ES2153081T3 - Forma cristalina alternativa de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona). - Google Patents

Forma cristalina alternativa de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona).

Info

Publication number
ES2153081T3
ES2153081T3 ES96306336T ES96306336T ES2153081T3 ES 2153081 T3 ES2153081 T3 ES 2153081T3 ES 96306336 T ES96306336 T ES 96306336T ES 96306336 T ES96306336 T ES 96306336T ES 2153081 T3 ES2153081 T3 ES 2153081T3
Authority
ES
Spain
Prior art keywords
tazofelona
bis
methyl
crystal form
tiazolidinona
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96306336T
Other languages
English (en)
Inventor
Marvin Martin Hansen
Allen Robert Harkness
Susan Marie Reutzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2153081T3 publication Critical patent/ES2153081T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

LA INVENCION PROPORCIONA UNA NUEVA FORMA CRISTALINA, FORMA II DE (+,-)-5-{[3,5-BIS(1,1-DIMETILETIL)-4-HIDROXIFENIL] METIL}-4TIAZOLIDINONA, QUE PRESENTA UN PATRON DE DIFRACCION DE POLVO DE RAYOS X CON SEPARACIONES D A 5,64; 5,16; 4,90; 4,66; Y 4,49 AMSTRONGS. ES UTIL PARA EL TRATAMIENTO DE LA INFLAMACION, LA ENFERMEDAD INFLAMATORIA DEL COLON, ALERGIAS, ARTRITIS E HIPOGLICEMIA EN SU NUEVA FORMA FISICA; TAMBIEN SE PROPORCIONAN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHA FORMA NUEVA. SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE LA FORMA II DE LA TAZOFELONA.
ES96306336T 1995-09-07 1996-09-02 Forma cristalina alternativa de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona). Expired - Lifetime ES2153081T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US335695P 1995-09-07 1995-09-07

Publications (1)

Publication Number Publication Date
ES2153081T3 true ES2153081T3 (es) 2001-02-16

Family

ID=21705475

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96306336T Expired - Lifetime ES2153081T3 (es) 1995-09-07 1996-09-02 Forma cristalina alternativa de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona).

Country Status (29)

Country Link
EP (1) EP0761656B1 (es)
JP (1) JPH11514978A (es)
KR (1) KR19990044453A (es)
CN (1) CN1082958C (es)
AR (2) AR003484A1 (es)
AT (1) ATE198476T1 (es)
AU (1) AU716684B2 (es)
BR (1) BR9610201A (es)
CA (1) CA2231132A1 (es)
CO (1) CO4750653A1 (es)
CZ (1) CZ68098A3 (es)
DE (1) DE69611407T2 (es)
DK (1) DK0761656T3 (es)
EA (1) EA000258B1 (es)
ES (1) ES2153081T3 (es)
GR (1) GR3035656T3 (es)
HU (1) HUP9901458A3 (es)
IN (1) IN182320B (es)
MY (1) MY132351A (es)
NO (1) NO309719B1 (es)
NZ (1) NZ316810A (es)
PE (1) PE23298A1 (es)
PL (1) PL325602A1 (es)
PT (1) PT761656E (es)
SI (1) SI0761656T1 (es)
TR (1) TR199800398T1 (es)
TW (1) TW460471B (es)
WO (1) WO1997009320A1 (es)
ZA (1) ZA967422B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US538690A (en) * 1895-05-07 Automatic watering-trough for animals
ZA9010041B (en) * 1989-12-21 1992-08-26 Lilly Co Eli Compounds for treating inflammatory bowel disease
US5216002A (en) * 1989-12-21 1993-06-01 Eli Lilly And Company Method of treating inflammatory bowel disease

Also Published As

Publication number Publication date
PT761656E (pt) 2001-04-30
NO309719B1 (no) 2001-03-19
SI0761656T1 (en) 2001-06-30
NO980913L (no) 1998-03-03
TR199800398T1 (xx) 1998-05-21
JPH11514978A (ja) 1999-12-21
CA2231132A1 (en) 1997-03-13
ATE198476T1 (de) 2001-01-15
NO980913D0 (no) 1998-03-03
GR3035656T3 (en) 2001-06-29
WO1997009320A1 (en) 1997-03-13
ZA967422B (en) 1998-03-02
AU716684B2 (en) 2000-03-02
PE23298A1 (es) 1998-05-05
DE69611407D1 (de) 2001-02-08
PL325602A1 (en) 1998-08-03
EP0761656A1 (en) 1997-03-12
EA199800275A1 (ru) 1998-08-27
HUP9901458A2 (hu) 1999-09-28
TW460471B (en) 2001-10-21
EP0761656B1 (en) 2001-01-03
CZ68098A3 (cs) 1998-08-12
HUP9901458A3 (en) 2000-05-29
MY132351A (en) 2007-10-31
IN182320B (es) 1999-03-20
CN1200730A (zh) 1998-12-02
CO4750653A1 (es) 1999-03-31
KR19990044453A (ko) 1999-06-25
DK0761656T3 (da) 2001-02-05
DE69611407T2 (de) 2001-06-13
AU6912796A (en) 1997-03-27
MX9801705A (es) 1998-05-31
BR9610201A (pt) 1998-08-11
EA000258B1 (ru) 1999-02-25
AR003484A1 (es) 1998-08-05
CN1082958C (zh) 2002-04-17
AR003483A1 (es) 1998-08-05
NZ316810A (en) 1999-07-29

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