ES2173516T3 - Composicion de ibuprofeno bebible. - Google Patents
Composicion de ibuprofeno bebible.Info
- Publication number
- ES2173516T3 ES2173516T3 ES97953861T ES97953861T ES2173516T3 ES 2173516 T3 ES2173516 T3 ES 2173516T3 ES 97953861 T ES97953861 T ES 97953861T ES 97953861 T ES97953861 T ES 97953861T ES 2173516 T3 ES2173516 T3 ES 2173516T3
- Authority
- ES
- Spain
- Prior art keywords
- ibuprofen
- composition
- preparation
- less
- waterproof
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UNA COMPOSICION A BASE DE IBUPROFENO QUE PERMITE OBTENER UN PREPARADO ACUOSO CON UN PH MENOR A 7 CUANDO SE AÑADE AGUA A DICHA COMPOSICION. ESTA COMPOSICION CONTIENE UNO O VARIOS MEDICAMENTOS, INCLUYENDO UN MEDICAMENTO A BASE DE IBUPROFENO QUE CONSTITUYE UN PRINCIPIO ACTIVO A BASE DE IBUPROFENO QUE SE CARACTERIZA POR UN PUNTO DE FUSION DE MENOS DE 100 GRADOS C, CUANDO SE COMBINA CON AGUA PARA DAR UN PREPARADO ACUOSO CON UN PH INFERIOR A 7 Y UN MATERIAL FOSFOLIPIDO MEZCLADO HOMOGENEAMENTE CON EL MEDICAMENTO A BASE DE IBUPROFENO. LA MATERIA FOSFOLIPIDA PUEDE DAR UN PREPARADO ACUOSO EN FORMA DE EMULSION O DE DISPERSION QUE COMPRENDE UNA FASE ACUOSA CASI DESPROVISTA DEL PRINCIPIO ACTIVO IBUPROFENO Y UNA FASE DISCRETA CONSTITUIDA BASICAMENTE DE LA MATERIA FOSFOLIPIDA CONSIDERADA Y UN PRINCIPIO ACTIVO FARMACOLOGICAMENTE INSOLUBLE QUE COMPRENDE EL PRINCIPIO ACTIVO IBUPROFENO CUANDO SE AÑADE AGUA A LA COMPOSICION. ESTA INVENCION SE REFIERE TAMBIEN A UNOS PREPARADOSACUOSOS BEBIBLES (EN PARTICULAR EMULSIONES CALENTADAS) OBTENIDAS A PARTIR DE LA COMPOSICION Y A UN PROCEDIMIENTO DE ELABORACION DE ESTOS PREPARADOS ACUOSOS BEBIBLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9625589.8A GB9625589D0 (en) | 1996-12-10 | 1996-12-10 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173516T3 true ES2173516T3 (es) | 2002-10-16 |
Family
ID=10804192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97953861T Expired - Lifetime ES2173516T3 (es) | 1996-12-10 | 1997-12-09 | Composicion de ibuprofeno bebible. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6287592B1 (es) |
EP (1) | EP0946156B1 (es) |
JP (1) | JP2001508768A (es) |
KR (1) | KR20000069418A (es) |
CN (1) | CN1275910A (es) |
AR (1) | AR010758A1 (es) |
AT (1) | ATE213628T1 (es) |
AU (1) | AU723608B2 (es) |
BG (1) | BG103552A (es) |
CA (1) | CA2274773C (es) |
CZ (1) | CZ204599A3 (es) |
DE (1) | DE69710774T2 (es) |
DK (1) | DK0946156T3 (es) |
ES (1) | ES2173516T3 (es) |
GB (1) | GB9625589D0 (es) |
HK (1) | HK1021941A1 (es) |
HU (1) | HUP0003583A2 (es) |
IL (1) | IL130367A0 (es) |
NO (1) | NO992806L (es) |
NZ (1) | NZ336079A (es) |
PL (1) | PL338920A1 (es) |
PT (1) | PT946156E (es) |
RU (1) | RU2207851C2 (es) |
SK (1) | SK76799A3 (es) |
TR (1) | TR199901250T2 (es) |
WO (1) | WO1998025595A2 (es) |
ZA (1) | ZA9711029B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040077604A1 (en) * | 2001-12-19 | 2004-04-22 | Lenard Lichtenberger | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity |
ES2227479T3 (es) * | 2001-03-26 | 2005-04-01 | Giventis Gmbh | Alimento destinado a aumentar la capacidad cognitiva. |
US20040132823A1 (en) * | 2001-11-02 | 2004-07-08 | Leo Pavliv | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
