BR0007665A - Métodos para a separação de um tocoferol a partir de uma mistura contendo tocoferol e suas composições - Google Patents
Métodos para a separação de um tocoferol a partir de uma mistura contendo tocoferol e suas composiçõesInfo
- Publication number
- BR0007665A BR0007665A BR0007665-1A BR0007665A BR0007665A BR 0007665 A BR0007665 A BR 0007665A BR 0007665 A BR0007665 A BR 0007665A BR 0007665 A BR0007665 A BR 0007665A
- Authority
- BR
- Brazil
- Prior art keywords
- tocopherol
- mixture
- fatty acid
- phase
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title abstract 22
- 229960001295 tocopherol Drugs 0.000 title abstract 22
- 229930003799 tocopherol Natural products 0.000 title abstract 22
- 235000010384 tocopherol Nutrition 0.000 title abstract 22
- 239000011732 tocopherol Substances 0.000 title abstract 22
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title abstract 22
- 239000000203 mixture Substances 0.000 title abstract 15
- 238000000034 method Methods 0.000 title abstract 4
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 6
- 229930195729 fatty acid Natural products 0.000 abstract 6
- 239000000194 fatty acid Substances 0.000 abstract 6
- 150000004665 fatty acids Chemical class 0.000 abstract 6
- 238000000605 extraction Methods 0.000 abstract 4
- 239000002904 solvent Substances 0.000 abstract 4
- DFUSDJMZWQVQSF-XLGIIRLISA-N (2r)-2-methyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 DFUSDJMZWQVQSF-XLGIIRLISA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000021588 free fatty acids Nutrition 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000005830 nonesterified fatty acids Chemical class 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
"MéTODOS PARA A SEPARAçãO DE UM TOCOFEROL A PARTIR DE UMA MISTURA CONTENDO TOCOFEROL E SUAS COMPOSIçõES". A invenção se refere a um método para a separação de tocoferol a partir de uma primeira mistura tocoferol através do aquecimento da primeira mistura tocoferol composta de pelo menos um tocoferol, um ácido graxo, e um composto de esterificação para esterificar o ácido graxo para produzir uma segunda mistura tocoferol composta de tocoferol, ácido graxo esterificado, e ácido graxo não esterificado; destilar a segunda mistura tocoferol com o ácido graxo esterificado para remover o ácido graxo não esterificado da segunda mistura tocoferol para produzir uma terceira mistura tocoferol composta de tocoferol, com o ácido graxo não esterificado substancialmente removido; destilar a terceira mistura tocoferol por um período de tempo suficiente e temperatura para remover substancialmente o tocoferol da terceira mistura tocoferol para produzir uma quarta mistura tocoferol composta do tocoferol removido e um componente não-tocol; e extrair o tocoferol da quarta mistura tocoferol com um solvente de extração composto de um solvente orgânico polar, que é miscível com água para produzir um sistema de duas fases composto de uma primeira fase contendo a maior parte do solvente de extração e a segunda fase, onde a seletividade do solvente de extração para o tocoferol relativamente ao componente não-tocol é maior do que a unidade, e remover a primeira fase a partir da segunda fase, com a condição de que o solvente de extração não é um álcool puro. A invenção adicionalmente se refere a composições produzidas através dos métodos da presente invenção.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/237,406 US6159347A (en) | 1998-01-29 | 1999-01-26 | Methods for separating a tocol from a tocol-containing mixture |
