DE69424577D1 - Mitomycin enthaltende arzneimittelabgabesysteme - Google Patents
Mitomycin enthaltende arzneimittelabgabesystemeInfo
- Publication number
- DE69424577D1 DE69424577D1 DE69424577T DE69424577T DE69424577D1 DE 69424577 D1 DE69424577 D1 DE 69424577D1 DE 69424577 T DE69424577 T DE 69424577T DE 69424577 T DE69424577 T DE 69424577T DE 69424577 D1 DE69424577 D1 DE 69424577D1
- Authority
- DE
- Germany
- Prior art keywords
- mmc
- pct
- groups
- carrier polymer
- spacer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9317213A GB2282384B8 (en) | 1993-08-18 | 1993-08-18 | Drug delivery agents incorporating mitomycin |
PCT/IB1994/000259 WO1995005200A1 (en) | 1993-08-18 | 1994-08-17 | Drug delivery agents incorporating mitomycin |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69424577D1 true DE69424577D1 (de) | 2000-06-21 |
DE69424577T2 DE69424577T2 (de) | 2001-02-22 |
Family
ID=10740702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69424577T Expired - Fee Related DE69424577T2 (de) | 1993-08-18 | 1994-08-17 | Mitomycin enthaltende arzneimittelabgabesysteme |
Country Status (12)
Country | Link |
---|---|
US (1) | US5738864A (de) |
EP (1) | EP0804246B1 (de) |
JP (1) | JPH09501674A (de) |
AT (1) | ATE192933T1 (de) |
CA (1) | CA2168007C (de) |
DE (1) | DE69424577T2 (de) |
DK (1) | DK0804246T3 (de) |
ES (1) | ES2145832T3 (de) |
GB (1) | GB2282384B8 (de) |
GR (1) | GR3034174T3 (de) |
PT (1) | PT804246E (de) |
WO (1) | WO1995005200A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5850855A (en) * | 1990-01-09 | 1998-12-22 | Ems-Inventa Ag | Flexible coolant conduit and method of making same |
IL131162A0 (en) * | 1997-02-26 | 2001-01-28 | Lilly Co Eli | Selective epoxidation process for preparing pharmaceutical compounds |
US6251866B1 (en) | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
KR20010090602A (ko) * | 1998-10-30 | 2001-10-18 | 스즈키 다다시 | 디디에스 화합물 및 그의 측정방법 |
US7220414B2 (en) * | 2000-09-06 | 2007-05-22 | A.P. Pharma, Inc. | Degradable polyacetal polymers |
US20030124742A1 (en) * | 2001-08-22 | 2003-07-03 | Prakash Ramesh K. | Conjugates targeted to target receptors |
EP1620060B1 (de) * | 2003-04-29 | 2010-03-24 | The General Hospital Corporation | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
WO2006020719A2 (en) * | 2004-08-11 | 2006-02-23 | Arqule, Inc. | Aminoacid conjugates of beta - lapachone for tumor targeting |
US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
US20070128118A1 (en) | 2005-12-05 | 2007-06-07 | Nitto Denko Corporation | Polyglutamate-amino acid conjugates and methods |
US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
JP5286822B2 (ja) * | 2007-02-22 | 2013-09-11 | Jsr株式会社 | ポリアミノ酸またはポリアミノ酸系共重合体の製造方法 |
WO2008124735A2 (en) * | 2007-04-10 | 2008-10-16 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
CN101687835B (zh) | 2007-04-30 | 2015-08-19 | 艾科尔公司 | 苯醌化合物的羟基磺酸盐和它们的应用 |
EP2155253A2 (de) * | 2007-05-09 | 2010-02-24 | Nitto Denko Corporation | Polyglutamatkonjugate und polyglutamat-aminosäure-konjugate mit mehreren wirkstoffen |
CN101678123B (zh) * | 2007-05-09 | 2014-07-16 | 日东电工株式会社 | 包含疏水性化合物和聚氨基酸结合物的组合物 |
CN101730549B (zh) * | 2007-05-09 | 2015-12-09 | 日东电工株式会社 | 与铂类药物结合的聚合物 |
JP2011513412A (ja) * | 2008-03-06 | 2011-04-28 | 日東電工株式会社 | ポリマーパクリタキセル結合体を含む癌を治療するための薬学組成物 |
EP3655039A1 (de) * | 2017-07-17 | 2020-05-27 | Technische Universiteit Eindhoven | Anwendbare chemische zusammensetzung mit einem an eine hydrophobe gruppe konjugierten mittel und einem träger |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541436A (en) * | 1976-02-02 | 1979-02-28 | Searle & Co | Immunological materials |
JP2528477B2 (ja) * | 1987-09-07 | 1996-08-28 | 三共株式会社 | 高分子制癌剤の増強剤 |
AU628846B2 (en) * | 1988-08-23 | 1992-09-24 | Georgetown University | Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof |
JPH0762049B2 (ja) * | 1991-03-18 | 1995-07-05 | 工業技術院長 | 高分子マイトマイシンc誘導体及びその製造方法 |
JPH05252673A (ja) * | 1992-03-05 | 1993-09-28 | Honda Motor Co Ltd | 電源装置 |
-
1993
- 1993-08-18 GB GB9317213A patent/GB2282384B8/en not_active Expired - Fee Related
-
1994
- 1994-08-17 ES ES94923825T patent/ES2145832T3/es not_active Expired - Lifetime
- 1994-08-17 PT PT94923825T patent/PT804246E/pt unknown
- 1994-08-17 DE DE69424577T patent/DE69424577T2/de not_active Expired - Fee Related
- 1994-08-17 DK DK94923825T patent/DK0804246T3/da active
- 1994-08-17 US US08/602,733 patent/US5738864A/en not_active Expired - Fee Related
- 1994-08-17 CA CA002168007A patent/CA2168007C/en not_active Expired - Fee Related
- 1994-08-17 AT AT94923825T patent/ATE192933T1/de not_active IP Right Cessation
- 1994-08-17 EP EP94923825A patent/EP0804246B1/de not_active Expired - Lifetime
- 1994-08-17 WO PCT/IB1994/000259 patent/WO1995005200A1/en active IP Right Grant
- 1994-08-17 JP JP7506852A patent/JPH09501674A/ja active Pending
-
2000
- 2000-08-10 GR GR20000401869T patent/GR3034174T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB2282384B8 (en) | 1997-09-04 |
CA2168007A1 (en) | 1995-02-23 |
CA2168007C (en) | 2001-06-12 |
US5738864A (en) | 1998-04-14 |
ES2145832T3 (es) | 2000-07-16 |
GB2282384A (en) | 1995-04-05 |
DE69424577T2 (de) | 2001-02-22 |
GB9317213D0 (en) | 1993-10-06 |
GB2282384B (en) | 1997-09-03 |
PT804246E (pt) | 2000-08-31 |
EP0804246B1 (de) | 2000-05-17 |
WO1995005200A1 (en) | 1995-02-23 |
EP0804246A1 (de) | 1997-11-05 |
GR3034174T3 (en) | 2000-11-30 |
ATE192933T1 (de) | 2000-06-15 |
JPH09501674A (ja) | 1997-02-18 |
DK0804246T3 (da) | 2000-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: ZEITLER, VOLPERT, KANDLBINDER, 80539 MUENCHEN |
|
8339 | Ceased/non-payment of the annual fee |