptor and the use thereof |
| IL100810A (en) * | 1992-01-30 | 1996-12-05 | Yeda Res & Dev | Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods |
-
1992
- 1992-12-31 DE DE4244580A patent/DE4244580A1/de not_active Ceased
-
1993
- 1993-12-24 DK DK94903874T patent/DK0677044T3/da active
- 1993-12-24 DE DE59309101T patent/DE59309101D1/de not_active Expired - Lifetime
- 1993-12-24 ES ES98121244T patent/ES2234065T3/es not_active Expired - Lifetime
- 1993-12-24 EP EP04017617A patent/EP1493432A1/de not_active Withdrawn
- 1993-12-24 PT PT98113132T patent/PT887418E/pt unknown
- 1993-12-24 WO PCT/EP1993/003687 patent/WO1994015923A2/de active IP Right Grant
- 1993-12-24 AT AT98113132T patent/ATE226943T1/de not_active IP Right Cessation
- 1993-12-24 EP EP94903874A patent/EP0677044B1/de not_active Expired - Lifetime
- 1993-12-24 DK DK98113132T patent/DK0887418T3/da active
- 1993-12-24 EP EP98113132A patent/EP0887418B1/de not_active Expired - Lifetime
- 1993-12-24 DE DE1993510369 patent/DE59310369D1/de not_active Expired - Lifetime
- 1993-12-24 DE DE59310311T patent/DE59310311D1/de not_active Expired - Lifetime
- 1993-12-24 ES ES98113132T patent/ES2186059T3/es not_active Expired - Lifetime
- 1993-12-24 AT AT98121244T patent/ATE284448T1/de active
- 1993-12-24 AT AT94903874T patent/ATE172750T1/de not_active IP Right Cessation
- 1993-12-24 EP EP98121244A patent/EP0915167B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0677044B1 (de) | 1998-10-28 |
| DK0677044T3 (da) | 1999-07-12 |
| EP0677044A1 (de) | 1995-10-18 |
| ES2186059T3 (es) | 2003-05-01 |
| EP0887418B1 (de) | 2002-10-30 |
| DE59310311D1 (de) | 2002-12-05 |
| ES2234065T3 (es) | 2005-06-16 |
| EP0915167A1 (de) | 1999-05-12 |
| WO1994015923A2 (de) | 1994-07-21 |
| EP0915167B1 (de) | 2004-12-08 |
| EP0887418A3 (de) | 1999-01-13 |
| DE59309101D1 (de) | 1998-12-03 |
| DE59310369D1 (de) | 2005-01-13 |
| WO1994015923A3 (de) | 1994-09-29 |
| ATE172750T1 (de) | 1998-11-15 |
| ATE226943T1 (de) | 2002-11-15 |
| EP1493432A1 (de) | 2005-01-05 |
| DE4244580A1 (de) | 1994-07-07 |
| EP0887418A2 (de) | 1998-12-30 |
| ATE284448T1 (de) | 2004-12-15 |
| DK0887418T3 (da) | 2003-02-24 |
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