| US09/237,384 US6224717B1 (en) | 1998-01-29 | 1999-01-26 | Methods for separating a tocotrienol from a tocol-containing mixture and compositions thereof |
| US09/360,947 US6706898B2 (en) | 1998-01-29 | 1999-07-27 | Methods for separating a tocopherol from a tocopherol-containing mixture |
| PCT/US2000/001624 WO2000043095A2 (en) | 1999-01-26 | 2000-01-27 | Methods for separating a tocopherol from a tocopherol-containing mixture and compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0007665A true BR0007665A (pt) | 2002-04-09 |
Family
ID=27398974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0007665-1A Withdrawn BR0007665A (pt) | 1999-01-26 | 2000-01-27 | Métodos para a separação de um tocoferol a partir de uma mistura contendo tocoferol e suas composições |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6706898B2 (pt) |
| EP (1) | EP1163235A4 (pt) |
| CN (1) | CN1348448A (pt) |
| AU (1) | AU759309B2 (pt) |
| BR (1) | BR0007665A (pt) |
| CA (1) | CA2359938A1 (pt) |
| WO (1) | WO2000043095A2 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395915B1 (en) | 1999-09-10 | 2002-05-28 | Technikrom, Inc. | Method for producing purified tocotrienols and tocopherols using liquid chromatography |
| NL1013682C2 (nl) * | 1999-11-26 | 2001-05-30 | Purac Biochem Bv | Werkwijze en inrichting voor het zuiveren van een waterige oplossing van melkzuur. |
| MY138186A (en) * | 2000-12-14 | 2009-05-29 | Supervitamins Sdn Bhd | Recovery of minor components and refining of vegetable oils and fats |
| US6838104B2 (en) * | 2000-12-20 | 2005-01-04 | Archer Daniels Midland Company | Process for the production of tocotrienols |
| WO2003037884A2 (en) | 2001-09-19 | 2003-05-08 | Archer-Daniels-Midland Company | Process for separation of tocopherols |
| EP1440687A4 (en) * | 2001-10-09 | 2005-08-17 | Japanese Res & Dev Ass For New | ANTIRADIC AND FAT COMPOSITIONS, FOODS, BEVERAGES, MEDICINAL PRODUCTS OR FEED AGENTS CONTAINING THESE ANTIRADICAS |
| MY119891A (en) * | 2001-10-11 | 2005-07-29 | Hygeia Ind Inc | Method for producing purified tocotrienols and tocopherols using liquid chromatography. |
| US6673945B2 (en) | 2001-11-08 | 2004-01-06 | Archer-Daniels Midland Company | Process for production of high purity tocopherols |
| UA78066C2 (en) * | 2002-06-19 | 2007-02-15 | Process for recovery of plant sterols and tocopherols from deodorized distillates | |
| US7461048B2 (en) * | 2003-07-21 | 2008-12-02 | Aureon Laboratories, Inc. | Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition |
| US7174900B2 (en) * | 2004-01-16 | 2007-02-13 | Teresa Lane | Hair accessory utilizing a drawable member and a securing member |
| BRPI0620310B1 (pt) * | 2005-12-16 | 2017-12-05 | Archer-Daniels-Midland Company | A method for preparing a composition enriched in compounds containing unsaturated carbon chains by simulated moving bed chromatography using an adsorbent containing silver ions |
| DE102007061436A1 (de) | 2007-12-20 | 2009-06-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Gewinnung von Fettbegleitstoffen aus Kraftstoffen und Verwendung dieses Verfahrens |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2432181A (en) | 1944-08-11 | 1947-12-09 | Colgate Palmolive Peet Co | Vitamin recovery |
| US2866797A (en) | 1954-11-01 | 1958-12-30 | Gen Mills Inc | Improved process of isolating sterols |
| US3153055A (en) | 1962-03-20 | 1964-10-13 | Eastman Kodak Co | Process for separating tocopherols and sterols from deodorizer sludge and the like |
