ES2171189T3 - Derivados de fenilo tri-sustituidos utiles como inhibidores de pde iv. - Google Patents

Derivados de fenilo tri-sustituidos utiles como inhibidores de pde iv.

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Publication number
ES2171189T3
ES2171189T3 ES95922640T ES95922640T ES2171189T3 ES 2171189 T3 ES2171189 T3 ES 2171189T3 ES 95922640 T ES95922640 T ES 95922640T ES 95922640 T ES95922640 T ES 95922640T ES 2171189 T3 ES2171189 T3 ES 2171189T3
Authority
ES
Spain
Prior art keywords
alkyl
tri
group
substituted phenyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95922640T
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English (en)
Inventor
John Clifford Head
Graham John Warrellow
Rikki Peter Alexander
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UCB Celltech Ltd
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Celltech R&D Ltd
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    • C—CHEMISTRY; METALLURGY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Abstract

Un compuesto de fórmula (1) que es un inhibidor de la PDE IV(Ver fórmula)en cuya fórmula=W- es =C(Y)- donde Y es un grupo -OR a en el cual R a es un grupo alquilo C1-6 sustituido opcionalmente con uno o más átomos de halógeno;Les -OR, donde R es un grupo alquilo C1-6 o alquenilo C2-6 sustituido opcionalmente con uno, dos o tres sustituyentes seleccionados de átomos de halógeno o grupos hidroxilo, alcoxi C1-6, -CO2R 8 , -CONR 9 R 10 ,-CSNR 9 R 10 o -CN (donde R 8 , R 9 y R 10 son iguales o diferentes y son átomos de hidrógeno o gruposalquilo C1-3 o fenilo, naftilo, bencilo o fenetilo) o un grupo cicloalquilo o cicloalquenilo C3-8 sustituidoopcionalmente con uno, dos o tres átomos de halógeno o grupos hidroxilo, alquilo C1-6 o alcoxi C1-6;Z es un grupo(1) -C(R 3 )(R 4 )C(R 5 )(R 6 )(R 7 ) o(2)-C(R 4 )=C(R 5 )(R 6 ) donde R 3 es un átomo de hidrógeno;R 4 es...
ES95922640T 1994-06-22 1995-06-22 Derivados de fenilo tri-sustituidos utiles como inhibidores de pde iv. Expired - Lifetime ES2171189T3 (es)

Applications Claiming Priority (1)

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GB9412573A GB9412573D0 (en) 1994-06-22 1994-06-22 Chemical compounds

Publications (1)

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ES2171189T3 true ES2171189T3 (es) 2002-09-01

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US (2) US5780477A (es)
EP (1) EP0766670B1 (es)
JP (1) JP3833246B2 (es)
AT (1) ATE215073T1 (es)
AU (1) AU707816B2 (es)
DE (1) DE69526080T2 (es)
DK (1) DK0766670T3 (es)
ES (1) ES2171189T3 (es)
GB (1) GB9412573D0 (es)
PT (1) PT766670E (es)
WO (1) WO1995035284A1 (es)

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AU2746795A (en) 1996-01-15
ATE215073T1 (de) 2002-04-15
EP0766670A1 (en) 1997-04-09
JP3833246B2 (ja) 2006-10-11
US5780477A (en) 1998-07-14
DE69526080D1 (de) 2002-05-02
JPH10504530A (ja) 1998-05-06
GB9412573D0 (en) 1994-08-10
WO1995035284A1 (en) 1995-12-28
AU707816B2 (en) 1999-07-22
US6297264B1 (en) 2001-10-02
DE69526080T2 (de) 2002-10-31
EP0766670B1 (en) 2002-03-27
PT766670E (pt) 2002-07-31
DK0766670T3 (da) 2002-04-22

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