ES2177139T3 - Procedimiento para la preparacion de derivados de 3-amino-pirrolidina. - Google Patents
Procedimiento para la preparacion de derivados de 3-amino-pirrolidina.Info
- Publication number
- ES2177139T3 ES2177139T3 ES99100213T ES99100213T ES2177139T3 ES 2177139 T3 ES2177139 T3 ES 2177139T3 ES 99100213 T ES99100213 T ES 99100213T ES 99100213 T ES99100213 T ES 99100213T ES 2177139 T3 ES2177139 T3 ES 2177139T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- formula
- amino
- derivatives
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE DERIVADOS DE 3 - AMINO - PIRROLIDINA REPRESENTADOS POR LA FORMULA (I): DONDE R 1 REPRESENTA UN HIDROGENO, UN ALQUILO, UN CICLOALQUILO, UN ALQUENILO, UN ARILO O UN GRUPO PROTECTOR DE AMINO; R 2 Y R 3 REPRESENTAN CADA UNO, IN DEPENDIENTEMENTE, UN HIDROGENO, UN ALQUILO, UN CICLOALQUILO, UN ALQUENILO O UN ARILO. DICHA PREPARACION SE LLEVA A CABO MEDIANTE LA CONVERSION DE UN COMPUESTO REPRESENTADO POR LA FORMULA (II): DONDE, X REPRESENTA UN GRUPO HIDROXILO PROTEGIDO; EN PRESENCIA DE UNA AMINA PRIMARIA DE FORMULA R 1 NH 2 EN EL DERIVADO DE PIRROLIDINA REPRESENTADO POR LA FORMULA (III): DONDE, X Y R 1 REPRESENTAN LO QUE ANTERIORMENTE SE MENCIONO. DICHO COMPUESTO REACCIONA POSTERIORMENTE EN PRESENCIA DE R SUP,2 R 3 NH Y BAJO PRESION. LA INVENCION TAMBIEN SE REFIERE A LA UTILIZACION DE ESTE PROCESO PARA LA PRODUCCION DE DE DERIVADOS DE VINILPIRROLIDINA - CEFALOSPORINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98100381 | 1998-01-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2177139T3 true ES2177139T3 (es) | 2002-12-01 |
Family
ID=8231254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99100213T Expired - Lifetime ES2177139T3 (es) | 1998-01-12 | 1999-01-08 | Procedimiento para la preparacion de derivados de 3-amino-pirrolidina. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5977381A (es) |
EP (1) | EP0928787B1 (es) |
JP (1) | JP3639449B2 (es) |
KR (1) | KR19990067824A (es) |
CN (1) | CN1229077A (es) |
AT (1) | ATE218546T1 (es) |
CA (1) | CA2258166A1 (es) |
DE (1) | DE69901627T2 (es) |
DK (1) | DK0928787T3 (es) |
ES (1) | ES2177139T3 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100295740B1 (ko) * | 1998-09-17 | 2001-11-05 | 박영구 | N-치환된-하이드록시고리화알킬아민유도체의제조방법 |
DE60123513T2 (de) * | 2000-04-19 | 2007-05-10 | Basilea Pharmaceutica Ag | Verfahren zur Herstellung von D-Asparaginderivaten |
FR2817550B1 (fr) * | 2000-12-01 | 2005-04-29 | Ppg Sipsy | Procede de preparation de derives de pyrrolidine substituee |
US6348600B1 (en) * | 2001-02-20 | 2002-02-19 | Toray Industries, Inc. | Methods for making optically active 3-aminopyrrolidine-2,5-dione derivative and optically active 3-aminopyrrolidine derivative |
JP4481659B2 (ja) * | 2002-03-29 | 2010-06-16 | 株式会社カネカ | 1−ベンジル−3−アミノピロリジンの光学純度向上方法及びそれに用いられる塩 |
CN1331852C (zh) * | 2005-08-25 | 2007-08-15 | 浙江大学 | N-取代基-3-氨基吡咯烷及其二盐酸盐的合成方法 |
EP1924549A1 (en) * | 2005-08-31 | 2008-05-28 | Pfizer Products Inc. | Direct aminolysis |
