ES2172033T3 - Inhibidores de farnesil transferasa. - Google Patents

Inhibidores de farnesil transferasa.

Info

Publication number
ES2172033T3
ES2172033T3 ES97953000T ES97953000T ES2172033T3 ES 2172033 T3 ES2172033 T3 ES 2172033T3 ES 97953000 T ES97953000 T ES 97953000T ES 97953000 T ES97953000 T ES 97953000T ES 2172033 T3 ES2172033 T3 ES 2172033T3
Authority
ES
Spain
Prior art keywords
rent
hydrogen
general formula
radical
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97953000T
Other languages
English (en)
Inventor
Jean-Dominique Bourzat
Alain Commercon
Norbert Dereu
Patrick Mailliet
Fabienne Sounigo-Thompson
Jean-Paul Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2172033T3 publication Critical patent/ES2172033T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NUEVOS PRODUCTOS DE FORMULA GENERAL (I), SUS PREPARACIONES, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y SU UTILIZACION PARA LA PREPARACION D MEDICAMENTOS. EN LA FORMULA GENERAL (I), AR PRESENTA UN RADICAL FENILO SUSTITUIDO O CONDENSADO, O UN RADICAL AROMATICO POLICICLICO O HETEROCICLICO, R REPRESENTA UN RADICAL DE FORMULA GENERAL -(CH 2 ) M X 1 - CH 2 ) N - Z EN EL QUE X 1 ENLACE SENCILLO, O, S, M = 0, 1; N = 0, 1, 2; PUDIENDO LOS RADICALES CH 2 SER SUSTITUIDOS, Z REPRESENTA CARBOXILO, COOR 6 (R 6 = ALQUILO), CON(R 7 )(R 8 ) (R 7 0 HIDROGENO O ALQUIL O) Y R 8 = HIDROGENO, HIDROXI, ARILSULFONILO, HETEROCICLO, AMINO OPCONALMENTE SUSUTITUIDO, ALQUILOXILO OPCIONALMENTE SUSTITUIDO, ALQUILO OPCIONALMENTE SUSTITUIDO, AMINO, PO(OR 9 ) 2 (R 9 = HIDROGENO O ALQUILO, UN RADICAL -NH - CO - T (T = HIDROGENO O ALQUILO OPCIONALMENTE SUSTITUIDO) O BIEN UN RADICAL DE FORMULA (II), R 1 Y R 2 = HIDROGENO O HALOGENO O ALQUILO, ALQUILOXILO OPCIONALMENTE SUSTITUIDO, ALQUILTIO, ALQUILOXICABONILO O BIEN R1 Y R 2 EN ORTO EL UNO RESPECTO AL OTRO, FORMAN UN HETEROCICLO QUE CONTIENE 1 O 2 HETEROATOMOS OPCIONALMENTE SUSTITUIDO, R 3 Y R 4 = HIDROGENO O HALOGENO O ALQUILO, ALCENILO, ALQUILOXILO, ALQUILTIO, CARBOXILO O ALQUILOXICARBONILO, R 5 = HIDROGENO, ALQUI LO, ALQUILTIO; X = O O S O -NH-, -CO-, METILENO, VINILDIILO, ALCEN - 1,1 - DIILO O CICLOALCAN - 1,1 - DIILO E Y = O O S EN FORMA RACEMICA ASI COMO LOS ISOMEROS OPTICOS Y LAS SALES DEL PRODUCTO DE FORMULA GENERAL (I). LOS PRODUCTOS DE FORMULA (I) SON INHIBIDORES DE FARNESIL TRANSFERASA QUE PRESENTAN PROPIEDADES ANTITUMORALES Y ANTILEUCEMICAS NOTABLES.
ES97953000T 1996-12-30 1997-12-23 Inhibidores de farnesil transferasa. Expired - Lifetime ES2172033T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9616206A FR2757855B1 (fr) 1996-12-30 1996-12-30 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2172033T3 true ES2172033T3 (es) 2002-09-16

Family

ID=9499293

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97953000T Expired - Lifetime ES2172033T3 (es) 1996-12-30 1997-12-23 Inhibidores de farnesil transferasa.

