UY24832A1 - Nuevos compuestos derivados del benzoperhidroisoindol, útiles como inhibidores de la farnesil transferasa, procedimiento para prepararlos, los intermediarios de sintesis y su preparación, las composiciones farmacéuticas que contienen dichos derivados - Google Patents

Nuevos compuestos derivados del benzoperhidroisoindol, útiles como inhibidores de la farnesil transferasa, procedimiento para prepararlos, los intermediarios de sintesis y su preparación, las composiciones farmacéuticas que contienen dichos derivados

Info

Publication number
UY24832A1
UY24832A1 UY24832A UY24832A UY24832A1 UY 24832 A1 UY24832 A1 UY 24832A1 UY 24832 A UY24832 A UY 24832A UY 24832 A UY24832 A UY 24832A UY 24832 A1 UY24832 A1 UY 24832A1
Authority
UY
Uruguay
Prior art keywords
preparation
pharmaceutical compositions
derivatives
useful
compositions containing
Prior art date
Application number
UY24832A
Other languages
English (en)
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of UY24832A1 publication Critical patent/UY24832A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nuevos compuestos derivados del benzoperhidroisoindol, útiles como inhibidores de la farnesil transferasa y se han revelado como agentes antitumorales y antileucémicos, procedimiento para prepararlos, los intermediarios de síntesis y su preparación, las composiciones farmacéuticas que contienen dichos derivados y la utilización de los mismos para la preparación de dichas composiciones farmacéuticas.
UY24832A 1996-12-30 1997-12-30 Nuevos compuestos derivados del benzoperhidroisoindol, útiles como inhibidores de la farnesil transferasa, procedimiento para prepararlos, los intermediarios de sintesis y su preparación, las composiciones farmacéuticas que contienen dichos derivados UY24832A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9616206A FR2757855B1 (fr) 1996-12-30 1996-12-30 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
UY24832A1 true UY24832A1 (es) 2001-08-27

Family

ID=9499293

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24832A UY24832A1 (es) 1996-12-30 1997-12-30 Nuevos compuestos derivados del benzoperhidroisoindol, útiles como inhibidores de la farnesil transferasa, procedimiento para prepararlos, los intermediarios de sintesis y su preparación, las composiciones farmacéuticas que contienen dichos derivados

Country Status (32)

Country Link
EP (1) EP0948483B1 (es)
JP (1) JP2001509147A (es)
KR (1) KR20000062391A (es)
AR (1) AR008950A1 (es)
AT (1) ATE214367T1 (es)
AU (1) AU741921B2 (es)
BR (1) BR9714498A (es)
CA (1) CA2275943A1 (es)
CO (1) CO4920252A1 (es)
CZ (1) CZ233599A3 (es)
DE (1) DE69711081T2 (es)
DK (1) DK0948483T3 (es)
DZ (1) DZ2389A1 (es)
EA (1) EA002114B1 (es)
ES (1) ES2172033T3 (es)
FR (1) FR2757855B1 (es)
HU (1) HUP0001747A3 (es)
ID (1) ID22922A (es)
IL (1) IL130453A0 (es)
MA (1) MA26460A1 (es)
NO (1) NO993225L (es)
NZ (1) NZ336042A (es)
PE (1) PE28199A1 (es)
PL (1) PL334345A1 (es)
PT (1) PT948483E (es)
SK (1) SK88399A3 (es)
TN (1) TNSN97214A1 (es)
TR (1) TR199901502T2 (es)
UY (1) UY24832A1 (es)
WO (1) WO1998029390A1 (es)
YU (1) YU30299A (es)
ZA (1) ZA9711734B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2787327B1 (fr) * 1998-12-21 2003-01-17 Aventis Pharma Sa Compositions contenant des inhibiteurs de farnesyle transferase
FR2796641B1 (fr) * 1999-07-22 2001-09-21 Aventis Pharma Sa Nouveau procede de preparation de composes benzoperhydroisoindole
FR2796640A1 (fr) * 1999-07-22 2001-01-26 Aventis Pharma Sa Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments
FR2845994B1 (fr) * 2002-10-18 2006-05-19 Servier Lab Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2005089504A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT75308A (en) * 1993-11-05 1997-05-28 Warner Lambert Co Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
FR2736641B1 (fr) * 1995-07-10 1997-08-22 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
WO1998029390A1 (fr) 1998-07-09
ZA9711734B (en) 1998-06-25
DE69711081T2 (de) 2002-08-01
TR199901502T2 (xx) 1999-09-21
EA002114B1 (ru) 2001-12-24
DZ2389A1 (fr) 2002-12-28
CO4920252A1 (es) 2000-05-29
HUP0001747A3 (en) 2000-10-30
CZ233599A3 (cs) 1999-09-15
EP0948483A1 (fr) 1999-10-13
ES2172033T3 (es) 2002-09-16
MA26460A1 (fr) 2004-12-20
KR20000062391A (ko) 2000-10-25
BR9714498A (pt) 2000-03-21
PT948483E (pt) 2002-08-30
HUP0001747A2 (hu) 2000-09-28
AR008950A1 (es) 2000-02-23
AU741921B2 (en) 2001-12-13
ATE214367T1 (de) 2002-03-15
PL334345A1 (en) 2000-02-28
NO993225D0 (no) 1999-06-29
CA2275943A1 (fr) 1998-07-09
DE69711081D1 (de) 2002-04-18
JP2001509147A (ja) 2001-07-10
PE28199A1 (es) 1999-06-05
TNSN97214A1 (fr) 2005-03-15
NZ336042A (en) 2000-12-22
IL130453A0 (en) 2000-06-01
DK0948483T3 (da) 2002-07-01
ID22922A (es) 1999-12-16
FR2757855A1 (fr) 1998-07-03
EP0948483B1 (fr) 2002-03-13
NO993225L (no) 1999-08-24
SK88399A3 (en) 2000-05-16
FR2757855B1 (fr) 1999-01-29
EA199900608A1 (ru) 2000-02-28
AU5669498A (en) 1998-07-31
YU30299A (sh) 2002-03-18

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20130225