DK510282A - Benzodiazepinreceptoraktive forbindelser og fremgangsmaade til fremstilling af samme - Google Patents

Benzodiazepinreceptoraktive forbindelser og fremgangsmaade til fremstilling af samme Download PDF

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Publication number
DK510282A
DK510282A DK510282A DK510282A DK510282A DK 510282 A DK510282 A DK 510282A DK 510282 A DK510282 A DK 510282A DK 510282 A DK510282 A DK 510282A DK 510282 A DK510282 A DK 510282A
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DK
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Prior art keywords
hydrogen
formula
image
benzodiazepinreceptor
procedures
Prior art date
Application number
DK510282A
Other languages
English (en)
Other versions
DK151808C (da
DK151808B (da
Inventor
Claus Thyco Braestrup
Joergen Anders Christensen
Mogens Engelstoft
Frank Waetjen
Original Assignee
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan As filed Critical Ferrosan As
Priority to DK510282A priority Critical patent/DK151808C/da
Priority to FI834137A priority patent/FI78095C/fi
Priority to AT83730110T priority patent/ATE32721T1/de
Priority to EP83730110A priority patent/EP0109921B1/en
Priority to DE8383730110T priority patent/DE3375785D1/de
Priority to IE2644/83A priority patent/IE56233B1/xx
Priority to NO834187A priority patent/NO163820C/no
Priority to JP58213456A priority patent/JPS59104385A/ja
Priority to ES83527295A priority patent/ES8504196A1/es
Priority to US06/551,818 priority patent/US4507313A/en
Priority to ES529149A priority patent/ES8507143A1/es
Priority to ES529150A priority patent/ES8507144A1/es
Publication of DK510282A publication Critical patent/DK510282A/da
Priority to DK123685A priority patent/DK151809C/da
Publication of DK151808B publication Critical patent/DK151808B/da
Application granted granted Critical
Publication of DK151808C publication Critical patent/DK151808C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK510282A 1982-11-15 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater DK151808C (da)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DK510282A DK151808C (da) 1982-11-16 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
FI834137A FI78095C (fi) 1982-11-16 1983-11-11 Foerfarande foer framstaellning av som psykofarmaceutiska medel anvaendbara oxadiazolyl-imidazo/1,4/ bensodiazepinderivat.
AT83730110T ATE32721T1 (de) 1982-11-16 1983-11-12 Benzodiazepin-rezeptoren und ihre herstellung.
EP83730110A EP0109921B1 (en) 1982-11-16 1983-11-12 Benzodiazepine receptors and their preparation
DE8383730110T DE3375785D1 (en) 1982-11-16 1983-11-12 Benzodiazepine receptors and their preparation
IE2644/83A IE56233B1 (en) 1982-11-16 1983-11-14 Benzodiazepine receptors and their preparation
NO834187A NO163820C (no) 1982-11-16 1983-11-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive oksadiazolylbenzodiazepinderivater.
JP58213456A JPS59104385A (ja) 1982-11-16 1983-11-15 オキサジアゾリル−イミダゾ−〔１，４〕ベンゾジアゼピン誘導体、その製法及びこれを含有する中枢神経系疾患治療剤
ES83527295A ES8504196A1 (es) 1982-11-16 1983-11-15 Metodo de preparar derivados de oxadiazolil-imidazo (1,4) benzodiazepina
US06/551,818 US4507313A (en) 1982-11-15 1983-11-15 Oxadiazolyl-imidazo-[1,4]benzodiazepines and their use in treatment of diseases of the central nervous system
ES529149A ES8507143A1 (es) 1982-11-16 1984-01-25 Metodo de preparar derivados de oxadiazolil-imidazo (1, 4) benzodiazepina
ES529150A ES8507144A1 (es) 1982-11-16 1984-01-25 Metodo de preparar derivados de oxadiazolil-imidazo (1, 4) benzodiazepina
DK123685A DK151809C (da) 1982-11-16 1985-03-19 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK510282A DK151808C (da) 1982-11-16 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
DK510282 1982-11-16

