EA199700063A1 - Фторпроизводные фенилзамещенных 4-азастероидов - Google Patents
Фторпроизводные фенилзамещенных 4-азастероидовInfo
- Publication number
- EA199700063A1 EA199700063A1 EA199700063A EA199700063A EA199700063A1 EA 199700063 A1 EA199700063 A1 EA 199700063A1 EA 199700063 A EA199700063 A EA 199700063A EA 199700063 A EA199700063 A EA 199700063A EA 199700063 A1 EA199700063 A1 EA 199700063A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- hydrogen atom
- alkyl group
- fluorine atoms
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Соединения формулы I, где символобозначает одинарную или двойную связь; R обозначает атом водорода или C-C-алкильную группу; Rи R'представляют собой, независимо друг от друга, C-C-алкильные группы, замещенные одним или более атомами фтора; Rи Rкаждый независимо друг от друга отбирается из группы, включающей атом водорода; фенильную группу; C-C-алкильную группу, незамещенную или замещенную одним или более атомами фтора; атом галогена; цианогруппу (CN); группу OR, где Rобозначает атом водорода или C-C-алкильную группу, группу SR, где Rобозначает атом водорода или C-C-алкильную группу; и группу COR, где Rобозначает группу OR, в которой Rсоответствует данному выше определению или является C-C-алкильной группой, незамещенной или замещенной одним или более атомами фтора. Они используются как ингибиторы 5α-редуктазы тестостерона.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9518858.7A GB9518858D0 (en) | 1995-09-14 | 1995-09-14 | Phenylsubstituted 4-azasteroid fluoroderivatives |
PCT/EP1996/003518 WO1997010257A1 (en) | 1995-09-14 | 1996-08-09 | Phenylsubstituted 4-azasteroid fluoroderivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199700063A1 true EA199700063A1 (ru) | 1997-12-30 |
EA000362B1 EA000362B1 (ru) | 1999-06-24 |
Family
ID=10780746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199700063A EA000362B1 (ru) | 1995-09-14 | 1996-08-09 | Фторпроизводные фенилзамещенных 4-азастероидов и их применение |
Country Status (28)
Country | Link |
---|---|
US (2) | US5922728A (ru) |
EP (1) | EP0793671B1 (ru) |
JP (1) | JPH10509188A (ru) |
KR (1) | KR100448745B1 (ru) |
CN (1) | CN1104439C (ru) |
AR (1) | AR004511A1 (ru) |
AT (1) | ATE189681T1 (ru) |
AU (1) | AU715858B2 (ru) |
BR (1) | BR9606638A (ru) |
CA (1) | CA2204002A1 (ru) |
CZ (1) | CZ291450B6 (ru) |
DE (1) | DE69606623T2 (ru) |
DK (1) | DK0793671T3 (ru) |
EA (1) | EA000362B1 (ru) |
ES (1) | ES2144765T3 (ru) |
GB (1) | GB9518858D0 (ru) |
GR (1) | GR3033315T3 (ru) |
HU (1) | HUP9702038A3 (ru) |
IL (1) | IL120742A (ru) |
MY (1) | MY116271A (ru) |
NO (1) | NO309527B1 (ru) |
NZ (1) | NZ316060A (ru) |
PL (1) | PL185196B1 (ru) |
PT (1) | PT793671E (ru) |
TW (1) | TW357149B (ru) |
UA (1) | UA66748C2 (ru) |
WO (1) | WO1997010257A1 (ru) |
ZA (1) | ZA967631B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6548491B2 (en) * | 1997-12-24 | 2003-04-15 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
US6054446A (en) * | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
WO2001062259A1 (en) | 2000-02-25 | 2001-08-30 | Hollis Eden Pharmaceuticals | Method of treatment of prostate cancer |
US7402577B2 (en) * | 2001-10-03 | 2008-07-22 | Merck & Co., Inc. | Androstane 17-beta-carboxamides as androgen receptor modulators |
