ES2151511T3 - Derivado de tiazolina. - Google Patents

Derivado de tiazolina.

Info

Publication number
ES2151511T3
ES2151511T3 ES93914969T ES93914969T ES2151511T3 ES 2151511 T3 ES2151511 T3 ES 2151511T3 ES 93914969 T ES93914969 T ES 93914969T ES 93914969 T ES93914969 T ES 93914969T ES 2151511 T3 ES2151511 T3 ES 2151511T3
Authority
ES
Spain
Prior art keywords
alcoxicarbonilo
aralquilo
rent
thiazoline
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93914969T
Other languages
English (en)
Inventor
Masakazu Sato
Akira Manaka
Keiko Takahashi
Yutaka Kawashima
Katsuo Hatayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2151511T3 publication Critical patent/ES2151511T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)

Abstract

PROPORCIONAR UN COMPUESTO EXCELENTE EN ANTAGONISMO RECEPTOR FIBRINOGENO Y ANTAGONISMO DE FACTOR DE ADHESION. UN DERIVADO DE TIAZOLINA, REPRESENTADO POR LA FORMULA GENERAL (I) Y UNA SAL DEL MISMO, DONDE R1 REPRESENTA CIANO, CARBAMOILO, TIOCARBAMOILO, MORFOLINOTIOCARBONILO, ALQUILTIOIMIDOILO, -C( = NH) 11R12 (DONDE R11 Y R12 REPRESENTAN CADA UNO HIDROGENO, ALQUILO, ALCOXICARBONILO, CICLOALQUILO, FENILO, FENILO SUSTITUIDO, ARALQUILO O ARALQUILO SUSTITUIDO, O ALTERNATIVAMENTE R11 Y R12 PUEDEN COMBINARSE EL UNO CON EL OTRO PARA REPRESENTAR UN GRUPO HETEROCICLICO MONOVALENTE, JUNTAMENTE CON EL ATOMO DE NITROGENO ADYACENTE) O IMIDAZOLINA UILO; R3 REPRESENTA CARBOXI, HIDROXI, ALCOXICARBONILO, BENZILOXYCARBONILO O PIRIDIL METILOXICARBONILO; Y N REPRESENTA UN NUMERO ENTERO DE 1 A 3.
ES93914969T 1992-07-15 1993-07-08 Derivado de tiazolina. Expired - Lifetime ES2151511T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18833592 1992-07-15
JP31840292 1992-11-27

Publications (1)

Publication Number Publication Date
ES2151511T3 true ES2151511T3 (es) 2001-01-01

Family

ID=26504855

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93914969T Expired - Lifetime ES2151511T3 (es) 1992-07-15 1993-07-08 Derivado de tiazolina.

Country Status (12)

Country Link
EP (1) EP0649843B1 (es)
JP (1) JP3079570B2 (es)
KR (1) KR100267883B1 (es)
AT (1) ATE196137T1 (es)
AU (1) AU666568B2 (es)
CA (1) CA2140006A1 (es)
DE (1) DE69329385T2 (es)
DK (1) DK0649843T3 (es)
ES (1) ES2151511T3 (es)
GR (1) GR3034922T3 (es)
PT (1) PT649843E (es)
WO (1) WO1994002472A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4303676A1 (de) * 1993-02-09 1994-08-11 Bayer Ag 1-Aryltriazolin(thi)one
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
CA2180634A1 (en) * 1994-01-14 1995-07-20 Masakazu Sato Thiazoline derivative
WO1995034543A1 (en) * 1994-06-13 1995-12-21 Taisho Pharmaceutical Co., Ltd. Thiazoline derivative
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
CN1066451C (zh) * 1995-07-07 2001-05-30 大正制药株式会社 噻唑啉衍生物及其组合物和用途
WO1997003075A1 (fr) * 1995-07-07 1997-01-30 Taisho Pharmaceutical Co., Ltd. Derives de la thiazoline
AU6318996A (en) * 1995-07-07 1997-02-10 Taisho Pharmaceutical Co., Ltd. 4-alkylthiazoline derivatives
WO1997003059A1 (fr) * 1995-07-13 1997-01-30 Taisho Pharmaceutical Co., Ltd. Derives de 4-(aminomethyle substitue)thiazoline
AR012443A1 (es) * 1997-04-16 2000-10-18 Uriach & Cia Sa J Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos
AU735144B2 (en) * 1997-07-23 2001-07-05 Yamanouchi Pharmaceutical Co., Ltd. Novel hexahydro-1,4-diazepine derivatives or their salts