Publications (3)

Publication Number Publication Date
DK510282A true DK510282A (da) 1984-05-17
DK151808B DK151808B (da) 1988-01-04
DK151808C DK151808C (da) 1988-06-20

Family

ID=8139462

Family Applications (1)

Application Number Title Priority Date Filing Date
DK510282A DK151808C (da) 1982-11-15 1982-11-16 Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater

Country Status (10)

Country Link
US (1) US4507313A (da)
EP (1) EP0109921B1 (da)
JP (1) JPS59104385A (da)
AT (1) ATE32721T1 (da)
DE (1) DE3375785D1 (da)
DK (1) DK151808C (da)
ES (3) ES8504196A1 (da)
FI (1) FI78095C (da)
IE (1) IE56233B1 (da)
NO (1) NO163820C (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA845757B (en) * 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
NZ210850A (en) * 1984-01-19 1988-10-28 Hoffmann La Roche Imidazodiazepine derivatives and pharmaceutical compositions
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DE202441T1 (de) * 1985-05-17 1987-03-19 Aktieselskabet Ferrosan, Soeborg Oxadiazolylimidazobenzodiazepine, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
EP0226282B1 (en) * 1985-10-17 1989-07-05 A/S Ferrosan Heterocyclic compounds and their preparation and use
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
GB8923008D0 (en) * 1989-10-12 1989-11-29 Roussel Lab Ltd Chemical compounds
GB8927928D0 (en) * 1989-12-11 1990-02-14 Roussel Lab Ltd Chemical compounds
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5317018A (en) * 1992-06-09 1994-05-31 Armin Walser Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy
DK0730581T3 (da) * 1993-11-22 2001-11-26 Merck & Co Inc 3-acylaminobezazepiner
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
CA2143246C (en) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
KR970705395A (ko) * 1994-08-18 1997-10-09 폴락 도나 엘. 2,3-디하이드로-1-(2,2,2-트리플루오로에틸)-2-옥소-5-페닐-1H-1,4-벤조디아제핀(2,3-Dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines)
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
WO1996040656A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3yl)-3-amides
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
KR101589314B1 (ko) * 2007-08-20 2016-01-28 에보텍 인터내셔널 게엠베하 수면 장애의 치료
US8119629B2 (en) 2007-10-03 2012-02-21 Bristol-Meyers Squibb Company Carboxamide GABAA α2 modulators
WO2016037111A1 (en) * 2014-09-05 2016-03-10 Mazak Corporation Vertical machine tool apparatus and method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509371B2 (en) * 1975-08-07 1980-05-08 F. Hoffmann-La Roche Ag Diazepine Derivatives
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines

Also Published As

Publication number Publication date
IE832644L (en) 1984-05-15
ES529149A0 (es) 1985-09-01
ATE32721T1 (de) 1988-03-15
ES527295A0 (es) 1985-04-16
FI834137A (fi) 1984-05-17
FI78095B (fi) 1989-02-28
US4507313A (en) 1985-03-26
FI834137A0 (fi) 1983-11-11
NO163820C (no) 1990-08-01
ES8507143A1 (es) 1985-09-01
DK151808C (da) 1988-06-20
JPS635031B2 (da) 1988-02-01
DK151808B (da) 1988-01-04
NO834187L (no) 1984-05-18
ES529150A0 (es) 1985-09-01
NO163820B (no) 1990-04-17
JPS59104385A (ja) 1984-06-16
EP0109921B1 (en) 1988-03-02
EP0109921A1 (en) 1984-05-30
DE3375785D1 (en) 1988-04-07
FI78095C (fi) 1989-06-12
IE56233B1 (en) 1991-05-22
ES8507144A1 (es) 1985-09-01
ES8504196A1 (es) 1985-04-16

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