US8030501B2 (en) * | 2006-07-28 | 2011-10-04 | Kaneka Corporation | Process for producing optically active 3-amino nitrogen-containing compounds |
CN101759620B (zh) * | 2010-01-19 | 2013-08-28 | 苏州天马精细化学品股份有限公司 | 3-氨基吡咯烷盐酸盐的合成方法 |
CN101955457A (zh) * | 2010-09-21 | 2011-01-26 | 海门慧聚药业有限公司 | 光学活性3-氨基吡咯烷、3-氨基哌啶烷及其衍生物的一种通用制备方法 |
CN103570601B (zh) * | 2012-07-20 | 2016-03-30 | 重庆博腾制药科技股份有限公司 | 一种光学活性药物中间体的制备方法 |
CN111592480B (zh) * | 2020-06-18 | 2023-06-23 | 山西千岫制药有限公司 | 一种头孢吡普酯中间体(r)-1-叔丁氧基羰基-3-氨基吡咯烷的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1392194A (en) * | 1971-09-23 | 1975-04-30 | Wyeth John & Brother Ltd | Pyrrolidine derivatives |
US4785119A (en) * | 1985-10-11 | 1988-11-15 | Tokyo Kasei Kogyo Co., Ltd. | 3-aminopyrrolidine compound and process for preparation thereof |
US4916141A (en) * | 1989-03-28 | 1990-04-10 | Warner-Lambert Company | (S)-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid |
DE3910920A1 (de) * | 1989-04-05 | 1990-10-11 | Bayer Ag | Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren |
US5177217A (en) * | 1992-04-27 | 1993-01-05 | Warner-Lambert Company | Process for the manufacture of (S)-3-amino-1-substituted-pyrrolidines |
JPH07233146A (ja) * | 1994-02-23 | 1995-09-05 | Dai Ichi Seiyaku Co Ltd | ラセミ化法 |
JPH0853412A (ja) * | 1994-08-11 | 1996-02-27 | Sankyo Co Ltd | 光学活性な3−アミノピロリジン誘導体 |
JP3716376B2 (ja) * | 1995-10-26 | 2005-11-16 | 東レ・ファインケミカル株式会社 | 光学分割剤およびそれを用いた光学活性3−アミノピロリジン誘導体の製造法 |
US5703244A (en) * | 1996-11-21 | 1997-12-30 | Abbott Laboratories | Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds |
TW415949B (en) * | 1996-12-19 | 2000-12-21 | Hoffmann La Roche | Vinyl pyrrolidine cephalosporin derivatives with basic substituents |
-
1998
- 1998-12-17 US US09/213,465 patent/US5977381A/en not_active Expired - Lifetime
-
1999
- 1999-01-08 CA CA002258166A patent/CA2258166A1/en not_active Abandoned
- 1999-01-08 EP EP99100213A patent/EP0928787B1/en not_active Expired - Lifetime
- 1999-01-08 ES ES99100213T patent/ES2177139T3/es not_active Expired - Lifetime
- 1999-01-08 DK DK99100213T patent/DK0928787T3/da active
- 1999-01-08 DE DE69901627T patent/DE69901627T2/de not_active Expired - Lifetime
- 1999-01-08 AT AT99100213T patent/ATE218546T1/de active
- 1999-01-11 KR KR1019990000385A patent/KR19990067824A/ko active IP Right Grant
- 1999-01-12 CN CN99101055A patent/CN1229077A/zh active Pending
- 1999-01-12 JP JP00489899A patent/JP3639449B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0928787A1 (en) | 1999-07-14 |
JP3639449B2 (ja) | 2005-04-20 |
DK0928787T3 (da) | 2002-09-23 |
KR19990067824A (ko) | 1999-08-25 |
ATE218546T1 (de) | 2002-06-15 |
DE69901627T2 (de) | 2003-02-20 |
DE69901627D1 (de) | 2002-07-11 |
US5977381A (en) | 1999-11-02 |
CN1229077A (zh) | 1999-09-22 |
CA2258166A1 (en) | 1999-07-12 |
EP0928787B1 (en) | 2002-06-05 |
JP2000053642A (ja) | 2000-02-22 |
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