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1197259B (it) * 1986-09-23 1988-11-30 Valeas Spa Derivati ammidici eterociclici di acidi benzoici sostituiti e composizione terapeutiche che li contengono come principi attivi
JPH0250148A (ja) * 1988-05-16 1990-02-20 Konica Corp 熱現像カラー感光材料

Also Published As

Publication number Publication date
AU4513693A (en) 1994-02-14
GR3034922T3 (en) 2001-02-28
DK0649843T3 (da) 2000-10-09
CA2140006A1 (en) 1994-02-03
KR100267883B1 (ko) 2000-10-16
EP0649843B1 (en) 2000-09-06
KR950702194A (ko) 1995-06-19
JP3079570B2 (ja) 2000-08-21
EP0649843A4 (en) 1995-02-22
PT649843E (pt) 2000-12-29
DE69329385T2 (de) 2001-01-04
WO1994002472A1 (en) 1994-02-03
ATE196137T1 (de) 2000-09-15
DE69329385D1 (de) 2000-10-12
AU666568B2 (en) 1996-02-15
EP0649843A1 (en) 1995-04-26

Similar Documents

Publication Publication Date Title
MX9303158A (es) Derivados de aminoquinolona substituidos con grupoarilo o con un grupo heterociclico aromatico; y agente anti-vih.
DK51986A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
ES2151511T3 (es) Derivado de tiazolina.
CO5070570A1 (es) DERIVADOS DE TIROSINA COMO ACTIVADORES DE hPPAR Y hPPARalfa Y UNA COMPOSICION FARMACEUTICA QUE LOS CONTIENE
DE122006000027I2 (de) Aminderivate
SE7903392L (sv) Basiska respektive katjonaktiva sulfonsyragrupphaltiga monoazo- eller disazoforeningar
FR2518088B1 (fr) Nouveaux derives d'aminoacides, et leur application therapeutique
AR000038A2 (es) Compuestos intermediarios de piridinosulfonamida sustituidos, y procedimientos para su obtencion.
AR002241A1 (es) Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo.
PT1140916E (pt) Acetais heteroarilo ciclicos
DK157295C (da) Tetrahydrobenzindoler og deres anvendelse som laegemidler
ES446222A1 (es) Un procedimiento para la preparacion de nuevos derivados de salicilanilida.
KR850003719A (ko) 시아노피라졸 제초제에 대한 개량
ES2094812T3 (es) Un procedimiento mejorado para la preparacion de derivados sustituidos de indolona.
ES2038754T3 (es) Agentes antiarritmicos.
GB1150747A (en) Nitrogen-Containing Sulphonic Acids and Their Use in the Electrodeposition of Copper
ES8801895A1 (es) Procedimiento para la obtencion de benzamidas
ES378815A1 (es) Procedimiento para la preparacion de s-dioxidos de oxo-di- hidro-benzotiazimina.
ES269319A1 (es) Procedimiento de aplicaciën de compuestos nematocidas
IT1223067B (it) Composto fotocromatico ed articoli fotocromatici che lo contengono
NZ501982A (en) N-oxide forms of 2,4,4-trisubstituted-1,3-dioxolane as anti-fungal agents
KR830005188A (ko) 혈당강하성 구아닐 아미딘의 제조방법
AR247390A1 (es) Compuestos aril-propil-aminicos dotados de alta actividad antifungica y procedimiento para producirlos
GB1314937A (en) Phenyl-urea derivatives and herbicidal
ES2120971T3 (es) Colorantes monoazoicos con 2,6-diaminopiridinas como componentes de copulacion.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 649843

Country of ref document: ES