US7329750B2 (en) * | 2003-06-30 | 2008-02-12 | Merck & Co., Inc. | 17-Acetamido-4-azasteroid derivatives as androgen receptor modulators |
WO2005005380A2 (en) * | 2003-06-30 | 2005-01-20 | Merck & Co., Inc. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
AU2004255749B2 (en) | 2003-06-30 | 2008-12-18 | Merck Sharp & Dohme Corp. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
CA2530048A1 (en) * | 2003-06-30 | 2005-01-20 | Merck & Co., Inc. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
CN103787894B (zh) * | 2014-02-08 | 2015-09-16 | 济南大学 | 从甲苯二异氰酸酯制备过程中形成的残渣废料中回收甲苯二胺的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9002922D0 (en) * | 1990-02-09 | 1990-04-04 | Erba Carlo Spa | 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation |
GB9216284D0 (en) * | 1992-07-31 | 1992-09-16 | Erba Carlo Spa | Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives |
GB9216329D0 (en) * | 1992-07-31 | 1992-09-16 | Erba Carlo Spa | 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives |
GB9608045D0 (en) * | 1996-04-18 | 1996-06-19 | Pharmacia Spa | Process for preparing steroids having a carboxamide side-chain |
US5686501A (en) * | 1996-04-19 | 1997-11-11 | Foamex L.P. | Breathable open cell urethane polymers |
-
1995
- 1995-09-14 GB GBGB9518858.7A patent/GB9518858D0/en active Pending
-
1996
- 1996-08-09 WO PCT/EP1996/003518 patent/WO1997010257A1/en active IP Right Grant
- 1996-08-09 PL PL96320114A patent/PL185196B1/pl not_active IP Right Cessation
- 1996-08-09 BR BR9606638A patent/BR9606638A/pt not_active Application Discontinuation
- 1996-08-09 EP EP96928436A patent/EP0793671B1/en not_active Expired - Lifetime
- 1996-08-09 PT PT96928436T patent/PT793671E/pt unknown
- 1996-08-09 US US08/836,052 patent/US5922728A/en not_active Expired - Fee Related
- 1996-08-09 ES ES96928436T patent/ES2144765T3/es not_active Expired - Lifetime
- 1996-08-09 CN CN96191076A patent/CN1104439C/zh not_active Expired - Fee Related
- 1996-08-09 UA UA97062805A patent/UA66748C2/xx unknown
- 1996-08-09 HU HU9702038A patent/HUP9702038A3/hu unknown
- 1996-08-09 AU AU68205/96A patent/AU715858B2/en not_active Ceased
- 1996-08-09 NZ NZ316060A patent/NZ316060A/xx unknown
- 1996-08-09 KR KR1019970703203A patent/KR100448745B1/ko not_active IP Right Cessation
- 1996-08-09 AT AT96928436T patent/ATE189681T1/de not_active IP Right Cessation
- 1996-08-09 CA CA002204002A patent/CA2204002A1/en not_active Abandoned
- 1996-08-09 DE DE69606623T patent/DE69606623T2/de not_active Expired - Fee Related
- 1996-08-09 EA EA199700063A patent/EA000362B1/ru not_active IP Right Cessation
- 1996-08-09 CZ CZ19971460A patent/CZ291450B6/cs not_active IP Right Cessation
- 1996-08-09 JP JP9511593A patent/JPH10509188A/ja not_active Withdrawn
- 1996-08-09 IL IL12074296A patent/IL120742A/en not_active IP Right Cessation
- 1996-08-09 DK DK96928436T patent/DK0793671T3/da active
- 1996-09-05 TW TW085110841A patent/TW357149B/zh active
- 1996-09-09 AR ARP960104280A patent/AR004511A1/es unknown
- 1996-09-10 ZA ZA967631A patent/ZA967631B/xx unknown
- 1996-09-13 MY MYPI96003782A patent/MY116271A/en unknown
-
1997
- 1997-05-13 NO NO972186A patent/NO309527B1/no unknown
-
1999
- 1999-04-28 US US09/300,454 patent/US6114345A/en not_active Expired - Fee Related
-
2000
- 2000-04-26 GR GR20000400999T patent/GR3033315T3/el not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |