ES2146212T3 - Proteinas de union a antigenos trivalentes monoespecificas. - Google Patents
Proteinas de union a antigenos trivalentes monoespecificas.Info
- Publication number
- ES2146212T3 ES2146212T3 ES92912329T ES92912329T ES2146212T3 ES 2146212 T3 ES2146212 T3 ES 2146212T3 ES 92912329 T ES92912329 T ES 92912329T ES 92912329 T ES92912329 T ES 92912329T ES 2146212 T3 ES2146212 T3 ES 2146212T3
- Authority
- ES
- Spain
- Prior art keywords
- union
- proteins
- specific trivalent
- trivalent antigens
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SUMINISTRA UNA PROTEINA QUE SE UNE A LOS ANTIGENOS MONOESPECIFICA, TRI O TETRAVALENTE QUE COMPRENDE TRES O CUATRO FRAGMENTOS FAB UNIDOS UNOS A LOS OTROS DE FORMA COVALENTE MEDIANTE UNA ESTRUCTURA DE CONEXION, DICHA PROTEINA NO ES UNA INMUNOGLOBULINA NATURAL. ADEMAS, SE SUMINISTRAN NUEVAS ESTRUCTURAS DE CONEXION PARA SU USO EN EL ENSAMBLAJE DE LAS PROTEINAS DE LA INVENCION Y MEDIOS PARA SUJETAR UN GRUPO ETIQUETADOR A LAS MISMAS. LAS PROTEINAS DE LA INVENCION SON UTILES, POR EJEMPLO, EN EL TRATAMIENTO Y LA DIAGNOSIS DEL CANCER.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919112536A GB9112536D0 (en) | 1991-06-11 | 1991-06-11 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2146212T3 true ES2146212T3 (es) | 2000-08-01 |
Family
ID=10696461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92912329T Expired - Lifetime ES2146212T3 (es) | 1991-06-11 | 1992-06-11 | Proteinas de union a antigenos trivalentes monoespecificas. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0560947B1 (es) |
JP (1) | JP3373849B2 (es) |
KR (1) | KR930701490A (es) |
AT (1) | ATE192457T1 (es) |
AU (1) | AU1971692A (es) |
CA (1) | CA2088367C (es) |
DE (1) | DE69230994T2 (es) |
DK (1) | DK0560947T3 (es) |
ES (1) | ES2146212T3 (es) |
FI (1) | FI930580A (es) |
GB (1) | GB9112536D0 (es) |
NO (1) | NO930440L (es) |
NZ (1) | NZ243099A (es) |
WO (1) | WO1992022583A2 (es) |
ZA (1) | ZA924271B (es) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2173910T3 (es) * | 1992-12-10 | 2002-11-01 | Celltech Therapeutics Ltd | Anticuerpos humanizados dirigidos contra el antigeno a33. |
DE4310141A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Homobidentale trifunktionelle Linker |
DE4310142A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung |
GB9812545D0 (en) | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
GB9824632D0 (en) | 1998-11-10 | 1999-01-06 | Celltech Therapeutics Ltd | Biological compounds |
US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
NZ568033A (en) | 1998-11-27 | 2011-04-29 | Darwin Discovery Ltd | Compositions and methods for increasing bone mineralization |
NZ521540A (en) | 2000-04-11 | 2004-09-24 | Genentech Inc | Multivalent antibodies and uses therefor |
GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
EP1534753B1 (en) | 2002-05-28 | 2011-08-03 | UCB Pharma, S.A. | Peg positional isomer of an anti-tnfalpha antibody (cdp870) |
CA2499300A1 (en) | 2002-10-31 | 2004-05-21 | Genentech, Inc. | Methods and compositions for increasing antibody production |
GB0303337D0 (en) | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
US8129505B2 (en) | 2005-09-14 | 2012-03-06 | Ucb Pharma S.A. | Comb polymers |
BRPI0619595B8 (pt) | 2005-12-09 | 2022-12-13 | Ucb Pharma Sa | anticorpo neutralizante, sequência de dna isolada, vetor de clonagem ou expressão, célula hospedeira, processo para a produção de um anticorpo, composição farmacêutica, e, uso de um anticorpo neutralizante humanizado |
CA2646391A1 (en) | 2006-03-22 | 2007-09-27 | Viral Logic Systems Technology Corp. | Methods for identifying polypeptide targets and uses thereof for treating immunological diseases |
US8377448B2 (en) | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
