DE69715191T2 - Verfahren zur Herstellung von Mikropartikeln - Google Patents

Verfahren zur Herstellung von Mikropartikeln

Info

Publication number
DE69715191T2
DE69715191T2 DE69715191T DE69715191T DE69715191T2 DE 69715191 T2 DE69715191 T2 DE 69715191T2 DE 69715191 T DE69715191 T DE 69715191T DE 69715191 T DE69715191 T DE 69715191T DE 69715191 T2 DE69715191 T2 DE 69715191T2
Authority
DE
Germany
Prior art keywords
microparticles
production
organic solvent
total weight
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715191T
Other languages
English (en)
Other versions
DE69715191D1 (de
Inventor
E Rickey
Michael Ramstack
H Lewis
Louis Mesens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Janssen Pharmaceutica NV
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24582704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69715191(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV, Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Janssen Pharmaceutica NV
Priority claimed from PCT/EP1997/002431 external-priority patent/WO1997041837A2/en
Application granted granted Critical
Publication of DE69715191D1 publication Critical patent/DE69715191D1/de
Publication of DE69715191T2 publication Critical patent/DE69715191T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
DE69715191T 1996-05-07 1997-05-06 Verfahren zur Herstellung von Mikropartikeln Expired - Lifetime DE69715191T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64391996A 1996-05-07 1996-05-07
PCT/EP1997/002431 WO1997041837A2 (en) 1996-05-07 1997-05-06 Microparticles

Publications (2)

Publication Number Publication Date
DE69715191D1 DE69715191D1 (de) 2002-10-10
DE69715191T2 true DE69715191T2 (de) 2003-04-30

Family

ID=24582704

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69737515T Expired - Lifetime DE69737515T2 (de) 1996-05-07 1997-05-06 Micropartikel
DE69715191T Expired - Lifetime DE69715191T2 (de) 1996-05-07 1997-05-06 Verfahren zur Herstellung von Mikropartikeln

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69737515T Expired - Lifetime DE69737515T2 (de) 1996-05-07 1997-05-06 Micropartikel

Country Status (11)

Country Link
EP (1) EP1210942B1 (de)
AT (2) ATE223206T1 (de)
CY (1) CY2318B1 (de)
DE (2) DE69737515T2 (de)
DK (2) DK1210942T3 (de)
ES (2) ES2284776T3 (de)
HK (2) HK1016884A1 (de)
MY (1) MY118174A (de)
PT (2) PT1210942E (de)
SI (2) SI0904063T1 (de)
TR (1) TR199802258T2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
AU2002337692B2 (en) 2001-09-26 2007-09-13 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
HUE030789T2 (en) 2007-05-18 2017-06-28 Durect Corp Improved depot formulation
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
CN101801415B (zh) 2007-05-25 2015-09-23 Rb医药品有限公司 利培酮化合物的持续递送制剂
CN105163719B (zh) 2013-03-11 2019-03-08 度瑞公司 包含高粘度液体载体的可注射控制释放组合物
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CN104226191B (zh) * 2014-09-01 2017-04-19 南京理工大学 乙基纤维素多孔颗粒的常温制备方法
CA3096511A1 (en) * 2018-04-23 2019-10-31 Graybug Vision, Inc. Improved continuous microparticle manufacture

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US5478564A (en) * 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
DK0669128T3 (da) * 1992-11-17 2000-06-19 Yoshitomi Pharmaceutical Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme
DE69415684T2 (de) * 1993-10-22 1999-06-10 Genentech Inc Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe
JPH09505308A (ja) * 1993-11-19 1997-05-27 アルカーミズ・コントロールド・セラピューティクス・インコーポレイテッド・トゥー 生物学的活性剤を含有する生分解性微粒子の製造
ES2236700T3 (es) * 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-benzazoles microencapsulados.

Also Published As

Publication number Publication date
ES2284776T3 (es) 2007-11-16
EP1210942B1 (de) 2007-03-21
PT1210942E (pt) 2007-06-26
HK1047539A1 (en) 2003-02-28
PT904063E (pt) 2003-01-31
SI0904063T1 (en) 2003-02-28
ATE357218T1 (de) 2007-04-15
EP1210942A2 (de) 2002-06-05
DE69737515T2 (de) 2007-12-06
DE69715191D1 (de) 2002-10-10
MY118174A (en) 2004-09-30
HK1016884A1 (en) 1999-11-12
DK1210942T3 (da) 2007-07-23
EP1210942A3 (de) 2004-05-26
DK0904063T3 (da) 2002-12-16
ATE223206T1 (de) 2002-09-15
DE69737515D1 (de) 2007-05-03
ES2183172T3 (es) 2003-03-16
SI1210942T1 (sl) 2007-10-31
TR199802258T2 (en) 2001-11-21
HK1047539B (zh) 2007-08-24
CY2318B1 (en) 2003-11-14

Similar Documents

Publication Publication Date Title
DE69104727T2 (de) Biologisch aktives material, das kovalent auf azlacton-funktionalisierten polymertraegern immobilisiert ist, und verfahren zu seiner herstellung.
DE68909712T2 (de) Biomedizinisches Material und Verfahren zu seiner Herstellung.
DE69715191T2 (de) Verfahren zur Herstellung von Mikropartikeln
DE69711523D1 (de) Abbaubares Polymer und Verfahren zu seiner Herstellung
DE69711230D1 (de) Biologisch aktive substanzen, verfahren zur herstellung und sie enthaltende zusammensetzungen
DE538049T1 (de) Hochmolekulares Pullulan und Verfahren zur seiner Herstellung.
DE69021341D1 (de) Härtungsmittel, verfahren zu seiner herstellung und damit hergestellte härtbare zusammensetzung.
DE19881845D2 (de) Verfahren zur Pfropfung von Lignin, danach hergestellte Polymerisate und deren Verwendung
DE69825809D1 (de) Hoch wasserabsorbierendes Polymer und Verfahren zu seiner Herstellung
DE69009840D1 (de) Wasser absorbierendes Verbundmaterial und Verfahren zu seiner Herstellung.
DE69318946D1 (de) Biologisch abbaubares, optisch aktives Lactonpolymer und Verfahren zu seiner Herstellung
DE59703693D1 (de) Pflanzenbehandlungsmittel
DE69527088T2 (de) Tierkotbehandlungsmaterial und verfahren zu dessen herstellung
DE3874732D1 (de) Weisses deodorierungsmittel und verfahren zu seiner herstellung.
DE59109252D1 (de) Mehrkomponentenmaterial und verfahren zu seiner herstellung
DE69204900D1 (de) Verbessertes Gummi-Metall-Lager und Verfahren zu seiner Herstellung.
DE69736376D1 (de) Material zur tierabfallbehandlung und verfahren zur dessen herstellung
DE69702753D1 (de) Platte, paneel oder ähnliche artikel aus thermoformbarem mehrsichtigem material und verfahren zur herstellung derselben
DE69719210D1 (de) Verfahren zur herstellung von 2-amino-2-imidazolinen, guanidinen, und 2-amino-3,4,5,6-tetrahydropyrimidinen
DE69300632D1 (de) Leitfähiges material mit hoher härte und verfahren zu seiner herstellung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition