ATE192933T1 - Mitomycin enthaltende arzneimittelabgabesysteme - Google Patents

Mitomycin enthaltende arzneimittelabgabesysteme

Info

Publication number
ATE192933T1
ATE192933T1 AT94923825T AT94923825T ATE192933T1 AT E192933 T1 ATE192933 T1 AT E192933T1 AT 94923825 T AT94923825 T AT 94923825T AT 94923825 T AT94923825 T AT 94923825T AT E192933 T1 ATE192933 T1 AT E192933T1
Authority
AT
Austria
Prior art keywords
mmc
pct
groups
carrier polymer
spacer
Prior art date
Application number
AT94923825T
Other languages
English (en)
Inventor
Etienne Honore Schacht
Paolo Ferruti
Ruth Duncan
Original Assignee
Europ Economic Community
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europ Economic Community filed Critical Europ Economic Community
Application granted granted Critical
Publication of ATE192933T1 publication Critical patent/ATE192933T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT94923825T 1993-08-18 1994-08-17 Mitomycin enthaltende arzneimittelabgabesysteme ATE192933T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9317213A GB2282384B8 (en) 1993-08-18 1993-08-18 Drug delivery agents incorporating mitomycin
PCT/IB1994/000259 WO1995005200A1 (en) 1993-08-18 1994-08-17 Drug delivery agents incorporating mitomycin

Publications (1)

Publication Number Publication Date
ATE192933T1 true ATE192933T1 (de) 2000-06-15

Family

ID=10740702

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923825T ATE192933T1 (de) 1993-08-18 1994-08-17 Mitomycin enthaltende arzneimittelabgabesysteme

Country Status (12)

Country Link
US (1) US5738864A (de)
EP (1) EP0804246B1 (de)
JP (1) JPH09501674A (de)
AT (1) ATE192933T1 (de)
CA (1) CA2168007C (de)
DE (1) DE69424577T2 (de)
DK (1) DK0804246T3 (de)
ES (1) ES2145832T3 (de)
GB (1) GB2282384B8 (de)
GR (1) GR3034174T3 (de)
PT (1) PT804246E (de)
WO (1) WO1995005200A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5850855A (en) * 1990-01-09 1998-12-22 Ems-Inventa Ag Flexible coolant conduit and method of making same
IL131162A0 (en) * 1997-02-26 2001-01-28 Lilly Co Eli Selective epoxidation process for preparing pharmaceutical compounds
US6251866B1 (en) 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
KR20010090602A (ko) * 1998-10-30 2001-10-18 스즈키 다다시 디디에스 화합물 및 그의 측정방법
US7220414B2 (en) * 2000-09-06 2007-05-22 A.P. Pharma, Inc. Degradable polyacetal polymers
US20030124742A1 (en) * 2001-08-22 2003-07-03 Prakash Ramesh K. Conjugates targeted to target receptors
EP1620060B1 (de) * 2003-04-29 2010-03-24 The General Hospital Corporation Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln
WO2006020719A2 (en) * 2004-08-11 2006-02-23 Arqule, Inc. Aminoacid conjugates of beta - lapachone for tumor targeting
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
US20070128118A1 (en) 2005-12-05 2007-06-07 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
JP5286822B2 (ja) * 2007-02-22 2013-09-11 Ｊｓｒ株式会社 ポリアミノ酸またはポリアミノ酸系共重合体の製造方法
WO2008124735A2 (en) * 2007-04-10 2008-10-16 Nitto Denko Corporation Multi-functional polyglutamate drug carriers
CN101687835B (zh) 2007-04-30 2015-08-19 艾科尔公司 苯醌化合物的羟基磺酸盐和它们的应用
EP2155253A2 (de) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamatkonjugate und polyglutamat-aminosäure-konjugate mit mehreren wirkstoffen
CN101678123B (zh) * 2007-05-09 2014-07-16 日东电工株式会社 包含疏水性化合物和聚氨基酸结合物的组合物
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
JP2011513412A (ja) * 2008-03-06 2011-04-28 日東電工株式会社 ポリマーパクリタキセル結合体を含む癌を治療するための薬学組成物
EP3655039A1 (de) * 2017-07-17 2020-05-27 Technische Universiteit Eindhoven Anwendbare chemische zusammensetzung mit einem an eine hydrophobe gruppe konjugierten mittel und einem träger

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1541436A (en) * 1976-02-02 1979-02-28 Searle & Co Immunological materials
JP2528477B2 (ja) * 1987-09-07 1996-08-28 三共株式会社 高分子制癌剤の増強剤
AU628846B2 (en) * 1988-08-23 1992-09-24 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
JPH0762049B2 (ja) * 1991-03-18 1995-07-05 工業技術院長 高分子マイトマイシンｃ誘導体及びその製造方法
JPH05252673A (ja) * 1992-03-05 1993-09-28 Honda Motor Co Ltd 電源装置

Also Published As

Publication number Publication date
GB2282384B8 (en) 1997-09-04
CA2168007A1 (en) 1995-02-23
DE69424577D1 (de) 2000-06-21
CA2168007C (en) 2001-06-12
US5738864A (en) 1998-04-14
ES2145832T3 (es) 2000-07-16
GB2282384A (en) 1995-04-05
DE69424577T2 (de) 2001-02-22
GB9317213D0 (en) 1993-10-06
GB2282384B (en) 1997-09-03
PT804246E (pt) 2000-08-31
EP0804246B1 (de) 2000-05-17
WO1995005200A1 (en) 1995-02-23
EP0804246A1 (de) 1997-11-05
GR3034174T3 (en) 2000-11-30
JPH09501674A (ja) 1997-02-18
DK0804246T3 (da) 2000-11-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee