ATE223206T1 - Verfahren zur herstellung von mikropartikeln - Google Patents

Verfahren zur herstellung von mikropartikeln

Info

Publication number
ATE223206T1
ATE223206T1 AT97923063T AT97923063T ATE223206T1 AT E223206 T1 ATE223206 T1 AT E223206T1 AT 97923063 T AT97923063 T AT 97923063T AT 97923063 T AT97923063 T AT 97923063T AT E223206 T1 ATE223206 T1 AT E223206T1
Authority
AT
Austria
Prior art keywords
microparticles
producing microparticles
organic solvent
total weight
active agent
Prior art date
Application number
AT97923063T
Other languages
English (en)
Inventor
Michael E Rickey
J Michael Ramstack
Danny H Lewis
Jean Louis Mesens
Original Assignee
Alkermes Inc
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24582704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE223206(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Inc, Janssen Pharmaceutica Nv filed Critical Alkermes Inc
Priority claimed from PCT/EP1997/002431 external-priority patent/WO1997041837A2/en
Application granted granted Critical
Publication of ATE223206T1 publication Critical patent/ATE223206T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT97923063T 1996-05-07 1997-05-06 Verfahren zur herstellung von mikropartikeln ATE223206T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64391996A 1996-05-07 1996-05-07
PCT/EP1997/002431 WO1997041837A2 (en) 1996-05-07 1997-05-06 Microparticles

Publications (1)

Publication Number Publication Date
ATE223206T1 true ATE223206T1 (de) 2002-09-15

Family

ID=24582704

Family Applications (2)

Application Number Title Priority Date Filing Date
AT97923063T ATE223206T1 (de) 1996-05-07 1997-05-06 Verfahren zur herstellung von mikropartikeln
AT02075905T ATE357218T1 (de) 1996-05-07 1997-05-06 Micropartikel

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02075905T ATE357218T1 (de) 1996-05-07 1997-05-06 Micropartikel

Country Status (11)

Country Link
EP (1) EP1210942B1 (de)
AT (2) ATE223206T1 (de)
CY (1) CY2318B1 (de)
DE (2) DE69715191T2 (de)
DK (2) DK1210942T3 (de)
ES (2) ES2284776T3 (de)
HK (2) HK1016884A1 (de)
MY (1) MY118174A (de)
PT (2) PT904063E (de)
SI (2) SI0904063T1 (de)
TR (1) TR199802258T2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
EP2167039B1 (de) 2007-05-18 2016-09-28 Durect Corporation Verbesserte depot-formulierungen
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
CA2687979C (en) 2007-05-25 2017-07-04 Tolmar Therapeutics, Inc. Sustained delivery formulations of risperidone compounds
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
US9737605B2 (en) 2013-03-11 2017-08-22 Durect Corporation Injectable controlled release composition comprising high viscosity liquid carrier
CN104226191B (zh) * 2014-09-01 2017-04-19 南京理工大学 乙基纤维素多孔颗粒的常温制备方法
CN112236459A (zh) * 2018-04-23 2021-01-15 灰色视觉公司 改善的连续微粒制造

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US5478564A (en) * 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
ATE188375T1 (de) * 1992-11-17 2000-01-15 Yoshitomi Pharmaceutical Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung
DK0724433T3 (da) * 1993-10-22 1999-08-30 Genentech Inc Fremgangsmåde til fremstilling af mikrosfærer med et tørringstrin i fluidiseret leje
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
EP1649850A1 (de) * 1993-11-19 2006-04-26 Alkermes Controlled Therapeutics Inc. II Herstellung biodegradierbarer Mikroteilchen, die ein biologisch aktives Mittel enthalten

Also Published As

Publication number Publication date
DE69715191D1 (de) 2002-10-10
CY2318B1 (en) 2003-11-14
HK1047539B (zh) 2007-08-24
PT904063E (pt) 2003-01-31
HK1047539A1 (en) 2003-02-28
DE69737515T2 (de) 2007-12-06
DE69737515D1 (de) 2007-05-03
SI0904063T1 (en) 2003-02-28
DK0904063T3 (da) 2002-12-16
EP1210942B1 (de) 2007-03-21
HK1016884A1 (en) 1999-11-12
SI1210942T1 (sl) 2007-10-31
ES2183172T3 (es) 2003-03-16
TR199802258T2 (en) 2001-11-21
DK1210942T3 (da) 2007-07-23
EP1210942A3 (de) 2004-05-26
ES2284776T3 (es) 2007-11-16
DE69715191T2 (de) 2003-04-30
ATE357218T1 (de) 2007-04-15
MY118174A (en) 2004-09-30
PT1210942E (pt) 2007-06-26
EP1210942A2 (de) 2002-06-05

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