ES2145832T3 - Agentes de administracion de farmacos que incorporan mitomicina. - Google Patents
Agentes de administracion de farmacos que incorporan mitomicina.Info
- Publication number
- ES2145832T3 ES2145832T3 ES94923825T ES94923825T ES2145832T3 ES 2145832 T3 ES2145832 T3 ES 2145832T3 ES 94923825 T ES94923825 T ES 94923825T ES 94923825 T ES94923825 T ES 94923825T ES 2145832 T3 ES2145832 T3 ES 2145832T3
- Authority
- ES
- Spain
- Prior art keywords
- mmc
- pct
- groups
- carrier polymer
- spacer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN CONJUGADO DE UN POLIMERO DE SOPORTE Y MOLECULAS DE UN FARMACO DE MITOMICINA (MMC) QUE CONTIENEN UN ANILLO DE AZIRIDINA QUE SE PREPARA ACOPLANDO LAS MOLECULAS DE MMC A TRAVES DE SUS GRUPOS IMINO DE AZIRIDINA A GRUPOS SEPARADORES QUE TERMINAN EN GRUPO AMINO PROTEGIDOS, DESPROTEGIENDO DICHOS GRUPOS AMINO, RECUPERANDO Y PURIFICANDO LOS DERIVADOS DE SEPARADOR Y MMC Y ACOPLANDO A CONTINUACION ESTOS DERIVADOS A TRAVES DE GRUPOS AMINO TERMINALES DESPROTEGIDOS AL POLIMERO DE SOPORTE. ALTERNATIVAMENTE, LA MMC SE PUEDE TRATAR PRIMERO CON UN AGENTE DE ACTIVACION, EJ. CARBODIIMIDAZOL, PARA FORMAR UN DERIVADO DE MMC ACTIVADA QUE A CONTINUACION SE ACOPLA DIRECTAMENTE A LOS GRUPOS SEPARADORES ENLAZADOS AL POLIMERO DE SOPORTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9317213A GB2282384B8 (en) | 1993-08-18 | 1993-08-18 | Drug delivery agents incorporating mitomycin |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2145832T3 true ES2145832T3 (es) | 2000-07-16 |
Family
ID=10740702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94923825T Expired - Lifetime ES2145832T3 (es) | 1993-08-18 | 1994-08-17 | Agentes de administracion de farmacos que incorporan mitomicina. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5738864A (es) |
EP (1) | EP0804246B1 (es) |
JP (1) | JPH09501674A (es) |
AT (1) | ATE192933T1 (es) |
CA (1) | CA2168007C (es) |
DE (1) | DE69424577T2 (es) |
DK (1) | DK0804246T3 (es) |
ES (1) | ES2145832T3 (es) |
GB (1) | GB2282384B8 (es) |
GR (1) | GR3034174T3 (es) |
PT (1) | PT804246E (es) |
WO (1) | WO1995005200A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5850855A (en) * | 1990-01-09 | 1998-12-22 | Ems-Inventa Ag | Flexible coolant conduit and method of making same |
BR9811252A (pt) * | 1997-02-26 | 2000-09-26 | Lilly Co Eli | Processo para preparação de compostos farmacêuticos |
US6251866B1 (en) | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
ID29943A (id) * | 1998-10-30 | 2001-10-25 | Daiichi Seiyaku Co | Senyawa dds dan metode pengukurannya |
AU2001288829A1 (en) * | 2000-09-06 | 2002-03-22 | Ap Pharma, Inc. | Degradable polyacetal polymers |
WO2003017938A2 (en) * | 2001-08-22 | 2003-03-06 | Watson Pharmaceuticals, Inc. | Conjugates targeted to target receptors |
AU2004233997C1 (en) * | 2003-04-29 | 2014-01-30 | Massachusetts Institiute Of Technology | Methods and devices for the sustained release of multiple drugs |
US7812051B2 (en) | 2004-08-11 | 2010-10-12 | Arqule, Inc. | Pharmaceutical compositions of β-lapachone and β-lapachone analogs with improved tumor targeting potential |
US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