| US3335154A (en) | 1963-06-04 | 1967-08-08 | Eastman Kodak Co | Separation of tocopherols and sterols from deodorizer sludge and the like |
| US4454329A (en) | 1980-07-04 | 1984-06-12 | The Nisshin Oil Mills, Ltd. | Process for preparation of tocopherol concentrates |
| JPS58144382A (ja) | 1982-02-19 | 1983-08-27 | Agency Of Ind Science & Technol | トコフエロ−ル及びトコトリエノ−ルの分離方法 |
| US4480108A (en) | 1983-08-01 | 1984-10-30 | Eastman Kodak Company | Process for separation of tocopherol homologues |
| JPS6048981A (ja) | 1983-08-29 | 1985-03-16 | Showa Denko Kk | 高純度トコフェロ−ルの製造方法 |
| JPS60149582A (ja) | 1984-01-14 | 1985-08-07 | Mitsui Petrochem Ind Ltd | トコフエロ−ルの精製方法 |
| JPS60185776A (ja) | 1984-03-05 | 1985-09-21 | Riken Vitamin Co Ltd | トコフエロ−ルの精製濃縮法 |
| US4550183A (en) | 1984-08-02 | 1985-10-29 | Henkel Corporation | Purification of tocopherols |
| DE3582904D1 (de) | 1984-08-02 | 1991-06-27 | Henkel Corp | Reinigung von tocopherolen durch extraktion. |
| JPS6193178A (ja) | 1984-10-12 | 1986-05-12 | Agency Of Ind Science & Technol | トコトリエノ−ル類の分離方法 |
| DE3615029A1 (de) | 1985-05-06 | 1986-11-06 | Henkel Corp., Minneapolis, Minn. | Methanol-extraktion von tocopherol |
| JPH029875A (ja) | 1988-03-16 | 1990-01-12 | Bio Ind Kyokai | トコフェロール及びトコトリエノールの製造方法 |
| JPH03127730A (ja) | 1989-10-11 | 1991-05-30 | Kikaku Nijiyuuichi:Kk | ビタミンｅの製造方法 |
| SG69971A1 (en) | 1990-05-23 | 2000-01-25 | Lipogenics Inc | Process for recovering tocotrienols tocopherals and tocotrienol-like compounds |
| US5487817A (en) | 1993-02-11 | 1996-01-30 | Hoffmann-La Roche Inc. | Process for tocopherols and sterols from natural sources |
| DE69429884T2 (de) | 1993-08-06 | 2002-08-14 | Henkel Corp | Wiedergewinnung von Tocopherolen |
| US5512691A (en) | 1994-11-07 | 1996-04-30 | Eastman Chemical Company | Process for the production of tocopherol concentrates |
| US5660691A (en) | 1995-11-13 | 1997-08-26 | Eastman Chemical Company | Process for the production of tocotrienol/tocopherol blend concentrates |
| US5703252A (en) | 1995-12-13 | 1997-12-30 | Henkel Corporation | Recovery of Tocopherols |
| EP1051411B1 (en) | 1998-01-29 | 2002-08-28 | Eastman Chemical Company | Methods for separating a tocol from a tocol-containing mixture |
| BR9911873A (pt) | 1998-07-06 | 2001-03-27 | Eastman Chem Co | Processo para produzir fitol, um derivado de fiteno, isofitol, um derivado de isofiteno, ou uma mistura dos mesmos, composto de epoxifitila substituìdo, composto de fiteno substituìdo, processo para produzir o mesmo, processo para produzir alfa-tocoferol, e, processo para coverter geranilgeraniol a alfa-tocoferol |
-
1999
- 1999-07-27 US US09/360,947 patent/US6706898B2/en not_active Expired - Fee Related
-
2000
- 2000-01-27 CA CA002359938A patent/CA2359938A1/en not_active Abandoned
- 2000-01-27 EP EP00907000A patent/EP1163235A4/en not_active Withdrawn
- 2000-01-27 CN CN00804330.2A patent/CN1348448A/zh active Pending
- 2000-01-27 BR BR0007665-1A patent/BR0007665A/pt not_active Withdrawn
- 2000-01-27 AU AU28571/00A patent/AU759309B2/en not_active Ceased
- 2000-01-27 WO PCT/US2000/001624 patent/WO2000043095A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2857100A (en) | 2000-08-07 |
| WO2000043095A2 (en) | 2000-07-27 |
| EP1163235A4 (en) | 2002-06-26 |
| WO2000043095A3 (en) | 2000-09-28 |
| US20020042527A1 (en) | 2002-04-11 |
| US6706898B2 (en) | 2004-03-16 |
| EP1163235A2 (en) | 2001-12-19 |
| CA2359938A1 (en) | 2000-07-27 |
| CN1348448A (zh) | 2002-05-08 |
| AU759309B2 (en) | 2003-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007. |