ES2178384T3 - Metodos para separar un tocol de una mezcla que contiene tocoles. - Google Patents
Metodos para separar un tocol de una mezcla que contiene tocoles.Info
- Publication number
- ES2178384T3 ES2178384T3 ES99904266T ES99904266T ES2178384T3 ES 2178384 T3 ES2178384 T3 ES 2178384T3 ES 99904266 T ES99904266 T ES 99904266T ES 99904266 T ES99904266 T ES 99904266T ES 2178384 T3 ES2178384 T3 ES 2178384T3
- Authority
- ES
- Spain
- Prior art keywords
- tocol
- stumps
- mixture
- fatty acid
- separate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
Abstract
Un método para separar un tocol de una primera mezcla de tocoles que comprende al menos un tocol, un primer ácido graso, y un compuesto esterificante, que comprende: (a) calentar la primera mezcla de tocoles que comprende el tocol, el primer ácido graso y el compuesto esterificante durante un tiempo y a temperatura suficientes para esterificar sustancialmente el primer ácido graso con el compuesto esterificante para producir una segunda mezcla de tocoles que comprende el tocol, primer ácido graso esterificado y primer ácido graso sin esterificar; (b) destilar la segunda mezcla de tocoles durante un tiempo y a temperatura suficientes para separar sustancialmente el primer ácido graso sin esterificar de la segunda mezcla de tocoles para producir una tercera mezcla de tocoles que comprende el tocol y ácido graso esterificado, con el primer ácido graso sin esterificar sustancialmente separado; (c) destilar la tercera mezcla de tocoles durante un tiempo y a temperatura suficientes para separar sustancialmente el tocol de la tercera mezcla de tocoles para producir una cuarta mezcla de tocoles que comprende el tocol y un componente distinto de tocol separados; y (d) extraer el tocol de la cuarta mezcla de tocoles con un disolvente de extracción que comprende un disolvente orgánico polar que es miscible con agua para producir un sistema líquido de dos fases que comprende una primera fase que contiene una mayoría del disolvente de extracción y una segunda fase, en la que la selectividad del disolvente de extracción por el tocol con respecto al componente distinto de tocol de la cuarta mezcla de tocoles es mayor que la unidad, y separar la primera fase de la segunda fase, con la condición de que el disolvente de extracción no sea un alcohol puro, en el que la etapa (b) se puede llevar a cabo antes que la etapa (c), o la etapa (c) se puede llevar a cabo antes que la etapa (b), en el que las etapas (b) y (c) se llevan a cabo después de la etapa (a) y antes que la etapa (d).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7296398P | 1998-01-29 | 1998-01-29 | |
| US7296298P | 1998-01-29 | 1998-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2178384T3 true ES2178384T3 (es) | 2002-12-16 |
Family
ID=26753962
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99904266T Expired - Lifetime ES2178384T3 (es) | 1998-01-29 | 1999-01-26 | Metodos para separar un tocol de una mezcla que contiene tocoles. |
| ES99904267T Expired - Lifetime ES2207931T3 (es) | 1998-01-29 | 1999-01-26 | Procedimientos para separar un tocotrienol de una mezcla a base de tocol y composiciones producidas segun dichos procedimientos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99904267T Expired - Lifetime ES2207931T3 (es) | 1998-01-29 | 1999-01-26 | Procedimientos para separar un tocotrienol de una mezcla a base de tocol y composiciones producidas segun dichos procedimientos. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6159347A (es) |