ATE465205T1 (de) | 2005-12-05 | 2010-05-15 | Nitto Denko Corp | Polyglutamat-aminosäure-konjugate und verfahren |
US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
JP5286822B2 (ja) * | 2007-02-22 | 2013-09-11 | Jsr株式会社 | ポリアミノ酸またはポリアミノ酸系共重合体の製造方法 |
CN104800856A (zh) * | 2007-04-10 | 2015-07-29 | 日东电工株式会社 | 多功能聚谷氨酸盐药物载体 |
WO2008134088A1 (en) | 2007-04-30 | 2008-11-06 | Arqule, Inc. | Hydroxy sulfonate of quinone compounds and their uses |
WO2008141110A2 (en) * | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
CN101730549B (zh) * | 2007-05-09 | 2015-12-09 | 日东电工株式会社 | 与铂类药物结合的聚合物 |
PT2155255E (pt) | 2007-05-09 | 2013-10-15 | Nitto Denko Corp | Composições que incluem um composto hidrofóbico e um conjugado de poliaminoácido |
RU2010137032A (ru) * | 2008-03-06 | 2012-04-20 | Нитто Денко Корпорейшн (Jp) | Конъюгаты паклитаксела с полимером и способы лечения рака |
EP3655039A1 (en) * | 2017-07-17 | 2020-05-27 | Technische Universiteit Eindhoven | Applicable chemical composition comprising an agent conjugated to a hydrophobic moiety and a carrier |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541436A (en) * | 1976-02-02 | 1979-02-28 | Searle & Co | Immunological materials |
JP2528477B2 (ja) * | 1987-09-07 | 1996-08-28 | 三共株式会社 | 高分子制癌剤の増強剤 |
KR900701269A (ko) * | 1988-08-23 | 1990-12-01 | 원본미기재 | 골수독성이 낮은 미토마이신 유도체, 그 제조방법 및 그이용 |
JPH0762049B2 (ja) * | 1991-03-18 | 1995-07-05 | 工業技術院長 | 高分子マイトマイシンc誘導体及びその製造方法 |
JPH05252673A (ja) * | 1992-03-05 | 1993-09-28 | Honda Motor Co Ltd | 電源装置 |
-
1993
- 1993-08-18 GB GB9317213A patent/GB2282384B8/en not_active Expired - Fee Related
-
1994
- 1994-08-17 DE DE69424577T patent/DE69424577T2/de not_active Expired - Fee Related
- 1994-08-17 ES ES94923825T patent/ES2145832T3/es not_active Expired - Lifetime
- 1994-08-17 PT PT94923825T patent/PT804246E/pt unknown
- 1994-08-17 EP EP94923825A patent/EP0804246B1/en not_active Expired - Lifetime
- 1994-08-17 WO PCT/IB1994/000259 patent/WO1995005200A1/en active IP Right Grant
- 1994-08-17 US US08/602,733 patent/US5738864A/en not_active Expired - Fee Related
- 1994-08-17 AT AT94923825T patent/ATE192933T1/de not_active IP Right Cessation
- 1994-08-17 DK DK94923825T patent/DK0804246T3/da active
- 1994-08-17 CA CA002168007A patent/CA2168007C/en not_active Expired - Fee Related
- 1994-08-17 JP JP7506852A patent/JPH09501674A/ja active Pending
-
2000
- 2000-08-10 GR GR20000401869T patent/GR3034174T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0804246B1 (en) | 2000-05-17 |
GB2282384A (en) | 1995-04-05 |
DE69424577T2 (de) | 2001-02-22 |
DE69424577D1 (de) | 2000-06-21 |
CA2168007A1 (en) | 1995-02-23 |
CA2168007C (en) | 2001-06-12 |
EP0804246A1 (en) | 1997-11-05 |
GB2282384B (en) | 1997-09-03 |
JPH09501674A (ja) | 1997-02-18 |
ATE192933T1 (de) | 2000-06-15 |
GB9317213D0 (en) | 1993-10-06 |
GR3034174T3 (en) | 2000-11-30 |
GB2282384B8 (en) | 1997-09-04 |
DK0804246T3 (da) | 2000-11-13 |
US5738864A (en) | 1998-04-14 |
PT804246E (pt) | 2000-08-31 |
WO1995005200A1 (en) | 1995-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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