MY143789A (en) * | 2003-02-18 | 2011-07-15 | Helsinn Healthcare Sa | Use of palonosetron treating post- operative nausea and vomiting |
WO2005051347A2 (en) * | 2003-10-30 | 2005-06-09 | Dianne Elizabeth Marshall | A simple process and formulation for making taste- masked ibuprofen liquid preparations and similar good-tasting preparation of other pharmaceutically active or bitter, poor tasting compounds for the production of liquid preparations |
US20050255154A1 (en) * | 2004-05-11 | 2005-11-17 | Lena Pereswetoff-Morath | Method and composition for treating rhinitis |
US20050266031A1 (en) * | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
KR100582604B1 (ko) | 2004-06-16 | 2006-05-23 | 보람제약주식회사 | 항산화제를 포함한 이부프로펜 및 덱시부프로펜의마이크로 에멀젼과 이를 이용한 투명 액제 및 투명연질캡슐 제제 |
DE102004043824A1 (de) * | 2004-09-10 | 2006-03-16 | Cognis Ip Management Gmbh | Emulsionen mit ungesättigten Fettsäuren und deren Estern |
US20060292225A1 (en) * | 2005-06-24 | 2006-12-28 | Felix Arthur M | Water soluble analgesic formulations and methods for production |
US20140072617A1 (en) * | 2007-09-26 | 2014-03-13 | Lvmh Recherche | Method for preventing or slowing down the appearance of the effects of skin ageing using a tocopheryl phosphate in liposomes |
US20110308985A1 (en) * | 2009-02-26 | 2011-12-22 | Gina Van Bogaert | Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof |
GB2469849A (en) * | 2009-04-29 | 2010-11-03 | Perrigo | Unit dose sachets comprising Ibuprofen |
PT2387391T (pt) * | 2009-07-24 | 2017-04-20 | Mika Pharma Ges Für Die Entw Und Vermarktung Pharmazeutischer Produkte Mbh | Processo para o desenvolvimento de uma composição líquida a ser aplicada na forma de espuma sobre a pele e composição de aplicação tópica |
GB2477590A (en) * | 2010-02-05 | 2011-08-10 | Biocopea Ltd | A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier |
US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US20130309215A1 (en) * | 2012-05-15 | 2013-11-21 | Mika Pharma Gesellschaft Fur Die Entwicklung Und Vermarktung Pharmazeutischer Produkte Mbh | Pharmaceutical composition |
WO2015163832A1 (en) | 2014-04-25 | 2015-10-29 | Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. | An ibuprofen and famotidine combined composition having improved stability |
ES2835720T3 (es) * | 2014-06-11 | 2021-06-23 | Poviva Corp | Composiciones de alimentos y bebidas infusionadas con agentes activos lipófilos y métodos de uso de las mismas |
WO2015191728A1 (en) * | 2014-06-11 | 2015-12-17 | Poviva Tea, Llc | Food and beverage compositions infused with lipophilic active agents and methods of use thereof |
US11007161B1 (en) | 2014-12-31 | 2021-05-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermatic surfactant films |
US10596117B1 (en) | 2014-12-31 | 2020-03-24 | Eric Morrison | Lipoleosomes as carriers for aromatic amide anesthetic compounds |
US10561627B2 (en) | 2014-12-31 | 2020-02-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films |
WO2021216475A1 (en) | 2020-04-20 | 2021-10-28 | Poviva Corp. | Compositions and methods for enhanced delivery of antiviral agents |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52111533A (en) | 1976-03-12 | 1977-09-19 | Kanebo Ltd | Preparation of fine powder of ibuprophene |