| EP (2) | EP1051412B1 (es) |
| JP (2) | JP2002501915A (es) |
| CN (2) | CN1221542C (es) |
| BR (2) | BR9908141A (es) |
| ES (2) | ES2178384T3 (es) |
| MY (1) | MY124273A (es) |
| WO (2) | WO1999038860A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6706898B2 (en) | 1998-01-29 | 2004-03-16 | Archer-Daniels-Midland Company | Methods for separating a tocopherol from a tocopherol-containing mixture |
| AU5041400A (en) | 1999-05-24 | 2000-12-12 | America River Nutrition, Inc. | Tocotrienols and geranylgeraniol from LTiGTbixa orellanaLT/iGT byproducts |
| US6395915B1 (en) | 1999-09-10 | 2002-05-28 | Technikrom, Inc. | Method for producing purified tocotrienols and tocopherols using liquid chromatography |
| US6706474B1 (en) * | 2000-06-27 | 2004-03-16 | Board Of Trustees Of The University Of Illinois | Nucleic acid enzyme biosensors for ions |
| US6838104B2 (en) * | 2000-12-20 | 2005-01-04 | Archer Daniels Midland Company | Process for the production of tocotrienols |
| US6867308B2 (en) | 2001-09-19 | 2005-03-15 | Archer-Daniels-Midland Company | Process for separation of tocopherols |
| US6890719B2 (en) | 2002-05-10 | 2005-05-10 | The Board Of Trustess Of The University Of Illinois | Fluorescence based biosensor |
| US7461048B2 (en) * | 2003-07-21 | 2008-12-02 | Aureon Laboratories, Inc. | Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition |
| KR20060134913A (ko) * | 2003-09-10 | 2006-12-28 | 이스트만 케미칼 컴파니 | 피토리피드 조성물의 회수 방법 |
| US7416756B2 (en) * | 2003-09-10 | 2008-08-26 | Eastman Chemical Company | Process for the recovery of a phytolipid composition |
| WO2005035491A2 (en) * | 2003-10-10 | 2005-04-21 | Yasoo Health, Inc. | PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS FROM 2- VINYLCHROMANE COMPOUND |
| MY173044A (en) * | 2003-11-19 | 2019-12-20 | Carotech Bhd | Recovery of phytonutriens from oils |
| EA035619B1 (ru) | 2005-06-01 | 2020-07-16 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Композиции для использования в способе лечения митохондриальных нарушений |
| US7892734B2 (en) * | 2005-08-11 | 2011-02-22 | The Board Of Trustees Of The University Of Illinois | Aptamer based colorimetric sensor systems |
| EP1986636B1 (en) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
| US7799554B2 (en) * | 2006-03-16 | 2010-09-21 | The Board Of Trustees Of The University Of Illinois | Lateral flow devices |
| US8415461B2 (en) * | 2007-01-19 | 2013-04-09 | The Board Of Trustees Of The University Of Illinois | Amphiphilic substances and functionalized lipid vesicles including the same |
| US8058415B2 (en) * | 2007-04-24 | 2011-11-15 | The Board Of Trustees Of The University Of Illinois | Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes |
| KR101481197B1 (ko) * | 2007-05-24 | 2015-01-09 | 로더스 크로클란 비.브이. | 토코페롤 및 토코트리에놀을 함유하는 조성물의 제조방법 |
| WO2009012309A2 (en) * | 2007-07-16 | 2009-01-22 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for divalent copper ion detection |
| US8568690B2 (en) * | 2007-07-31 | 2013-10-29 | The Board Of Trustees Of The University Of Illinois | MRI contrast agents and high-throughput screening by MRI |
| WO2009045632A2 (en) | 2007-08-10 | 2009-04-09 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for mercury detection |
