ES2180982T3 - Metodo para fabricar dispositivos de liberacion controlada basados en polimeros. - Google Patents

Metodo para fabricar dispositivos de liberacion controlada basados en polimeros.

Info

Publication number
ES2180982T3
ES2180982T3 ES97921491T ES97921491T ES2180982T3 ES 2180982 T3 ES2180982 T3 ES 2180982T3 ES 97921491 T ES97921491 T ES 97921491T ES 97921491 T ES97921491 T ES 97921491T ES 2180982 T3 ES2180982 T3 ES 2180982T3
Authority
ES
Spain
Prior art keywords
polymer
drug
polymers
devices based
forming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97921491T
Other languages
English (en)
Inventor
Paul A Burke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ES2180982T3 publication Critical patent/ES2180982T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Polymerisation Methods In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE EXPONE UN PROCEDIMIENTO PARA FORMAR MICROPARTICULAS DE POLIMEROS/DROGAS, QUE COMPRENDE LOS PASOS DE (1) FORMAR UNA SOLUCION DE POLIMERO/MEZCLA DE FARMACOS QUE COMPRENDE UN POLIMERO DISUELTO EN UN DISOLVENTE ORGANICO Y UN FARMACO LABIL SUSPENDIDO; (2) RETIRAR EL DISOLVENTE DE LA MEZCLA DE SOLUCION POLIMERICA/FARMACO, FORMANDOSE DE ESA MANERA UNA MATRIZ SOLIDA POLIMERO/FARMACO; Y (3) FRAGMENTAR LA MATRIZ POLIMERO/FARMACO A UNA TEMPERATURA INFERIOR A LA TEMPERATURA DE TRANSICION VITREA DE LA MATRIZ POLIMERO/FARMACO, OBTENIENDOSE DE ESE MODO MICROPARTICULAS DE LA MATRIZ POLIMERO/FARMACO. EN UNA REALIZACION, EL DISOLVENTE SE RETIRA DE UNA MEZCLA DE SOLUCION POLIMERICA/FARMACO CONGELANDO LA MEZCLA SOLUCION POLIMERICA/FARMACO Y EXTRAYENDO EL DISOLVENTE DE LA MATRIZ SOLIDA RESULTANTE DE SOLUCION POLIMERICA/FARMACO. EL POLIMERO PUEDE SER UN POLIMERO BIOCOMPATIBLE, COMO POR EJEMPLO EL POLI(ACIDO LACTICO - CO - ACIDO GLUCOLICO). EL FARMACO PUEDE SER UN FARMACO LABIL, COMO POR EJEMPLO UNA PROTEINA,O UN POLINUCLEOTIDO. OTRA REALIZACION MAS DE LA PRESENTE INVENCION INCLUYE UN PROCEDIMIENTO PARA OBTENER UNA MASA IMPLANTABLE DE MATRIZ POLIMERO/FARMACO, Y QUE INCLUYE LOS PASOS DE (1) FORMAR UNA MEZCLA DE SOLUCION POLIMERICA/FARMACO QUE INCLUYA UN POLIMERO DISUELTO EN UN DISOLVENTE ORGANICO Y UN FARMACO LABIL SUSPENDIDO; (2) RETIRAR EL DISOLVENTE DE LA MEZCLA DE SOLUCION POLIMERICA/FARMACO, FORMANDOSE ASI UNA MATRIZ POLIMERO SOLIDO/FARMACO; Y (3) COMPRIMIR MECANICAMENTE LA MATRIZ POLIMERO/FARMACO, OBTENIENDOSE ASI UNA MASA IMPLANTABLE DE LA MATRIZ DE POLIMERO/FARMACO.
ES97921491T 1996-05-14 1997-05-01 Metodo para fabricar dispositivos de liberacion controlada basados en polimeros. Expired - Lifetime ES2180982T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/649,128 US5817343A (en) 1996-05-14 1996-05-14 Method for fabricating polymer-based controlled-release devices

Publications (1)

Publication Number Publication Date
ES2180982T3 true ES2180982T3 (es) 2003-02-16

Family

ID=24603582

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97921491T Expired - Lifetime ES2180982T3 (es) 1996-05-14 1997-05-01 Metodo para fabricar dispositivos de liberacion controlada basados en polimeros.

Country Status (11)

Country Link
US (3) US5817343A (es)
EP (1) EP0914095B1 (es)
JP (1) JP2000513333A (es)
AT (1) ATE221373T1 (es)
AU (1) AU718866B2 (es)
CA (1) CA2253667A1 (es)
DE (1) DE69714448T2 (es)
DK (1) DK0914095T3 (es)
ES (1) ES2180982T3 (es)
PT (1) PT914095E (es)
WO (1) WO1997042940A1 (es)

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EP0914095A1 (en) 1999-05-12
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DE69714448T2 (de) 2002-11-14
AU718866B2 (en) 2000-04-20
US6183781B1 (en) 2001-02-06
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