JP4780405B2 (ja) * | 2006-08-29 | 2011-09-28 | アイシン精機株式会社 | 結合親和性を利用する被検物質の測定方法、及び被検物質の測定のための結合親和性解析の制御方法 |
EP1897886A1 (en) * | 2006-09-08 | 2008-03-12 | Bayer Schering Pharma Aktiengesellschaft | Compounds as aptamer-dimers and their uses in diagnosis and therapy |
GB0620729D0 (en) | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
GB0807413D0 (en) | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
SG2014014708A (en) | 2009-02-17 | 2014-05-29 | Ucb Pharma Sa | Antibody molecules having specificity for human ox40 |
GB0904214D0 (en) | 2009-03-11 | 2009-04-22 | Ucb Pharma Sa | Biological products |
WO2011030107A1 (en) | 2009-09-10 | 2011-03-17 | Ucb Pharma S.A. | Multivalent antibodies |
US8734798B2 (en) | 2009-10-27 | 2014-05-27 | Ucb Pharma S.A. | Function modifying NAv 1.7 antibodies |
US9234037B2 (en) | 2009-10-27 | 2016-01-12 | Ucb Biopharma Sprl | Method to generate antibodies to ion channels |
GB0922434D0 (en) | 2009-12-22 | 2010-02-03 | Ucb Pharma Sa | antibodies and fragments thereof |
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CN101962503B (zh) * | 2010-08-27 | 2013-01-02 | 东华大学 | 耐高温电磁线自粘漆及其制备方法 |
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EP2546267A1 (en) | 2011-07-13 | 2013-01-16 | UCB Pharma S.A. | Bacterial host strain expressing recombinant DsbC |
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GB8903022D0 (en) * | 1989-02-10 | 1989-03-30 | Celltech Ltd | Chemical compounds |
AU6290090A (en) * | 1989-08-29 | 1991-04-08 | University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
WO1991006305A1 (en) * | 1989-11-07 | 1991-05-16 | Bristol-Myers Squibb Company | Oligomeric immunoglobulins |
US5091542A (en) * | 1990-03-09 | 1992-02-25 | Hybritech Incorporated | Tris-maleimido compounds as intermediates in trifunctional antibody synthesis |
GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
-
1991
- 1991-06-11 GB GB919112536A patent/GB9112536D0/en active Pending
-
1992
- 1992-06-11 WO PCT/GB1992/001047 patent/WO1992022583A2/en active IP Right Grant
- 1992-06-11 KR KR1019930700387A patent/KR930701490A/ko not_active Application Discontinuation
- 1992-06-11 AU AU19716/92A patent/AU1971692A/en not_active Abandoned
- 1992-06-11 DK DK92912329T patent/DK0560947T3/da active
- 1992-06-11 DE DE69230994T patent/DE69230994T2/de not_active Expired - Lifetime
- 1992-06-11 CA CA002088367A patent/CA2088367C/en not_active Expired - Lifetime
- 1992-06-11 EP EP92912329A patent/EP0560947B1/en not_active Expired - Lifetime
- 1992-06-11 ZA ZA924271A patent/ZA924271B/xx unknown
- 1992-06-11 JP JP51108392A patent/JP3373849B2/ja not_active Expired - Fee Related
- 1992-06-11 NZ NZ243099A patent/NZ243099A/en not_active IP Right Cessation
- 1992-06-11 ES ES92912329T patent/ES2146212T3/es not_active Expired - Lifetime
- 1992-06-11 AT AT92912329T patent/ATE192457T1/de not_active IP Right Cessation
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1993
- 1993-02-09 NO NO93930440A patent/NO930440L/no unknown
- 1993-02-10 FI FI930580A patent/FI930580A/fi not_active Application Discontinuation
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AU1971692A (en) | 1993-01-12 |
GB9112536D0 (en) | 1991-07-31 |
KR930701490A (ko) | 1993-06-11 |
NZ243099A (en) | 1996-07-26 |
EP0560947B1 (en) | 2000-05-03 |
JPH06502657A (ja) | 1994-03-24 |
FI930580A (fi) | 1993-04-02 |
WO1992022583A3 (en) | 1993-04-01 |
EP0560947A1 (en) | 1993-09-22 |
ZA924271B (en) | 1993-12-13 |
NO930440D0 (no) | 1993-02-09 |
ATE192457T1 (de) | 2000-05-15 |
CA2088367C (en) | 2002-08-20 |
NO930440L (no) | 1993-04-02 |
DE69230994T2 (de) | 2001-02-01 |
CA2088367A1 (en) | 1992-12-12 |
WO1992022583A2 (en) | 1992-12-23 |
DE69230994D1 (de) | 2000-06-08 |
DK0560947T3 (da) | 2000-08-07 |
FI930580A0 (fi) | 1993-02-10 |
JP3373849B2 (ja) | 2003-02-04 |
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