| US20090090894A1 (en) * | 2007-10-05 | 2009-04-09 | Bin Wang | Separation and extraction system |
| US20100105039A1 (en) * | 2008-06-03 | 2010-04-29 | Yi Lu | Label-free colorimetric detection |
| EP2344142B1 (en) | 2008-09-10 | 2024-06-26 | PTC Therapeutics, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| US8062893B2 (en) | 2008-10-10 | 2011-11-22 | The Board Of Trustees Of The University Of Illinois | Fluorescent sensor for mercury |
| WO2010051277A1 (en) * | 2008-10-28 | 2010-05-06 | Edison Pharmaceuticals, Inc. | Process for the production of alpha-tocotrienol and derivatives |
| CA2777479C (en) | 2009-04-28 | 2017-10-17 | Ptc Therapeutics, Inc. | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| JP2012531411A (ja) | 2009-06-25 | 2012-12-10 | アンペア ライフ サイエンシーズ，インコーポレイテッド | トコトリエノールまたはトコトリエノール濃縮抽出物を用いた広汎性発達障害の処置 |
| US8815156B2 (en) | 2010-07-19 | 2014-08-26 | Andalyze, Inc. | Sensor housing and reagent chemistry |
| CA2842486C (en) | 2011-07-19 | 2022-09-06 | Edison Pharmaceuticals, Inc. | Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| EA201390236A1 (ru) | 2012-01-25 | 2014-10-30 | Асахи Касеи Кемикалз Корпорейшн | Способ разделения |
| EP2810940A1 (en) * | 2013-06-06 | 2014-12-10 | Sulzer Chemtech AG | A Process to Prepare A Tocopherol Concentrate |
| US9512098B1 (en) | 2014-02-03 | 2016-12-06 | Board Of Trustees Of The University Of Arkansas | Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates |
| SG11201606162XA (en) | 2014-02-11 | 2016-08-30 | Evonik Membrane Extraction Technology Ltd | Method for producing vitamine e-enriched, especially tocotrienol-enriched, compositions from natural oils |
| JP7117241B2 (ja) | 2015-12-16 | 2022-08-12 | ピーティーシー セラピューティクス， インコーポレイテッド | 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法 |
| EP3389646A1 (en) | 2015-12-17 | 2018-10-24 | BioElectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| MY184673A (en) * | 2018-03-16 | 2021-04-15 | Palm Nutraceuticals Sdn Bhd | A process of preparing vitamin e concentrate |
| CN110251980B (zh) * | 2019-04-22 | 2021-03-23 | 中建安装集团有限公司 | 一种二恶烷水溶液中提纯优品级二恶烷的装置及方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2866797A (en) | 1954-11-01 | 1958-12-30 | Gen Mills Inc | Improved process of isolating sterols |
| US3153055A (en) * | 1962-03-20 | 1964-10-13 | Eastman Kodak Co | Process for separating tocopherols and sterols from deodorizer sludge and the like |
| US3335154A (en) * | 1963-06-04 | 1967-08-08 | Eastman Kodak Co | Separation of tocopherols and sterols from deodorizer sludge and the like |
| US4454329A (en) * | 1980-07-04 | 1984-06-12 | The Nisshin Oil Mills, Ltd. | Process for preparation of tocopherol concentrates |
| US4480108A (en) * | 1983-08-01 | 1984-10-30 | Eastman Kodak Company | Process for separation of tocopherol homologues |
| JPS6048981A (ja) | 1983-08-29 | 1985-03-16 | Showa Denko Kk | 高純度トコフェロ−ルの製造方法 |
| JPS60149582A (ja) | 1984-01-14 | 1985-08-07 | Mitsui Petrochem Ind Ltd | トコフエロ−ルの精製方法 |
| JPS60185776A (ja) | 1984-03-05 | 1985-09-21 | Riken Vitamin Co Ltd | トコフエロ−ルの精製濃縮法 |
| US4550183A (en) * | 1984-08-02 | 1985-10-29 | Henkel Corporation | Purification of tocopherols |
| EP0171009B1 (en) * | 1984-08-02 | 1991-05-22 | HENKEL CORPORATION (a Delaware corp.) | Purification of tocopherols by extraction |
| JPS6160619A (ja) * | 1984-08-31 | 1986-03-28 | Eisai Co Ltd | 分散性粉末 |
| JPS6193178A (ja) * | 1984-10-12 | 1986-05-12 | Agency Of Ind Science & Technol | トコトリエノ−ル類の分離方法 |