DE2914788A1 (de) * | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung |
JPS5859912A (ja) | 1981-10-06 | 1983-04-09 | Green Cross Corp:The | 鎮痛消炎物質脂肪乳剤 |
JPS5913720A (ja) | 1982-07-15 | 1984-01-24 | Green Cross Corp:The | フルルビプロフエン脂肪乳剤 |
JPS60208910A (ja) | 1984-03-31 | 1985-10-21 | Green Cross Corp:The | 水難溶性薬物・リン脂質複合体の製造方法 |
JPH0611697B2 (ja) | 1985-02-28 | 1994-02-16 | エスエス製薬株式会社 | 経口投与持続性カプセル剤 |
US4816247A (en) | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
US4879108A (en) * | 1985-12-20 | 1989-11-07 | Warner-Lambert Company | Confectionery delivery system for antipyretics |
GB8623557D0 (en) | 1986-10-01 | 1986-11-05 | Boots Co Plc | Therapeutic agents |
GB8630273D0 (en) | 1986-12-18 | 1987-01-28 | Til Medical Ltd | Pharmaceutical delivery systems |
CA1319886C (en) | 1987-02-03 | 1993-07-06 | Alberto Ferro | Mixed micelle solutions |
US5288500A (en) * | 1987-03-13 | 1994-02-22 | Benzon Pharma A/S | Oral composition containing particles comprising an active substance |
IT1226549B (it) * | 1988-07-12 | 1991-01-24 | Resa Farma | Composizioni farmaceutiche ad attivita' analgesica ed antiinfiammatoria per uso orale, dotate di ottima palatabilita' ed esenti da effetti irritanti sulle mucose. |
US4975465A (en) | 1989-03-28 | 1990-12-04 | American Home Products Corporation | Orally administrable ibuprofen compositions |
JP2844756B2 (ja) | 1989-12-01 | 1999-01-06 | 日本新薬株式会社 | 脂肪乳剤 |
GB9007052D0 (en) | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
US5149655A (en) * | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
US5110606A (en) * | 1990-11-13 | 1992-05-05 | Affinity Biotech, Inc. | Non-aqueous microemulsions for drug delivery |
GB9207990D0 (en) * | 1992-04-10 | 1992-05-27 | Smithkline Beecham Plc | Pharmaceutical composition |
WO1994005260A1 (en) | 1992-09-03 | 1994-03-17 | Affinity Biotech, Inc. | Taste-masking pharmaceutical compositions and methods for making the same |
GB9302720D0 (en) * | 1993-02-11 | 1993-03-24 | Scherer Ltd R P | Products in capsule form for use in aqueous solution |
US5785976A (en) * | 1993-03-05 | 1998-07-28 | Pharmacia & Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
CA2091152C (en) * | 1993-03-05 | 2005-05-03 | Kirsten Westesen | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
CA2120197A1 (en) | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
US5407921A (en) | 1993-07-01 | 1995-04-18 | Kao Corporation | Method for suppressing bitter taste |
DE4323636A1 (de) | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
ZA945944B (en) | 1993-08-13 | 1996-02-08 | Eurand America Inc | Procedure for encapsulating nsaids |
US5672358A (en) * | 1994-06-21 | 1997-09-30 | Ascent Pharmaceuticals, Inc. | Controlled release aqueous emulsion |
CA2153553A1 (en) | 1994-07-13 | 1996-01-14 | Hidekazu Suzuki | Stable lipid emulsion |
IT1270678B (it) | 1994-10-20 | 1997-05-07 | Bayer Ag | Liposomi al chetoprofen |
DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
TW442287B (en) * | 1995-06-13 | 2001-06-23 | American Home Produits Corp | Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac) |
IT1276160B1 (it) | 1995-11-22 | 1997-10-27 | Recordati Chem Pharm | Composizioni farmaceutiche orali a pronto rilascio per sospensioni estemporanee |
