CO4750653A1 - Forma cristalina alternativa de tazofelona - Google Patents

Forma cristalina alternativa de tazofelona

Info

Publication number
CO4750653A1
CO4750653A1 CO96047346A CO96047346A CO4750653A1 CO 4750653 A1 CO4750653 A1 CO 4750653A1 CO 96047346 A CO96047346 A CO 96047346A CO 96047346 A CO96047346 A CO 96047346A CO 4750653 A1 CO4750653 A1 CO 4750653A1
Authority
CO
Colombia
Prior art keywords
tazofelona
crystalline form
dimethylethyl
hydroxyphenyl
bis
Prior art date
Application number
CO96047346A
Other languages
English (en)
Inventor
Maryin Martin Hansen
Allen Robert Harkness
Susan Marie Reutzel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4750653A1 publication Critical patent/CO4750653A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Una Forma II de (±)-5-{[3,5-bis(1,1-dimetiletil)-4-hidroxifenil]metil}-4-tiazolidinona prácticamente pura que tiene los siguientes datos de difracción de rayos X obtenidos con una radicación de CuKa de ? = 1,53056Å: Separación d: Å Intensidad Relativa I/Io 5,64 10 5,1638 4,9O 37 4,66 57 4,49 41Un procedimiento para preparar y aislar la Forma II de (±)-5-{[3,5-bis(1,1-dimetiletil)-4- hidroxifenil]metil}-4-tiazolidinona prácticamente pura de acuerdo con la Reivindicación 1 que comprende suspender la Forma I en un disolvente orgánico.
CO96047346A 1995-09-07 1996-09-05 Forma cristalina alternativa de tazofelona CO4750653A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US335695P 1995-09-07 1995-09-07

Publications (1)

Publication Number Publication Date
CO4750653A1 true CO4750653A1 (es) 1999-03-31

Family

ID=21705475

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96047346A CO4750653A1 (es) 1995-09-07 1996-09-05 Forma cristalina alternativa de tazofelona

Country Status (29)

Country Link
EP (1) EP0761656B1 (es)
JP (1) JPH11514978A (es)
KR (1) KR19990044453A (es)
CN (1) CN1082958C (es)
AR (2) AR003484A1 (es)
AT (1) ATE198476T1 (es)
AU (1) AU716684B2 (es)
BR (1) BR9610201A (es)
CA (1) CA2231132A1 (es)
CO (1) CO4750653A1 (es)
CZ (1) CZ68098A3 (es)
DE (1) DE69611407T2 (es)
DK (1) DK0761656T3 (es)
EA (1) EA000258B1 (es)
ES (1) ES2153081T3 (es)
GR (1) GR3035656T3 (es)
HU (1) HUP9901458A3 (es)
IN (1) IN182320B (es)
MY (1) MY132351A (es)
NO (1) NO309719B1 (es)
NZ (1) NZ316810A (es)
PE (1) PE23298A1 (es)
PL (1) PL325602A1 (es)
PT (1) PT761656E (es)
SI (1) SI0761656T1 (es)
TR (1) TR199800398T1 (es)
TW (1) TW460471B (es)
WO (1) WO1997009320A1 (es)
ZA (1) ZA967422B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US538690A (en) * 1895-05-07 Automatic watering-trough for animals
US5216002A (en) * 1989-12-21 1993-06-01 Eli Lilly And Company Method of treating inflammatory bowel disease
ZA9010041B (en) * 1989-12-21 1992-08-26 Lilly Co Eli Compounds for treating inflammatory bowel disease

Also Published As

Publication number Publication date
PE23298A1 (es) 1998-05-05
AR003484A1 (es) 1998-08-05
EP0761656A1 (en) 1997-03-12
MX9801705A (es) 1998-05-31
CN1082958C (zh) 2002-04-17
PL325602A1 (en) 1998-08-03
DE69611407D1 (de) 2001-02-08
CN1200730A (zh) 1998-12-02
AU6912796A (en) 1997-03-27
JPH11514978A (ja) 1999-12-21
AU716684B2 (en) 2000-03-02
CZ68098A3 (cs) 1998-08-12
HUP9901458A3 (en) 2000-05-29
ES2153081T3 (es) 2001-02-16
EA199800275A1 (ru) 1998-08-27
CA2231132A1 (en) 1997-03-13
TW460471B (en) 2001-10-21
DK0761656T3 (da) 2001-02-05
EA000258B1 (ru) 1999-02-25
NO980913L (no) 1998-03-03
NZ316810A (en) 1999-07-29
EP0761656B1 (en) 2001-01-03
PT761656E (pt) 2001-04-30
ZA967422B (en) 1998-03-02
GR3035656T3 (en) 2001-06-29
TR199800398T1 (xx) 1998-05-21
SI0761656T1 (en) 2001-06-30
NO309719B1 (no) 2001-03-19
HUP9901458A2 (hu) 1999-09-28
IN182320B (es) 1999-03-20
BR9610201A (pt) 1998-08-11
KR19990044453A (ko) 1999-06-25
DE69611407T2 (de) 2001-06-13
ATE198476T1 (de) 2001-01-15
NO980913D0 (no) 1998-03-03
AR003483A1 (es) 1998-08-05
MY132351A (en) 2007-10-31
WO1997009320A1 (en) 1997-03-13

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