Country Status (32)

Country Link
EP (1) EP0948483B1 (es)
JP (1) JP2001509147A (es)
KR (1) KR20000062391A (es)
AR (1) AR008950A1 (es)
AT (1) ATE214367T1 (es)
AU (1) AU741921B2 (es)
BR (1) BR9714498A (es)
CA (1) CA2275943A1 (es)
CO (1) CO4920252A1 (es)
CZ (1) CZ233599A3 (es)
DE (1) DE69711081T2 (es)
DK (1) DK0948483T3 (es)
DZ (1) DZ2389A1 (es)
EA (1) EA002114B1 (es)
ES (1) ES2172033T3 (es)
FR (1) FR2757855B1 (es)
HU (1) HUP0001747A3 (es)
ID (1) ID22922A (es)
IL (1) IL130453A0 (es)
MA (1) MA26460A1 (es)
NO (1) NO993225L (es)
NZ (1) NZ336042A (es)
PE (1) PE28199A1 (es)
PL (1) PL334345A1 (es)
PT (1) PT948483E (es)
SK (1) SK88399A3 (es)
TN (1) TNSN97214A1 (es)
TR (1) TR199901502T2 (es)
UY (1) UY24832A1 (es)
WO (1) WO1998029390A1 (es)
YU (1) YU30299A (es)
ZA (1) ZA9711734B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2787327B1 (fr) * 1998-12-21 2003-01-17 Aventis Pharma Sa Compositions contenant des inhibiteurs de farnesyle transferase
FR2796640A1 (fr) * 1999-07-22 2001-01-26 Aventis Pharma Sa Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments
FR2796641B1 (fr) * 1999-07-22 2001-09-21 Aventis Pharma Sa Nouveau procede de preparation de composes benzoperhydroisoindole
FR2845994B1 (fr) * 2002-10-18 2006-05-19 Servier Lab Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2005089504A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100362338B1 (ko) * 1993-11-05 2003-04-08 워너-램버트 캄파니 단백질:파르네실트랜스퍼라아제의치환디-및트리펩티드억제제
FR2736641B1 (fr) * 1995-07-10 1997-08-22 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
CZ233599A3 (cs) 1999-09-15
KR20000062391A (ko) 2000-10-25
NO993225D0 (no) 1999-06-29
BR9714498A (pt) 2000-03-21
NO993225L (no) 1999-08-24
AU741921B2 (en) 2001-12-13
PE28199A1 (es) 1999-06-05
DE69711081T2 (de) 2002-08-01
TNSN97214A1 (fr) 2005-03-15
EA199900608A1 (ru) 2000-02-28
NZ336042A (en) 2000-12-22
EP0948483A1 (fr) 1999-10-13
ATE214367T1 (de) 2002-03-15
DE69711081D1 (de) 2002-04-18
CA2275943A1 (fr) 1998-07-09
ZA9711734B (en) 1998-06-25
AR008950A1 (es) 2000-02-23
IL130453A0 (en) 2000-06-01
WO1998029390A1 (fr) 1998-07-09
HUP0001747A3 (en) 2000-10-30
MA26460A1 (fr) 2004-12-20
FR2757855B1 (fr) 1999-01-29
EP0948483B1 (fr) 2002-03-13
YU30299A (sh) 2002-03-18
AU5669498A (en) 1998-07-31
JP2001509147A (ja) 2001-07-10
TR199901502T2 (xx) 1999-09-21
PT948483E (pt) 2002-08-30
DZ2389A1 (fr) 2002-12-28
FR2757855A1 (fr) 1998-07-03
ID22922A (es) 1999-12-16
DK0948483T3 (da) 2002-07-01
UY24832A1 (es) 2001-08-27
SK88399A3 (en) 2000-05-16
CO4920252A1 (es) 2000-05-29
EA002114B1 (ru) 2001-12-24
PL334345A1 (en) 2000-02-28
HUP0001747A2 (hu) 2000-09-28

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