ES2165859T3 - Derivados de benzoxazol y su uso como antagonistas del receptor serotonina 5ht3. - Google Patents

Derivados de benzoxazol y su uso como antagonistas del receptor serotonina 5ht3.

Info

Publication number
ES2165859T3
ES2165859T3 ES94105997T ES94105997T ES2165859T3 ES 2165859 T3 ES2165859 T3 ES 2165859T3 ES 94105997 T ES94105997 T ES 94105997T ES 94105997 T ES94105997 T ES 94105997T ES 2165859 T3 ES2165859 T3 ES 2165859T3
Authority
ES
Spain
Prior art keywords
replaced
instituted
different
group
analges
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94105997T
Other languages
English (en)
Inventor
Katsuyoshi Iwamatsu
Yasuo Sato
Kazuko Amano
Masaaki Izumi
Fukio Konno
Seiji Shibahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of ES2165859T3 publication Critical patent/ES2165859T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN DERIVADO DE BENZOXAZOL DE LA FORMULA (1) O (2) QUE TIENE UN GRUPO DIAMINA ALICICLICO EN LA POSICION DOS DONDE R1, R2, R3 Y R4 PUEDEN SER IDENTICOS O DIFERENTES Y CADA UNO REPRESENTA HIDROGENO, ALKILO INFERIOR SUSTITUIDO O INSUSTITUIDO, ALKENILO INFERIOR SUSTITUIDO O INSUSTITUIDO, HALOGENO, HIDROXILO, AMINO, ALKOXI INFERIOR, CARBOXILO, CARBAMOILO Y NITRO, O CUALQUIER DE LOS DOS DE R1 A R4 PUEDEN ESTAR ENLAZADOS JUNTOS PARA FORMAR UN TERCERO DE ESTRUCTURA DE ANILLO DE SIETE ELEMENTOS QUE COMPRENDE ATOMOS DE CARBONO SOLO O ATOMOS DE CARBONO Y 1 O 2 HETEROATOMOS, QUE PUEDEN SER SUSTITUIDOS. R5 Y R6 PUEDEN SER IDENTICOS O DIFERENTES Y CADA UNO REPRESENTA UN GRUPO ALKILO INFERIOR SUSTITUIDO O INSUSTITUIDO, ALKENILO INFERIOR SUSTITUIDO O INSUSTITUIDO, ARILAKILO SUSTITUIDO O INSUSTITUIDO O UN GRUPO ALCOXICARBONILO, O R5 Y R6 PUEDEN ESTAR ENLAZADOS JUNTOS PARA FORMAR UN TERCERO DE ESTRUCTURA EN ANILLO DE SIENTE ELEMENTOS QUE COMPRENDE ATOMOS DE CARBONO Y 1 O 2 ATOMOS DE NITROGENO, QUE PUEDEN SERSUSTITUIDOS: X_ ES UN ANION FARMACEUTICAMENTE ACEPTABLE; Y M Y N PUEDEN SER EL MISMO O DIFERENTE Y CADA UNO ES UN NUMERO ENTERO DE 1 A 3. EL COMPUESTO MUESTRA UN ANTAGONISMO DE RECEPTOR DE 5-HT3 EXCELENTE, Y ES UTIL COMO AGENTE ANTIEMETICO Y TAMBIEN COMO AGENTE DE CONTROL DE PERISTALSIS, AGENTES ANALGESICO, AGENTES ANTIANSIEDAD Y AGENTE DE TRATAMIENTO DE LA SICOFRENIA.
ES94105997T 1993-04-16 1994-04-18 Derivados de benzoxazol y su uso como antagonistas del receptor serotonina 5ht3. Expired - Lifetime ES2165859T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9008693 1993-04-16
JP04290994A JP3193560B2 (ja) 1993-04-16 1994-03-14 新規ベンゾオキサゾール誘導体

Publications (1)

Publication Number Publication Date
ES2165859T3 true ES2165859T3 (es) 2002-04-01

Family

ID=26382647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94105997T Expired - Lifetime ES2165859T3 (es) 1993-04-16 1994-04-18 Derivados de benzoxazol y su uso como antagonistas del receptor serotonina 5ht3.

Country Status (5)

Country Link
US (1) US5631257A (es)
EP (1) EP0621271B1 (es)
JP (1) JP3193560B2 (es)
DE (1) DE69428620T2 (es)
ES (1) ES2165859T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3520177B2 (ja) 1996-05-09 2004-04-19 明治製菓株式会社 セロトニン５−ｈｔ３受容体部分活性薬
KR20010103583A (ko) * 1998-10-19 2001-11-23 다니구치 미즈오 진통제
TW520370B (en) 1998-11-20 2003-02-11 Meiji Seika Kaisha Benzooxazole derivatives and a pharmaceutical composition containing the derivatives as an active ingredient
KR100321563B1 (ko) * 1999-10-26 2002-01-23 박호군 피리딜벤족사졸 유도체 및 그의 공중합체와, 이를 이용한 형광 화상 형성 방법
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
US20080093981A1 (en) * 2004-08-23 2008-04-24 Semiconductor Energy Laboratory Co., Ltd. Electron Injecting Composition, and Light Emitting Element and Light Emitting Device Using the Electron Injecting Composition
JPWO2006028161A1 (ja) 2004-09-09 2008-05-08 財団法人乙卯研究所 セロトニン５−ｈｔ３受容体作動薬
NZ570524A (en) 2006-03-28 2011-08-26 High Point Pharmaceuticals Llc Benzothiazoles having histamine H3 receptor activity
WO2008019363A2 (en) 2006-08-07 2008-02-14 Albany Molecular Research, Inc. 2-alkylbenzoxazole carboxamides as 5ht3 modulators
EP2061460A2 (en) * 2006-08-07 2009-05-27 Albany Molecular Research, Inc. 2-aminobenzoxazole carboxamides as 5ht3 modulators
JP6345664B2 (ja) * 2013-07-10 2018-06-20 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規ｐｄｅ４阻害剤
US10669283B2 (en) * 2016-12-26 2020-06-02 Meiji Seika Pharma Co., Ltd. Compound and pharmacologically acceptable salt thereof
KR20210024563A (ko) 2018-06-27 2021-03-05 메이지 세이카 파루마 가부시키가이샤 염증성 질환, 자가면역 질환, 섬유화 질환 및 암 질환의 치료제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297170A (es) * 1963-04-04 1900-01-01
DE3609597A1 (de) * 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
JPH0283375A (ja) * 1988-09-21 1990-03-23 Dainippon Pharmaceut Co Ltd ２−置換ピペラジニル−２−（１，２−ベンズイソキサゾール−３−イル）酢酸誘導体
NZ233525A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions
ES2038532B1 (es) * 1991-05-10 1994-02-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol.

Also Published As

Publication number Publication date
EP0621271A1 (en) 1994-10-26
JPH06345744A (ja) 1994-12-20
DE69428620D1 (de) 2001-11-22
US5631257A (en) 1997-05-20
JP3193560B2 (ja) 2001-07-30
DE69428620T2 (de) 2002-06-20
EP0621271B1 (en) 2001-10-17

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