FR2757855B1 - Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennentInfo
- Publication number
- FR2757855B1 FR2757855B1 FR9616206A FR9616206A FR2757855B1 FR 2757855 B1 FR2757855 B1 FR 2757855B1 FR 9616206 A FR9616206 A FR 9616206A FR 9616206 A FR9616206 A FR 9616206A FR 2757855 B1 FR2757855 B1 FR 2757855B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- transferase inhibitors
- farnesyl transferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/72—4,7-Endo-alkylene-iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (35)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9616206A FR2757855B1 (fr) | 1996-12-30 | 1996-12-30 | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
PE1997001089A PE28199A1 (es) | 1996-12-30 | 1997-12-03 | Nuevos inhibidores de farnesil transferasa, su preparacion, las composiciones farmaceuticas que las contienen y su utilizacion para la preparacion de medicamentos |
YU30299A YU30299A (sh) | 1996-12-30 | 1997-12-23 | Novi inhibitori farnezil-transferaze,njihovo dobijanje, farmaceutske smeše koje ih sadrže i njihova primena za dobijanje lekova |
SI9730310T SI0948483T1 (en) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitors |
IL13045397A IL130453A0 (en) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitors |
IDW990618A ID22922A (es) | 1996-12-30 | 1997-12-23 | |
PL97334345A PL334345A1 (en) | 1996-12-30 | 1997-12-23 | Novel farnesil transferase inhibitors, their production, pharmaceutic compositions containing them and their application in production drugs |
CA002275943A CA2275943A1 (fr) | 1996-12-30 | 1997-12-23 | Inhibiteurs de farnesyle transferase |
AU56694/98A AU741921B2 (en) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitors |
HU0001747A HUP0001747A3 (en) | 1996-12-30 | 1997-12-23 | 1h-benzo[+]isoindole derivatives as farnesyl transferase inhibitor, process for producing them and use of them for process pharmaceutical compositions |
CZ992335A CZ233599A3 (cs) | 1996-12-30 | 1997-12-23 | Inhibitory farnesyltransferázy, způsob jejich přípravy a farmaceutické prostředky, které je obsahují |
EA199900608A EA002114B1 (ru) | 1996-12-30 | 1997-12-23 | Новые ингибиторы фарнезилтрансферазы, способы их получения, содержащие их фармацевтические композиции и их применение для получения медикаментов |
TR1999/01502T TR199901502T2 (xx) | 1996-12-30 | 1997-12-23 | Farnesil transferaz� inhibit�rleri. |
PT97953000T PT948483E (pt) | 1996-12-30 | 1997-12-23 | Inibidores da farnesil-transferase |
DE69711081T DE69711081T2 (de) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitoren |
PCT/FR1997/002407 WO1998029390A1 (fr) | 1996-12-30 | 1997-12-23 | Inhibiteurs de farnesyle transferase |
NZ336042A NZ336042A (en) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitors |
EP97953000A EP0948483B1 (fr) | 1996-12-30 | 1997-12-23 | Inhibiteurs de farnesyle transferase |
DK97953000T DK0948483T3 (da) | 1996-12-30 | 1997-12-23 | Farnesyltransferaseinhibitorer |
AT97953000T ATE214367T1 (de) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitoren |
SK883-99A SK88399A3 (en) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitors |
JP52968698A JP2001509147A (ja) | 1996-12-30 | 1997-12-23 | ファルネシルトランスフェラーゼ阻害剤 |
BR9714498A BR9714498A (pt) | 1996-12-30 | 1997-12-23 | composição farmacêutica, e, associação de um produto. |
ES97953000T ES2172033T3 (es) | 1996-12-30 | 1997-12-23 | Inhibidores de farnesil transferasa. |
KR1019997005966A KR20000062391A (ko) | 1996-12-30 | 1997-12-23 | 파네실 트랜스퍼라제 억제제 |
TNTNSN97214A TNSN97214A1 (fr) | 1996-12-30 | 1997-12-26 | Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments |
MA24915A MA26460A1 (fr) | 1996-12-30 | 1997-12-26 | Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent. |
DZ970239A DZ2389A1 (fr) | 1996-12-30 | 1997-12-27 | Nouveaux inhibiteurs de farnesyle transférase leurpréparation les compositions pharmaceutiques qui les contiennent et leur utilisation pour la préparation de médicaments |
US08/999,408 US6013662A (en) | 1996-12-30 | 1997-12-29 | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments |
CO97075391A CO4920252A1 (es) | 1996-12-30 | 1997-12-29 | Nuevos derivados de benzoperhidroisoindol inhibidores de farnesil transferasa, su preparacion, las composiciones farmaceuticas que los contienen |
ZA9711734A ZA9711734B (en) | 1996-12-30 | 1997-12-30 | Novel farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. |
ARP970106263A AR008950A1 (es) | 1996-12-30 | 1997-12-30 | Nuevos compuestos derivados del benzoperhidroisoindol, procedimiento para prepararlos, los intermediarios de sintesis y los procedimientos paraprepararlos, las composiciones farmaceuticas que los contienen, la utilizacion de dichos compuestos para preparar dichas composiciones y las composiciones |
UY24832A UY24832A1 (es) | 1996-12-30 | 1997-12-30 | Nuevos compuestos derivados del benzoperhidroisoindol, útiles como inhibidores de la farnesil transferasa, procedimiento para prepararlos, los intermediarios de sintesis y su preparación, las composiciones farmacéuticas que contienen dichos derivados |
NO993225A NO993225L (no) | 1996-12-30 | 1999-06-29 | Farnesyltransferaseinhibitorer |
US09/346,303 US6218406B1 (en) | 1996-12-30 | 1999-07-02 | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9616206A FR2757855B1 (fr) | 1996-12-30 | 1996-12-30 | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2757855A1 FR2757855A1 (fr) | 1998-07-03 |
FR2757855B1 true FR2757855B1 (fr) | 1999-01-29 |
Family
ID=9499293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9616206A Expired - Fee Related FR2757855B1 (fr) | 1996-12-30 | 1996-12-30 | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (32)
Country | Link |
---|---|
EP (1) | EP0948483B1 (es) |
JP (1) | JP2001509147A (es) |
KR (1) | KR20000062391A (es) |
AR (1) | AR008950A1 (es) |
AT (1) | ATE214367T1 (es) |
AU (1) | AU741921B2 (es) |
BR (1) | BR9714498A (es) |
CA (1) | CA2275943A1 (es) |
CO (1) | CO4920252A1 (es) |
CZ (1) | CZ233599A3 (es) |
DE (1) | DE69711081T2 (es) |
DK (1) | DK0948483T3 (es) |
DZ (1) | DZ2389A1 (es) |
EA (1) | EA002114B1 (es) |
ES (1) | ES2172033T3 (es) |
FR (1) | FR2757855B1 (es) |
HU (1) | HUP0001747A3 (es) |
ID (1) | ID22922A (es) |
IL (1) | IL130453A0 (es) |
MA (1) | MA26460A1 (es) |
NO (1) | NO993225L (es) |
NZ (1) | NZ336042A (es) |
PE (1) | PE28199A1 (es) |
PL (1) | PL334345A1 (es) |
PT (1) | PT948483E (es) |
SK (1) | SK88399A3 (es) |
TN (1) | TNSN97214A1 (es) |
TR (1) | TR199901502T2 (es) |
UY (1) | UY24832A1 (es) |
WO (1) | WO1998029390A1 (es) |
YU (1) | YU30299A (es) |
ZA (1) | ZA9711734B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2787327B1 (fr) * | 1998-12-21 | 2003-01-17 | Aventis Pharma Sa | Compositions contenant des inhibiteurs de farnesyle transferase |
FR2796641B1 (fr) * | 1999-07-22 | 2001-09-21 | Aventis Pharma Sa | Nouveau procede de preparation de composes benzoperhydroisoindole |
FR2796640A1 (fr) * | 1999-07-22 | 2001-01-26 | Aventis Pharma Sa | Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments |
FR2845994B1 (fr) * | 2002-10-18 | 2006-05-19 | Servier Lab | Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP2007538004A (ja) * | 2004-03-18 | 2007-12-27 | ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド | シヌクレイノパチーを治療する方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT75308A (en) * | 1993-11-05 | 1997-05-28 | Warner Lambert Co | Substituted di- and tripeptide inhibitors of protein:farnesyl transferase |
FR2736641B1 (fr) * | 1995-07-10 | 1997-08-22 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1996
- 1996-12-30 FR FR9616206A patent/FR2757855B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-03 PE PE1997001089A patent/PE28199A1/es not_active Application Discontinuation
- 1997-12-23 YU YU30299A patent/YU30299A/sh unknown
- 1997-12-23 IL IL13045397A patent/IL130453A0/xx unknown
- 1997-12-23 SK SK883-99A patent/SK88399A3/sk unknown
- 1997-12-23 AT AT97953000T patent/ATE214367T1/de not_active IP Right Cessation
- 1997-12-23 CZ CZ992335A patent/CZ233599A3/cs unknown
- 1997-12-23 EA EA199900608A patent/EA002114B1/ru not_active IP Right Cessation
- 1997-12-23 EP EP97953000A patent/EP0948483B1/fr not_active Expired - Lifetime
- 1997-12-23 ES ES97953000T patent/ES2172033T3/es not_active Expired - Lifetime
- 1997-12-23 ID IDW990618A patent/ID22922A/id unknown
- 1997-12-23 DK DK97953000T patent/DK0948483T3/da active
- 1997-12-23 PL PL97334345A patent/PL334345A1/xx unknown
- 1997-12-23 DE DE69711081T patent/DE69711081T2/de not_active Expired - Fee Related
- 1997-12-23 TR TR1999/01502T patent/TR199901502T2/xx unknown
- 1997-12-23 WO PCT/FR1997/002407 patent/WO1998029390A1/fr not_active Application Discontinuation
- 1997-12-23 NZ NZ336042A patent/NZ336042A/xx unknown
- 1997-12-23 HU HU0001747A patent/HUP0001747A3/hu unknown
- 1997-12-23 KR KR1019997005966A patent/KR20000062391A/ko not_active Application Discontinuation
- 1997-12-23 PT PT97953000T patent/PT948483E/pt unknown
- 1997-12-23 BR BR9714498A patent/BR9714498A/pt not_active IP Right Cessation
- 1997-12-23 JP JP52968698A patent/JP2001509147A/ja not_active Ceased
- 1997-12-23 AU AU56694/98A patent/AU741921B2/en not_active Ceased
- 1997-12-23 CA CA002275943A patent/CA2275943A1/fr not_active Abandoned
- 1997-12-26 TN TNTNSN97214A patent/TNSN97214A1/fr unknown
- 1997-12-26 MA MA24915A patent/MA26460A1/fr unknown
- 1997-12-27 DZ DZ970239A patent/DZ2389A1/xx active
- 1997-12-29 CO CO97075391A patent/CO4920252A1/es unknown
- 1997-12-30 UY UY24832A patent/UY24832A1/es not_active Application Discontinuation
- 1997-12-30 ZA ZA9711734A patent/ZA9711734B/xx unknown
- 1997-12-30 AR ARP970106263A patent/AR008950A1/es unknown
-
1999
- 1999-06-29 NO NO993225A patent/NO993225L/no not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CD | Change of name or company name | ||
ST | Notification of lapse |