FI964229A0 - Menetelmä doksorubisiinin valmistamiseksi - Google Patents

Menetelmä doksorubisiinin valmistamiseksi

Info

Publication number
FI964229A0
FI964229A0 FI964229A FI964229A FI964229A0 FI 964229 A0 FI964229 A0 FI 964229A0 FI 964229 A FI964229 A FI 964229A FI 964229 A FI964229 A FI 964229A FI 964229 A0 FI964229 A0 FI 964229A0
Authority
FI
Finland
Prior art keywords
doxorubicin
preparation
Prior art date
Application number
FI964229A
Other languages
English (en)
Swedish (sv)
Other versions
FI112251B (fi
FI964229A (fi
Inventor
Inventi Augusto Solari
Umberto Breme
Anna Luisa Colombo
Charles Richard Hutchinson
Sharee Otten
Claudio Scotti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of FI964229A publication Critical patent/FI964229A/fi
Publication of FI964229A0 publication Critical patent/FI964229A0/fi
Application granted granted Critical
Publication of FI112251B publication Critical patent/FI112251B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI964229A 1995-02-27 1996-10-21 Menetelmä doksorubisiinin valmistamiseksi FI112251B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/396,218 US5695966A (en) 1995-02-27 1995-02-27 DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US39621895 1995-02-27
PCT/EP1996/000692 WO1996027014A1 (en) 1995-02-27 1996-02-20 Process for preparing doxorubicin
EP9600692 1996-02-20

Publications (3)

Publication Number Publication Date
FI964229A FI964229A (fi) 1996-10-21
FI964229A0 true FI964229A0 (fi) 1996-10-21
FI112251B FI112251B (fi) 2003-11-14

Family

ID=23566340

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964229A FI112251B (fi) 1995-02-27 1996-10-21 Menetelmä doksorubisiinin valmistamiseksi

Country Status (19)

Country Link
US (2) US5695966A (fi)
EP (1) EP0763112B1 (fi)
JP (1) JPH10505506A (fi)
KR (1) KR100414999B1 (fi)
CN (1) CN1118574C (fi)
AR (1) AR001014A1 (fi)
AT (1) ATE178653T1 (fi)
AU (1) AU711706B2 (fi)
CA (1) CA2188571A1 (fi)
DE (1) DE69601993T2 (fi)
ES (1) ES2132891T3 (fi)
FI (1) FI112251B (fi)
HU (1) HU220530B1 (fi)
IL (1) IL117246A0 (fi)
NO (1) NO964482L (fi)
RU (1) RU2205222C2 (fi)
TW (1) TW419521B (fi)
WO (1) WO1996027014A1 (fi)
ZA (1) ZA961555B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5695966A (en) * 1995-02-27 1997-12-09 Pharmacia & Upjohn S.P.A. DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin
EP0915983B1 (en) * 1997-03-06 2005-06-15 Pharmacia Italia S.p.A. Process for preparing doxorubicin
CA2326500A1 (en) * 1998-04-24 1999-11-04 Pharmacia & Upjohn S.P.A. Process for preparing doxorubicin
US7348420B2 (en) * 2003-04-25 2008-03-25 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
KR100629896B1 (ko) * 2005-04-28 2006-09-29 인하대학교 산학협력단 방선균 독소루비신 고생산 균주 및 독소루비신 생합성유전자군의 발현양상 분석을 위한 마이크로어레이칩
CN101016533B (zh) * 2005-11-09 2010-05-19 上海医药工业研究院 一种蒽环类抗生素产生工程菌及其应用
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
CN104059892A (zh) * 2013-03-18 2014-09-24 江苏禾昌生物科技有限公司 柔红霉素c-14羟化酶突变体及其基因工程菌的生产方法
CN105861455B (zh) 2016-05-16 2018-10-26 浙江海正药业股份有限公司 DoxA蛋白突变体及其编码基因与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
US5695966A (en) * 1995-02-27 1997-12-09 Pharmacia & Upjohn S.P.A. DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin

Also Published As

Publication number Publication date
WO1996027014A1 (en) 1996-09-06
EP0763112B1 (en) 1999-04-07
DE69601993D1 (de) 1999-05-12
DE69601993T2 (de) 1999-11-04
KR970702922A (ko) 1997-06-10
JPH10505506A (ja) 1998-06-02
HUP9603259A2 (en) 1997-05-28
NO964482D0 (no) 1996-10-22
AU4878496A (en) 1996-09-18
CN1147835A (zh) 1997-04-16
HUP9603259A3 (en) 2000-04-28
KR100414999B1 (ko) 2004-04-28
CN1118574C (zh) 2003-08-20
MX9605018A (es) 1998-05-31
FI112251B (fi) 2003-11-14
US5695966A (en) 1997-12-09
EP0763112A1 (en) 1997-03-19
TW419521B (en) 2001-01-21
CA2188571A1 (en) 1996-09-06
RU2205222C2 (ru) 2003-05-27
ES2132891T3 (es) 1999-08-16
AR001014A1 (es) 1997-08-27
US5786190A (en) 1998-07-28
ZA961555B (en) 1996-08-19
FI964229A (fi) 1996-10-21
NO964482L (no) 1996-12-23
ATE178653T1 (de) 1999-04-15
HU220530B1 (hu) 2002-03-28
IL117246A0 (en) 1996-06-18
AU711706B2 (en) 1999-10-21

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