ATE192933T1 - Mitomycin enthaltende arzneimittelabgabesysteme - Google Patents
Mitomycin enthaltende arzneimittelabgabesystemeInfo
- Publication number
- ATE192933T1 ATE192933T1 AT94923825T AT94923825T ATE192933T1 AT E192933 T1 ATE192933 T1 AT E192933T1 AT 94923825 T AT94923825 T AT 94923825T AT 94923825 T AT94923825 T AT 94923825T AT E192933 T1 ATE192933 T1 AT E192933T1
- Authority
- AT
- Austria
- Prior art keywords
- mmc
- pct
- groups
- carrier polymer
- spacer
- Prior art date
Links
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 title abstract 6
- 229930192392 Mitomycin Natural products 0.000 title abstract 5
- 229960004857 mitomycin Drugs 0.000 title abstract 5
- 238000012377 drug delivery Methods 0.000 title 1
- 125000003277 amino group Chemical group 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 125000006850 spacer group Chemical group 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000004069 aziridinyl group Chemical group 0.000 abstract 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9317213A GB2282384B8 (en) | 1993-08-18 | 1993-08-18 | Drug delivery agents incorporating mitomycin |
| PCT/IB1994/000259 WO1995005200A1 (en) | 1993-08-18 | 1994-08-17 | Drug delivery agents incorporating mitomycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE192933T1 true ATE192933T1 (de) | 2000-06-15 |
Family
ID=10740702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94923825T ATE192933T1 (de) | 1993-08-18 | 1994-08-17 | Mitomycin enthaltende arzneimittelabgabesysteme |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5738864A (de) |
| EP (1) | EP0804246B1 (de) |
| JP (1) | JPH09501674A (de) |
| AT (1) | ATE192933T1 (de) |
| CA (1) | CA2168007C (de) |
| DE (1) | DE69424577T2 (de) |
| DK (1) | DK0804246T3 (de) |
| ES (1) | ES2145832T3 (de) |
| GB (1) | GB2282384B8 (de) |
| GR (1) | GR3034174T3 (de) |
| PT (1) | PT804246E (de) |
| WO (1) | WO1995005200A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5850855A (en) * | 1990-01-09 | 1998-12-22 | Ems-Inventa Ag | Flexible coolant conduit and method of making same |
| IL131162A0 (en) * | 1997-02-26 | 2001-01-28 | Lilly Co Eli | Selective epoxidation process for preparing pharmaceutical compounds |
| US6251866B1 (en) * | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
| US6919076B1 (en) | 1998-01-20 | 2005-07-19 | Pericor Science, Inc. | Conjugates of agents and transglutaminase substrate linking molecules |
| US6958148B1 (en) | 1998-01-20 | 2005-10-25 | Pericor Science, Inc. | Linkage of agents to body tissue using microparticles and transglutaminase |
| EP1619210A1 (de) * | 1998-10-30 | 2006-01-25 | Daiichi Pharmaceutical Co., Ltd. | DDS-Verbindungen und Methoden ihrer Prüfung |
| AU2001288829A1 (en) | 2000-09-06 | 2002-03-22 | Ap Pharma, Inc. | Degradable polyacetal polymers |
| WO2003017938A2 (en) * | 2001-08-22 | 2003-03-06 | Watson Pharmaceuticals, Inc. | Conjugates targeted to target receptors |
| CA2523859C (en) * | 2003-04-29 | 2011-08-02 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
| CA2583700A1 (en) * | 2004-08-11 | 2006-02-23 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