US5891465A (en) | 1996-05-14 | 1999-04-06 | Biozone Laboratories, Inc. | Delivery of biologically active material in a liposomal formulation for administration into the mouth |
-
1996
- 1996-12-10 GB GBGB9625589.8A patent/GB9625589D0/en active Pending
-
1997
- 1997-12-09 AU AU57605/98A patent/AU723608B2/en not_active Expired
- 1997-12-09 JP JP52625398A patent/JP2001508768A/ja not_active Ceased
- 1997-12-09 DE DE69710774T patent/DE69710774T2/de not_active Expired - Lifetime
- 1997-12-09 CZ CZ992045A patent/CZ204599A3/cs unknown
- 1997-12-09 AT AT97953861T patent/ATE213628T1/de not_active IP Right Cessation
- 1997-12-09 US US09/319,242 patent/US6287592B1/en not_active Expired - Fee Related
- 1997-12-09 CN CN97181607A patent/CN1275910A/zh active Pending
- 1997-12-09 WO PCT/EP1997/007137 patent/WO1998025595A2/en not_active Application Discontinuation
- 1997-12-09 IL IL13036797A patent/IL130367A0/xx unknown
- 1997-12-09 KR KR1019997005194A patent/KR20000069418A/ko not_active Application Discontinuation
- 1997-12-09 HU HU0003583A patent/HUP0003583A2/hu unknown
- 1997-12-09 PT PT97953861T patent/PT946156E/pt unknown
- 1997-12-09 SK SK767-99A patent/SK76799A3/sk unknown
- 1997-12-09 EP EP97953861A patent/EP0946156B1/en not_active Expired - Lifetime
- 1997-12-09 TR TR1999/01250T patent/TR199901250T2/xx unknown
- 1997-12-09 ES ES97953861T patent/ES2173516T3/es not_active Expired - Lifetime
- 1997-12-09 RU RU99114830/14A patent/RU2207851C2/ru not_active IP Right Cessation
- 1997-12-09 ZA ZA9711029A patent/ZA9711029B/xx unknown
- 1997-12-09 CA CA002274773A patent/CA2274773C/en not_active Expired - Fee Related
- 1997-12-09 DK DK97953861T patent/DK0946156T3/da active
- 1997-12-09 PL PL97338920A patent/PL338920A1/xx unknown
- 1997-12-10 AR ARP970105797A patent/AR010758A1/es not_active Application Discontinuation
-
1999
- 1999-06-08 NZ NZ336079A patent/NZ336079A/en unknown
- 1999-06-09 NO NO992806A patent/NO992806L/no not_active Application Discontinuation
- 1999-07-05 BG BG103552A patent/BG103552A/xx unknown
-
2000
- 2000-02-17 HK HK00100956A patent/HK1021941A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA9711029B (en) | 1998-06-10 |
BG103552A (en) | 2000-04-28 |
TR199901250T2 (xx) | 2000-06-21 |
AU5760598A (en) | 1998-07-03 |
HUP0003583A2 (hu) | 2001-04-28 |
US6287592B1 (en) | 2001-09-11 |
DK0946156T3 (da) | 2002-06-10 |
ATE213628T1 (de) | 2002-03-15 |
RU2207851C2 (ru) | 2003-07-10 |
NO992806L (no) | 1999-08-09 |
HK1021941A1 (en) | 2000-07-21 |
SK76799A3 (en) | 2000-05-16 |
EP0946156B1 (en) | 2002-02-27 |
AU723608B2 (en) | 2000-08-31 |
DE69710774T2 (de) | 2002-10-31 |
CN1275910A (zh) | 2000-12-06 |
JP2001508768A (ja) | 2001-07-03 |
IL130367A0 (en) | 2000-06-01 |
PL338920A1 (en) | 2000-11-20 |
WO1998025595A2 (en) | 1998-06-18 |
EP0946156A2 (en) | 1999-10-06 |
NO992806D0 (no) | 1999-06-09 |
PT946156E (pt) | 2002-08-30 |
DE69710774D1 (de) | 2002-04-04 |
NZ336079A (en) | 2001-03-30 |
CA2274773A1 (en) | 1998-06-18 |
CZ204599A3 (cs) | 1999-09-15 |
KR20000069418A (ko) | 2000-11-25 |
GB9625589D0 (en) | 1997-01-29 |
AR010758A1 (es) | 2000-07-12 |
WO1998025595A3 (en) | 2000-05-04 |
CA2274773C (en) | 2008-08-26 |
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