| JPS61151186A (ja) * | 1984-12-24 | 1986-07-09 | Nisshin Oil Mills Ltd:The | トコトリエノ−ル類およびトコフエロ−ル類の濃縮法 |
| DE3615029A1 (de) | 1985-05-06 | 1986-11-06 | Henkel Corp., Minneapolis, Minn. | Methanol-extraktion von tocopherol |
| AU618791B2 (en) * | 1988-03-16 | 1992-01-09 | Bioindustry Development Centre | Production of high concentration tocopherols and tocotrienols from palm oil by-product |
| JPH03127730A (ja) | 1989-10-11 | 1991-05-30 | Kikaku Nijiyuuichi:Kk | ビタミンｅの製造方法 |
| WO1991017985A1 (en) * | 1990-05-23 | 1991-11-28 | Lipogenics, Inc. | Processes for recovering tocotrienols, tocopherols and tocotrienol-like compounds |
| US5487817A (en) * | 1993-02-11 | 1996-01-30 | Hoffmann-La Roche Inc. | Process for tocopherols and sterols from natural sources |
| BR9407179A (pt) * | 1993-08-06 | 1996-09-17 | Henkel Corp | Processos de recuperação tocoferóis a partir de uma mistura gordurosa compreendida de ácidos graxos e tocoferóis de evaporação para a separação de alquil ésteres inferiores de ácido graxo de uma mistura que compreende adicionalmente tocoferóis e esteróis e de separação de um ou mais compostos de tocoferol de um ou mais compostos de esterol |
| US5512691A (en) * | 1994-11-07 | 1996-04-30 | Eastman Chemical Company | Process for the production of tocopherol concentrates |
| US5660691A (en) * | 1995-11-13 | 1997-08-26 | Eastman Chemical Company | Process for the production of tocotrienol/tocopherol blend concentrates |
| US5703252A (en) * | 1995-12-13 | 1997-12-30 | Henkel Corporation | Recovery of Tocopherols |
-
1999
- 1999-01-26 EP EP99904267A patent/EP1051412B1/en not_active Expired - Lifetime
- 1999-01-26 CN CNB998024449A patent/CN1221542C/zh not_active Expired - Fee Related
- 1999-01-26 WO PCT/US1999/001571 patent/WO1999038860A1/en not_active Ceased
- 1999-01-26 EP EP99904266A patent/EP1051411B1/en not_active Expired - Lifetime
- 1999-01-26 US US09/237,406 patent/US6159347A/en not_active Expired - Fee Related
- 1999-01-26 JP JP2000529327A patent/JP2002501915A/ja active Pending
- 1999-01-26 JP JP2000529328A patent/JP2002501916A/ja active Pending
- 1999-01-26 BR BR9908141-5A patent/BR9908141A/pt not_active IP Right Cessation
- 1999-01-26 ES ES99904266T patent/ES2178384T3/es not_active Expired - Lifetime
- 1999-01-26 ES ES99904267T patent/ES2207931T3/es not_active Expired - Lifetime
- 1999-01-26 WO PCT/US1999/001570 patent/WO1999038859A1/en not_active Ceased
- 1999-01-26 US US09/237,384 patent/US6224717B1/en not_active Expired - Fee Related
- 1999-01-26 BR BR9907278-5A patent/BR9907278A/pt not_active IP Right Cessation
- 1999-01-26 CN CN99802443A patent/CN1295568A/zh active Pending
- 1999-01-28 MY MYPI99000291A patent/MY124273A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1314901A (zh) | 2001-09-26 |
| JP2002501915A (ja) | 2002-01-22 |
| ES2207931T3 (es) | 2004-06-01 |
| JP2002501916A (ja) | 2002-01-22 |
| EP1051411B1 (en) | 2002-08-28 |
| EP1051411A1 (en) | 2000-11-15 |
| WO1999038859A1 (en) | 1999-08-05 |
| MY124273A (en) | 2006-06-30 |
| CN1221542C (zh) | 2005-10-05 |
| CN1295568A (zh) | 2001-05-16 |
| BR9908141A (pt) | 2000-11-28 |
| US6224717B1 (en) | 2001-05-01 |
| BR9907278A (pt) | 2000-10-24 |
| WO1999038860A1 (en) | 1999-08-05 |
| US6159347A (en) | 2000-12-12 |
| EP1051412A1 (en) | 2000-11-15 |
| EP1051412B1 (en) | 2003-09-24 |
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