| DE602006007177D1 (de) | 2005-12-05 | 2009-07-16 | Nitto Denko Corp | Polyglutamat-aminosäure-konjugate und verfahren |
| US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
| JP5286822B2 (ja) * | 2007-02-22 | 2013-09-11 | Ｊｓｒ株式会社 | ポリアミノ酸またはポリアミノ酸系共重合体の製造方法 |
| CN101674852A (zh) * | 2007-04-10 | 2010-03-17 | 日东电工株式会社 | 多功能聚谷氨酸盐药物载体 |
| WO2008134088A1 (en) | 2007-04-30 | 2008-11-06 | Arqule, Inc. | Hydroxy sulfonate of quinone compounds and their uses |
| EP2155255B1 (de) | 2007-05-09 | 2013-08-14 | Nitto Denko Corporation | Zusammensetzungen, die eine hydrophobe Verbindung und ein Polyaminosäurekonjugat beinhalten |
| DK2155254T3 (da) * | 2007-05-09 | 2013-03-04 | Nitto Denko Corp | Med platinlægemidler konjugerede polymere |
| CN101707869A (zh) * | 2007-05-09 | 2010-05-12 | 日东电工株式会社 | 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 |
| CN104096236A (zh) * | 2008-03-06 | 2014-10-15 | 日东电工株式会社 | 用于治疗癌症的聚合物紫杉醇结合物和方法 |
| US20200164078A1 (en) * | 2017-07-17 | 2020-05-28 | Technische Universiteit Eindhoven | Applicable chemical composition comprising an agent conjugated to a hydrophobic moiety and a carrier |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1541436A (en) * | 1976-02-02 | 1979-02-28 | Searle & Co | Immunological materials |
| JP2528477B2 (ja) * | 1987-09-07 | 1996-08-28 | 三共株式会社 | 高分子制癌剤の増強剤 |
| EP0431008A4 (en) * | 1988-08-23 | 1992-03-11 | Georgetown University | Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof |
| JPH0762049B2 (ja) * | 1991-03-18 | 1995-07-05 | 工業技術院長 | 高分子マイトマイシンｃ誘導体及びその製造方法 |
| JPH05252673A (ja) * | 1992-03-05 | 1993-09-28 | Honda Motor Co Ltd | 電源装置 |
-
1993
- 1993-08-18 GB GB9317213A patent/GB2282384B8/en not_active Expired - Fee Related
-
1994
- 1994-08-17 EP EP94923825A patent/EP0804246B1/de not_active Expired - Lifetime
- 1994-08-17 PT PT94923825T patent/PT804246E/pt unknown
- 1994-08-17 CA CA002168007A patent/CA2168007C/en not_active Expired - Fee Related
- 1994-08-17 ES ES94923825T patent/ES2145832T3/es not_active Expired - Lifetime
- 1994-08-17 DK DK94923825T patent/DK0804246T3/da active
- 1994-08-17 JP JP7506852A patent/JPH09501674A/ja active Pending
- 1994-08-17 AT AT94923825T patent/ATE192933T1/de not_active IP Right Cessation
- 1994-08-17 US US08/602,733 patent/US5738864A/en not_active Expired - Fee Related
- 1994-08-17 DE DE69424577T patent/DE69424577T2/de not_active Expired - Fee Related
- 1994-08-17 WO PCT/IB1994/000259 patent/WO1995005200A1/en not_active Ceased
-
2000
- 2000-08-10 GR GR20000401869T patent/GR3034174T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0804246A1 (de) | 1997-11-05 |
| CA2168007A1 (en) | 1995-02-23 |
| ES2145832T3 (es) | 2000-07-16 |
| GR3034174T3 (en) | 2000-11-30 |
| DE69424577D1 (de) | 2000-06-21 |
| DK0804246T3 (da) | 2000-11-13 |
| CA2168007C (en) | 2001-06-12 |
| WO1995005200A1 (en) | 1995-02-23 |
| GB2282384B8 (en) | 1997-09-04 |
| GB2282384A (en) | 1995-04-05 |
| EP0804246B1 (de) | 2000-05-17 |
| GB9317213D0 (en) | 1993-10-06 |
| GB2282384B (en) | 1997-09-03 |
| US5738864A (en) | 1998-04-14 |
| JPH09501674A (ja) | 1997-02-18 |
| PT804246E (pt) | 2000-08-31 |
| DE69424577T2 (de) | 2001-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |