ES2132891T3 - Procedimiento de preparacion de doxorrubicina. - Google Patents
Procedimiento de preparacion de doxorrubicina.Info
- Publication number
- ES2132891T3 ES2132891T3 ES96904823T ES96904823T ES2132891T3 ES 2132891 T3 ES2132891 T3 ES 2132891T3 ES 96904823 T ES96904823 T ES 96904823T ES 96904823 T ES96904823 T ES 96904823T ES 2132891 T3 ES2132891 T3 ES 2132891T3
- Authority
- ES
- Spain
- Prior art keywords
- doxorrubicin
- preparation procedure
- daunorubicin
- doxorubicin
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
Abstract
LA CAPACIDAD DE CONVERTIR DAUNORUBICINA EN DOXORUBICINA PUEDE SER CONFERIDA EN UNA CELULA HUESPED MEDIANTE TRANSFORMACION CON UN VECTOR RECOMBINANTE QUE COMPRENDA ADN QUE CODIFIQUE 14HIDROXILASA DE DAUNORUBICINA. LA CELULA HUESPED PUEDE ENTONCES SER UTILIZADA PARA PRODUCIR DOXORUBICINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/396,218 US5695966A (en) | 1995-02-27 | 1995-02-27 | DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2132891T3 true ES2132891T3 (es) | 1999-08-16 |
Family
ID=23566340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96904823T Expired - Lifetime ES2132891T3 (es) | 1995-02-27 | 1996-02-20 | Procedimiento de preparacion de doxorrubicina. |
Country Status (19)
Country | Link |
---|---|
US (2) | US5695966A (es) |
EP (1) | EP0763112B1 (es) |
JP (1) | JPH10505506A (es) |
KR (1) | KR100414999B1 (es) |
CN (1) | CN1118574C (es) |
AR (1) | AR001014A1 (es) |
AT (1) | ATE178653T1 (es) |
AU (1) | AU711706B2 (es) |
CA (1) | CA2188571A1 (es) |
DE (1) | DE69601993T2 (es) |
ES (1) | ES2132891T3 (es) |
FI (1) | FI112251B (es) |
HU (1) | HU220530B1 (es) |
IL (1) | IL117246A0 (es) |
NO (1) | NO964482L (es) |
RU (1) | RU2205222C2 (es) |
TW (1) | TW419521B (es) |
WO (1) | WO1996027014A1 (es) |
ZA (1) | ZA961555B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5695966A (en) * | 1995-02-27 | 1997-12-09 | Pharmacia & Upjohn S.P.A. | DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin |
US5976830A (en) * | 1996-05-24 | 1999-11-02 | The Ohio State University Research Foundation | Methods of producing doxorubicin |
GB2330144B (en) * | 1997-03-06 | 2001-05-02 | Pharmacia & Upjohn Spa | Process for preparing doxorubicin |
CA2326500A1 (en) * | 1998-04-24 | 1999-11-04 | Pharmacia & Upjohn S.P.A. | Process for preparing doxorubicin |
EP2392581A3 (en) * | 2003-04-25 | 2012-03-07 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore |
WO2006111561A1 (en) * | 2005-04-21 | 2006-10-26 | Dsm Ip Assets B.V. | Improved microbial production of anthracyclins |
KR100629896B1 (ko) * | 2005-04-28 | 2006-09-29 | 인하대학교 산학협력단 | 방선균 독소루비신 고생산 균주 및 독소루비신 생합성유전자군의 발현양상 분석을 위한 마이크로어레이칩 |
CN101016533B (zh) * | 2005-11-09 | 2010-05-19 | 上海医药工业研究院 | 一种蒽环类抗生素产生工程菌及其应用 |
CN103087124B (zh) * | 2012-11-21 | 2016-01-13 | 浙江海正药业股份有限公司 | 一种制备阿霉素的方法 |
CN104059892A (zh) * | 2013-03-18 | 2014-09-24 | 江苏禾昌生物科技有限公司 | 柔红霉素c-14羟化酶突变体及其基因工程菌的生产方法 |
CN105861455B (zh) | 2016-05-16 | 2018-10-26 | 浙江海正药业股份有限公司 | DoxA蛋白突变体及其编码基因与应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57159496A (en) * | 1981-03-28 | 1982-10-01 | Sanraku Inc | Preparation of adriamycin |
US5695966A (en) * | 1995-02-27 | 1997-12-09 | Pharmacia & Upjohn S.P.A. | DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin |
US5976830A (en) * | 1996-05-24 | 1999-11-02 | The Ohio State University Research Foundation | Methods of producing doxorubicin |
-
1995
- 1995-02-27 US US08/396,218 patent/US5695966A/en not_active Expired - Fee Related
-
1996
- 1996-02-20 JP JP8525989A patent/JPH10505506A/ja not_active Ceased
- 1996-02-20 CA CA002188571A patent/CA2188571A1/en not_active Abandoned
- 1996-02-20 AU AU48784/96A patent/AU711706B2/en not_active Ceased
- 1996-02-20 HU HU9603259A patent/HU220530B1/hu unknown
- 1996-02-20 ES ES96904823T patent/ES2132891T3/es not_active Expired - Lifetime
- 1996-02-20 AT AT96904823T patent/ATE178653T1/de not_active IP Right Cessation
- 1996-02-20 KR KR1019960706026A patent/KR100414999B1/ko not_active IP Right Cessation
- 1996-02-20 RU RU96122866/13A patent/RU2205222C2/ru not_active IP Right Cessation
- 1996-02-20 WO PCT/EP1996/000692 patent/WO1996027014A1/en active IP Right Grant
- 1996-02-20 DE DE69601993T patent/DE69601993T2/de not_active Expired - Fee Related
- 1996-02-20 EP EP96904823A patent/EP0763112B1/en not_active Expired - Lifetime
- 1996-02-20 CN CN96190128A patent/CN1118574C/zh not_active Expired - Fee Related
- 1996-02-23 AR ARP960101492A patent/AR001014A1/es unknown
- 1996-02-23 IL IL11724696A patent/IL117246A0/xx not_active IP Right Cessation
- 1996-02-27 ZA ZA961555A patent/ZA961555B/xx unknown
- 1996-02-27 TW TW085102208A patent/TW419521B/zh active
- 1996-10-21 FI FI964229A patent/FI112251B/fi active
- 1996-10-22 NO NO964482A patent/NO964482L/no unknown
- 1996-12-03 US US08/760,116 patent/US5786190A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU711706B2 (en) | 1999-10-21 |
KR970702922A (ko) | 1997-06-10 |
CN1147835A (zh) | 1997-04-16 |
ATE178653T1 (de) | 1999-04-15 |
HUP9603259A2 (en) | 1997-05-28 |
CA2188571A1 (en) | 1996-09-06 |
FI964229A0 (fi) | 1996-10-21 |
ZA961555B (en) | 1996-08-19 |
AR001014A1 (es) | 1997-08-27 |
IL117246A0 (en) | 1996-06-18 |
MX9605018A (es) | 1998-05-31 |
FI964229A (fi) | 1996-10-21 |
WO1996027014A1 (en) | 1996-09-06 |
US5786190A (en) | 1998-07-28 |
EP0763112A1 (en) | 1997-03-19 |
NO964482D0 (no) | 1996-10-22 |
US5695966A (en) | 1997-12-09 |
FI112251B (fi) | 2003-11-14 |
TW419521B (en) | 2001-01-21 |
RU2205222C2 (ru) | 2003-05-27 |
HUP9603259A3 (en) | 2000-04-28 |
EP0763112B1 (en) | 1999-04-07 |
NO964482L (no) | 1996-12-23 |
DE69601993D1 (de) | 1999-05-12 |
HU220530B1 (hu) | 2002-03-28 |
DE69601993T2 (de) | 1999-11-04 |
AU4878496A (en) | 1996-09-18 |
JPH10505506A (ja) | 1998-06-02 |
KR100414999B1 (ko) | 2004-04-28 |
CN1118574C (zh) | 2003-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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